Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia
Identifieur interne : 001312 ( Main/Merge ); précédent : 001311; suivant : 001313Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia
Auteurs : Hanan H. Balkhy [Arabie saoudite] ; Thamer H. Alenazi [Arabie saoudite] ; Majid M. Alshamrani [Arabie saoudite] ; Henry Baffoe-Bonnie [Arabie saoudite] ; Yaseen Arabi [Arabie saoudite] ; Raed Hijazi [Arabie saoudite] ; Hail M. Al-Abdely [Arabie saoudite] ; Aiman El-Saed [Arabie saoudite] ; Sameera Al Johani [Arabie saoudite] ; Abdullah M. Assiri [Arabie saoudite] ; Abdulaziz Bin Saeed [Arabie saoudite]Source :
- Infection Control and Hospital Epidemiology [ 0899-823X ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Arabie saoudite (épidémiologie), Centres de soins tertiaires, Comorbidité, Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Femelle, Flambées de maladies, Humains, Infection croisée (), Infection croisée (microbiologie), Infection croisée (mortalité), Infection croisée (épidémiologie), Infections à coronavirus (), Infections à coronavirus (diagnostic), Infections à coronavirus (mortalité), Infections à coronavirus (épidémiologie), Lutte contre l'infection (), Mâle, Personnel de santé, RT-PCR, Septum nasal (microbiologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Transmission de maladie infectieuse du patient au professionnel de santé, Ventilation artificielle, Études prospectives.
- MESH :
- diagnostic : Infections à coronavirus.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- microbiologie : Infection croisée, Septum nasal.
- mortalité : Infection croisée, Infections à coronavirus.
- épidémiologie : Arabie saoudite, Infection croisée, Infections à coronavirus.
- Adulte, Adulte d'âge moyen, Centres de soins tertiaires, Comorbidité, Femelle, Flambées de maladies, Humains, Infection croisée, Infections à coronavirus, Lutte contre l'infection, Mâle, Personnel de santé, RT-PCR, Sujet âgé, Sujet âgé de 80 ans ou plus, Transmission de maladie infectieuse du patient au professionnel de santé, Ventilation artificielle, Études prospectives.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Comorbidity, Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Coronavirus Infections (mortality), Coronavirus Infections (prevention & control), Cross Infection (epidemiology), Cross Infection (microbiology), Cross Infection (mortality), Cross Infection (prevention & control), Disease Outbreaks, Female, Health Personnel, Humans, Infection Control (methods), Infectious Disease Transmission, Patient-to-Professional, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (isolation & purification), Nasal Septum (microbiology), Prospective Studies, Respiration, Artificial, Reverse Transcriptase Polymerase Chain Reaction, Saudi Arabia (epidemiology), Tertiary Care Centers.
- MESH :
- diagnosis : Coronavirus Infections.
- epidemiology : Coronavirus Infections, Cross Infection, Saudi Arabia.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- methods : Infection Control.
- microbiology : Cross Infection, Nasal Septum.
- mortality : Coronavirus Infections, Cross Infection.
- prevention & control : Coronavirus Infections, Cross Infection.
- Adult, Aged, Aged, 80 and over, Comorbidity, Disease Outbreaks, Female, Health Personnel, Humans, Infectious Disease Transmission, Patient-to-Professional, Male, Middle Aged, Prospective Studies, Respiration, Artificial, Reverse Transcriptase Polymerase Chain Reaction, Tertiary Care Centers.
Abstract
Since the first isolation of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia in 2012, sporadic cases, clusters, and sometimes large outbreaks have been reported.
To describe the recent (2015) MERS-CoV outbreak at a large tertiary care hospital in Riyadh, Saudi Arabia.
We conducted an epidemiologic outbreak investigation, including case finding and contact tracing and screening. MERS-CoV cases were categorized as suspected, probable, and confirmed. A confirmed case was defined as positive reverse transcription polymerase chain reaction test for MERS-CoV.
Of the 130 suspected cases, 81 (62%) were confirmed and 49 (38%) were probable. These included 87 patients (67%) and 43 healthcare workers (33%). Older age (mean [SD], 64.4 [18.3] vs 40.1 [11.3] years,
MERS-CoV remains a major healthcare threat. Early recognition of cases and rapid implementation of infection control measures are necessary.
Url:
DOI: 10.1017/ice.2016.132
PubMed: 27426423
PubMed Central: 7113028
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000D18
- to stream Pmc, to step Curation: 000D18
- to stream Pmc, to step Checkpoint: 000C02
- to stream PubMed, to step Corpus: 001044
- to stream PubMed, to step Curation: 001044
- to stream PubMed, to step Checkpoint: 001156
- to stream Ncbi, to step Merge: 001703
- to stream Ncbi, to step Curation: 001703
- to stream Ncbi, to step Checkpoint: 001703
Links to Exploration step
PMC:7113028Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia</title>
<author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name>
<affiliation><nlm:aff id="aff1"><institution>King Saud bin Abdulaziz University for Health Sciences</institution>
,<country>Riyadh Saudi Arabia</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="aff2"><addr-line>King Abdullah International Medical Research Center</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Infection Prevention and Control Department</addr-line>
,<addr-line>King Abdulaziz Medical City</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alenazi, Thamer H" sort="Alenazi, Thamer H" uniqKey="Alenazi T" first="Thamer H." last="Alenazi">Thamer H. Alenazi</name>
<affiliation><nlm:aff id="aff1"><institution>King Saud bin Abdulaziz University for Health Sciences</institution>
,<country>Riyadh Saudi Arabia</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Infection Prevention and Control Department</addr-line>
,<addr-line>King Abdulaziz Medical City</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alshamrani, Majid M" sort="Alshamrani, Majid M" uniqKey="Alshamrani M" first="Majid M." last="Alshamrani">Majid M. Alshamrani</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Infection Prevention and Control Department</addr-line>
,<addr-line>King Abdulaziz Medical City</addr-line>
,<addr-line>Jeddah</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baffoe Bonnie, Henry" sort="Baffoe Bonnie, Henry" uniqKey="Baffoe Bonnie H" first="Henry" last="Baffoe-Bonnie">Henry Baffoe-Bonnie</name>
<affiliation><nlm:aff id="aff1"><institution>King Saud bin Abdulaziz University for Health Sciences</institution>
,<country>Riyadh Saudi Arabia</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Infection Prevention and Control Department</addr-line>
,<addr-line>King Abdulaziz Medical City</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arabi, Yaseen" sort="Arabi, Yaseen" uniqKey="Arabi Y" first="Yaseen" last="Arabi">Yaseen Arabi</name>
<affiliation><nlm:aff id="aff1"><institution>King Saud bin Abdulaziz University for Health Sciences</institution>
,<country>Riyadh Saudi Arabia</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Intensive Care Department</addr-line>
,<addr-line>King Abdulaziz Medical City</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hijazi, Raed" sort="Hijazi, Raed" uniqKey="Hijazi R" first="Raed" last="Hijazi">Raed Hijazi</name>
<affiliation><nlm:aff id="aff1"><institution>King Saud bin Abdulaziz University for Health Sciences</institution>
,<country>Riyadh Saudi Arabia</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Emergency Care Department</addr-line>
,<addr-line>King Abdulaziz Medical City</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Al Abdely, Hail M" sort="Al Abdely, Hail M" uniqKey="Al Abdely H" first="Hail M." last="Al-Abdely">Hail M. Al-Abdely</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Ministry of Health</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="El Saed, Aiman" sort="El Saed, Aiman" uniqKey="El Saed A" first="Aiman" last="El-Saed">Aiman El-Saed</name>
<affiliation><nlm:aff id="aff1"><institution>King Saud bin Abdulaziz University for Health Sciences</institution>
,<country>Riyadh Saudi Arabia</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Infection Prevention and Control Department</addr-line>
,<addr-line>King Abdulaziz Medical City</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Al Johani, Sameera" sort="Al Johani, Sameera" uniqKey="Al Johani S" first="Sameera" last="Al Johani">Sameera Al Johani</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Pathology and Laboratory Medicine Department</addr-line>
,<addr-line>King Abdulaziz Medical City</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Assiri, Abdullah M" sort="Assiri, Abdullah M" uniqKey="Assiri A" first="Abdullah M." last="Assiri">Abdullah M. Assiri</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Ministry of Health</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>King Fahad Medical City</addr-line>
,<addr-line>Ministry of Health</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bin Saeed, Abdulaziz" sort="Bin Saeed, Abdulaziz" uniqKey="Bin Saeed A" first="Abdulaziz" last="Bin Saeed">Abdulaziz Bin Saeed</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Ministry of Health</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>King Saud University</institution>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27426423</idno>
<idno type="pmc">7113028</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113028</idno>
<idno type="RBID">PMC:7113028</idno>
<idno type="doi">10.1017/ice.2016.132</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000D18</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D18</idno>
<idno type="wicri:Area/Pmc/Curation">000D18</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D18</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000C02</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C02</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:27426423</idno>
<idno type="wicri:Area/PubMed/Corpus">001044</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001044</idno>
<idno type="wicri:Area/PubMed/Curation">001044</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001044</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001156</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001156</idno>
<idno type="wicri:Area/Ncbi/Merge">001703</idno>
<idno type="wicri:Area/Ncbi/Curation">001703</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001703</idno>
<idno type="wicri:doubleKey">0899-823X:2016:Balkhy H:description:of:a</idno>
<idno type="wicri:Area/Main/Merge">001312</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia</title>
<author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name>
<affiliation><nlm:aff id="aff1"><institution>King Saud bin Abdulaziz University for Health Sciences</institution>
,<country>Riyadh Saudi Arabia</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="aff2"><addr-line>King Abdullah International Medical Research Center</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Infection Prevention and Control Department</addr-line>
,<addr-line>King Abdulaziz Medical City</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alenazi, Thamer H" sort="Alenazi, Thamer H" uniqKey="Alenazi T" first="Thamer H." last="Alenazi">Thamer H. Alenazi</name>
<affiliation><nlm:aff id="aff1"><institution>King Saud bin Abdulaziz University for Health Sciences</institution>
,<country>Riyadh Saudi Arabia</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Infection Prevention and Control Department</addr-line>
,<addr-line>King Abdulaziz Medical City</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alshamrani, Majid M" sort="Alshamrani, Majid M" uniqKey="Alshamrani M" first="Majid M." last="Alshamrani">Majid M. Alshamrani</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Infection Prevention and Control Department</addr-line>
,<addr-line>King Abdulaziz Medical City</addr-line>
,<addr-line>Jeddah</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baffoe Bonnie, Henry" sort="Baffoe Bonnie, Henry" uniqKey="Baffoe Bonnie H" first="Henry" last="Baffoe-Bonnie">Henry Baffoe-Bonnie</name>
<affiliation><nlm:aff id="aff1"><institution>King Saud bin Abdulaziz University for Health Sciences</institution>
,<country>Riyadh Saudi Arabia</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Infection Prevention and Control Department</addr-line>
,<addr-line>King Abdulaziz Medical City</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arabi, Yaseen" sort="Arabi, Yaseen" uniqKey="Arabi Y" first="Yaseen" last="Arabi">Yaseen Arabi</name>
<affiliation><nlm:aff id="aff1"><institution>King Saud bin Abdulaziz University for Health Sciences</institution>
,<country>Riyadh Saudi Arabia</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Intensive Care Department</addr-line>
,<addr-line>King Abdulaziz Medical City</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hijazi, Raed" sort="Hijazi, Raed" uniqKey="Hijazi R" first="Raed" last="Hijazi">Raed Hijazi</name>
<affiliation><nlm:aff id="aff1"><institution>King Saud bin Abdulaziz University for Health Sciences</institution>
,<country>Riyadh Saudi Arabia</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Emergency Care Department</addr-line>
,<addr-line>King Abdulaziz Medical City</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Al Abdely, Hail M" sort="Al Abdely, Hail M" uniqKey="Al Abdely H" first="Hail M." last="Al-Abdely">Hail M. Al-Abdely</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Ministry of Health</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="El Saed, Aiman" sort="El Saed, Aiman" uniqKey="El Saed A" first="Aiman" last="El-Saed">Aiman El-Saed</name>
<affiliation><nlm:aff id="aff1"><institution>King Saud bin Abdulaziz University for Health Sciences</institution>
,<country>Riyadh Saudi Arabia</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Infection Prevention and Control Department</addr-line>
,<addr-line>King Abdulaziz Medical City</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Al Johani, Sameera" sort="Al Johani, Sameera" uniqKey="Al Johani S" first="Sameera" last="Al Johani">Sameera Al Johani</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Pathology and Laboratory Medicine Department</addr-line>
,<addr-line>King Abdulaziz Medical City</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Assiri, Abdullah M" sort="Assiri, Abdullah M" uniqKey="Assiri A" first="Abdullah M." last="Assiri">Abdullah M. Assiri</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Ministry of Health</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>King Fahad Medical City</addr-line>
,<addr-line>Ministry of Health</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bin Saeed, Abdulaziz" sort="Bin Saeed, Abdulaziz" uniqKey="Bin Saeed A" first="Abdulaziz" last="Bin Saeed">Abdulaziz Bin Saeed</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Ministry of Health</addr-line>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>King Saud University</institution>
,<addr-line>Riyadh</addr-line>
,<country>Saudi Arabia</country>
</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Infection Control and Hospital Epidemiology</title>
<idno type="ISSN">0899-823X</idno>
<idno type="eISSN">1559-6834</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Comorbidity</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (prevention & control)</term>
<term>Cross Infection (epidemiology)</term>
<term>Cross Infection (microbiology)</term>
<term>Cross Infection (mortality)</term>
<term>Cross Infection (prevention & control)</term>
<term>Disease Outbreaks</term>
<term>Female</term>
<term>Health Personnel</term>
<term>Humans</term>
<term>Infection Control (methods)</term>
<term>Infectious Disease Transmission, Patient-to-Professional</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term>
<term>Nasal Septum (microbiology)</term>
<term>Prospective Studies</term>
<term>Respiration, Artificial</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Saudi Arabia (epidemiology)</term>
<term>Tertiary Care Centers</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Arabie saoudite (épidémiologie)</term>
<term>Centres de soins tertiaires</term>
<term>Comorbidité</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term>
<term>Femelle</term>
<term>Flambées de maladies</term>
<term>Humains</term>
<term>Infection croisée ()</term>
<term>Infection croisée (microbiologie)</term>
<term>Infection croisée (mortalité)</term>
<term>Infection croisée (épidémiologie)</term>
<term>Infections à coronavirus ()</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (mortalité)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Lutte contre l'infection ()</term>
<term>Mâle</term>
<term>Personnel de santé</term>
<term>RT-PCR</term>
<term>Septum nasal (microbiologie)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Transmission de maladie infectieuse du patient au professionnel de santé</term>
<term>Ventilation artificielle</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Cross Infection</term>
<term>Saudi Arabia</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Infection Control</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Infection croisée</term>
<term>Septum nasal</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Cross Infection</term>
<term>Nasal Septum</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term>
<term>Cross Infection</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infection croisée</term>
<term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term>
<term>Cross Infection</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Arabie saoudite</term>
<term>Infection croisée</term>
<term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Comorbidity</term>
<term>Disease Outbreaks</term>
<term>Female</term>
<term>Health Personnel</term>
<term>Humans</term>
<term>Infectious Disease Transmission, Patient-to-Professional</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Respiration, Artificial</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Tertiary Care Centers</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Centres de soins tertiaires</term>
<term>Comorbidité</term>
<term>Femelle</term>
<term>Flambées de maladies</term>
<term>Humains</term>
<term>Infection croisée</term>
<term>Infections à coronavirus</term>
<term>Lutte contre l'infection</term>
<term>Mâle</term>
<term>Personnel de santé</term>
<term>RT-PCR</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Transmission de maladie infectieuse du patient au professionnel de santé</term>
<term>Ventilation artificielle</term>
<term>Études prospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="abs1" sec-type="general"><title>BACKGROUND</title>
<p>Since the first isolation of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia in 2012, sporadic cases, clusters, and sometimes large outbreaks have been reported.</p>
</sec>
<sec id="abs2" sec-type="general"><title>OBJECTIVE</title>
<p>To describe the recent (2015) MERS-CoV outbreak at a large tertiary care hospital in Riyadh, Saudi Arabia.</p>
</sec>
<sec id="abs3" sec-type="methods"><title>METHODS</title>
<p>We conducted an epidemiologic outbreak investigation, including case finding and contact tracing and screening. MERS-CoV cases were categorized as suspected, probable, and confirmed. A confirmed case was defined as positive reverse transcription polymerase chain reaction test for MERS-CoV.</p>
</sec>
<sec id="abs4" sec-type="results"><title>RESULTS</title>
<p>Of the 130 suspected cases, 81 (62%) were confirmed and 49 (38%) were probable. These included 87 patients (67%) and 43 healthcare workers (33%). Older age (mean [SD], 64.4 [18.3] vs 40.1 [11.3] years, <italic>P<</italic>
.001), symptoms (97% vs 58%, <italic>P<</italic>
.001), and comorbidity (99% vs 42%, <italic>P<</italic>
.001) were more common in patients than healthcare workers. Almost all patients (97%) were hospitalized whereas most healthcare workers (72%) were home isolated. Among 96 hospitalized cases, 63 (66%) required intensive care unit management and 60 (63%) required mechanical ventilation. Among all 130 cases, 51 (39%) died; all were patients (51 [59%]) with no deaths among healthcare workers. More than half (54%) of infections were believed to be caught at the emergency department. Strict infection control measures, including isolation and closure of the emergency department, were implemented to interrupt the chain of transmission and end the outbreak.</p>
</sec>
<sec id="abs5" sec-type="conclusion"><title>CONCLUSION</title>
<p>MERS-CoV remains a major healthcare threat. Early recognition of cases and rapid implementation of infection control measures are necessary.</p>
<p><italic>Infect Control Hosp Epidemiol</italic>
2016;1–9</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name>
</author>
<author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name>
</author>
<author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
<author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name>
</author>
<author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name>
</author>
<author><name sortKey="Perl, Tm" uniqKey="Perl T">TM Perl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name>
</author>
<author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A McGeer</name>
</author>
<author><name sortKey="Perl, Tm" uniqKey="Perl T">TM Perl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name>
</author>
<author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Alameer, K" uniqKey="Alameer K">K Alameer</name>
</author>
<author><name sortKey="Abukhzam, B" uniqKey="Abukhzam B">B Abukhzam</name>
</author>
<author><name sortKey="Khan, W" uniqKey="Khan W">W Khan</name>
</author>
<author><name sortKey="El Saed, A" uniqKey="El Saed A">A El-Saed</name>
</author>
<author><name sortKey="Balkhy, H" uniqKey="Balkhy H">H Balkhy</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name>
</author>
<author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name>
</author>
<author><name sortKey="Makhdoom, Hq" uniqKey="Makhdoom H">HQ Makhdoom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oboho, Ik" uniqKey="Oboho I">IK Oboho</name>
</author>
<author><name sortKey="Tomczyk, Sm" uniqKey="Tomczyk S">SM Tomczyk</name>
</author>
<author><name sortKey="Al Asmari, Am" uniqKey="Al Asmari A">AM Al-Asmari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Das, Km" uniqKey="Das K">KM Das</name>
</author>
<author><name sortKey="Lee, Ey" uniqKey="Lee E">EY Lee</name>
</author>
<author><name sortKey="Jawder, Se" uniqKey="Jawder S">SE Jawder</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Mizumoto, K" uniqKey="Mizumoto K">K Mizumoto</name>
</author>
<author><name sortKey="Saitoh, M" uniqKey="Saitoh M">M Saitoh</name>
</author>
<author><name sortKey="Chowell, G" uniqKey="Chowell G">G Chowell</name>
</author>
<author><name sortKey="Miyamatsu, Y" uniqKey="Miyamatsu Y">Y Miyamatsu</name>
</author>
<author><name sortKey="Nishiura, H" uniqKey="Nishiura H">H Nishiura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Balkhy, H" uniqKey="Balkhy H">H Balkhy</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001312 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001312 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Main |étape= Merge |type= RBID |clé= PMC:7113028 |texte= Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:27426423" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |