Dendritic cells: their significance in health and disease
Identifieur interne : 001E44 ( Istex/Corpus ); précédent : 001E43; suivant : 001E45Dendritic cells: their significance in health and disease
Auteurs : Robert KellerSource :
- Immunology Letters [ 0165-2478 ] ; 2001.
English descriptors
- KwdEn :
- APC, antigen-presenting cells, Ag, antigen, Antigen capture and presentation by dendritic cells, CTLs, cytotoxic T lymphocytes, DC-SIGN, a DC-specific C-type lectin, DC-STAMP, a DC-specific transmembrane protein, DCs, dendritic cells, Dendritic cell trafficking and maturation, Dendritic cells in clinically relevant situations, GC, germinal center, GM-CSF, granulocyte-macrophage colony-stimulating factor, HSP, heat shock protein, IFN, interferon, IL, interleukin, ILT3, myeloid cell surface molecule of the Ig superfamily involved in Ag processing, LCs, Langerhans cells, MDCs, myeloid DCs, MLR, mixed lymphocyte reaction, NK, natural killer cells, PDCs, plasmacytoid DCs, SCF, stem cell factor, TAP, the transporter associated with Ag processing, TCR, T cell receptor, TGFβ, transforming growth factor β, TNFα, tumor necrosis factor α, Th, T helper cells, The dendritic cell system.
- Teeft :
- Adhesion molecules, Antitumor immunotherapy, Autoimmune disease, Banchereau, Blood monocytes, Bone marrow, Caux, Cell area, Cell factor, Cell interaction, Cell lysates, Cell memory, Cell responses, Chemokines, Constitutive chemokines, Cord blood, Costimulatory molecules, Ctls, Cytokine, Dendritic, Dendritic cell 6accines, Dendritic cell system, Dendritic cells, Elsevier science, Flt3l, Functional properties, Germinal center, Growth factor, Growth factors, Heat shock protein, Helper cells, Hematopoietic, Hematopoietic progenitors, Hematopoietic system, Hengartner, House dust mite, Human blood, Human mdcs, Immune, Immune response, Immune responses, Immunol, Immunology, Immunotherapy, Important role, Infectious diseases, Innate immunity, Keller, Keller immunology letters, Langerhans cells, Lanzavecchia, Life cycle, Liposomal peptide vaccine, Long hand, Ludewig, Lymph nodes, Lymphocyte, Lymphoid, Major histocompatibility, Maturation, Maturation process, Mdcs, Molecule, Monocyte, Mononuclear phagocytes, Myeloid, Normal tissues, Other cell types, Other hand, Pathogen, Pathway, Pdcs, Peptide, Peripheral blood, Peripheral tissues, Precursor, Progenitor, Progenitor cells, Receptor, Secondary lymphoid organ, Secondary lymphoid organs, Subset, Trace population, Tumor necrosis factor, Tumor vaccination, Various stages, Viral, Viral vectors, Waal malefyt, Zinkernagel.
Abstract
Abstract: Dendritic cells (DCs) represent a heterogenous population of professional antigen-presenting cells. Precursor cells move via the blood to peripheral tissues. These immature DCs can take up invading pathogens and then rapidly migrate to the draining secondary lymphoid organs. Converted into antigen-presenting mature DCs, these cells are able to prime naive T cells and to initiate an adoptive immune response. The extraordinary functional profile suggests that, under certain preconditions, DCs may represent an ideal vector in the immunotherapy of cancer and infectious diseases
Url:
DOI: 10.1016/S0165-2478(01)00247-4
Links to Exploration step
ISTEX:33F66D4F12B00EC1B0B2F374155687393D8F14B5Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dendritic cells: their significance in health and disease</title><author><name sortKey="Keller, Robert" sort="Keller, Robert" uniqKey="Keller R" first="Robert" last="Keller">Robert Keller</name><affiliation><mods:affiliation>Department of Pathology, Institute of Experimental Immunology, University of Zurich, CH-8091 Zurich, Switzerland</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:33F66D4F12B00EC1B0B2F374155687393D8F14B5</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1016/S0165-2478(01)00247-4</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-X46QRDZQ-K/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001E44</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001E44</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Dendritic cells: their significance in health and disease</title><author><name sortKey="Keller, Robert" sort="Keller, Robert" uniqKey="Keller R" first="Robert" last="Keller">Robert Keller</name><affiliation><mods:affiliation>Department of Pathology, Institute of Experimental Immunology, University of Zurich, CH-8091 Zurich, Switzerland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Immunology Letters</title><title level="j" type="abbrev">IMLET</title><idno type="ISSN">0165-2478</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">78</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="113">113</biblScope><biblScope unit="page" to="122">122</biblScope></imprint><idno type="ISSN">0165-2478</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-2478</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>APC, antigen-presenting cells</term><term>Ag, antigen</term><term>Antigen capture and presentation by dendritic cells</term><term>CTLs, cytotoxic T lymphocytes</term><term>DC-SIGN, a DC-specific C-type lectin</term><term>DC-STAMP, a DC-specific transmembrane protein</term><term>DCs, dendritic cells</term><term>Dendritic cell trafficking and maturation</term><term>Dendritic cells in clinically relevant situations</term><term>GC, germinal center</term><term>GM-CSF, granulocyte-macrophage colony-stimulating factor</term><term>HSP, heat shock protein</term><term>IFN, interferon</term><term>IL, interleukin</term><term>ILT3, myeloid cell surface molecule of the Ig superfamily involved in Ag processing</term><term>LCs, Langerhans cells</term><term>MDCs, myeloid DCs</term><term>MLR, mixed lymphocyte reaction</term><term>NK, natural killer cells</term><term>PDCs, plasmacytoid DCs</term><term>SCF, stem cell factor</term><term>TAP, the transporter associated with Ag processing</term><term>TCR, T cell receptor</term><term>TGFβ, transforming growth factor β</term><term>TNFα, tumor necrosis factor α</term><term>Th, T helper cells</term><term>The dendritic cell system</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adhesion molecules</term><term>Antitumor immunotherapy</term><term>Autoimmune disease</term><term>Banchereau</term><term>Blood monocytes</term><term>Bone marrow</term><term>Caux</term><term>Cell area</term><term>Cell factor</term><term>Cell interaction</term><term>Cell lysates</term><term>Cell memory</term><term>Cell responses</term><term>Chemokines</term><term>Constitutive chemokines</term><term>Cord blood</term><term>Costimulatory molecules</term><term>Ctls</term><term>Cytokine</term><term>Dendritic</term><term>Dendritic cell 6accines</term><term>Dendritic cell system</term><term>Dendritic cells</term><term>Elsevier science</term><term>Flt3l</term><term>Functional properties</term><term>Germinal center</term><term>Growth factor</term><term>Growth factors</term><term>Heat shock protein</term><term>Helper cells</term><term>Hematopoietic</term><term>Hematopoietic progenitors</term><term>Hematopoietic system</term><term>Hengartner</term><term>House dust mite</term><term>Human blood</term><term>Human mdcs</term><term>Immune</term><term>Immune response</term><term>Immune responses</term><term>Immunol</term><term>Immunology</term><term>Immunotherapy</term><term>Important role</term><term>Infectious diseases</term><term>Innate immunity</term><term>Keller</term><term>Keller immunology letters</term><term>Langerhans cells</term><term>Lanzavecchia</term><term>Life cycle</term><term>Liposomal peptide vaccine</term><term>Long hand</term><term>Ludewig</term><term>Lymph nodes</term><term>Lymphocyte</term><term>Lymphoid</term><term>Major histocompatibility</term><term>Maturation</term><term>Maturation process</term><term>Mdcs</term><term>Molecule</term><term>Monocyte</term><term>Mononuclear phagocytes</term><term>Myeloid</term><term>Normal tissues</term><term>Other cell types</term><term>Other hand</term><term>Pathogen</term><term>Pathway</term><term>Pdcs</term><term>Peptide</term><term>Peripheral blood</term><term>Peripheral tissues</term><term>Precursor</term><term>Progenitor</term><term>Progenitor cells</term><term>Receptor</term><term>Secondary lymphoid organ</term><term>Secondary lymphoid organs</term><term>Subset</term><term>Trace population</term><term>Tumor necrosis factor</term><term>Tumor vaccination</term><term>Various stages</term><term>Viral</term><term>Viral vectors</term><term>Waal malefyt</term><term>Zinkernagel</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Dendritic cells (DCs) represent a heterogenous population of professional antigen-presenting cells. Precursor cells move via the blood to peripheral tissues. These immature DCs can take up invading pathogens and then rapidly migrate to the draining secondary lymphoid organs. Converted into antigen-presenting mature DCs, these cells are able to prime naive T cells and to initiate an adoptive immune response. The extraordinary functional profile suggests that, under certain preconditions, DCs may represent an ideal vector in the immunotherapy of cancer and infectious diseases</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>immunol</json:string><json:string>dendritic</json:string><json:string>cytokine</json:string><json:string>receptor</json:string><json:string>lymphoid</json:string><json:string>banchereau</json:string><json:string>dendritic cells</json:string><json:string>subset</json:string><json:string>mdcs</json:string><json:string>immune</json:string><json:string>keller</json:string><json:string>lanzavecchia</json:string><json:string>immunology</json:string><json:string>hematopoietic</json:string><json:string>lymphocyte</json:string><json:string>flt3l</json:string><json:string>chemokines</json:string><json:string>pathway</json:string><json:string>precursor</json:string><json:string>monocyte</json:string><json:string>keller immunology letters</json:string><json:string>progenitor</json:string><json:string>secondary lymphoid organs</json:string><json:string>ludewig</json:string><json:string>caux</json:string><json:string>pathogen</json:string><json:string>hengartner</json:string><json:string>cell responses</json:string><json:string>viral</json:string><json:string>zinkernagel</json:string><json:string>ctls</json:string><json:string>immunotherapy</json:string><json:string>pdcs</json:string><json:string>peptide</json:string><json:string>myeloid</json:string><json:string>secondary lymphoid organ</json:string><json:string>costimulatory molecules</json:string><json:string>bone marrow</json:string><json:string>other hand</json:string><json:string>maturation</json:string><json:string>cell lysates</json:string><json:string>viral vectors</json:string><json:string>immune responses</json:string><json:string>peripheral tissues</json:string><json:string>maturation process</json:string><json:string>other cell types</json:string><json:string>helper cells</json:string><json:string>innate immunity</json:string><json:string>cell interaction</json:string><json:string>growth factor</json:string><json:string>cell factor</json:string><json:string>hematopoietic progenitors</json:string><json:string>langerhans cells</json:string><json:string>cell area</json:string><json:string>various stages</json:string><json:string>progenitor cells</json:string><json:string>constitutive chemokines</json:string><json:string>cell memory</json:string><json:string>blood monocytes</json:string><json:string>major histocompatibility</json:string><json:string>immune response</json:string><json:string>life cycle</json:string><json:string>heat shock protein</json:string><json:string>human mdcs</json:string><json:string>adhesion molecules</json:string><json:string>cord blood</json:string><json:string>growth factors</json:string><json:string>important role</json:string><json:string>trace population</json:string><json:string>normal tissues</json:string><json:string>germinal center</json:string><json:string>hematopoietic system</json:string><json:string>autoimmune disease</json:string><json:string>human blood</json:string><json:string>house dust mite</json:string><json:string>dendritic cell 6accines</json:string><json:string>tumor necrosis factor</json:string><json:string>liposomal peptide vaccine</json:string><json:string>antitumor immunotherapy</json:string><json:string>peripheral blood</json:string><json:string>tumor vaccination</json:string><json:string>long hand</json:string><json:string>mononuclear phagocytes</json:string><json:string>functional properties</json:string><json:string>dendritic cell system</json:string><json:string>elsevier science</json:string><json:string>infectious diseases</json:string><json:string>waal malefyt</json:string><json:string>lymph nodes</json:string><json:string>molecule</json:string></teeft></keywords><author><json:item><name>Robert Keller</name><affiliations><json:string>Department of Pathology, Institute of Experimental Immunology, University of Zurich, CH-8091 Zurich, Switzerland</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>The dendritic cell system</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Dendritic cell trafficking and maturation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Antigen capture and presentation by dendritic cells</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Dendritic cells in clinically relevant situations</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Ag, antigen</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>APC, antigen-presenting cells</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>CTLs, cytotoxic T lymphocytes</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>DCs, dendritic cells</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>DC-SIGN, a DC-specific C-type lectin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>DC-STAMP, a DC-specific transmembrane protein</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>GC, germinal center</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>GM-CSF, granulocyte-macrophage colony-stimulating factor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>HSP, heat shock protein</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>IFN, interferon</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>IL, interleukin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>ILT3, myeloid cell surface molecule of the Ig superfamily involved in Ag processing</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>LCs, Langerhans cells</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MDCs, myeloid DCs</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MLR, mixed lymphocyte reaction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>NK, natural killer cells</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PDCs, plasmacytoid DCs</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SCF, stem cell factor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>TAP, the transporter associated with Ag processing</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>TCR, T cell receptor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>TGFβ, transforming growth factor β</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Th, T helper cells</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>TNFα, tumor necrosis factor α</value></json:item></subject><arkIstex>ark:/67375/6H6-X46QRDZQ-K</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Review article</json:string></originalGenre><abstract>Abstract: Dendritic cells (DCs) represent a heterogenous population of professional antigen-presenting cells. Precursor cells move via the blood to peripheral tissues. These immature DCs can take up invading pathogens and then rapidly migrate to the draining secondary lymphoid organs. Converted into antigen-presenting mature DCs, these cells are able to prime naive T cells and to initiate an adoptive immune response. The extraordinary functional profile suggests that, under certain preconditions, DCs may represent an ideal vector in the immunotherapy of cancer and infectious diseases</abstract><qualityIndicators><score>7.996</score><pdfWordCount>6872</pdfWordCount><pdfCharCount>42334</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>552 x 768 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>83</abstractWordCount><abstractCharCount>590</abstractCharCount><keywordCount>27</keywordCount></qualityIndicators><title>Dendritic cells: their significance in health and disease</title><pmid><json:string>11578684</json:string></pmid><pii><json:string>S0165-2478(01)00247-4</json:string></pii><genre><json:string>review-article</json:string></genre><host><title>Immunology Letters</title><language><json:string>unknown</json:string></language><publicationDate>2001</publicationDate><issn><json:string>0165-2478</json:string></issn><pii><json:string>S0165-2478(00)X0081-8</json:string></pii><volume>78</volume><issue>3</issue><pages><first>113</first><last>122</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>2001</json:string></date><geogName></geogName><orgName><json:string>Switzerland Received</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>R. Keller</json:string><json:string>Drs Luis</json:string><json:string>Iris Rehfuss</json:string><json:string>Bevan</json:string><json:string>Hans Hengartner</json:string></persName><placeName><json:string>Zurich</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>[94]</json:string><json:string>[89,90]</json:string><json:string>[78]</json:string><json:string>[91,96]</json:string><json:string>[34,36,37]</json:string><json:string>[48,49]</json:string><json:string>[29]</json:string><json:string>[82]</json:string><json:string>[81,82]</json:string><json:string>[99]</json:string><json:string>[39]</json:string><json:string>[92]</json:string><json:string>[104]</json:string><json:string>[1]</json:string><json:string>[98]</json:string><json:string>[22,32]</json:string><json:string>[107,108]</json:string><json:string>[49]</json:string><json:string>[91]</json:string><json:string>[68,69]</json:string><json:string>[59,60]</json:string><json:string>[86]</json:string><json:string>[8,20,21]</json:string><json:string>[106]</json:string><json:string>[5]</json:string><json:string>[26]</json:string><json:string>[62,63]</json:string><json:string>[78,79]</json:string><json:string>[41]</json:string><json:string>[103]</json:string><json:string>[76,24]</json:string><json:string>[36]</json:string><json:string>[65,16]</json:string><json:string>[9]</json:string><json:string>[84]</json:string><json:string>[11,12]</json:string><json:string>[79]</json:string><json:string>[16,17]</json:string><json:string>[105]</json:string><json:string>[2,19]</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-X46QRDZQ-K</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - immunology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - immunology</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Immunology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Immunology and Allergy</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - gastroenterologie. foie. pancreas. abdomen</json:string></inist></categories><publicationDate>2001</publicationDate><copyrightDate>2001</copyrightDate><doi><json:string>10.1016/S0165-2478(01)00247-4</json:string></doi><id>33F66D4F12B00EC1B0B2F374155687393D8F14B5</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-X46QRDZQ-K/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-X46QRDZQ-K/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-X46QRDZQ-K/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Dendritic cells: their significance in health and disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>©2001 Elsevier Science B.V.</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</p></availability><date>2001</date></publicationStmt><notesStmt><note type="review-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note type="content">Section title: Review</note><note type="content">Fig. 1: Major stages of myeloid dendritic cell (MDC) maturation. The MDC life history can be subdivided in a number of phases with distinct surface markers and distinct functionality.</note><note type="content">Fig. 2: The life cycle of myeloid dendritic cells (MDCs). Progenitors from bone marrow enter the circulation and home to peripheral tissues as immature MDCs. Invading pathogens are captured by MDCs and the antigen processed; in parallel, the ability to capture antigens is downregulated and the maturation of MDCs and their directed migration via afferent lymphatic to the secondary lymphoid organs induced. Mature MDCs now express peptide-MHC complexes, allowing the selection of antigen-specific T lymphocytes in the secondary lymphoid organs. The interaction with activated T cells in turn helps MDCs in terminal maturation. Activated T cells can reach the inflamed tissue; T helper cells can activate macrophages (mono/mø), NK cells and eosinophils (eos) via local secretion of cytokines; cytotoxic T cells (CTL) can lyse infected cells. On contact with T cells and mature DCs, also B lymphocytes become activated and are able to migrate into the damaged tissue, differentiate into plasma cells and neutralize pathogens via secreted antibody.</note><note type="content">Table 1: Characteristic surface phenotype of subsets of freshly ex vivo-isolated dendritic cells from human peripheral blood</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Dendritic cells: their significance in health and disease</title><author xml:id="author-0000"><persName><forename type="first">Robert</forename><surname>Keller</surname></persName><note type="biography">Tel.: +41-1-391-8980; fax: +41-1-391-8724</note><affiliation>Tel.: +41-1-391-8980; fax: +41-1-391-8724</affiliation><affiliation>Department of Pathology, Institute of Experimental Immunology, University of Zurich, CH-8091 Zurich, Switzerland</affiliation></author><idno type="istex">33F66D4F12B00EC1B0B2F374155687393D8F14B5</idno><idno type="ark">ark:/67375/6H6-X46QRDZQ-K</idno><idno type="DOI">10.1016/S0165-2478(01)00247-4</idno><idno type="PII">S0165-2478(01)00247-4</idno></analytic><monogr><title level="j">Immunology Letters</title><title level="j" type="abbrev">IMLET</title><idno type="pISSN">0165-2478</idno><idno type="PII">S0165-2478(00)X0081-8</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001"></date><biblScope unit="volume">78</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="113">113</biblScope><biblScope unit="page" to="122">122</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2001</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Dendritic cells (DCs) represent a heterogenous population of professional antigen-presenting cells. Precursor cells move via the blood to peripheral tissues. These immature DCs can take up invading pathogens and then rapidly migrate to the draining secondary lymphoid organs. Converted into antigen-presenting mature DCs, these cells are able to prime naive T cells and to initiate an adoptive immune response. The extraordinary functional profile suggests that, under certain preconditions, DCs may represent an ideal vector in the immunotherapy of cancer and infectious diseases</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>The dendritic cell system</term></item><item><term>Dendritic cell trafficking and maturation</term></item><item><term>Antigen capture and presentation by dendritic cells</term></item><item><term>Dendritic cells in clinically relevant situations</term></item></list></keywords></textClass><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Abbreviations</head><item><term>Ag, antigen</term></item><item><term>APC, antigen-presenting cells</term></item><item><term>CTLs, cytotoxic T lymphocytes</term></item><item><term>DCs, dendritic cells</term></item><item><term>DC-SIGN, a DC-specific C-type lectin</term></item><item><term>DC-STAMP, a DC-specific transmembrane protein</term></item><item><term>GC, germinal center</term></item><item><term>GM-CSF, granulocyte-macrophage colony-stimulating factor</term></item><item><term>HSP, heat shock protein</term></item><item><term>IFN, interferon</term></item><item><term>IL, interleukin</term></item><item><term>ILT3, myeloid cell surface molecule of the Ig superfamily involved in Ag processing</term></item><item><term>LCs, Langerhans cells</term></item><item><term>MDCs, myeloid DCs</term></item><item><term>MLR, mixed lymphocyte reaction</term></item><item><term>NK, natural killer cells</term></item><item><term>PDCs, plasmacytoid DCs</term></item><item><term>SCF, stem cell factor</term></item><item><term>TAP, the transporter associated with Ag processing</term></item><item><term>TCR, T cell receptor</term></item><item><term>TGFβ, transforming growth factor β</term></item><item><term>Th, T helper cells</term></item><item><term>TNFα, tumor necrosis factor α</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2001">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-X46QRDZQ-K/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="gr1"></istex:entity><istex:entity SYSTEM="gr2" NDATA="IMAGE" name="gr2"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="rev" xml:lang="en"><item-info><jid>IMLET</jid><aid>3442</aid><ce:pii>S0165-2478(01)00247-4</ce:pii><ce:doi>10.1016/S0165-2478(01)00247-4</ce:doi><ce:copyright type="full-transfer" year="2001">Elsevier Science B.V.</ce:copyright></item-info><head><ce:dochead><ce:textfn>Review</ce:textfn></ce:dochead><ce:title>Dendritic cells: their significance in health and disease</ce:title><ce:author-group><ce:author><ce:given-name>Robert</ce:given-name><ce:surname>Keller</ce:surname><ce:cross-ref refid="COR1">*</ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Department of Pathology, Institute of Experimental Immunology, University of Zurich, CH-8091 Zurich, Switzerland</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>*</ce:label><ce:text>Tel.: +41-1-391-8980; fax: +41-1-391-8724</ce:text></ce:correspondence></ce:author-group><ce:date-received day="26" month="6" year="2001"></ce:date-received><ce:date-accepted day="27" month="6" year="2001"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Dendritic cells (DCs) represent a heterogenous population of professional antigen-presenting cells. Precursor cells move via the blood to peripheral tissues. These immature DCs can take up invading pathogens and then rapidly migrate to the draining secondary lymphoid organs. Converted into antigen-presenting mature DCs, these cells are able to prime naive T cells and to initiate an adoptive immune response. The extraordinary functional profile suggests that, under certain preconditions, DCs may represent an ideal vector in the immunotherapy of cancer and infectious diseases</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>The dendritic cell system</ce:text></ce:keyword><ce:keyword><ce:text>Dendritic cell trafficking and maturation</ce:text></ce:keyword><ce:keyword><ce:text>Antigen capture and presentation by dendritic cells</ce:text></ce:keyword><ce:keyword><ce:text>Dendritic cells in clinically relevant situations</ce:text></ce:keyword></ce:keywords><ce:keywords class="abr"><ce:section-title>Abbreviations</ce:section-title><ce:keyword><ce:text>Ag, antigen</ce:text></ce:keyword><ce:keyword><ce:text>APC, antigen-presenting cells</ce:text></ce:keyword><ce:keyword><ce:text>CTLs, cytotoxic T lymphocytes</ce:text></ce:keyword><ce:keyword><ce:text>DCs, dendritic cells</ce:text></ce:keyword><ce:keyword><ce:text>DC-SIGN, a DC-specific C-type lectin</ce:text></ce:keyword><ce:keyword><ce:text>DC-STAMP, a DC-specific transmembrane protein</ce:text></ce:keyword><ce:keyword><ce:text>GC, germinal center</ce:text></ce:keyword><ce:keyword><ce:text>GM-CSF, granulocyte-macrophage colony-stimulating factor</ce:text></ce:keyword><ce:keyword><ce:text>HSP, heat shock protein</ce:text></ce:keyword><ce:keyword><ce:text>IFN, interferon</ce:text></ce:keyword><ce:keyword><ce:text>IL, interleukin</ce:text></ce:keyword><ce:keyword><ce:text>ILT3, myeloid cell surface molecule of the Ig superfamily involved in Ag processing</ce:text></ce:keyword><ce:keyword><ce:text>LCs, Langerhans cells</ce:text></ce:keyword><ce:keyword><ce:text>MDCs, myeloid DCs</ce:text></ce:keyword><ce:keyword><ce:text>MLR, mixed lymphocyte reaction</ce:text></ce:keyword><ce:keyword><ce:text>NK, natural killer cells</ce:text></ce:keyword><ce:keyword><ce:text>PDCs, plasmacytoid DCs</ce:text></ce:keyword><ce:keyword><ce:text>SCF, stem cell factor</ce:text></ce:keyword><ce:keyword><ce:text>TAP, the transporter associated with Ag processing</ce:text></ce:keyword><ce:keyword><ce:text>TCR, T cell receptor</ce:text></ce:keyword><ce:keyword><ce:text>TGFβ, transforming growth factor β</ce:text></ce:keyword><ce:keyword><ce:text>Th, T helper cells</ce:text></ce:keyword><ce:keyword><ce:text>TNFα, tumor necrosis factor α</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Dendritic cells: their significance in health and disease</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Dendritic cells: their significance in health and disease</title></titleInfo><name type="personal"><namePart type="given">Robert</namePart><namePart type="family">Keller</namePart><affiliation>Department of Pathology, Institute of Experimental Immunology, University of Zurich, CH-8091 Zurich, Switzerland</affiliation><description>Tel.: +41-1-391-8980; fax: +41-1-391-8724</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="Review article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">2001</dateIssued><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Dendritic cells (DCs) represent a heterogenous population of professional antigen-presenting cells. Precursor cells move via the blood to peripheral tissues. These immature DCs can take up invading pathogens and then rapidly migrate to the draining secondary lymphoid organs. Converted into antigen-presenting mature DCs, these cells are able to prime naive T cells and to initiate an adoptive immune response. The extraordinary functional profile suggests that, under certain preconditions, DCs may represent an ideal vector in the immunotherapy of cancer and infectious diseases</abstract><note type="content">Section title: Review</note><note type="content">Fig. 1: Major stages of myeloid dendritic cell (MDC) maturation. The MDC life history can be subdivided in a number of phases with distinct surface markers and distinct functionality.</note><note type="content">Fig. 2: The life cycle of myeloid dendritic cells (MDCs). Progenitors from bone marrow enter the circulation and home to peripheral tissues as immature MDCs. Invading pathogens are captured by MDCs and the antigen processed; in parallel, the ability to capture antigens is downregulated and the maturation of MDCs and their directed migration via afferent lymphatic to the secondary lymphoid organs induced. Mature MDCs now express peptide-MHC complexes, allowing the selection of antigen-specific T lymphocytes in the secondary lymphoid organs. The interaction with activated T cells in turn helps MDCs in terminal maturation. Activated T cells can reach the inflamed tissue; T helper cells can activate macrophages (mono/mø), NK cells and eosinophils (eos) via local secretion of cytokines; cytotoxic T cells (CTL) can lyse infected cells. On contact with T cells and mature DCs, also B lymphocytes become activated and are able to migrate into the damaged tissue, differentiate into plasma cells and neutralize pathogens via secreted antibody.</note><note type="content">Table 1: Characteristic surface phenotype of subsets of freshly ex vivo-isolated dendritic cells from human peripheral blood</note><subject lang="en"><genre>Keywords</genre><topic>The dendritic cell system</topic><topic>Dendritic cell trafficking and maturation</topic><topic>Antigen capture and presentation by dendritic cells</topic><topic>Dendritic cells in clinically relevant situations</topic></subject><subject lang="en"><genre>Abbreviations</genre><topic>Ag, antigen</topic><topic>APC, antigen-presenting cells</topic><topic>CTLs, cytotoxic T lymphocytes</topic><topic>DCs, dendritic cells</topic><topic>DC-SIGN, a DC-specific C-type lectin</topic><topic>DC-STAMP, a DC-specific transmembrane protein</topic><topic>GC, germinal center</topic><topic>GM-CSF, granulocyte-macrophage colony-stimulating factor</topic><topic>HSP, heat shock protein</topic><topic>IFN, interferon</topic><topic>IL, interleukin</topic><topic>ILT3, myeloid cell surface molecule of the Ig superfamily involved in Ag processing</topic><topic>LCs, Langerhans cells</topic><topic>MDCs, myeloid DCs</topic><topic>MLR, mixed lymphocyte reaction</topic><topic>NK, natural killer cells</topic><topic>PDCs, plasmacytoid DCs</topic><topic>SCF, stem cell factor</topic><topic>TAP, the transporter associated with Ag processing</topic><topic>TCR, T cell receptor</topic><topic>TGFβ, transforming growth factor β</topic><topic>Th, T helper cells</topic><topic>TNFα, tumor necrosis factor α</topic></subject><relatedItem type="host"><titleInfo><title>Immunology Letters</title></titleInfo><titleInfo type="abbreviated"><title>IMLET</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">2001</dateIssued></originInfo><identifier type="ISSN">0165-2478</identifier><identifier type="PII">S0165-2478(00)X0081-8</identifier><part><date>2001</date><detail type="volume"><number>78</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue-pages"><start>113</start><end>219</end></extent><extent unit="pages"><start>113</start><end>122</end></extent></part></relatedItem><identifier type="istex">33F66D4F12B00EC1B0B2F374155687393D8F14B5</identifier><identifier type="ark">ark:/67375/6H6-X46QRDZQ-K</identifier><identifier type="DOI">10.1016/S0165-2478(01)00247-4</identifier><identifier type="PII">S0165-2478(01)00247-4</identifier><accessCondition type="use and reproduction" contentType="copyright">©2001 Elsevier Science B.V.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource><recordOrigin>Elsevier Science B.V., ©2001</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-X46QRDZQ-K/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E44 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001E44 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:33F66D4F12B00EC1B0B2F374155687393D8F14B5
|texte= Dendritic cells: their significance in health and disease
}}
| This area was generated with Dilib version V0.6.33. |  |