COVID-19: A promising cure for the global panic
Identifieur interne : 000279 ( Main/Merge ); précédent : 000278; suivant : 000280COVID-19: A promising cure for the global panic
Auteurs : Balachandar Vellingiri [Inde] ; Kaavya Jayaramayya [Inde] ; Mahalaxmi Iyer [Inde] ; Arul Narayanasamy [Inde] ; Vivekanandhan Govindasamy [Inde] ; Bupesh Giridharan [Inde] ; Singaravelu Ganesan [Inde] ; Anila Venugopal [Inde] ; Dhivya Venkatesan [Inde] ; Harsha Ganesan [Inde] ; Kamarajan Rajagopalan [Inde] ; Pattanathu K. S. M. Rahman [Royaume-Uni] ; Ssang-Goo Cho [Corée du Sud] ; Nachimuthu Senthil Kumar [Inde] ; Mohana Devi Subramaniam [Inde]Source :
- The Science of the Total Environment [ 0048-9697 ] ; 2020.
Abstract
The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.
Url:
DOI: 10.1016/j.scitotenv.2020.138277
PubMed: 32278175
PubMed Central: 7128376
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<author><name sortKey="Rahman, Pattanathu K S M" sort="Rahman, Pattanathu K S M" uniqKey="Rahman P" first="Pattanathu K. S. M." last="Rahman">Pattanathu K. S. M. Rahman</name>
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<author><name sortKey="Cho, Ssang Goo" sort="Cho, Ssang Goo" uniqKey="Cho S" first="Ssang-Goo" last="Cho">Ssang-Goo Cho</name>
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<author><name sortKey="Kumar, Nachimuthu Senthil" sort="Kumar, Nachimuthu Senthil" uniqKey="Kumar N" first="Nachimuthu Senthil" last="Kumar">Nachimuthu Senthil Kumar</name>
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</author>
<author><name sortKey="Subramaniam, Mohana Devi" sort="Subramaniam, Mohana Devi" uniqKey="Subramaniam M" first="Mohana Devi" last="Subramaniam">Mohana Devi Subramaniam</name>
<affiliation wicri:level="1"><nlm:aff id="af0055">Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai 600 006, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai 600 006</wicri:regionArea>
<wicri:noRegion>Chennai 600 006</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">The Science of the Total Environment</title>
<idno type="ISSN">0048-9697</idno>
<idno type="eISSN">1879-1026</idno>
<imprint><date when="2020">2020</date>
</imprint>
</series>
</biblStruct>
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<profileDesc><textClass></textClass>
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<front><div type="abstract" xml:lang="en"><p>The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.</p>
</div>
</front>
</TEI>
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