Distribution of hepatitis B virus DNA sequences in different peripheral blood mononuclear cell subsets in HBs antigen‐positive and negative patients
Identifieur interne : 004522 ( Main/Merge ); précédent : 004521; suivant : 004523Distribution of hepatitis B virus DNA sequences in different peripheral blood mononuclear cell subsets in HBs antigen‐positive and negative patients
Auteurs : Y. Calmus [France] ; P. Marcellin ; G. Beaurain [France] ; L. Chatenoud [France] ; C. Bréchot [France]Source :
- European Journal of Clinical Investigation [ 0014-2972 ] ; 1994-08.
Abstract
Abstract. Hepatitis B virus (HBV) DNA sequences have been detected in leucocytes from HBV‐infected individuals. The aim of this study was to assess the specificity of HBV for a special leucocyte subset in nine healthy chronic HBV carriers, nine HBs antigen‐positive patients with chronic active hepatitis, 16 HBs antigen‐negative haemophiliacs with HBc and/or HBs antibodies, and 10 patients with HBV‐related systemic necrotizing vasculitis. HBV‐DNA sequences were found by Southern blot hybridization in the leucocytes of 15 out of the 44 (34%) patients. The prevalence was not significantly different between the four groups. HBV‐DNA was found in the CD4+ cells (9/11) as well as in the CD8+ cells (4/11), B cells (4/12) and monocytes (2/12). In conclusion, leucocytes, and particularly CD4+ lymphocytes, are frequently infected by HBV in patients with HBV serum markers.
Url:
DOI: 10.1111/j.1365-2362.1994.tb01105.x
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<front><div type="abstract" xml:lang="en">Abstract. Hepatitis B virus (HBV) DNA sequences have been detected in leucocytes from HBV‐infected individuals. The aim of this study was to assess the specificity of HBV for a special leucocyte subset in nine healthy chronic HBV carriers, nine HBs antigen‐positive patients with chronic active hepatitis, 16 HBs antigen‐negative haemophiliacs with HBc and/or HBs antibodies, and 10 patients with HBV‐related systemic necrotizing vasculitis. HBV‐DNA sequences were found by Southern blot hybridization in the leucocytes of 15 out of the 44 (34%) patients. The prevalence was not significantly different between the four groups. HBV‐DNA was found in the CD4+ cells (9/11) as well as in the CD8+ cells (4/11), B cells (4/12) and monocytes (2/12). In conclusion, leucocytes, and particularly CD4+ lymphocytes, are frequently infected by HBV in patients with HBV serum markers.</div>
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