High production of interleukin-10 and interferon-γ in influenza-associated MERS in the early phase.
Identifieur interne : 000981 ( Ncbi/Checkpoint ); précédent : 000980; suivant : 000982High production of interleukin-10 and interferon-γ in influenza-associated MERS in the early phase.
Auteurs : Shinichiro Morichi [Japon] ; Hisashi Kawashima ; Hiroaki Ioi ; Gaku Yamanaka ; Yasuyo Kashiwagi ; Akinori HoshikaSource :
- Pediatrics international : official journal of the Japan Pediatric Society [ 1442-200X ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
- biosynthèse : Interféron gamma, Interleukine-10.
- métabolisme : Encéphalite virale, Grippe humaine, Maladies de la rate.
- virologie : Maladies de la rate.
- Enfant, Facteurs temps, Grippe humaine, Humains, Mâle.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Interferon-gamma, Interleukin-10.
- complications : Influenza, Human.
- metabolism : Encephalitis, Viral, Influenza, Human, Splenic Diseases.
- virology : Splenic Diseases.
- Child, Humans, Male, Time Factors.
Abstract
Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza-associated encephalopathy. There was no elevation of Interleukin (IL)-1β, which induces convulsion. The inhibitory cytokines of IL-10 and IFN-γ were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL-10 and IFN-γ might work to localize the lesion and to prevent sequelae.
DOI: 10.1111/j.1442-200X.2011.03483.x
PubMed: 22830540
Affiliations:
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last="Ioi">Hiroaki Ioi</name></author><author><name sortKey="Yamanaka, Gaku" sort="Yamanaka, Gaku" uniqKey="Yamanaka G" first="Gaku" last="Yamanaka">Gaku Yamanaka</name></author><author><name sortKey="Kashiwagi, Yasuyo" sort="Kashiwagi, Yasuyo" uniqKey="Kashiwagi Y" first="Yasuyo" last="Kashiwagi">Yasuyo Kashiwagi</name></author><author><name sortKey="Hoshika, Akinori" sort="Hoshika, Akinori" uniqKey="Hoshika A" first="Akinori" last="Hoshika">Akinori Hoshika</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22830540</idno><idno type="pmid">22830540</idno><idno type="doi">10.1111/j.1442-200X.2011.03483.x</idno><idno type="wicri:Area/PubMed/Corpus">001D62</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001D62</idno><idno type="wicri:Area/PubMed/Curation">001D62</idno><idno type="wicri:explorRef" wicri:stream="PubMed" 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type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kawashima, Hisashi" sort="Kawashima, Hisashi" uniqKey="Kawashima H" first="Hisashi" last="Kawashima">Hisashi Kawashima</name></author><author><name sortKey="Ioi, Hiroaki" sort="Ioi, Hiroaki" uniqKey="Ioi H" first="Hiroaki" last="Ioi">Hiroaki Ioi</name></author><author><name sortKey="Yamanaka, Gaku" sort="Yamanaka, Gaku" uniqKey="Yamanaka G" first="Gaku" last="Yamanaka">Gaku Yamanaka</name></author><author><name sortKey="Kashiwagi, Yasuyo" sort="Kashiwagi, Yasuyo" uniqKey="Kashiwagi Y" first="Yasuyo" last="Kashiwagi">Yasuyo Kashiwagi</name></author><author><name sortKey="Hoshika, Akinori" sort="Hoshika, Akinori" uniqKey="Hoshika A" first="Akinori" last="Hoshika">Akinori Hoshika</name></author></analytic><series><title level="j">Pediatrics international : official journal of the Japan Pediatric Society</title><idno type="eISSN">1442-200X</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term><term>Encephalitis, Viral (metabolism)</term><term>Humans</term><term>Influenza, Human (complications)</term><term>Influenza, Human (metabolism)</term><term>Interferon-gamma (biosynthesis)</term><term>Interleukin-10 (biosynthesis)</term><term>Male</term><term>Splenic Diseases (metabolism)</term><term>Splenic Diseases (virology)</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Encéphalite virale (métabolisme)</term><term>Enfant</term><term>Facteurs temps</term><term>Grippe humaine ()</term><term>Grippe humaine (métabolisme)</term><term>Humains</term><term>Interféron gamma (biosynthèse)</term><term>Interleukine-10 (biosynthèse)</term><term>Maladies de la rate (métabolisme)</term><term>Maladies de la rate (virologie)</term><term>Mâle</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interferon-gamma</term><term>Interleukin-10</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interféron gamma</term><term>Interleukine-10</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Encephalitis, Viral</term><term>Influenza, Human</term><term>Splenic Diseases</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Encéphalite virale</term><term>Grippe humaine</term><term>Maladies de la rate</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Maladies de la rate</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Splenic Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Humans</term><term>Male</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Enfant</term><term>Facteurs temps</term><term>Grippe humaine</term><term>Humains</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza-associated encephalopathy. There was no elevation of Interleukin (IL)-1β, which induces convulsion. The inhibitory cytokines of IL-10 and IFN-γ were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL-10 and IFN-γ might work to localize the lesion and to prevent sequelae.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Hoshika, Akinori" sort="Hoshika, Akinori" uniqKey="Hoshika A" first="Akinori" last="Hoshika">Akinori Hoshika</name><name sortKey="Ioi, Hiroaki" sort="Ioi, Hiroaki" uniqKey="Ioi H" first="Hiroaki" last="Ioi">Hiroaki Ioi</name><name sortKey="Kashiwagi, Yasuyo" sort="Kashiwagi, Yasuyo" uniqKey="Kashiwagi Y" first="Yasuyo" last="Kashiwagi">Yasuyo Kashiwagi</name><name sortKey="Kawashima, Hisashi" sort="Kawashima, Hisashi" uniqKey="Kawashima H" first="Hisashi" last="Kawashima">Hisashi Kawashima</name><name sortKey="Yamanaka, Gaku" sort="Yamanaka, Gaku" uniqKey="Yamanaka G" first="Gaku" last="Yamanaka">Gaku Yamanaka</name></noCountry><country name="Japon"><region name="Région de Kantō"><name sortKey="Morichi, Shinichiro" sort="Morichi, Shinichiro" uniqKey="Morichi S" first="Shinichiro" last="Morichi">Shinichiro Morichi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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