Human β-defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen-specific immunity
Identifieur interne : 000951 ( Main/Exploration ); précédent : 000950; suivant : 000952Human β-defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen-specific immunity
Auteurs : Ju Kim [Corée du Sud] ; Ye Lin Yang [Corée du Sud] ; Sun-Hee Jang [Corée du Sud] ; Yong-Suk Jang [Corée du Sud]Source :
- Virology Journal [ 1743-422X ] ; 2018.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques (administration et posologie), Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Antigènes viraux (), Antigènes viraux (immunologie), Antiviraux (immunologie), Cellules Vero, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Femelle, Glycoprotéine de spicule des coronavirus (), Glycoprotéine de spicule des coronavirus (immunologie), Humains, Immunité acquise (immunologie), Immunité innée (immunologie), Infections à coronavirus (), Infections à coronavirus (immunologie), Lignée cellulaire tumorale, Macrophages (immunologie), Souris, Souris de lignée C57BL, Vaccins antiviraux (administration et posologie), Vaccins antiviraux (immunologie), Vaccins sous-unitaires (administration et posologie), Vaccins sous-unitaires (immunologie), bêta-Défensines (), bêta-Défensines (immunologie).
- MESH :
- administration et posologie : Adjuvants immunologiques, Vaccins antiviraux, Vaccins sous-unitaires.
- immunologie : Antigènes viraux, Antiviraux, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Immunité acquise, Immunité innée, Infections à coronavirus, Macrophages, Vaccins antiviraux, Vaccins sous-unitaires, bêta-Défensines.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- Animaux, Antigènes viraux, Cellules Vero, Coronavirus du syndrome respiratoire du Moyen-Orient, Femelle, Glycoprotéine de spicule des coronavirus, Humains, Infections à coronavirus, Lignée cellulaire tumorale, Souris, Souris de lignée C57BL, bêta-Défensines.
English descriptors
- KwdEn :
- Adaptive Immunity (immunology), Adjuvants, Immunologic (administration & dosage), Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Antigens, Viral (chemistry), Antigens, Viral (immunology), Antiviral Agents (immunology), Cell Line, Tumor, Chlorocebus aethiops, Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Female, Humans, Immunity, Innate (immunology), Macrophages (immunology), Mice, Mice, Inbred C57BL, Middle East Respiratory Syndrome Coronavirus (chemistry), Middle East Respiratory Syndrome Coronavirus (immunology), Spike Glycoprotein, Coronavirus (chemistry), Spike Glycoprotein, Coronavirus (immunology), THP-1 Cells, Vaccines, Subunit (administration & dosage), Vaccines, Subunit (immunology), Vero Cells, Viral Vaccines (administration & dosage), Viral Vaccines (immunology), beta-Defensins (chemistry), beta-Defensins (immunology).
- MESH :
- chemical , administration & dosage : Adjuvants, Immunologic, Vaccines, Subunit, Viral Vaccines.
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , chemistry : Antigens, Viral, Spike Glycoprotein, Coronavirus, beta-Defensins.
- chemistry : Middle East Respiratory Syndrome Coronavirus.
- immunology : Adaptive Immunity, Antigens, Viral, Antiviral Agents, Coronavirus Infections, Immunity, Innate, Macrophages, Middle East Respiratory Syndrome Coronavirus, Spike Glycoprotein, Coronavirus, Vaccines, Subunit, Viral Vaccines, beta-Defensins.
- prevention & control : Coronavirus Infections.
- Animals, Cell Line, Tumor, Chlorocebus aethiops, Female, Humans, Mice, Mice, Inbred C57BL, THP-1 Cells, Vero Cells.
Abstract
Antimicrobial peptides (AMPs) are primarily known for their innate immune defense against invading microorganisms, including viruses. In addition, recent research has suggested their modulatory activity in immune induction. Given that most subunit vaccines require an adjuvant to achieve effective immune induction through the activation of innate immunity, AMPs are plausible candidate molecules for stimulating not only innate immune but also adaptive immune responses.
In this study, we investigated the ability of human β-defensin (HBD) 2 to promote antiviral immunity in vitro and in vivo using a receptor-binding domain (RBD) of Middle East respiratory syndrome-coronavirus (MERS-CoV) spike protein (S RBD) as a model antigen (Ag). When HBD 2-conjugated S RBD was used to treat THP-1 human monocytic cells, the expression levels of antiviral (IFN-β, IFN-γ, MxA, PKR, and RNaseL) and primary immune-inducing (NOD2, TNF-α, IL-1β, and IL-6) molecules were enhanced compared to those expressed after treatment with S RBD only. The expression of chemokines capable of recruiting leukocytes, including monocytes/macrophages, natural killer cells, granulocytes, T cells, and dendritic cells, was also increased following HBD 2-conjugated S RBD treatment. More important, immunization of mice with HBD 2-conjugated S RBD enhanced the immunogenicity of the S RBD and elicited a higher S RBD-specific neutralizing antibody response than S RBD alone.
We conclude that HBD 2 activates the primary antiviral innate immune response and may also mediate the induction of an effective adaptive immune response against a conjugated Ag.
Url:
DOI: 10.1186/s12985-018-1035-2
PubMed: 30089512
PubMed Central: 6083524
Affiliations:
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C57BL</term><term>Vaccins antiviraux (administration et posologie)</term><term>Vaccins antiviraux (immunologie)</term><term>Vaccins sous-unitaires (administration et posologie)</term><term>Vaccins sous-unitaires (immunologie)</term><term>bêta-Défensines ()</term><term>bêta-Défensines (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adjuvants, Immunologic</term><term>Vaccines, Subunit</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antigens, Viral</term><term>Spike Glycoprotein, Coronavirus</term><term>beta-Defensins</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Vaccins 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Subunit</term><term>Viral Vaccines</term><term>beta-Defensins</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Chlorocebus aethiops</term><term>Female</term><term>Humans</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>THP-1 Cells</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Antigènes viraux</term><term>Cellules Vero</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Femelle</term><term>Glycoprotéine de spicule des coronavirus</term><term>Humains</term><term>Infections à coronavirus</term><term>Lignée cellulaire tumorale</term><term>Souris</term><term>Souris de lignée C57BL</term><term>bêta-Défensines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">Antimicrobial peptides (AMPs) are primarily known for their innate immune defense against invading microorganisms, including viruses. In addition, recent research has suggested their modulatory activity in immune induction. Given that most subunit vaccines require an adjuvant to achieve effective immune induction through the activation of innate immunity, AMPs are plausible candidate molecules for stimulating not only innate immune but also adaptive immune responses.</p></sec><sec><title>Results</title><p id="Par2">In this study, we investigated the ability of human β-defensin (HBD) 2 to promote antiviral immunity in vitro and in vivo using a receptor-binding domain (RBD) of Middle East respiratory syndrome-coronavirus (MERS-CoV) spike protein (S RBD) as a model antigen (Ag). When HBD 2-conjugated S RBD was used to treat THP-1 human monocytic cells, the expression levels of antiviral (IFN-β, IFN-γ, MxA, PKR, and RNaseL) and primary immune-inducing (NOD2, TNF-α, IL-1β, and IL-6) molecules were enhanced compared to those expressed after treatment with S RBD only. The expression of chemokines capable of recruiting leukocytes, including monocytes/macrophages, natural killer cells, granulocytes, T cells, and dendritic cells, was also increased following HBD 2-conjugated S RBD treatment. More important, immunization of mice with HBD 2-conjugated S RBD enhanced the immunogenicity of the S RBD and elicited a higher S RBD-specific neutralizing antibody response than S RBD alone.</p></sec><sec><title>Conclusions</title><p id="Par3">We conclude that HBD 2 activates the primary antiviral innate immune response and may also mediate the induction of an effective adaptive immune response against a conjugated Ag.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name></author><author><name sortKey="Nguyen, Mt" uniqKey="Nguyen M">MT Nguyen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aoshi, T" uniqKey="Aoshi T">T Aoshi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ko, Ej" uniqKey="Ko E">EJ Ko</name></author><author><name sortKey="Lee, Yt" uniqKey="Lee Y">YT Lee</name></author><author><name sortKey="Lee, Y" uniqKey="Lee Y">Y Lee</name></author><author><name sortKey="Kim, Kh" uniqKey="Kim K">KH Kim</name></author><author><name sortKey="Kang, Sm" uniqKey="Kang S">SM Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuroda, E" uniqKey="Kuroda E">E Kuroda</name></author><author><name sortKey="Coban, C" uniqKey="Coban C">C Coban</name></author><author><name sortKey="Ishii, Kj" uniqKey="Ishii K">KJ Ishii</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casta Eda Sanchez, Ji" uniqKey="Casta Eda Sanchez J">JI Castañeda-Sánchez</name></author><author><name sortKey="Dominguez Martinez, Da" uniqKey="Dominguez Martinez D">DA Domínguez-Martínez</name></author><author><name sortKey="Olivar Espinosa, N" uniqKey="Olivar Espinosa N">N Olivar-Espinosa</name></author><author><name sortKey="Garcia Perez, Be" uniqKey="Garcia Perez B">BE García-Pérez</name></author><author><name sortKey="Loro O Pino, Ma" uniqKey="Loro O Pino M">MA Loroño-Pino</name></author><author><name sortKey="Luna Herrera, J" uniqKey="Luna Herrera J">J Luna-Herrera</name></author><author><name sortKey="Salazar, Mi" uniqKey="Salazar M">MI Salazar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diamond, G" uniqKey="Diamond G">G Diamond</name></author><author><name sortKey="Beckloff, N" uniqKey="Beckloff N">N Beckloff</name></author><author><name sortKey="Weinberg, A" uniqKey="Weinberg A">A Weinberg</name></author><author><name sortKey="Kisich, Ko" uniqKey="Kisich K">KO Kisich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilson, Ss" uniqKey="Wilson S">SS Wilson</name></author><author><name sortKey="Wiens, Me" uniqKey="Wiens M">ME Wiens</name></author><author><name sortKey="Smith, Jg" uniqKey="Smith J">JG Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oppenheim, Jj" uniqKey="Oppenheim J">JJ Oppenheim</name></author><author><name 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Shakhov</name></author><author><name sortKey="Chertov, O" uniqKey="Chertov O">O Chertov</name></author><author><name sortKey="Shirakawa, Ak" uniqKey="Shirakawa A">AK Shirakawa</name></author><author><name sortKey="Farber, Jm" uniqKey="Farber J">JM Farber</name></author><author><name sortKey="Segal, Dm" uniqKey="Segal D">DM Segal</name></author><author><name sortKey="Oppenheim, Jj" uniqKey="Oppenheim J">JJ Oppenheim</name></author><author><name sortKey="Kwak, Lw" uniqKey="Kwak L">LW Kwak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biragyn, A" uniqKey="Biragyn A">A Biragyn</name></author><author><name sortKey="Coscia, M" uniqKey="Coscia M">M Coscia</name></author><author><name sortKey="Nagashima, K" uniqKey="Nagashima K">K Nagashima</name></author><author><name sortKey="Sanford, M" uniqKey="Sanford M">M Sanford</name></author><author><name sortKey="Young, Ha" uniqKey="Young H">HA Young</name></author><author><name sortKey="Olkhanud, P" uniqKey="Olkhanud P">P Olkhanud</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Kim, Ju" sort="Kim, Ju" uniqKey="Kim J" first="Ju" last="Kim">Ju Kim</name></noRegion><name sortKey="Jang, Sun Hee" sort="Jang, Sun Hee" uniqKey="Jang S" first="Sun-Hee" last="Jang">Sun-Hee Jang</name><name sortKey="Jang, Yong Suk" sort="Jang, Yong Suk" uniqKey="Jang Y" first="Yong-Suk" last="Jang">Yong-Suk Jang</name><name sortKey="Jang, Yong Suk" sort="Jang, Yong Suk" uniqKey="Jang Y" first="Yong-Suk" last="Jang">Yong-Suk Jang</name><name sortKey="Yang, Ye Lin" sort="Yang, Ye Lin" uniqKey="Yang Y" first="Ye Lin" last="Yang">Ye Lin Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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