A highly efficient and effective motif discovery method for ChIP-seq/ChIP-chip data using positional information
Identifieur interne : 000918 ( Ncbi/Checkpoint ); précédent : 000917; suivant : 000919A highly efficient and effective motif discovery method for ChIP-seq/ChIP-chip data using positional information
Auteurs : Xiaotu Ma ; Ashwinikumar Kulkarni ; Zhihua Zhang ; Zhenyu Xuan ; Robert Serfling [États-Unis] ; Michael Q. Zhang [République populaire de Chine]Source :
- Nucleic Acids Research [ 0305-1048 ] ; 2011.
Descripteurs français
- KwdFr :
- Algorithmes, Analyse de regroupements, Analyse de séquence d'ADN, Animaux, Cellules souches embryonnaires (métabolisme), Drosophila melanogaster (génétique), Facteurs de transcription (métabolisme), Immunoprécipitation de la chromatine, Logiciel, Motifs nucléotidiques, Protéines de répression, Réseaux de régulation génique, Simulation numérique, Sites de fixation, Souris, Séquençage nucléotidique à haut débit, Séquençage par oligonucléotides en batterie, Éléments de régulation transcriptionnelle.
- MESH :
- génétique : Drosophila melanogaster.
- métabolisme : Cellules souches embryonnaires, Facteurs de transcription.
- Algorithmes, Analyse de regroupements, Analyse de séquence d'ADN, Animaux, Immunoprécipitation de la chromatine, Logiciel, Motifs nucléotidiques, Protéines de répression, Réseaux de régulation génique, Simulation numérique, Sites de fixation, Souris, Séquençage nucléotidique à haut débit, Séquençage par oligonucléotides en batterie, Éléments de régulation transcriptionnelle.
English descriptors
- KwdEn :
- Algorithms, Animals, Binding Sites, CCCTC-Binding Factor, Chromatin Immunoprecipitation, Cluster Analysis, Computer Simulation, Drosophila melanogaster (genetics), Embryonic Stem Cells (metabolism), Gene Regulatory Networks, High-Throughput Nucleotide Sequencing, Mice, Nucleotide Motifs, Oligonucleotide Array Sequence Analysis, Regulatory Elements, Transcriptional, Repressor Proteins, Sequence Analysis, DNA, Software, Transcription Factors (metabolism).
- MESH :
- chemical , metabolism : Transcription Factors.
- chemical : CCCTC-Binding Factor, Repressor Proteins.
- genetics : Drosophila melanogaster.
- metabolism : Embryonic Stem Cells.
- Algorithms, Animals, Binding Sites, Chromatin Immunoprecipitation, Cluster Analysis, Computer Simulation, Gene Regulatory Networks, High-Throughput Nucleotide Sequencing, Mice, Nucleotide Motifs, Oligonucleotide Array Sequence Analysis, Regulatory Elements, Transcriptional, Sequence Analysis, DNA, Software.
Abstract
Identification of DNA motifs from ChIP-seq/ChIP-chip [chromatin immunoprecipitation (ChIP)] data is a powerful method for understanding the transcriptional regulatory network. However, most established methods are designed for small sample sizes and are inefficient for ChIP data. Here we propose a new
Url:
DOI: 10.1093/nar/gkr1135
PubMed: 22228832
PubMed Central: 3326300
Affiliations:
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PMC:3326300Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Identification of DNA motifs from ChIP-seq/ChIP-chip [chromatin immunoprecipitation (ChIP)] data is a powerful method for understanding the transcriptional regulatory network. However, most established methods are designed for small sample sizes and are inefficient for ChIP data. Here we propose a new <italic>k-</italic>
mer occurrence model to reflect the fact that functional DNA <italic>k</italic>
-mers often cluster around ChIP peak summits. With this model, we introduced a new measure to discover functional <italic>k-</italic>
mers. Using simulation, we demonstrated that our method is more robust against noises in ChIP data than available methods. A novel word clustering method is also implemented to group similar <italic>k</italic>
-mers into position weight matrices (PWMs). Our method was applied to a diverse set of ChIP experiments to demonstrate its high sensitivity and specificity. Importantly, our method is much faster than several other methods for large sample sizes. Thus, we have developed an efficient and effective motif discovery method for ChIP experiments.</p>
</div>
</front>
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<author><name sortKey="Li, N" uniqKey="Li N">N Li</name>
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<author><name sortKey="Church, Gm" uniqKey="Church G">GM Church</name>
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<author><name sortKey="De Moor, B" uniqKey="De Moor B">B De Moor</name>
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</author>
<author><name sortKey="Fu, Y" uniqKey="Fu Y">Y Fu</name>
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</author>
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</author>
<author><name sortKey="Teichmann, Sa" uniqKey="Teichmann S">SA Teichmann</name>
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<author><name sortKey="Thongjuea, S" uniqKey="Thongjuea S">S Thongjuea</name>
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</author>
<author><name sortKey="Arenillas, D" uniqKey="Arenillas D">D Arenillas</name>
</author>
<author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name>
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<author><name sortKey="Valen, E" uniqKey="Valen E">E Valen</name>
</author>
<author><name sortKey="Yusuf, D" uniqKey="Yusuf D">D Yusuf</name>
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</author>
<author><name sortKey="Lu, Zj" uniqKey="Lu Z">ZJ Lu</name>
</author>
<author><name sortKey="Van Nostrand, El" uniqKey="Van Nostrand E">EL Van Nostrand</name>
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<author><name sortKey="Cheng, C" uniqKey="Cheng C">C Cheng</name>
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<author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name>
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<author><name sortKey="Yip, Ky" uniqKey="Yip K">KY Yip</name>
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<author><name sortKey="Robilotto, R" uniqKey="Robilotto R">R Robilotto</name>
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</author>
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</author>
<author><name sortKey="Ernst, J" uniqKey="Ernst J">J Ernst</name>
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<author><name sortKey="Kharchenko, Pv" uniqKey="Kharchenko P">PV Kharchenko</name>
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<author><name sortKey="Kheradpour, P" uniqKey="Kheradpour P">P Kheradpour</name>
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<author><name sortKey="Eaton, Ml" uniqKey="Eaton M">ML Eaton</name>
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</author>
<author><name sortKey="Ma, L" uniqKey="Ma L">L Ma</name>
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<author><name sortKey="Lin, Mf" uniqKey="Lin M">MF Lin</name>
</author>
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<biblStruct><analytic><author><name sortKey="Jothi, R" uniqKey="Jothi R">R Jothi</name>
</author>
<author><name sortKey="Cuddapah, S" uniqKey="Cuddapah S">S Cuddapah</name>
</author>
<author><name sortKey="Barski, A" uniqKey="Barski A">A Barski</name>
</author>
<author><name sortKey="Cui, K" uniqKey="Cui K">K Cui</name>
</author>
<author><name sortKey="Zhao, K" uniqKey="Zhao K">K Zhao</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Bailey, Tl" uniqKey="Bailey T">TL Bailey</name>
</author>
<author><name sortKey="Elkan, C" uniqKey="Elkan C">C Elkan</name>
</author>
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<biblStruct><analytic><author><name sortKey="Zhang, Mq" uniqKey="Zhang M">MQ Zhang</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Buhler, J" uniqKey="Buhler J">J Buhler</name>
</author>
<author><name sortKey="Tompa, M" uniqKey="Tompa M">M Tompa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eskin, E" uniqKey="Eskin E">E Eskin</name>
</author>
<author><name sortKey="Pevzner, Pa" uniqKey="Pevzner P">PA Pevzner</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Ettwiller, L" uniqKey="Ettwiller L">L Ettwiller</name>
</author>
<author><name sortKey="Paten, B" uniqKey="Paten B">B Paten</name>
</author>
<author><name sortKey="Ramialison, M" uniqKey="Ramialison M">M Ramialison</name>
</author>
<author><name sortKey="Birney, E" uniqKey="Birney E">E Birney</name>
</author>
<author><name sortKey="Wittbrodt, J" uniqKey="Wittbrodt J">J Wittbrodt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fratkin, E" uniqKey="Fratkin E">E Fratkin</name>
</author>
<author><name sortKey="Naughton, Bt" uniqKey="Naughton B">BT Naughton</name>
</author>
<author><name sortKey="Brutlag, Dl" uniqKey="Brutlag D">DL Brutlag</name>
</author>
<author><name sortKey="Batzoglou, S" uniqKey="Batzoglou S">S Batzoglou</name>
</author>
</analytic>
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</author>
<author><name sortKey="Altschul, Sf" uniqKey="Altschul S">SF Altschul</name>
</author>
<author><name sortKey="Boguski, Ms" uniqKey="Boguski M">MS Boguski</name>
</author>
<author><name sortKey="Liu, Js" uniqKey="Liu J">JS Liu</name>
</author>
<author><name sortKey="Neuwald, Af" uniqKey="Neuwald A">AF Neuwald</name>
</author>
<author><name sortKey="Wootton, Jc" uniqKey="Wootton J">JC Wootton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Xs" uniqKey="Liu X">XS Liu</name>
</author>
<author><name sortKey="Brutlag, Dl" uniqKey="Brutlag D">DL Brutlag</name>
</author>
<author><name sortKey="Liu, Js" uniqKey="Liu J">JS Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marsan, L" uniqKey="Marsan L">L Marsan</name>
</author>
<author><name sortKey="Sagot, Mf" uniqKey="Sagot M">MF Sagot</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pavesi, G" uniqKey="Pavesi G">G Pavesi</name>
</author>
<author><name sortKey="Mereghetti, P" uniqKey="Mereghetti P">P Mereghetti</name>
</author>
<author><name sortKey="Mauri, G" uniqKey="Mauri G">G Mauri</name>
</author>
<author><name sortKey="Pesole, G" uniqKey="Pesole G">G Pesole</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roth, Fp" uniqKey="Roth F">FP Roth</name>
</author>
<author><name sortKey="Hughes, Jd" uniqKey="Hughes J">JD Hughes</name>
</author>
<author><name sortKey="Estep, Pw" uniqKey="Estep P">PW Estep</name>
</author>
<author><name sortKey="Church, Gm" uniqKey="Church G">GM Church</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vardhanabhuti, S" uniqKey="Vardhanabhuti S">S Vardhanabhuti</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Hannenhalli, S" uniqKey="Hannenhalli S">S Hannenhalli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Linhart, C" uniqKey="Linhart C">C Linhart</name>
</author>
<author><name sortKey="Halperin, Y" uniqKey="Halperin Y">Y Halperin</name>
</author>
<author><name sortKey="Shamir, R" uniqKey="Shamir R">R Shamir</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Nk" uniqKey="Kim N">NK Kim</name>
</author>
<author><name sortKey="Tharakaraman, K" uniqKey="Tharakaraman K">K Tharakaraman</name>
</author>
<author><name sortKey="Marino Ramirez, L" uniqKey="Marino Ramirez L">L Marino-Ramirez</name>
</author>
<author><name sortKey="Spouge, Jl" uniqKey="Spouge J">JL Spouge</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Narang, V" uniqKey="Narang V">V Narang</name>
</author>
<author><name sortKey="Mittal, A" uniqKey="Mittal A">A Mittal</name>
</author>
<author><name sortKey="Sung, Wk" uniqKey="Sung W">WK Sung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Keilwagen, J" uniqKey="Keilwagen J">J Keilwagen</name>
</author>
<author><name sortKey="Grau, J" uniqKey="Grau J">J Grau</name>
</author>
<author><name sortKey="Paponov, Ia" uniqKey="Paponov I">IA Paponov</name>
</author>
<author><name sortKey="Posch, S" uniqKey="Posch S">S Posch</name>
</author>
<author><name sortKey="Strickert, M" uniqKey="Strickert M">M Strickert</name>
</author>
<author><name sortKey="Grosse, I" uniqKey="Grosse I">I Grosse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hu, M" uniqKey="Hu M">M Hu</name>
</author>
<author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name>
</author>
<author><name sortKey="Taylor, Jm" uniqKey="Taylor J">JM Taylor</name>
</author>
<author><name sortKey="Chinnaiyan, Am" uniqKey="Chinnaiyan A">AM Chinnaiyan</name>
</author>
<author><name sortKey="Qin, Zs" uniqKey="Qin Z">ZS Qin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kulakovskiy, Iv" uniqKey="Kulakovskiy I">IV Kulakovskiy</name>
</author>
<author><name sortKey="Boeva, Va" uniqKey="Boeva V">VA Boeva</name>
</author>
<author><name sortKey="Favorov, Av" uniqKey="Favorov A">AV Favorov</name>
</author>
<author><name sortKey="Makeev, Vj" uniqKey="Makeev V">VJ Makeev</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schmid, Cd" uniqKey="Schmid C">CD Schmid</name>
</author>
<author><name sortKey="Bucher, P" uniqKey="Bucher P">P Bucher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ji, H" uniqKey="Ji H">H Ji</name>
</author>
<author><name sortKey="Jiang, H" uniqKey="Jiang H">H Jiang</name>
</author>
<author><name sortKey="Ma, W" uniqKey="Ma W">W Ma</name>
</author>
<author><name sortKey="Johnson, Ds" uniqKey="Johnson D">DS Johnson</name>
</author>
<author><name sortKey="Myers, Rm" uniqKey="Myers R">RM Myers</name>
</author>
<author><name sortKey="Wong, Wh" uniqKey="Wong W">WH Wong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corbo, Jc" uniqKey="Corbo J">JC Corbo</name>
</author>
<author><name sortKey="Lawrence, Ka" uniqKey="Lawrence K">KA Lawrence</name>
</author>
<author><name sortKey="Karlstetter, M" uniqKey="Karlstetter M">M Karlstetter</name>
</author>
<author><name sortKey="Myers, Ca" uniqKey="Myers C">CA Myers</name>
</author>
<author><name sortKey="Abdelaziz, M" uniqKey="Abdelaziz M">M Abdelaziz</name>
</author>
<author><name sortKey="Dirkes, W" uniqKey="Dirkes W">W Dirkes</name>
</author>
<author><name sortKey="Weigelt, K" uniqKey="Weigelt K">K Weigelt</name>
</author>
<author><name sortKey="Seifert, M" uniqKey="Seifert M">M Seifert</name>
</author>
<author><name sortKey="Benes, V" uniqKey="Benes V">V Benes</name>
</author>
<author><name sortKey="Fritsche, Lg" uniqKey="Fritsche L">LG Fritsche</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Robertson, G" uniqKey="Robertson G">G Robertson</name>
</author>
<author><name sortKey="Hirst, M" uniqKey="Hirst M">M Hirst</name>
</author>
<author><name sortKey="Bainbridge, M" uniqKey="Bainbridge M">M Bainbridge</name>
</author>
<author><name sortKey="Bilenky, M" uniqKey="Bilenky M">M Bilenky</name>
</author>
<author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name>
</author>
<author><name sortKey="Zeng, T" uniqKey="Zeng T">T Zeng</name>
</author>
<author><name sortKey="Euskirchen, G" uniqKey="Euskirchen G">G Euskirchen</name>
</author>
<author><name sortKey="Bernier, B" uniqKey="Bernier B">B Bernier</name>
</author>
<author><name sortKey="Varhol, R" uniqKey="Varhol R">R Varhol</name>
</author>
<author><name sortKey="Delaney, A" uniqKey="Delaney A">A Delaney</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barski, A" uniqKey="Barski A">A Barski</name>
</author>
<author><name sortKey="Cuddapah, S" uniqKey="Cuddapah S">S Cuddapah</name>
</author>
<author><name sortKey="Cui, K" uniqKey="Cui K">K Cui</name>
</author>
<author><name sortKey="Roh, Ty" uniqKey="Roh T">TY Roh</name>
</author>
<author><name sortKey="Schones, De" uniqKey="Schones D">DE Schones</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Wei, G" uniqKey="Wei G">G Wei</name>
</author>
<author><name sortKey="Chepelev, I" uniqKey="Chepelev I">I Chepelev</name>
</author>
<author><name sortKey="Zhao, K" uniqKey="Zhao K">K Zhao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johnson, Ds" uniqKey="Johnson D">DS Johnson</name>
</author>
<author><name sortKey="Mortazavi, A" uniqKey="Mortazavi A">A Mortazavi</name>
</author>
<author><name sortKey="Myers, Rm" uniqKey="Myers R">RM Myers</name>
</author>
<author><name sortKey="Wold, B" uniqKey="Wold B">B Wold</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wederell, Ed" uniqKey="Wederell E">ED Wederell</name>
</author>
<author><name sortKey="Bilenky, M" uniqKey="Bilenky M">M Bilenky</name>
</author>
<author><name sortKey="Cullum, R" uniqKey="Cullum R">R Cullum</name>
</author>
<author><name sortKey="Thiessen, N" uniqKey="Thiessen N">N Thiessen</name>
</author>
<author><name sortKey="Dagpinar, M" uniqKey="Dagpinar M">M Dagpinar</name>
</author>
<author><name sortKey="Delaney, A" uniqKey="Delaney A">A Delaney</name>
</author>
<author><name sortKey="Varhol, R" uniqKey="Varhol R">R Varhol</name>
</author>
<author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name>
</author>
<author><name sortKey="Zeng, T" uniqKey="Zeng T">T Zeng</name>
</author>
<author><name sortKey="Bernier, B" uniqKey="Bernier B">B Bernier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Th" uniqKey="Kim T">TH Kim</name>
</author>
<author><name sortKey="Abdullaev, Zk" uniqKey="Abdullaev Z">ZK Abdullaev</name>
</author>
<author><name sortKey="Smith, Ad" uniqKey="Smith A">AD Smith</name>
</author>
<author><name sortKey="Ching, Ka" uniqKey="Ching K">KA Ching</name>
</author>
<author><name sortKey="Loukinov, Di" uniqKey="Loukinov D">DI Loukinov</name>
</author>
<author><name sortKey="Green, Rd" uniqKey="Green R">RD Green</name>
</author>
<author><name sortKey="Zhang, Mq" uniqKey="Zhang M">MQ Zhang</name>
</author>
<author><name sortKey="Lobanenkov, Vv" uniqKey="Lobanenkov V">VV Lobanenkov</name>
</author>
<author><name sortKey="Ren, B" uniqKey="Ren B">B Ren</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bradley, Rk" uniqKey="Bradley R">RK Bradley</name>
</author>
<author><name sortKey="Li, Xy" uniqKey="Li X">XY Li</name>
</author>
<author><name sortKey="Trapnell, C" uniqKey="Trapnell C">C Trapnell</name>
</author>
<author><name sortKey="Davidson, S" uniqKey="Davidson S">S Davidson</name>
</author>
<author><name sortKey="Pachter, L" uniqKey="Pachter L">L Pachter</name>
</author>
<author><name sortKey="Chu, Hc" uniqKey="Chu H">HC Chu</name>
</author>
<author><name sortKey="Tonkin, La" uniqKey="Tonkin L">LA Tonkin</name>
</author>
<author><name sortKey="Biggin, Md" uniqKey="Biggin M">MD Biggin</name>
</author>
<author><name sortKey="Eisen, Mb" uniqKey="Eisen M">MB Eisen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name>
</author>
<author><name sortKey="Xu, H" uniqKey="Xu H">H Xu</name>
</author>
<author><name sortKey="Yuan, P" uniqKey="Yuan P">P Yuan</name>
</author>
<author><name sortKey="Fang, F" uniqKey="Fang F">F Fang</name>
</author>
<author><name sortKey="Huss, M" uniqKey="Huss M">M Huss</name>
</author>
<author><name sortKey="Vega, Vb" uniqKey="Vega V">VB Vega</name>
</author>
<author><name sortKey="Wong, E" uniqKey="Wong E">E Wong</name>
</author>
<author><name sortKey="Orlov, Yl" uniqKey="Orlov Y">YL Orlov</name>
</author>
<author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name>
</author>
<author><name sortKey="Jiang, J" uniqKey="Jiang J">J Jiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name>
</author>
<author><name sortKey="Meyer, Ca" uniqKey="Meyer C">CA Meyer</name>
</author>
<author><name sortKey="Eeckhoute, J" uniqKey="Eeckhoute J">J Eeckhoute</name>
</author>
<author><name sortKey="Johnson, Ds" uniqKey="Johnson D">DS Johnson</name>
</author>
<author><name sortKey="Bernstein, Be" uniqKey="Bernstein B">BE Bernstein</name>
</author>
<author><name sortKey="Nusbaum, C" uniqKey="Nusbaum C">C Nusbaum</name>
</author>
<author><name sortKey="Myers, Rm" uniqKey="Myers R">RM Myers</name>
</author>
<author><name sortKey="Brown, M" uniqKey="Brown M">M Brown</name>
</author>
<author><name sortKey="Li, W" uniqKey="Li W">W Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wilbanks, Eg" uniqKey="Wilbanks E">EG Wilbanks</name>
</author>
<author><name sortKey="Facciotti, Mt" uniqKey="Facciotti M">MT Facciotti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dean, N" uniqKey="Dean N">N Dean</name>
</author>
<author><name sortKey="Raftery, Ae" uniqKey="Raftery A">AE Raftery</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schones, De" uniqKey="Schones D">DE Schones</name>
</author>
<author><name sortKey="Sumazin, P" uniqKey="Sumazin P">P Sumazin</name>
</author>
<author><name sortKey="Zhang, Mq" uniqKey="Zhang M">MQ Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mahony, S" uniqKey="Mahony S">S Mahony</name>
</author>
<author><name sortKey="Auron, Pe" uniqKey="Auron P">PE Auron</name>
</author>
<author><name sortKey="Benos, Pv" uniqKey="Benos P">PV Benos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Ad" uniqKey="Smith A">AD Smith</name>
</author>
<author><name sortKey="Sumazin, P" uniqKey="Sumazin P">P Sumazin</name>
</author>
<author><name sortKey="Zhang, Mq" uniqKey="Zhang M">MQ Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sinha, S" uniqKey="Sinha S">S Sinha</name>
</author>
<author><name sortKey="Tompa, M" uniqKey="Tompa M">M Tompa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sumazin, P" uniqKey="Sumazin P">P Sumazin</name>
</author>
<author><name sortKey="Chen, G" uniqKey="Chen G">G Chen</name>
</author>
<author><name sortKey="Hata, N" uniqKey="Hata N">N Hata</name>
</author>
<author><name sortKey="Smith, Ad" uniqKey="Smith A">AD Smith</name>
</author>
<author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name>
</author>
<author><name sortKey="Zhang, Mq" uniqKey="Zhang M">MQ Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Valouev, A" uniqKey="Valouev A">A Valouev</name>
</author>
<author><name sortKey="Johnson, Ds" uniqKey="Johnson D">DS Johnson</name>
</author>
<author><name sortKey="Sundquist, A" uniqKey="Sundquist A">A Sundquist</name>
</author>
<author><name sortKey="Medina, C" uniqKey="Medina C">C Medina</name>
</author>
<author><name sortKey="Anton, E" uniqKey="Anton E">E Anton</name>
</author>
<author><name sortKey="Batzoglou, S" uniqKey="Batzoglou S">S Batzoglou</name>
</author>
<author><name sortKey="Myers, Rm" uniqKey="Myers R">RM Myers</name>
</author>
<author><name sortKey="Sidow, A" uniqKey="Sidow A">A Sidow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bailey, Tl" uniqKey="Bailey T">TL Bailey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cao, Ar" uniqKey="Cao A">AR Cao</name>
</author>
<author><name sortKey="Rabinovich, R" uniqKey="Rabinovich R">R Rabinovich</name>
</author>
<author><name sortKey="Xu, M" uniqKey="Xu M">M Xu</name>
</author>
<author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name>
</author>
<author><name sortKey="Jin, Vx" uniqKey="Jin V">VX Jin</name>
</author>
<author><name sortKey="Farnham, Pj" uniqKey="Farnham P">PJ Farnham</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tuteja, G" uniqKey="Tuteja G">G Tuteja</name>
</author>
<author><name sortKey="White, P" uniqKey="White P">P White</name>
</author>
<author><name sortKey="Schug, J" uniqKey="Schug J">J Schug</name>
</author>
<author><name sortKey="Kaestner, Kh" uniqKey="Kaestner K">KH Kaestner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liang, Hl" uniqKey="Liang H">HL Liang</name>
</author>
<author><name sortKey="Nien, Cy" uniqKey="Nien C">CY Nien</name>
</author>
<author><name sortKey="Liu, Hy" uniqKey="Liu H">HY Liu</name>
</author>
<author><name sortKey="Metzstein, Mm" uniqKey="Metzstein M">MM Metzstein</name>
</author>
<author><name sortKey="Kirov, N" uniqKey="Kirov N">N Kirov</name>
</author>
<author><name sortKey="Rushlow, C" uniqKey="Rushlow C">C Rushlow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wei, Gh" uniqKey="Wei G">GH Wei</name>
</author>
<author><name sortKey="Badis, G" uniqKey="Badis G">G Badis</name>
</author>
<author><name sortKey="Berger, Mf" uniqKey="Berger M">MF Berger</name>
</author>
<author><name sortKey="Kivioja, T" uniqKey="Kivioja T">T Kivioja</name>
</author>
<author><name sortKey="Palin, K" uniqKey="Palin K">K Palin</name>
</author>
<author><name sortKey="Enge, M" uniqKey="Enge M">M Enge</name>
</author>
<author><name sortKey="Bonke, M" uniqKey="Bonke M">M Bonke</name>
</author>
<author><name sortKey="Jolma, A" uniqKey="Jolma A">A Jolma</name>
</author>
<author><name sortKey="Varjosalo, M" uniqKey="Varjosalo M">M Varjosalo</name>
</author>
<author><name sortKey="Gehrke, Ar" uniqKey="Gehrke A">AR Gehrke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Berger, Mf" uniqKey="Berger M">MF Berger</name>
</author>
<author><name sortKey="Philippakis, Aa" uniqKey="Philippakis A">AA Philippakis</name>
</author>
<author><name sortKey="Qureshi, Am" uniqKey="Qureshi A">AM Qureshi</name>
</author>
<author><name sortKey="He, Fs" uniqKey="He F">FS He</name>
</author>
<author><name sortKey="Estep, Pw" uniqKey="Estep P">PW Estep</name>
</author>
<author><name sortKey="Bulyk, Ml" uniqKey="Bulyk M">ML Bulyk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Whitington, T" uniqKey="Whitington T">T Whitington</name>
</author>
<author><name sortKey="Frith, Mc" uniqKey="Frith M">MC Frith</name>
</author>
<author><name sortKey="Johnson, J" uniqKey="Johnson J">J Johnson</name>
</author>
<author><name sortKey="Bailey, Tl" uniqKey="Bailey T">TL Bailey</name>
</author>
</analytic>
</biblStruct>
</listBibl>
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<name sortKey="Ma, Xiaotu" sort="Ma, Xiaotu" uniqKey="Ma X" first="Xiaotu" last="Ma">Xiaotu Ma</name>
<name sortKey="Xuan, Zhenyu" sort="Xuan, Zhenyu" uniqKey="Xuan Z" first="Zhenyu" last="Xuan">Zhenyu Xuan</name>
<name sortKey="Zhang, Zhihua" sort="Zhang, Zhihua" uniqKey="Zhang Z" first="Zhihua" last="Zhang">Zhihua Zhang</name>
</noCountry>
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</region>
</country>
<country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Michael Q" sort="Zhang, Michael Q" uniqKey="Zhang M" first="Michael Q." last="Zhang">Michael Q. Zhang</name>
</noRegion>
</country>
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