MersV1, Ncbi, Merge, bibRecord, 000191

Characterization of the endokinins: human tachykinins with cardiovascular activity.

Identifieur interne : 000191 ( Ncbi/Merge ); précédent : 000190; suivant : 000192

Characterization of the endokinins: human tachykinins with cardiovascular activity.

Auteurs : Nigel M. Page [Royaume-Uni] ; Nicola J. Bell ; Sheila M. Gardiner ; Isaac T. Manyonda ; Kerensa J. Brayley ; Philip G. Strange ; Philip J. Lowry

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2003.

RBID : pubmed:12716968

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Astrocytoma, Base Sequence, Cardiovascular Physiological Phenomena, Cardiovascular System (drug effects), Consensus Sequence, DNA Primers, Exons, Glioblastoma, Humans, Introns, Mice, Molecular Sequence Data, Polymerase Chain Reaction, Sequence Alignment, Sequence Homology, Amino Acid, Tachykinins (chemistry), Tachykinins (genetics), Tachykinins (pharmacology), Tumor Cells, Cultured.
MESH :
- chemical , chemistry : Tachykinins.
- chemical , genetics : Tachykinins.
- chemical , pharmacology : Tachykinins.
- chemical : DNA Primers.
- drug effects : Cardiovascular System.
- Amino Acid Sequence, Animals, Astrocytoma, Base Sequence, Cardiovascular Physiological Phenomena, Consensus Sequence, Exons, Glioblastoma, Humans, Introns, Mice, Molecular Sequence Data, Polymerase Chain Reaction, Sequence Alignment, Sequence Homology, Amino Acid, Tumor Cells, Cultured.

Abstract

We report four human tachykinins, endokinins A, B, C, and D (EKA-D), encoded from a single tachykinin precursor 4 gene that generates four mRNAs (alpha, beta, gamma, and delta). Tachykinin 4 gene expression was detected primarily in adrenal gland and in the placenta, where, like neurokinin B, significant amounts of EKB-like immunoreactivity were detected. EKA/B 10-mers displayed equivalent affinity for the three tachykinin receptors as substance P (SP), whereas a 32-mer N-terminal extended form of EKB was significantly more potent than EKA/B or SP. EKC/D, which possess a previously uncharacterized tachykinin motif, FQGLL-NH(2), displayed low potency. EKA/B displayed identical hemodynamic effects to SP in rats, causing short-lived falls in mean arterial blood pressure associated with tachycardia, mesenteric vasoconstriction, and marked hindquarter vasodilatation. Thus, EKA/B could be the endocrineparacrine agonists at peripheral SP receptors and there may be as yet an unidentified receptor(s) for EKC/D.

DOI: 10.1073/pnas.0931458100
PubMed: 12716968

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Links to Exploration step

pubmed:12716968

Le document en format XML

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<front><div type="abstract" xml:lang="en">We report four human tachykinins, endokinins A, B, C, and D (EKA-D), encoded from a single tachykinin precursor 4 gene that generates four mRNAs (alpha, beta, gamma, and delta). Tachykinin 4 gene expression was detected primarily in adrenal gland and in the placenta, where, like neurokinin B, significant amounts of EKB-like immunoreactivity were detected. EKA/B 10-mers displayed equivalent affinity for the three tachykinin receptors as substance P (SP), whereas a 32-mer N-terminal extended form of EKB was significantly more potent than EKA/B or SP. EKC/D, which possess a previously uncharacterized tachykinin motif, FQGLL-NH(2), displayed low potency. EKA/B displayed identical hemodynamic effects to SP in rats, causing short-lived falls in mean arterial blood pressure associated with tachycardia, mesenteric vasoconstriction, and marked hindquarter vasodilatation. Thus, EKA/B could be the endocrineparacrine agonists at peripheral SP receptors and there may be as yet an unidentified receptor(s) for EKC/D.</div>
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<Abstract><AbstractText>We report four human tachykinins, endokinins A, B, C, and D (EKA-D), encoded from a single tachykinin precursor 4 gene that generates four mRNAs (alpha, beta, gamma, and delta). Tachykinin 4 gene expression was detected primarily in adrenal gland and in the placenta, where, like neurokinin B, significant amounts of EKB-like immunoreactivity were detected. EKA/B 10-mers displayed equivalent affinity for the three tachykinin receptors as substance P (SP), whereas a 32-mer N-terminal extended form of EKB was significantly more potent than EKA/B or SP. EKC/D, which possess a previously uncharacterized tachykinin motif, FQGLL-NH(2), displayed low potency. EKA/B displayed identical hemodynamic effects to SP in rats, causing short-lived falls in mean arterial blood pressure associated with tachycardia, mesenteric vasoconstriction, and marked hindquarter vasodilatation. Thus, EKA/B could be the endocrineparacrine agonists at peripheral SP receptors and there may be as yet an unidentified receptor(s) for EKC/D.</AbstractText>
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<Reference><Citation>Peptides. 1998;19(5):949-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9663462</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neuroimmunol. 1998 Nov 2;91(1-2):121-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9846828</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Peptides. 2000 Nov;21(11):1587-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11090912</ArticleId>
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</Reference>
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<affiliations><list><country><li>Royaume-Uni</li>
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<tree><noCountry><name sortKey="Bell, Nicola J" sort="Bell, Nicola J" uniqKey="Bell N" first="Nicola J" last="Bell">Nicola J. Bell</name>
<name sortKey="Brayley, Kerensa J" sort="Brayley, Kerensa J" uniqKey="Brayley K" first="Kerensa J" last="Brayley">Kerensa J. Brayley</name>
<name sortKey="Gardiner, Sheila M" sort="Gardiner, Sheila M" uniqKey="Gardiner S" first="Sheila M" last="Gardiner">Sheila M. Gardiner</name>
<name sortKey="Lowry, Philip J" sort="Lowry, Philip J" uniqKey="Lowry P" first="Philip J" last="Lowry">Philip J. Lowry</name>
<name sortKey="Manyonda, Isaac T" sort="Manyonda, Isaac T" uniqKey="Manyonda I" first="Isaac T" last="Manyonda">Isaac T. Manyonda</name>
<name sortKey="Strange, Philip G" sort="Strange, Philip G" uniqKey="Strange P" first="Philip G" last="Strange">Philip G. Strange</name>
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<country name="Royaume-Uni"><noRegion><name sortKey="Page, Nigel M" sort="Page, Nigel M" uniqKey="Page N" first="Nigel M" last="Page">Nigel M. Page</name>
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   |texte=   Characterization of the endokinins: human tachykinins with cardiovascular activity.
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Characterization of the endokinins: human tachykinins with cardiovascular activity.

Characterization of the endokinins: human tachykinins with cardiovascular activity.

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