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Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia.

Identifieur interne : 001044 ( PubMed/Curation ); précédent : 001043; suivant : 001045

Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia.

Auteurs : Hanan H. Balkhy ; Thamer H. Alenazi ; Majid M. Alshamrani [Arabie saoudite] ; Henry Baffoe-Bonnie ; Yaseen Arabi ; Raed Hijazi ; Hail M. Al-Abdely [Arabie saoudite] ; Aiman El-Saed ; Sameera Al Johani [Arabie saoudite] ; Abdullah M. Assiri [Arabie saoudite] ; Abdulaziz Bin Saeed [Arabie saoudite]

Source :

Infection control and hospital epidemiology [ 1559-6834 ] ; 2016.

RBID : pubmed:27426423

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Arabie saoudite (épidémiologie), Centres de soins tertiaires, Comorbidité, Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Femelle, Flambées de maladies, Humains, Infection croisée (), Infection croisée (microbiologie), Infection croisée (mortalité), Infection croisée (épidémiologie), Infections à coronavirus (), Infections à coronavirus (diagnostic), Infections à coronavirus (mortalité), Infections à coronavirus (épidémiologie), Lutte contre l'infection (), Mâle, Personnel de santé, RT-PCR, Septum nasal (microbiologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Transmission de maladie infectieuse du patient au professionnel de santé, Ventilation artificielle, Études prospectives.
MESH :
- diagnostic : Infections à coronavirus.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- microbiologie : Infection croisée, Septum nasal.
- mortalité : Infection croisée, Infections à coronavirus.
- épidémiologie : Arabie saoudite, Infection croisée, Infections à coronavirus.
- Adulte, Adulte d'âge moyen, Centres de soins tertiaires, Comorbidité, Femelle, Flambées de maladies, Humains, Infection croisée, Infections à coronavirus, Lutte contre l'infection, Mâle, Personnel de santé, RT-PCR, Sujet âgé, Sujet âgé de 80 ans ou plus, Transmission de maladie infectieuse du patient au professionnel de santé, Ventilation artificielle, Études prospectives.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Comorbidity, Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Coronavirus Infections (mortality), Coronavirus Infections (prevention & control), Cross Infection (epidemiology), Cross Infection (microbiology), Cross Infection (mortality), Cross Infection (prevention & control), Disease Outbreaks, Female, Health Personnel, Humans, Infection Control (methods), Infectious Disease Transmission, Patient-to-Professional, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (isolation & purification), Nasal Septum (microbiology), Prospective Studies, Respiration, Artificial, Reverse Transcriptase Polymerase Chain Reaction, Saudi Arabia (epidemiology), Tertiary Care Centers.
MESH :
- diagnosis : Coronavirus Infections.
- epidemiology : Coronavirus Infections, Cross Infection, Saudi Arabia.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- methods : Infection Control.
- microbiology : Cross Infection, Nasal Septum.
- mortality : Coronavirus Infections, Cross Infection.
- prevention & control : Coronavirus Infections, Cross Infection.
- Adult, Aged, Aged, 80 and over, Comorbidity, Disease Outbreaks, Female, Health Personnel, Humans, Infectious Disease Transmission, Patient-to-Professional, Male, Middle Aged, Prospective Studies, Respiration, Artificial, Reverse Transcriptase Polymerase Chain Reaction, Tertiary Care Centers.

Abstract

BACKGROUND Since the first isolation of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia in 2012, sporadic cases, clusters, and sometimes large outbreaks have been reported. OBJECTIVE To describe the recent (2015) MERS-CoV outbreak at a large tertiary care hospital in Riyadh, Saudi Arabia. METHODS We conducted an epidemiologic outbreak investigation, including case finding and contact tracing and screening. MERS-CoV cases were categorized as suspected, probable, and confirmed. A confirmed case was defined as positive reverse transcription polymerase chain reaction test for MERS-CoV. RESULTS Of the 130 suspected cases, 81 (62%) were confirmed and 49 (38%) were probable. These included 87 patients (67%) and 43 healthcare workers (33%). Older age (mean [SD], 64.4 [18.3] vs 40.1 [11.3] years, P<.001), symptoms (97% vs 58%, P<.001), and comorbidity (99% vs 42%, P<.001) were more common in patients than healthcare workers. Almost all patients (97%) were hospitalized whereas most healthcare workers (72%) were home isolated. Among 96 hospitalized cases, 63 (66%) required intensive care unit management and 60 (63%) required mechanical ventilation. Among all 130 cases, 51 (39%) died; all were patients (51 [59%]) with no deaths among healthcare workers. More than half (54%) of infections were believed to be caught at the emergency department. Strict infection control measures, including isolation and closure of the emergency department, were implemented to interrupt the chain of transmission and end the outbreak. CONCLUSION MERS-CoV remains a major healthcare threat. Early recognition of cases and rapid implementation of infection control measures are necessary. Infect Control Hosp Epidemiol 2016;1-9.

DOI: 10.1017/ice.2016.132
PubMed: 27426423

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Hanan H. Balkhy

<affiliation><nlm:affiliation>1King Saud bin Abdulaziz University for Health Sciences,Riyadh Saudi Arabia.</nlm:affiliation>
<wicri:noCountry code="subField">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>

Thamer H. Alenazi

<affiliation><nlm:affiliation>1King Saud bin Abdulaziz University for Health Sciences,Riyadh Saudi Arabia.</nlm:affiliation>
<wicri:noCountry code="subField">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>

Henry Baffoe-Bonnie

<affiliation><nlm:affiliation>1King Saud bin Abdulaziz University for Health Sciences,Riyadh Saudi Arabia.</nlm:affiliation>
<wicri:noCountry code="subField">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>

Yaseen Arabi

<affiliation><nlm:affiliation>1King Saud bin Abdulaziz University for Health Sciences,Riyadh Saudi Arabia.</nlm:affiliation>
<wicri:noCountry code="subField">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>

Raed Hijazi

<affiliation><nlm:affiliation>1King Saud bin Abdulaziz University for Health Sciences,Riyadh Saudi Arabia.</nlm:affiliation>
<wicri:noCountry code="subField">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>

Aiman El-Saed

<affiliation><nlm:affiliation>1King Saud bin Abdulaziz University for Health Sciences,Riyadh Saudi Arabia.</nlm:affiliation>
<wicri:noCountry code="subField">Riyadh Saudi Arabia</wicri:noCountry>
</affiliation>

Le document en format XML

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<term>Health Personnel</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en">BACKGROUND Since the first isolation of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia in 2012, sporadic cases, clusters, and sometimes large outbreaks have been reported. OBJECTIVE To describe the recent (2015) MERS-CoV outbreak at a large tertiary care hospital in Riyadh, Saudi Arabia. METHODS We conducted an epidemiologic outbreak investigation, including case finding and contact tracing and screening. MERS-CoV cases were categorized as suspected, probable, and confirmed. A confirmed case was defined as positive reverse transcription polymerase chain reaction test for MERS-CoV. RESULTS Of the 130 suspected cases, 81 (62%) were confirmed and 49 (38%) were probable. These included 87 patients (67%) and 43 healthcare workers (33%). Older age (mean [SD], 64.4 [18.3] vs 40.1 [11.3] years, P<.001), symptoms (97% vs 58%, P<.001), and comorbidity (99% vs 42%, P<.001) were more common in patients than healthcare workers. Almost all patients (97%) were hospitalized whereas most healthcare workers (72%) were home isolated. Among 96 hospitalized cases, 63 (66%) required intensive care unit management and 60 (63%) required mechanical ventilation. Among all 130 cases, 51 (39%) died; all were patients (51 [59%]) with no deaths among healthcare workers. More than half (54%) of infections were believed to be caught at the emergency department. Strict infection control measures, including isolation and closure of the emergency department, were implemented to interrupt the chain of transmission and end the outbreak. CONCLUSION MERS-CoV remains a major healthcare threat. Early recognition of cases and rapid implementation of infection control measures are necessary. Infect Control Hosp Epidemiol 2016;1-9.</div>
</front>
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<Title>Infection control and hospital epidemiology</Title>
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<ELocationID EIdType="doi" ValidYN="Y">10.1017/ice.2016.132</ELocationID>
<Abstract><AbstractText>BACKGROUND Since the first isolation of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia in 2012, sporadic cases, clusters, and sometimes large outbreaks have been reported. OBJECTIVE To describe the recent (2015) MERS-CoV outbreak at a large tertiary care hospital in Riyadh, Saudi Arabia. METHODS We conducted an epidemiologic outbreak investigation, including case finding and contact tracing and screening. MERS-CoV cases were categorized as suspected, probable, and confirmed. A confirmed case was defined as positive reverse transcription polymerase chain reaction test for MERS-CoV. RESULTS Of the 130 suspected cases, 81 (62%) were confirmed and 49 (38%) were probable. These included 87 patients (67%) and 43 healthcare workers (33%). Older age (mean [SD], 64.4 [18.3] vs 40.1 [11.3] years, P<.001), symptoms (97% vs 58%, P<.001), and comorbidity (99% vs 42%, P<.001) were more common in patients than healthcare workers. Almost all patients (97%) were hospitalized whereas most healthcare workers (72%) were home isolated. Among 96 hospitalized cases, 63 (66%) required intensive care unit management and 60 (63%) required mechanical ventilation. Among all 130 cases, 51 (39%) died; all were patients (51 [59%]) with no deaths among healthcare workers. More than half (54%) of infections were believed to be caught at the emergency department. Strict infection control measures, including isolation and closure of the emergency department, were implemented to interrupt the chain of transmission and end the outbreak. CONCLUSION MERS-CoV remains a major healthcare threat. Early recognition of cases and rapid implementation of infection control measures are necessary. Infect Control Hosp Epidemiol 2016;1-9.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Balkhy</LastName>
<ForeName>Hanan H</ForeName>
<Initials>HH</Initials>
<AffiliationInfo><Affiliation>1King Saud bin Abdulaziz University for Health Sciences,Riyadh Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alenazi</LastName>
<ForeName>Thamer H</ForeName>
<Initials>TH</Initials>
<AffiliationInfo><Affiliation>1King Saud bin Abdulaziz University for Health Sciences,Riyadh Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alshamrani</LastName>
<ForeName>Majid M</ForeName>
<Initials>MM</Initials>
<AffiliationInfo><Affiliation>4Infection Prevention and Control Department,King Abdulaziz Medical City,Jeddah,Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baffoe-Bonnie</LastName>
<ForeName>Henry</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>1King Saud bin Abdulaziz University for Health Sciences,Riyadh Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Arabi</LastName>
<ForeName>Yaseen</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>1King Saud bin Abdulaziz University for Health Sciences,Riyadh Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hijazi</LastName>
<ForeName>Raed</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>1King Saud bin Abdulaziz University for Health Sciences,Riyadh Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Al-Abdely</LastName>
<ForeName>Hail M</ForeName>
<Initials>HM</Initials>
<AffiliationInfo><Affiliation>7Ministry of Health,Riyadh,Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>El-Saed</LastName>
<ForeName>Aiman</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>1King Saud bin Abdulaziz University for Health Sciences,Riyadh Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Al Johani</LastName>
<ForeName>Sameera</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>8Pathology and Laboratory Medicine Department,King Abdulaziz Medical City,Riyadh,Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Assiri</LastName>
<ForeName>Abdullah M</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>7Ministry of Health,Riyadh,Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bin Saeed</LastName>
<ForeName>Abdulaziz</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>7Ministry of Health,Riyadh,Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>07</Month>
<Day>18</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Infect Control Hosp Epidemiol</MedlineTA>
<NlmUniqueID>8804099</NlmUniqueID>
<ISSNLinking>0899-823X</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<CitationSubset>N</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003428" MajorTopicYN="N">Cross Infection</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
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<MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName>
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<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName>
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<MeshHeading><DescriptorName UI="D012121" MajorTopicYN="N">Respiration, Artificial</DescriptorName>
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<MeshHeading><DescriptorName UI="D012529" MajorTopicYN="N">Saudi Arabia</DescriptorName>
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Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia.

Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia.

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