Distribution of hepatitis B virus DNA sequences in different peripheral blood mononuclear cell subsets in HBs antigen‐positive and negative patients
Identifieur interne : 000F47 ( Istex/Corpus ); précédent : 000F46; suivant : 000F48Distribution of hepatitis B virus DNA sequences in different peripheral blood mononuclear cell subsets in HBs antigen‐positive and negative patients
Auteurs : Y. Calmus ; P. Marcellin ; G. Beaurain ; L. Chatenoud ; C. BréchotSource :
- European Journal of Clinical Investigation [ 0014-2972 ] ; 1994-08.
Abstract
Abstract. Hepatitis B virus (HBV) DNA sequences have been detected in leucocytes from HBV‐infected individuals. The aim of this study was to assess the specificity of HBV for a special leucocyte subset in nine healthy chronic HBV carriers, nine HBs antigen‐positive patients with chronic active hepatitis, 16 HBs antigen‐negative haemophiliacs with HBc and/or HBs antibodies, and 10 patients with HBV‐related systemic necrotizing vasculitis. HBV‐DNA sequences were found by Southern blot hybridization in the leucocytes of 15 out of the 44 (34%) patients. The prevalence was not significantly different between the four groups. HBV‐DNA was found in the CD4+ cells (9/11) as well as in the CD8+ cells (4/11), B cells (4/12) and monocytes (2/12). In conclusion, leucocytes, and particularly CD4+ lymphocytes, are frequently infected by HBV in patients with HBV serum markers.
Url:
DOI: 10.1111/j.1365-2362.1994.tb01105.x
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Bréchot</name><affiliation><mods:affiliation>§INSERM U‐75, Faculté de Médecine Necker, Paris, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">European Journal of Clinical Investigation</title><title level="j" type="alt">EUROPEAN JOURNAL OF CLINICAL INVESTIGATION</title><idno type="ISSN">0014-2972</idno><idno type="eISSN">1365-2362</idno><imprint><biblScope unit="vol">24</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="548">548</biblScope><biblScope unit="page" to="552">552</biblScope><biblScope unit="page-count">5</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1994-08">1994-08</date></imprint><idno type="ISSN">0014-2972</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-2972</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract. Hepatitis B virus (HBV) DNA sequences have been detected in leucocytes from HBV‐infected individuals. The aim of this study was to assess the specificity of HBV for a special leucocyte subset in nine healthy chronic HBV carriers, nine HBs antigen‐positive patients with chronic active hepatitis, 16 HBs antigen‐negative haemophiliacs with HBc and/or HBs antibodies, and 10 patients with HBV‐related systemic necrotizing vasculitis. HBV‐DNA sequences were found by Southern blot hybridization in the leucocytes of 15 out of the 44 (34%) patients. The prevalence was not significantly different between the four groups. HBV‐DNA was found in the CD4+ cells (9/11) as well as in the CD8+ cells (4/11), B cells (4/12) and monocytes (2/12). In conclusion, leucocytes, and particularly CD4+ lymphocytes, are frequently infected by HBV in patients with HBV serum markers.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>pbmc</json:string><json:string>lymphocyte</json:string><json:string>monocyte</json:string><json:string>vasculitis</json:string><json:string>subset</json:string><json:string>mononuclear</json:string><json:string>mononuclear cell</json:string><json:string>leucocyte</json:string><json:string>haemophiliac</json:string><json:string>immune</json:string><json:string>virol</json:string><json:string>viral</json:string><json:string>hybridization</json:string><json:string>chronic hepatitis</json:string><json:string>replication</json:string><json:string>hepatitis</json:string><json:string>peripheral blood mononuclear cell</json:string><json:string>monocyte fraction</json:string><json:string>virus infection</json:string><json:string>systemic necrotizing vasculitis</json:string><json:string>cell fraction</json:string><json:string>chronic liver disease</json:string><json:string>negative patient</json:string><json:string>mononuclear blood cell</json:string><json:string>fetal calf serum</json:string><json:string>chronic active hepatitis</json:string><json:string>laboratoire faculte</json:string><json:string>immunodeficiency syndrome</json:string><json:string>chronic carrier</json:string><json:string>serum marker</json:string><json:string>medecine necker</json:string><json:string>interface ring</json:string><json:string>blood cell</json:string><json:string>immune abnormality</json:string><json:string>petri dish</json:string><json:string>human immunodeficiency virus</json:string><json:string>cell suspension</json:string><json:string>fluorescence microscope</json:string><json:string>peripheral blood lymphocyte</json:string><json:string>different cell fraction</json:string><json:string>standard kit</json:string><json:string>replication marker</json:string><json:string>intermediate replicative form</json:string><json:string>bone marrow</json:string><json:string>viral genome</json:string><json:string>immune complex</json:string><json:string>liver transplantation</json:string><json:string>asymptomatic hbsag carrier</json:string><json:string>extrahepatic site</json:string><json:string>monoclonal antibody</json:string></teeft></keywords><author><json:item><name>Y. CALMUS</name><affiliations><json:string>*Laboratoire d'Immunologie, Faculté de Médecine Cochin‐Port‐Royal, Paris</json:string><json:string>Correspondence address: Service du Pr Chapuis, Hôpital Cochin, 27, rue du Faubourg Saint‐Jacques, 75014 Paris, France.</json:string></affiliations></json:item><json:item><name>P. MARCELLIN</name><affiliations><json:string>†Service d'Hépatologie, Hôpital Beaujon, Clichy</json:string></affiliations></json:item><json:item><name>G. BEAURAIN</name><affiliations><json:string>‡Laboratoire d'Immunologie, Faculté de Médecine Necker, Paris</json:string></affiliations></json:item><json:item><name>L. CHATENOUD</name><affiliations><json:string>‡Laboratoire d'Immunologie, Faculté de Médecine Necker, Paris</json:string></affiliations></json:item><json:item><name>C. 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The aim of this study was to assess the specificity of HBV for a special leucocyte subset in nine healthy chronic HBV carriers, nine HBs antigen‐positive patients with chronic active hepatitis, 16 HBs antigen‐negative haemophiliacs with HBc and/or HBs antibodies, and 10 patients with HBV‐related systemic necrotizing vasculitis. HBV‐DNA sequences were found by Southern blot hybridization in the leucocytes of 15 out of the 44 (34%) patients. The prevalence was not significantly different between the four groups. HBV‐DNA was found in the CD4+ cells (9/11) as well as in the CD8+ cells (4/11), B cells (4/12) and monocytes (2/12). 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In conclusion, leucocytes, and particularly CD4+ lymphocytes, are frequently infected by HBV in patients with HBV serum markers.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">Hepatitis B virus</term><term xml:id="k2">human immunodeficiency virus</term><term xml:id="k3">lymphocytes</term><term xml:id="k4">monocytes.</term></keywords><keywords rend="tocHeading1"><term>Original Article</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-WB4FV1P5-J/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1365-2362</doi><issn type="print">0014-2972</issn><issn type="electronic">1365-2362</issn><idGroup><id type="product" value="ECI"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF CLINICAL INVESTIGATION">European Journal of Clinical Investigation</title></titleGroup></publicationMeta><publicationMeta level="part" position="08008"><doi origin="wiley">10.1111/eci.1994.24.issue-8</doi><numberingGroup><numbering type="journalVolume" number="24">24</numbering><numbering type="journalIssue" number="8">8</numbering></numberingGroup><coverDate startDate="1994-08">August 1994</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0054800" status="forIssue"><doi origin="wiley">10.1111/j.1365-2362.1994.tb01105.x</doi><idGroup><id type="unit" value="ECI548"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="tocHeading1">Original Article</title></titleGroup><eventGroup><event type="firstOnline" date="2008-03-20"></event><event type="publishedOnlineFinalForm" date="2008-03-20"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.6 mode:FullText source:HeaderRef result:HeaderRef" date="2010-04-20"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-20"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="548">548</numbering><numbering type="pageLast" number="552">552</numbering></numberingGroup><correspondenceTo>Service du Pr Chapuis, Hôpital Cochin, 27, rue du Faubourg Saint‐Jacques, 75014 Paris, France.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ECI.ECI548.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 14 June 1993 and in revised form 20 January 1994; accepted 24 January 1994</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="28"></count><count type="linksCrossRef" number="6"></count></countGroup><titleGroup><title type="main">Distribution of hepatitis B virus DNA sequences in different peripheral blood mononuclear cell subsets in HBs antigen‐positive and negative patients</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>Y.</givenNames><familyName>CALMUS</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>P.</givenNames><familyName>MARCELLIN</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>G.</givenNames><familyName>BEAURAIN</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a3"><personName><givenNames>L.</givenNames><familyName>CHATENOUD</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a4"><personName><givenNames>C.</givenNames><familyName>BRÉCHOT</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>*Laboratoire d'Immunologie, Faculté de Médecine Cochin‐Port‐Royal, Paris</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>†Service d'Hépatologie, Hôpital Beaujon, Clichy</unparsedAffiliation></affiliation><affiliation xml:id="a3"><unparsedAffiliation>‡Laboratoire d'Immunologie, Faculté de Médecine Necker, Paris</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="FR"><unparsedAffiliation>§INSERM U‐75, Faculté de Médecine Necker, Paris, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Hepatitis B virus</keyword><keyword xml:id="k2">human immunodeficiency virus</keyword><keyword xml:id="k3">lymphocytes</keyword><keyword xml:id="k4">monocytes.</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Abstract. </b> Hepatitis B virus (HBV) DNA sequences have been detected in leucocytes from HBV‐infected individuals. The aim of this study was to assess the specificity of HBV for a special leucocyte subset in nine healthy chronic HBV carriers, nine HBs antigen‐positive patients with chronic active hepatitis, 16 HBs antigen‐negative haemophiliacs with HBc and/or HBs antibodies, and 10 patients with HBV‐related systemic necrotizing vasculitis. HBV‐DNA sequences were found by Southern blot hybridization in the leucocytes of 15 out of the 44 (34%) patients. The prevalence was not significantly different between the four groups. HBV‐DNA was found in the CD4+ cells (9/11) as well as in the CD8+ cells (4/11), B cells (4/12) and monocytes (2/12). In conclusion, leucocytes, and particularly CD4+ lymphocytes, are frequently infected by HBV in patients with HBV serum markers.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Distribution of hepatitis B virus DNA sequences in different peripheral blood mononuclear cell subsets in HBs antigen‐positive and negative patients</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Distribution of hepatitis B virus DNA sequences in different peripheral blood mononuclear cell subsets in HBs antigen‐positive and negative patients</title></titleInfo><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">CALMUS</namePart><affiliation>*Laboratoire d'Immunologie, Faculté de Médecine Cochin‐Port‐Royal, Paris</affiliation><affiliation>Correspondence address: Service du Pr Chapuis, Hôpital Cochin, 27, rue du Faubourg Saint‐Jacques, 75014 Paris, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">MARCELLIN</namePart><affiliation>†Service d'Hépatologie, Hôpital Beaujon, Clichy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">BEAURAIN</namePart><affiliation>‡Laboratoire d'Immunologie, Faculté de Médecine Necker, Paris</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">CHATENOUD</namePart><affiliation>‡Laboratoire d'Immunologie, Faculté de Médecine Necker, Paris</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">BRÉCHOT</namePart><affiliation>§INSERM U‐75, Faculté de Médecine Necker, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1994-08</dateIssued><edition>Received 14 June 1993 and in revised form 20 January 1994; accepted 24 January 1994</edition><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="references">28</extent><extent unit="linksCrossRef">6</extent></physicalDescription><abstract lang="en">Abstract. Hepatitis B virus (HBV) DNA sequences have been detected in leucocytes from HBV‐infected individuals. The aim of this study was to assess the specificity of HBV for a special leucocyte subset in nine healthy chronic HBV carriers, nine HBs antigen‐positive patients with chronic active hepatitis, 16 HBs antigen‐negative haemophiliacs with HBc and/or HBs antibodies, and 10 patients with HBV‐related systemic necrotizing vasculitis. HBV‐DNA sequences were found by Southern blot hybridization in the leucocytes of 15 out of the 44 (34%) patients. The prevalence was not significantly different between the four groups. HBV‐DNA was found in the CD4+ cells (9/11) as well as in the CD8+ cells (4/11), B cells (4/12) and monocytes (2/12). In conclusion, leucocytes, and particularly CD4+ lymphocytes, are frequently infected by HBV in patients with HBV serum markers.</abstract><subject lang="en"><genre>keywords</genre><topic>Hepatitis B virus</topic><topic>human immunodeficiency virus</topic><topic>lymphocytes</topic><topic>monocytes.</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Clinical Investigation</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0014-2972</identifier><identifier type="eISSN">1365-2362</identifier><identifier type="DOI">10.1111/(ISSN)1365-2362</identifier><identifier type="PublisherID">ECI</identifier><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>548</start><end>552</end><total>5</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Significance of extrahepatic replication of hepatitis B virus</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Omata</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Omata M. 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