Respiratory Tract Samples, Viral Load, and Genome Fraction Yield in Patients With Middle East Respiratory Syndrome
Identifieur interne : 001B06 ( Main/Merge ); précédent : 001B05; suivant : 001B07Respiratory Tract Samples, Viral Load, and Genome Fraction Yield in Patients With Middle East Respiratory Syndrome
Auteurs : Ziad A. Memish ; Jaffar A. Al-Tawfiq ; Hatem Q. Makhdoom ; Abdullah Assiri ; Raafat F. Alhakeem ; Ali Albarrak ; Sarah Alsubaie ; Abdullah A. Al-Rabeeah ; Waleed H. Hajomar ; Raheela Hussain ; Ali M. Kheyami ; Abdullah Almutairi ; Esam I. Azhar ; Christian Drosten [Allemagne] ; Simon J. Watson ; Paul Kellam ; Matthew Cotten ; Alimuddin Zumla [Royaume-Uni]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Infections à coronavirus.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Appareil respiratoire, Infections à coronavirus.
- Charge virale, Humains, Réaction de polymérisation en chaîne.
English descriptors
- KwdEn :
- MESH :
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- pathology : Coronavirus Infections.
- virology : Coronavirus Infections, Respiratory System.
- Humans, Polymerase Chain Reaction, Viral Load.
Abstract
Url:
DOI: 10.1093/infdis/jiu292
PubMed: 24837403
PubMed Central: 7107391
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PMC:7107391Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Respiratory Tract Samples, Viral Load, and Genome Fraction Yield in Patients With Middle East Respiratory Syndrome</title>
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<author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name>
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<author><name sortKey="Hajomar, Waleed H" sort="Hajomar, Waleed H" uniqKey="Hajomar W" first="Waleed H." last="Hajomar">Waleed H. Hajomar</name>
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<author><name sortKey="Almutairi, Abdullah" sort="Almutairi, Abdullah" uniqKey="Almutairi A" first="Abdullah" last="Almutairi">Abdullah Almutairi</name>
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<author><name sortKey="Azhar, Esam I" sort="Azhar, Esam I" uniqKey="Azhar E" first="Esam I." last="Azhar">Esam I. Azhar</name>
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<author><name sortKey="Watson, Simon J" sort="Watson, Simon J" uniqKey="Watson S" first="Simon J." last="Watson">Simon J. Watson</name>
<affiliation><nlm:aff id="af12"><institution>Wellcome Trust Sanger Institute</institution>
,<addr-line>Hinxton</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kellam, Paul" sort="Kellam, Paul" uniqKey="Kellam P" first="Paul" last="Kellam">Paul Kellam</name>
<affiliation><nlm:aff id="af12"><institution>Wellcome Trust Sanger Institute</institution>
,<addr-line>Hinxton</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cotten, Matthew" sort="Cotten, Matthew" uniqKey="Cotten M" first="Matthew" last="Cotten">Matthew Cotten</name>
<affiliation><nlm:aff id="af12"><institution>Wellcome Trust Sanger Institute</institution>
,<addr-line>Hinxton</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zumla, Alimuddin" sort="Zumla, Alimuddin" uniqKey="Zumla A" first="Alimuddin" last="Zumla">Alimuddin Zumla</name>
<affiliation><nlm:aff id="af1"><institution>Global Centre for Mass Gatherings Medicine and Ministry of Health, Riyadh, Kingdom of Saudi Arabia and College of Medicine, Alfaisal University,</institution>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af13"><addr-line>Division of Infection and Immunity</addr-line>
,<institution>University College London (UCL), and UCL Hospitals National Health Service Foundation Trust</institution>
,<country>United Kingdom</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Infectious Diseases</title>
<idno type="ISSN">0022-1899</idno>
<idno type="eISSN">1537-6613</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus Infections (pathology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Humans</term>
<term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term>
<term>Polymerase Chain Reaction</term>
<term>Respiratory System (virology)</term>
<term>Viral Load</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Appareil respiratoire (virologie)</term>
<term>Charge virale</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term>
<term>Humains</term>
<term>Infections à coronavirus (anatomopathologie)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Réaction de polymérisation en chaîne</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Appareil respiratoire</term>
<term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Respiratory System</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Polymerase Chain Reaction</term>
<term>Viral Load</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Charge virale</term>
<term>Humains</term>
<term>Réaction de polymérisation en chaîne</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p><bold><italic>Background.</italic>
</bold>
Analysis of clinical samples from patients with new viral infections is critical to confirm the diagnosis, to specify the viral load, and to sequence data necessary for characterizing the viral kinetics, transmission, and evolution. We analyzed samples from 112 patients infected with the recently discovered Middle East respiratory syndrome coronavirus (MERS-CoV).</p>
<p><bold><italic>Methods.</italic>
</bold>
Respiratory tract samples from cases of MERS-CoV infection confirmed by polymerase chain reaction (PCR) were investigated to determine the MERS-CoV load and fraction of the MERS-CoV genome. These values were analyzed to determine associations with clinical sample type.</p>
<p><bold><italic>Results.</italic>
</bold>
Samples from 112 individuals in which MERS-CoV was detected by PCR were analyzed, of which 13 were sputum samples, 64 were nasopharyngeal swab specimens, 30 were tracheal aspirates, and 3 were bronchoalveolar lavage specimens; 2 samples were of unknown origin. Tracheal aspirates yielded significantly higher MERS-CoV loads, compared with nasopharyngeal swab specimens (<italic>P</italic>
= .005) and sputum specimens (<italic>P</italic>
= .0001). Tracheal aspirates had viral loads similar to those in bronchoalveolar lavage samples (<italic>P</italic>
= .3079). Bronchoalveolar lavage samples and tracheal aspirates had significantly higher genome fraction than nasopharyngeal swab specimens (<italic>P</italic>
= .0095 and <italic>P</italic>
= .0002, respectively) and sputum samples (<italic>P</italic>
= .0009 and <italic>P</italic>
= .0001, respectively). The genome yield from tracheal aspirates and bronchoalveolar lavage samples were similar (<italic>P</italic>
= .1174).</p>
<p><bold><italic>Conclusions.</italic>
</bold>
Lower respiratory tract samples yield significantly higher MERS-CoV loads and genome fractions than upper respiratory tract samples.</p>
</div>
</front>
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</listBibl>
</div1>
</back>
</TEI>
</record>
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