Characterization of the endokinins: human tachykinins with cardiovascular activity.
Identifieur interne : 003262 ( Main/Merge ); précédent : 003261; suivant : 003263Characterization of the endokinins: human tachykinins with cardiovascular activity.
Auteurs : Nigel M. Page [Royaume-Uni] ; Nicola J. Bell ; Sheila M. Gardiner ; Isaac T. Manyonda ; Kerensa J. Brayley ; Philip G. Strange ; Philip J. LowrySource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2003.
Descripteurs français
- KwdFr :
- Alignement de séquences, Amorces ADN, Animaux, Astrocytome, Cellules cancéreuses en culture, Données de séquences moléculaires, Exons, Glioblastome, Humains, Introns, Phénomènes physiologiques cardiovasculaires, Réaction de polymérisation en chaîne, Similitude de séquences d'acides aminés, Souris, Système cardiovasculaire (), Séquence consensus, Séquence d'acides aminés, Séquence nucléotidique, Tachykinines (), Tachykinines (génétique), Tachykinines (pharmacologie).
- MESH :
- génétique : Tachykinines.
- pharmacologie : Tachykinines.
- Alignement de séquences, Amorces ADN, Animaux, Astrocytome, Cellules cancéreuses en culture, Données de séquences moléculaires, Exons, Glioblastome, Humains, Introns, Phénomènes physiologiques cardiovasculaires, Réaction de polymérisation en chaîne, Similitude de séquences d'acides aminés, Souris, Système cardiovasculaire, Séquence consensus, Séquence d'acides aminés, Séquence nucléotidique, Tachykinines.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Astrocytoma, Base Sequence, Cardiovascular Physiological Phenomena, Cardiovascular System (drug effects), Consensus Sequence, DNA Primers, Exons, Glioblastoma, Humans, Introns, Mice, Molecular Sequence Data, Polymerase Chain Reaction, Sequence Alignment, Sequence Homology, Amino Acid, Tachykinins (chemistry), Tachykinins (genetics), Tachykinins (pharmacology), Tumor Cells, Cultured.
- MESH :
- chemical , chemistry : Tachykinins.
- chemical , genetics : Tachykinins.
- chemical , pharmacology : Tachykinins.
- chemical : DNA Primers.
- drug effects : Cardiovascular System.
- Amino Acid Sequence, Animals, Astrocytoma, Base Sequence, Cardiovascular Physiological Phenomena, Consensus Sequence, Exons, Glioblastoma, Humans, Introns, Mice, Molecular Sequence Data, Polymerase Chain Reaction, Sequence Alignment, Sequence Homology, Amino Acid, Tumor Cells, Cultured.
Abstract
We report four human tachykinins, endokinins A, B, C, and D (EKA-D), encoded from a single tachykinin precursor 4 gene that generates four mRNAs (alpha, beta, gamma, and delta). Tachykinin 4 gene expression was detected primarily in adrenal gland and in the placenta, where, like neurokinin B, significant amounts of EKB-like immunoreactivity were detected. EKA/B 10-mers displayed equivalent affinity for the three tachykinin receptors as substance P (SP), whereas a 32-mer N-terminal extended form of EKB was significantly more potent than EKA/B or SP. EKC/D, which possess a previously uncharacterized tachykinin motif, FQGLL-NH(2), displayed low potency. EKA/B displayed identical hemodynamic effects to SP in rats, causing short-lived falls in mean arterial blood pressure associated with tachycardia, mesenteric vasoconstriction, and marked hindquarter vasodilatation. Thus, EKA/B could be the endocrineparacrine agonists at peripheral SP receptors and there may be as yet an unidentified receptor(s) for EKC/D.
DOI: 10.1073/pnas.0931458100
PubMed: 12716968
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pubmed:12716968Le document en format XML
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Gardiner</name></author><author><name sortKey="Manyonda, Isaac T" sort="Manyonda, Isaac T" uniqKey="Manyonda I" first="Isaac T" last="Manyonda">Isaac T. Manyonda</name></author><author><name sortKey="Brayley, Kerensa J" sort="Brayley, Kerensa J" uniqKey="Brayley K" first="Kerensa J" last="Brayley">Kerensa J. Brayley</name></author><author><name sortKey="Strange, Philip G" sort="Strange, Philip G" uniqKey="Strange P" first="Philip G" last="Strange">Philip G. Strange</name></author><author><name sortKey="Lowry, Philip J" sort="Lowry, Philip J" uniqKey="Lowry P" first="Philip J" last="Lowry">Philip J. 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Page</name><affiliation wicri:level="1"><nlm:affiliation>School of Animal and Microbial Sciences, University of Reading, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Animal and Microbial Sciences, University of Reading</wicri:regionArea><wicri:noRegion>University of Reading</wicri:noRegion></affiliation></author><author><name sortKey="Bell, Nicola J" sort="Bell, Nicola J" uniqKey="Bell N" first="Nicola J" last="Bell">Nicola J. Bell</name></author><author><name sortKey="Gardiner, Sheila M" sort="Gardiner, Sheila M" uniqKey="Gardiner S" first="Sheila M" last="Gardiner">Sheila M. Gardiner</name></author><author><name sortKey="Manyonda, Isaac T" sort="Manyonda, Isaac T" uniqKey="Manyonda I" first="Isaac T" last="Manyonda">Isaac T. Manyonda</name></author><author><name sortKey="Brayley, Kerensa J" sort="Brayley, Kerensa J" uniqKey="Brayley K" first="Kerensa J" last="Brayley">Kerensa J. Brayley</name></author><author><name sortKey="Strange, Philip G" sort="Strange, Philip G" uniqKey="Strange P" first="Philip G" last="Strange">Philip G. Strange</name></author><author><name sortKey="Lowry, Philip J" sort="Lowry, Philip J" uniqKey="Lowry P" first="Philip J" last="Lowry">Philip J. Lowry</name></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Astrocytoma</term><term>Base Sequence</term><term>Cardiovascular Physiological Phenomena</term><term>Cardiovascular System (drug effects)</term><term>Consensus Sequence</term><term>DNA Primers</term><term>Exons</term><term>Glioblastoma</term><term>Humans</term><term>Introns</term><term>Mice</term><term>Molecular Sequence Data</term><term>Polymerase Chain Reaction</term><term>Sequence Alignment</term><term>Sequence Homology, Amino Acid</term><term>Tachykinins (chemistry)</term><term>Tachykinins (genetics)</term><term>Tachykinins (pharmacology)</term><term>Tumor Cells, Cultured</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term><term>Amorces ADN</term><term>Animaux</term><term>Astrocytome</term><term>Cellules cancéreuses en culture</term><term>Données de séquences moléculaires</term><term>Exons</term><term>Glioblastome</term><term>Humains</term><term>Introns</term><term>Phénomènes physiologiques cardiovasculaires</term><term>Réaction de polymérisation en chaîne</term><term>Similitude de séquences d'acides aminés</term><term>Souris</term><term>Système cardiovasculaire ()</term><term>Séquence consensus</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Tachykinines ()</term><term>Tachykinines (génétique)</term><term>Tachykinines (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Tachykinins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Tachykinins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Tachykinins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>DNA Primers</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cardiovascular System</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Tachykinines</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Tachykinines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Astrocytoma</term><term>Base Sequence</term><term>Cardiovascular Physiological Phenomena</term><term>Consensus Sequence</term><term>Exons</term><term>Glioblastoma</term><term>Humans</term><term>Introns</term><term>Mice</term><term>Molecular Sequence Data</term><term>Polymerase Chain Reaction</term><term>Sequence Alignment</term><term>Sequence Homology, Amino Acid</term><term>Tumor Cells, Cultured</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term><term>Amorces ADN</term><term>Animaux</term><term>Astrocytome</term><term>Cellules cancéreuses en culture</term><term>Données de séquences moléculaires</term><term>Exons</term><term>Glioblastome</term><term>Humains</term><term>Introns</term><term>Phénomènes physiologiques cardiovasculaires</term><term>Réaction de polymérisation en chaîne</term><term>Similitude de séquences d'acides aminés</term><term>Souris</term><term>Système cardiovasculaire</term><term>Séquence consensus</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Tachykinines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report four human tachykinins, endokinins A, B, C, and D (EKA-D), encoded from a single tachykinin precursor 4 gene that generates four mRNAs (alpha, beta, gamma, and delta). Tachykinin 4 gene expression was detected primarily in adrenal gland and in the placenta, where, like neurokinin B, significant amounts of EKB-like immunoreactivity were detected. EKA/B 10-mers displayed equivalent affinity for the three tachykinin receptors as substance P (SP), whereas a 32-mer N-terminal extended form of EKB was significantly more potent than EKA/B or SP. EKC/D, which possess a previously uncharacterized tachykinin motif, FQGLL-NH(2), displayed low potency. EKA/B displayed identical hemodynamic effects to SP in rats, causing short-lived falls in mean arterial blood pressure associated with tachycardia, mesenteric vasoconstriction, and marked hindquarter vasodilatation. Thus, EKA/B could be the endocrineparacrine agonists at peripheral SP receptors and there may be as yet an unidentified receptor(s) for EKC/D.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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