The DnaK Chaperone Uses Different Mechanisms To Promote and Inhibit Replication of Vibrio cholerae Chromosome 2
Identifieur interne : 000B65 ( Main/Merge ); précédent : 000B64; suivant : 000B66The DnaK Chaperone Uses Different Mechanisms To Promote and Inhibit Replication of Vibrio cholerae Chromosome 2
Auteurs : Jyoti K. Jha [États-Unis] ; Mi Li [États-Unis] ; Rodolfo Ghirlando [États-Unis] ; Lisa M. Miller Jenkins [États-Unis] ; Alexander Wlodawer [États-Unis] ; Dhruba Chattoraj [États-Unis]Source :
- mBio [ 2150-7511 ] ; 2017.
Descripteurs français
- KwdFr :
- ADN bactérien (métabolisme), Chaperons moléculaires (métabolisme), Chromosomes de bactérie (métabolisme), Helicase (métabolisme), Liaison aux protéines, Multimérisation de protéines, Origine de réplication, Protéines bactériennes (métabolisme), Réplication de l'ADN, Transactivateurs (métabolisme), Vibrio cholerae (croissance et développement), Vibrio cholerae (enzymologie), Vibrio cholerae (génétique).
- MESH :
- croissance et développement : Vibrio cholerae.
- enzymologie : Vibrio cholerae.
- génétique : Vibrio cholerae.
- métabolisme : ADN bactérien, Chaperons moléculaires, Chromosomes de bactérie, Helicase, Protéines bactériennes, Transactivateurs.
- Liaison aux protéines, Multimérisation de protéines, Origine de réplication, Réplication de l'ADN.
English descriptors
- KwdEn :
- Bacterial Proteins (metabolism), Chromosomes, Bacterial (metabolism), DNA Helicases (metabolism), DNA Replication, DNA, Bacterial (metabolism), Molecular Chaperones (metabolism), Protein Binding, Protein Multimerization, Replication Origin, Trans-Activators (metabolism), Vibrio cholerae (enzymology), Vibrio cholerae (genetics), Vibrio cholerae (growth & development).
- MESH :
- chemical , metabolism : Bacterial Proteins, DNA Helicases, DNA, Bacterial, Molecular Chaperones, Trans-Activators.
- enzymology : Vibrio cholerae.
- genetics : Vibrio cholerae.
- growth & development : Vibrio cholerae.
- metabolism : Chromosomes, Bacterial.
- DNA Replication, Protein Binding, Protein Multimerization, Replication Origin.
Abstract
Replication of
Url:
DOI: 10.1128/mBio.00427-17
PubMed: 28420739
PubMed Central: 5395669
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PMC:5395669Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The DnaK Chaperone Uses Different Mechanisms To Promote and Inhibit Replication of <italic>Vibrio cholerae</italic>
Chromosome 2</title>
<author><name sortKey="Jha, Jyoti K" sort="Jha, Jyoti K" uniqKey="Jha J" first="Jyoti K." last="Jha">Jyoti K. Jha</name>
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<author><name sortKey="Li, Mi" sort="Li, Mi" uniqKey="Li M" first="Mi" last="Li">Mi Li</name>
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<author><name sortKey="Ghirlando, Rodolfo" sort="Ghirlando, Rodolfo" uniqKey="Ghirlando R" first="Rodolfo" last="Ghirlando">Rodolfo Ghirlando</name>
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<author><name sortKey="Wlodawer, Alexander" sort="Wlodawer, Alexander" uniqKey="Wlodawer A" first="Alexander" last="Wlodawer">Alexander Wlodawer</name>
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<author><name sortKey="Chattoraj, Dhruba" sort="Chattoraj, Dhruba" uniqKey="Chattoraj D" first="Dhruba" last="Chattoraj">Dhruba Chattoraj</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Laboratory of Biochemistry and Molecular Biology, CCR, NCI, NIH, Bethesda, Maryland, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Biochemistry and Molecular Biology, CCR, NCI, NIH, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
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<series><title level="j">mBio</title>
<idno type="eISSN">2150-7511</idno>
<imprint><date when="2017">2017</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bacterial Proteins (metabolism)</term>
<term>Chromosomes, Bacterial (metabolism)</term>
<term>DNA Helicases (metabolism)</term>
<term>DNA Replication</term>
<term>DNA, Bacterial (metabolism)</term>
<term>Molecular Chaperones (metabolism)</term>
<term>Protein Binding</term>
<term>Protein Multimerization</term>
<term>Replication Origin</term>
<term>Trans-Activators (metabolism)</term>
<term>Vibrio cholerae (enzymology)</term>
<term>Vibrio cholerae (genetics)</term>
<term>Vibrio cholerae (growth & development)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN bactérien (métabolisme)</term>
<term>Chaperons moléculaires (métabolisme)</term>
<term>Chromosomes de bactérie (métabolisme)</term>
<term>Helicase (métabolisme)</term>
<term>Liaison aux protéines</term>
<term>Multimérisation de protéines</term>
<term>Origine de réplication</term>
<term>Protéines bactériennes (métabolisme)</term>
<term>Réplication de l'ADN</term>
<term>Transactivateurs (métabolisme)</term>
<term>Vibrio cholerae (croissance et développement)</term>
<term>Vibrio cholerae (enzymologie)</term>
<term>Vibrio cholerae (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Bacterial Proteins</term>
<term>DNA Helicases</term>
<term>DNA, Bacterial</term>
<term>Molecular Chaperones</term>
<term>Trans-Activators</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Vibrio cholerae</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Vibrio cholerae</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Vibrio cholerae</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Vibrio cholerae</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Vibrio cholerae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Vibrio cholerae</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Chromosomes, Bacterial</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ADN bactérien</term>
<term>Chaperons moléculaires</term>
<term>Chromosomes de bactérie</term>
<term>Helicase</term>
<term>Protéines bactériennes</term>
<term>Transactivateurs</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>DNA Replication</term>
<term>Protein Binding</term>
<term>Protein Multimerization</term>
<term>Replication Origin</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Liaison aux protéines</term>
<term>Multimérisation de protéines</term>
<term>Origine de réplication</term>
<term>Réplication de l'ADN</term>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>Replication of <italic>Vibrio cholerae</italic>
chromosome 2 (Chr2) depends on molecular chaperone DnaK to facilitate binding of the initiator (RctB) to the replication origin. The binding occurs at two kinds of site, 12-mers and 39-mers, which promote and inhibit replication, respectively. Here we show that DnaK employs different mechanisms to enhance the two kinds of binding. We found that mutations in <italic>rctB</italic>
that reduce DnaK binding also reduce 12-mer binding and initiation. The initiation defect is suppressed by second-site mutations that increase 12-mer binding only marginally. Instead, they reduce replication inhibitory mechanisms: RctB dimerization and 39-mer binding. One suppressing change was in a dimerization domain which is folded similarly to the initiator of an iteron plasmid—the presumed progenitor of Chr2. In plasmids, DnaK promotes initiation by reducing dimerization. A different mutation was in the 39-mer binding domain of RctB and inactivated it, indicating an alternative suppression mechanism. Paradoxically, although DnaK increases 39-mer binding, the increase was also achieved by inactivating the DnaK binding site of RctB. This result suggests that the site inhibits the 39-mer binding domain (via autoinhibition) when prevented from binding DnaK. Taken together, our results reveal an important feature of the transition from plasmid to chromosome: the Chr2 initiator retains the plasmid-like dimerization domain and its control by chaperones but uses the chaperones in an unprecedented way to control the inhibitory 39-mer binding.</p>
</div>
</front>
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