Detection of new genetic variants of Betacoronaviruses in Endemic Frugivorous Bats of Madagascar
Identifieur interne : 001837 ( Main/Merge ); précédent : 001836; suivant : 001838Detection of new genetic variants of Betacoronaviruses in Endemic Frugivorous Bats of Madagascar
Auteurs : Norosoa H. Razanajatovo ; Lalaina A. Nomenjanahary ; David A. Wilkinson [France] ; Julie H. Razafimanahaka [Madagascar] ; Steven M. Goodman [Madagascar] ; Richard K. Jenkins ; Julia Pg Jones ; Jean-Michel HeraudSource :
- Virology Journal [ 1743-422X ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Coronaviridae.
- isolement et purification : Coronaviridae.
- médecine vétérinaire : Infections à Coronaviridae.
- virologie : Chiroptera.
- Animaux, Coronaviridae, Gènes viraux, Géographie, Madagascar, Phylogénie, Variation génétique.
- Wicri :
- geographic : Madagascar.
- topic : Chiroptera.
English descriptors
- KwdEn :
- MESH :
- geographic : Madagascar.
- classification : Coronaviridae.
- genetics : Coronaviridae.
- isolation & purification : Coronaviridae.
- veterinary : Coronaviridae Infections.
- virology : Chiroptera.
- Animals, Genes, Viral, Genetic Variation, Geography, Phylogeny.
- mix :
Abstract
Bats are amongst the natural reservoirs of many coronaviruses (CoVs) of which some can lead to severe infection in human. African bats are known to harbor a range of pathogens (e.g., Ebola and Marburg viruses) that can infect humans and cause disease outbreaks. A recent study in South Africa isolated a genetic variant closely related to MERS-CoV from an insectivorous bat. Though Madagascar is home to 44 bat species (41 insectivorous and 3 frugivorous) of which 34 are endemic, no data exists concerning the circulation of CoVs in the island’s chiropteran fauna. Certain Malagasy bats can be frequently found in close contact with humans and frugivorous bats feed in the same trees where people collect and consume fruits and are hunted and consumed as bush meat. The purpose of our study is to detect and identify CoVs from frugivorous bats in Madagascar to evaluate the risk of human infection from infected bats.
Frugivorous bats belonging to three species were captured in four different regions of Madagascar. We analyzed fecal and throat swabs to detect the presence of virus through amplification of the RNA-dependent RNA polymerase (RdRp) gene, which is highly conserved in all known coronaviruses. Phylogenetic analyses were performed from positive specimens.
From 351 frugivorous bats, we detected 14 coronaviruses from two endemic bats species, of which 13 viruses were identified from
Our findings suggest that CoVs circulate in frugivorous bats of Madagascar, demonstrating the needs to evaluate spillover risk to human populations especially for individuals that hunt and consume infected bats. Possible dispersal mechanisms as to how coronaviruses arrived on Madagascar are discussed.
Url:
DOI: 10.1186/s12985-015-0271-y
PubMed: 25888853
PubMed Central: 4404003
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PMC:4404003Le document en format XML
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<term>Chiroptera (virology)</term>
<term>Coronaviridae (classification)</term>
<term>Coronaviridae (genetics)</term>
<term>Coronaviridae (isolation & purification)</term>
<term>Coronaviridae Infections (veterinary)</term>
<term>Genes, Viral</term>
<term>Genetic Variation</term>
<term>Geography</term>
<term>Madagascar</term>
<term>Phylogeny</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Chiroptera (virologie)</term>
<term>Coronaviridae ()</term>
<term>Coronaviridae (génétique)</term>
<term>Coronaviridae (isolement et purification)</term>
<term>Gènes viraux</term>
<term>Géographie</term>
<term>Infections à Coronaviridae (médecine vétérinaire)</term>
<term>Madagascar</term>
<term>Phylogénie</term>
<term>Variation génétique</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Madagascar</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Coronaviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronaviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronaviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronaviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronaviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à Coronaviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronaviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Genes, Viral</term>
<term>Genetic Variation</term>
<term>Geography</term>
<term>Phylogeny</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Coronaviridae</term>
<term>Gènes viraux</term>
<term>Géographie</term>
<term>Madagascar</term>
<term>Phylogénie</term>
<term>Variation génétique</term>
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</keywords>
<keywords scheme="mix" xml:lang="en"><term>Chiroptera</term>
<term>Coronavirus</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p id="Par1">Bats are amongst the natural reservoirs of many coronaviruses (CoVs) of which some can lead to severe infection in human. African bats are known to harbor a range of pathogens (e.g., Ebola and Marburg viruses) that can infect humans and cause disease outbreaks. A recent study in South Africa isolated a genetic variant closely related to MERS-CoV from an insectivorous bat. Though Madagascar is home to 44 bat species (41 insectivorous and 3 frugivorous) of which 34 are endemic, no data exists concerning the circulation of CoVs in the island’s chiropteran fauna. Certain Malagasy bats can be frequently found in close contact with humans and frugivorous bats feed in the same trees where people collect and consume fruits and are hunted and consumed as bush meat. The purpose of our study is to detect and identify CoVs from frugivorous bats in Madagascar to evaluate the risk of human infection from infected bats.</p>
</sec>
<sec><title>Methods</title>
<p id="Par2">Frugivorous bats belonging to three species were captured in four different regions of Madagascar. We analyzed fecal and throat swabs to detect the presence of virus through amplification of the RNA-dependent RNA polymerase (RdRp) gene, which is highly conserved in all known coronaviruses. Phylogenetic analyses were performed from positive specimens.</p>
</sec>
<sec><title>Results</title>
<p id="Par3">From 351 frugivorous bats, we detected 14 coronaviruses from two endemic bats species, of which 13 viruses were identified from <italic>Pteropus rufus</italic>
and one from <italic>Eidolon dupreanum</italic>
, giving an overall prevalence of 4.5%. Phylogenetic analysis revealed that the Malagasy strains belong to the genus <italic>Betacoronavirus</italic>
but form three distinct clusters, which seem to represent previously undescribed genetic lineages.</p>
</sec>
<sec><title>Conclusions</title>
<p id="Par4">Our findings suggest that CoVs circulate in frugivorous bats of Madagascar, demonstrating the needs to evaluate spillover risk to human populations especially for individuals that hunt and consume infected bats. Possible dispersal mechanisms as to how coronaviruses arrived on Madagascar are discussed.</p>
</sec>
</div>
</front>
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</author>
<author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name>
</author>
<author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name>
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</author>
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<front><div type="abstract" xml:lang="en"> <p>BACKGROUND:Bats are amongst the natural reservoirs of many coronaviruses (CoVs) of which some can lead to severe infection in human. African bats are known to harbor a range of pathogens (e.g., Ebola and Marburg viruses) that can infect humans and cause disease outbreaks. A recent study in South Africa isolated a genetic variant closely related to MERS-CoV from an insectivorous bat. Though Madagascar is home to 44 bat species (41 insectivorous and 3 frugivorous) of which 34 are endemic, no data exists concerning the circulation of CoVs in the island's chiropteran fauna. Certain Malagasy bats can be frequently found in close contact with humans and frugivorous bats feed in the same trees where people collect and consume fruits and are hunted and consumed as bush meat. The purpose of our study is to detect and identify CoVs from frugivorous bats in Madagascar to evaluate the risk of human infection from infected bats.METHODS:Frugivorous bats belonging to three species were captured in four different regions of Madagascar. We analyzed fecal and throat swabs to detect the presence of virus through amplification of the RNA-dependent RNA polymerase (RdRp) gene, which is highly conserved in all known coronaviruses. Phylogenetic analyses were performed from positive specimens.RESULTS:From 351 frugivorous bats, we detected 14 coronaviruses from two endemic bats species, of which 13 viruses were identified from Pteropus rufus and one from Eidolon dupreanum, giving an overall prevalence of 4.5%. Phylogenetic analysis revealed that the Malagasy strains belong to the genus Betacoronavirus but form three distinct clusters, which seem to represent previously undescribed genetic lineages.CONCLUSIONS:Our findings suggest that CoVs circulate in frugivorous bats of Madagascar, demonstrating the needs to evaluate spillover risk to human populations especially for individuals that hunt and consume infected bats. Possible dispersal mechanisms as to how coronaviruses arrived on Madagascar are discussed.</p>
</div>
</front>
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<PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Detection of new genetic variants of <italic>Betacoronaviruses</italic>
in Endemic Frugivorous Bats of Madagascar</title>
<author><name sortKey="Razanajatovo, Norosoa H" sort="Razanajatovo, Norosoa H" uniqKey="Razanajatovo N" first="Norosoa H" last="Razanajatovo">Norosoa H. Razanajatovo</name>
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Ambatofotsikely, BP 1274 Antananarivo Madagascar, Dummy_Only</nlm:aff>
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Ambatofotsikely, BP 1274 Antananarivo Madagascar, Dummy_Only</nlm:aff>
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BP 906 Antananarivo, Madagascar</nlm:aff>
<country xml:lang="fr">Madagascar</country>
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Bangor, Gwynedd United Kingdom</nlm:aff>
<wicri:noCountry code="subfield">Gwynedd United Kingdom</wicri:noCountry>
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Ambatofotsikely, BP 1274 Antananarivo Madagascar, Dummy_Only</nlm:aff>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Detection of new genetic variants of <italic>Betacoronaviruses</italic>
in Endemic Frugivorous Bats of Madagascar</title>
<author><name sortKey="Razanajatovo, Norosoa H" sort="Razanajatovo, Norosoa H" uniqKey="Razanajatovo N" first="Norosoa H" last="Razanajatovo">Norosoa H. Razanajatovo</name>
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Ambatofotsikely, BP 1274 Antananarivo Madagascar, Dummy_Only</nlm:aff>
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<author><name sortKey="Nomenjanahary, Lalaina A" sort="Nomenjanahary, Lalaina A" uniqKey="Nomenjanahary L" first="Lalaina A" last="Nomenjanahary">Lalaina A. Nomenjanahary</name>
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Ambatofotsikely, BP 1274 Antananarivo Madagascar, Dummy_Only</nlm:aff>
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<author><name sortKey="Wilkinson, David A" sort="Wilkinson, David A" uniqKey="Wilkinson D" first="David A" last="Wilkinson">David A. Wilkinson</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Recherche et de Veille sur les Maladies Emergentes dans l’Ocean Indien (CRVOI), Plateforme de Recherche CYROI, 2 rue Maxime Riviere, 97490 Sainte Clotilde La Reunion</wicri:regionArea>
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<author><name sortKey="Razafimanahaka, Julie H" sort="Razafimanahaka, Julie H" uniqKey="Razafimanahaka J" first="Julie H" last="Razafimanahaka">Julie H. Razafimanahaka</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.473346.1</institution-id>
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BP 5181 Antananarivo, Madagascar</nlm:aff>
<country xml:lang="fr">Madagascar</country>
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BP 906 Antananarivo, Madagascar</nlm:aff>
<country xml:lang="fr">Madagascar</country>
<wicri:regionArea>BP 906 Antananarivo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goodman, Steven M" sort="Goodman, Steven M" uniqKey="Goodman S" first="Steven M" last="Goodman">Steven M. Goodman</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.452263.4</institution-id>
<institution>Association Vahatra,</institution>
</institution-wrap>
BP 3972 Antananarivo, Madagascar</nlm:aff>
<country xml:lang="fr">Madagascar</country>
<wicri:regionArea>BP 3972 Antananarivo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jenkins, Richard K" sort="Jenkins, Richard K" uniqKey="Jenkins R" first="Richard K" last="Jenkins">Richard K. Jenkins</name>
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<institution-id institution-id-type="ISNI">0000000118820937</institution-id>
<institution>School of Environment, Natural Resources and Geography,</institution>
<institution>Bangor University,</institution>
</institution-wrap>
Bangor, Gwynedd United Kingdom</nlm:aff>
<wicri:noCountry code="subfield">Gwynedd United Kingdom</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jones, Julia Pg" sort="Jones, Julia Pg" uniqKey="Jones J" first="Julia Pg" last="Jones">Julia Pg Jones</name>
<affiliation><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.7362.0</institution-id>
<institution-id institution-id-type="ISNI">0000000118820937</institution-id>
<institution>School of Environment, Natural Resources and Geography,</institution>
<institution>Bangor University,</institution>
</institution-wrap>
Bangor, Gwynedd United Kingdom</nlm:aff>
<wicri:noCountry code="subfield">Gwynedd United Kingdom</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Heraud, Jean Michel" sort="Heraud, Jean Michel" uniqKey="Heraud J" first="Jean-Michel" last="Heraud">Jean-Michel Heraud</name>
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Ambatofotsikely, BP 1274 Antananarivo Madagascar, Dummy_Only</nlm:aff>
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</analytic>
<series><title level="j">Virology Journal</title>
<idno type="eISSN">1743-422X</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
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<term>Chiroptera (virology)</term>
<term>Coronaviridae (classification)</term>
<term>Coronaviridae (genetics)</term>
<term>Coronaviridae (isolation & purification)</term>
<term>Coronaviridae Infections (veterinary)</term>
<term>Genes, Viral</term>
<term>Genetic Variation</term>
<term>Geography</term>
<term>Madagascar</term>
<term>Phylogeny</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Chiroptera (virologie)</term>
<term>Coronaviridae ()</term>
<term>Coronaviridae (génétique)</term>
<term>Coronaviridae (isolement et purification)</term>
<term>Gènes viraux</term>
<term>Géographie</term>
<term>Infections à Coronaviridae (médecine vétérinaire)</term>
<term>Madagascar</term>
<term>Phylogénie</term>
<term>Variation génétique</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Madagascar</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Coronaviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronaviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronaviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronaviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronaviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à Coronaviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronaviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Genes, Viral</term>
<term>Genetic Variation</term>
<term>Geography</term>
<term>Phylogeny</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Coronaviridae</term>
<term>Gènes viraux</term>
<term>Géographie</term>
<term>Madagascar</term>
<term>Phylogénie</term>
<term>Variation génétique</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p id="Par1">Bats are amongst the natural reservoirs of many coronaviruses (CoVs) of which some can lead to severe infection in human. African bats are known to harbor a range of pathogens (e.g., Ebola and Marburg viruses) that can infect humans and cause disease outbreaks. A recent study in South Africa isolated a genetic variant closely related to MERS-CoV from an insectivorous bat. Though Madagascar is home to 44 bat species (41 insectivorous and 3 frugivorous) of which 34 are endemic, no data exists concerning the circulation of CoVs in the island’s chiropteran fauna. Certain Malagasy bats can be frequently found in close contact with humans and frugivorous bats feed in the same trees where people collect and consume fruits and are hunted and consumed as bush meat. The purpose of our study is to detect and identify CoVs from frugivorous bats in Madagascar to evaluate the risk of human infection from infected bats.</p>
</sec>
<sec><title>Methods</title>
<p id="Par2">Frugivorous bats belonging to three species were captured in four different regions of Madagascar. We analyzed fecal and throat swabs to detect the presence of virus through amplification of the RNA-dependent RNA polymerase (RdRp) gene, which is highly conserved in all known coronaviruses. Phylogenetic analyses were performed from positive specimens.</p>
</sec>
<sec><title>Results</title>
<p id="Par3">From 351 frugivorous bats, we detected 14 coronaviruses from two endemic bats species, of which 13 viruses were identified from <italic>Pteropus rufus</italic>
and one from <italic>Eidolon dupreanum</italic>
, giving an overall prevalence of 4.5%. Phylogenetic analysis revealed that the Malagasy strains belong to the genus <italic>Betacoronavirus</italic>
but form three distinct clusters, which seem to represent previously undescribed genetic lineages.</p>
</sec>
<sec><title>Conclusions</title>
<p id="Par4">Our findings suggest that CoVs circulate in frugivorous bats of Madagascar, demonstrating the needs to evaluate spillover risk to human populations especially for individuals that hunt and consume infected bats. Possible dispersal mechanisms as to how coronaviruses arrived on Madagascar are discussed.</p>
</sec>
</div>
</front>
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</author>
<author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name>
</author>
<author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Adams, Mj" uniqKey="Adams M">MJ Adams</name>
</author>
<author><name sortKey="Carstens, Eb" uniqKey="Carstens E">EB Carstens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heikkinen, T" uniqKey="Heikkinen T">T Heikkinen</name>
</author>
<author><name sortKey="Jarvinen, A" uniqKey="Jarvinen A">A Jarvinen</name>
</author>
</analytic>
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<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Van Der Hoek, L" uniqKey="Van Der Hoek L">L van der Hoek</name>
</author>
<author><name sortKey="Pyrc, K" uniqKey="Pyrc K">K Pyrc</name>
</author>
<author><name sortKey="Jebbink, Mf" uniqKey="Jebbink M">MF Jebbink</name>
</author>
<author><name sortKey="Vermeulen Oost, W" uniqKey="Vermeulen Oost W">W Vermeulen-Oost</name>
</author>
<author><name sortKey="Berkhout, Rj" uniqKey="Berkhout R">RJ Berkhout</name>
</author>
<author><name sortKey="Wolthers, Kc" uniqKey="Wolthers K">KC Wolthers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name>
</author>
<author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name>
</author>
<author><name sortKey="Chu, Cm" uniqKey="Chu C">CM Chu</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="Tsoi, Hw" uniqKey="Tsoi H">HW Tsoi</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bermingham, A" uniqKey="Bermingham A">A Bermingham</name>
</author>
<author><name sortKey="Chand, Ma" uniqKey="Chand M">MA Chand</name>
</author>
<author><name sortKey="Brown, Cs" uniqKey="Brown C">CS Brown</name>
</author>
<author><name sortKey="Aarons, E" uniqKey="Aarons E">E Aarons</name>
</author>
<author><name sortKey="Tong, C" uniqKey="Tong C">C Tong</name>
</author>
<author><name sortKey="Langrish, C" uniqKey="Langrish C">C Langrish</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name>
</author>
<author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name>
</author>
<author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
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