Dendritic cells: their significance in health and disease
Identifieur interne : 003612 ( Main/Merge ); précédent : 003611; suivant : 003613Dendritic cells: their significance in health and disease
Auteurs : Robert Keller [Suisse]Source :
- Immunology Letters [ 0165-2478 ] ; 2001.
English descriptors
- KwdEn :
- APC, antigen-presenting cells, Ag, antigen, Antigen capture and presentation by dendritic cells, CTLs, cytotoxic T lymphocytes, DC-SIGN, a DC-specific C-type lectin, DC-STAMP, a DC-specific transmembrane protein, DCs, dendritic cells, Dendritic cell trafficking and maturation, Dendritic cells in clinically relevant situations, GC, germinal center, GM-CSF, granulocyte-macrophage colony-stimulating factor, HSP, heat shock protein, IFN, interferon, IL, interleukin, ILT3, myeloid cell surface molecule of the Ig superfamily involved in Ag processing, LCs, Langerhans cells, MDCs, myeloid DCs, MLR, mixed lymphocyte reaction, NK, natural killer cells, PDCs, plasmacytoid DCs, SCF, stem cell factor, TAP, the transporter associated with Ag processing, TCR, T cell receptor, TGFβ, transforming growth factor β, TNFα, tumor necrosis factor α, Th, T helper cells, The dendritic cell system.
- Teeft :
- Adhesion molecules, Antitumor immunotherapy, Autoimmune disease, Banchereau, Blood monocytes, Bone marrow, Caux, Cell area, Cell factor, Cell interaction, Cell lysates, Cell memory, Cell responses, Chemokines, Constitutive chemokines, Cord blood, Costimulatory molecules, Ctls, Cytokine, Dendritic, Dendritic cell 6accines, Dendritic cell system, Dendritic cells, Elsevier science, Flt3l, Functional properties, Germinal center, Growth factor, Growth factors, Heat shock protein, Helper cells, Hematopoietic, Hematopoietic progenitors, Hematopoietic system, Hengartner, House dust mite, Human blood, Human mdcs, Immune, Immune response, Immune responses, Immunol, Immunology, Immunotherapy, Important role, Infectious diseases, Innate immunity, Keller, Keller immunology letters, Langerhans cells, Lanzavecchia, Life cycle, Liposomal peptide vaccine, Long hand, Ludewig, Lymph nodes, Lymphocyte, Lymphoid, Major histocompatibility, Maturation, Maturation process, Mdcs, Molecule, Monocyte, Mononuclear phagocytes, Myeloid, Normal tissues, Other cell types, Other hand, Pathogen, Pathway, Pdcs, Peptide, Peripheral blood, Peripheral tissues, Precursor, Progenitor, Progenitor cells, Receptor, Secondary lymphoid organ, Secondary lymphoid organs, Subset, Trace population, Tumor necrosis factor, Tumor vaccination, Various stages, Viral, Viral vectors, Waal malefyt, Zinkernagel.
Abstract
Abstract: Dendritic cells (DCs) represent a heterogenous population of professional antigen-presenting cells. Precursor cells move via the blood to peripheral tissues. These immature DCs can take up invading pathogens and then rapidly migrate to the draining secondary lymphoid organs. Converted into antigen-presenting mature DCs, these cells are able to prime naive T cells and to initiate an adoptive immune response. The extraordinary functional profile suggests that, under certain preconditions, DCs may represent an ideal vector in the immunotherapy of cancer and infectious diseases
Url:
DOI: 10.1016/S0165-2478(01)00247-4
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<affiliation wicri:level="4"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Pathology, Institute of Experimental Immunology, University of Zurich, CH-8091 Zurich</wicri:regionArea>
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<term>Ag, antigen</term>
<term>Antigen capture and presentation by dendritic cells</term>
<term>CTLs, cytotoxic T lymphocytes</term>
<term>DC-SIGN, a DC-specific C-type lectin</term>
<term>DC-STAMP, a DC-specific transmembrane protein</term>
<term>DCs, dendritic cells</term>
<term>Dendritic cell trafficking and maturation</term>
<term>Dendritic cells in clinically relevant situations</term>
<term>GC, germinal center</term>
<term>GM-CSF, granulocyte-macrophage colony-stimulating factor</term>
<term>HSP, heat shock protein</term>
<term>IFN, interferon</term>
<term>IL, interleukin</term>
<term>ILT3, myeloid cell surface molecule of the Ig superfamily involved in Ag processing</term>
<term>LCs, Langerhans cells</term>
<term>MDCs, myeloid DCs</term>
<term>MLR, mixed lymphocyte reaction</term>
<term>NK, natural killer cells</term>
<term>PDCs, plasmacytoid DCs</term>
<term>SCF, stem cell factor</term>
<term>TAP, the transporter associated with Ag processing</term>
<term>TCR, T cell receptor</term>
<term>TGFβ, transforming growth factor β</term>
<term>TNFα, tumor necrosis factor α</term>
<term>Th, T helper cells</term>
<term>The dendritic cell system</term>
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<keywords scheme="Teeft" xml:lang="en"><term>Adhesion molecules</term>
<term>Antitumor immunotherapy</term>
<term>Autoimmune disease</term>
<term>Banchereau</term>
<term>Blood monocytes</term>
<term>Bone marrow</term>
<term>Caux</term>
<term>Cell area</term>
<term>Cell factor</term>
<term>Cell interaction</term>
<term>Cell lysates</term>
<term>Cell memory</term>
<term>Cell responses</term>
<term>Chemokines</term>
<term>Constitutive chemokines</term>
<term>Cord blood</term>
<term>Costimulatory molecules</term>
<term>Ctls</term>
<term>Cytokine</term>
<term>Dendritic</term>
<term>Dendritic cell 6accines</term>
<term>Dendritic cell system</term>
<term>Dendritic cells</term>
<term>Elsevier science</term>
<term>Flt3l</term>
<term>Functional properties</term>
<term>Germinal center</term>
<term>Growth factor</term>
<term>Growth factors</term>
<term>Heat shock protein</term>
<term>Helper cells</term>
<term>Hematopoietic</term>
<term>Hematopoietic progenitors</term>
<term>Hematopoietic system</term>
<term>Hengartner</term>
<term>House dust mite</term>
<term>Human blood</term>
<term>Human mdcs</term>
<term>Immune</term>
<term>Immune response</term>
<term>Immune responses</term>
<term>Immunol</term>
<term>Immunology</term>
<term>Immunotherapy</term>
<term>Important role</term>
<term>Infectious diseases</term>
<term>Innate immunity</term>
<term>Keller</term>
<term>Keller immunology letters</term>
<term>Langerhans cells</term>
<term>Lanzavecchia</term>
<term>Life cycle</term>
<term>Liposomal peptide vaccine</term>
<term>Long hand</term>
<term>Ludewig</term>
<term>Lymph nodes</term>
<term>Lymphocyte</term>
<term>Lymphoid</term>
<term>Major histocompatibility</term>
<term>Maturation</term>
<term>Maturation process</term>
<term>Mdcs</term>
<term>Molecule</term>
<term>Monocyte</term>
<term>Mononuclear phagocytes</term>
<term>Myeloid</term>
<term>Normal tissues</term>
<term>Other cell types</term>
<term>Other hand</term>
<term>Pathogen</term>
<term>Pathway</term>
<term>Pdcs</term>
<term>Peptide</term>
<term>Peripheral blood</term>
<term>Peripheral tissues</term>
<term>Precursor</term>
<term>Progenitor</term>
<term>Progenitor cells</term>
<term>Receptor</term>
<term>Secondary lymphoid organ</term>
<term>Secondary lymphoid organs</term>
<term>Subset</term>
<term>Trace population</term>
<term>Tumor necrosis factor</term>
<term>Tumor vaccination</term>
<term>Various stages</term>
<term>Viral</term>
<term>Viral vectors</term>
<term>Waal malefyt</term>
<term>Zinkernagel</term>
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<front><div type="abstract" xml:lang="en">Abstract: Dendritic cells (DCs) represent a heterogenous population of professional antigen-presenting cells. Precursor cells move via the blood to peripheral tissues. These immature DCs can take up invading pathogens and then rapidly migrate to the draining secondary lymphoid organs. Converted into antigen-presenting mature DCs, these cells are able to prime naive T cells and to initiate an adoptive immune response. The extraordinary functional profile suggests that, under certain preconditions, DCs may represent an ideal vector in the immunotherapy of cancer and infectious diseases</div>
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