Potent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4
Identifieur interne : 000431 ( Main/Merge ); précédent : 000430; suivant : 000432Potent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4
Auteurs : Shuai Xia ; Qiaoshuai Lan ; Jing Pu ; Cong Wang ; Zezhong Liu ; Wei Xu ; Qian Wang ; Huan Liu [République populaire de Chine] ; Shibo Jiang [États-Unis] ; Lu LuSource :
- Viruses [ 1999-4915 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Peptides, Spike Glycoprotein, Coronavirus, Viral Fusion Proteins.
- chemistry : Middle East Respiratory Syndrome Coronavirus.
- virology : Chiroptera.
- Animals, Phylogeny, Protein Binding, Virus Internalization.
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 and caused continual outbreaks worldwide with high mortality. However, no effective anti-MERS-CoV drug is currently available. Recently, numerous evolutionary studies have suggested that MERS-CoV originated from bat coronavirus (BatCoV). We herein reported that three peptides derived from the HR2 region in spike protein of BatCoV HKU4, including HKU4-HR2P1, HKU4-HR2P2 and HKU4-HR2P3, could bind the MERS-CoV HR1-derived peptide to form a six-helix bundle (6-HB) with high stability. Moreover, these peptides, particularly HKU4-HR2P2 and HKU4-HR2P3, exhibited potent inhibitory activity against MERS-CoV S-mediated cell–cell fusion and viral infection, suggesting that these HKU4 HR2-derived peptides could be candidates for futher development as antiviral agents against MERS-CoV infection.
Url:
DOI: 10.3390/v11010056
PubMed: 30646495
PubMed Central: 6357153
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PMC:6357153Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Potent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4</title>
<author><name sortKey="Xia, Shuai" sort="Xia, Shuai" uniqKey="Xia S" first="Shuai" last="Xia">Shuai Xia</name>
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<author><name sortKey="Wang, Cong" sort="Wang, Cong" uniqKey="Wang C" first="Cong" last="Wang">Cong Wang</name>
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<author><name sortKey="Liu, Zezhong" sort="Liu, Zezhong" uniqKey="Liu Z" first="Zezhong" last="Liu">Zezhong Liu</name>
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<affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email>
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<author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name>
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<author><name sortKey="Lu, Lu" sort="Lu, Lu" uniqKey="Lu L" first="Lu" last="Lu">Lu Lu</name>
<affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Chiroptera (virology)</term>
<term>Middle East Respiratory Syndrome Coronavirus (chemistry)</term>
<term>Peptides (chemistry)</term>
<term>Phylogeny</term>
<term>Protein Binding</term>
<term>Spike Glycoprotein, Coronavirus (chemistry)</term>
<term>Viral Fusion Proteins (chemistry)</term>
<term>Virus Internalization</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Chiroptera (virologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term>
<term>Glycoprotéine de spicule des coronavirus ()</term>
<term>Liaison aux protéines</term>
<term>Peptides ()</term>
<term>Phylogénie</term>
<term>Protéines de fusion virale ()</term>
<term>Pénétration virale</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Peptides</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Fusion Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Phylogeny</term>
<term>Protein Binding</term>
<term>Virus Internalization</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Liaison aux protéines</term>
<term>Peptides</term>
<term>Phylogénie</term>
<term>Protéines de fusion virale</term>
<term>Pénétration virale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 and caused continual outbreaks worldwide with high mortality. However, no effective anti-MERS-CoV drug is currently available. Recently, numerous evolutionary studies have suggested that MERS-CoV originated from bat coronavirus (BatCoV). We herein reported that three peptides derived from the HR2 region in spike protein of BatCoV HKU4, including HKU4-HR2P1, HKU4-HR2P2 and HKU4-HR2P3, could bind the MERS-CoV HR1-derived peptide to form a six-helix bundle (6-HB) with high stability. Moreover, these peptides, particularly HKU4-HR2P2 and HKU4-HR2P3, exhibited potent inhibitory activity against MERS-CoV S-mediated cell–cell fusion and viral infection, suggesting that these HKU4 HR2-derived peptides could be candidates for futher development as antiviral agents against MERS-CoV infection.</p>
</div>
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