MersV1, PubMed, Checkpoint, bibRecord, 000894

Human β-defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen-specific immunity.

Identifieur interne : 000894 ( PubMed/Checkpoint ); précédent : 000893; suivant : 000895

Human β-defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen-specific immunity.

Auteurs : Ju Kim [Corée du Sud] ; Ye Lin Yang [Corée du Sud] ; Sun-Hee Jang [Corée du Sud] ; Yong-Suk Jang [Corée du Sud]

Source :

Virology journal [ 1743-422X ] ; 2018.

RBID : pubmed:30089512

Descripteurs français

English descriptors

KwdEn :
- Adaptive Immunity (immunology), Adjuvants, Immunologic (administration & dosage), Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Antigens, Viral (chemistry), Antigens, Viral (immunology), Antiviral Agents (immunology), Cell Line, Tumor, Chlorocebus aethiops, Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Female, Humans, Immunity, Innate (immunology), Macrophages (immunology), Mice, Mice, Inbred C57BL, Middle East Respiratory Syndrome Coronavirus (chemistry), Middle East Respiratory Syndrome Coronavirus (immunology), Spike Glycoprotein, Coronavirus (chemistry), Spike Glycoprotein, Coronavirus (immunology), THP-1 Cells, Vaccines, Subunit (administration & dosage), Vaccines, Subunit (immunology), Vero Cells, Viral Vaccines (administration & dosage), Viral Vaccines (immunology), beta-Defensins (chemistry), beta-Defensins (immunology).
MESH :
- chemical , administration & dosage : Adjuvants, Immunologic, Vaccines, Subunit, Viral Vaccines.
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , chemistry : Antigens, Viral, Spike Glycoprotein, Coronavirus, beta-Defensins.
- chemistry : Middle East Respiratory Syndrome Coronavirus.
- immunology : Adaptive Immunity, Antigens, Viral, Antiviral Agents, Coronavirus Infections, Immunity, Innate, Macrophages, Middle East Respiratory Syndrome Coronavirus, Spike Glycoprotein, Coronavirus, Vaccines, Subunit, Viral Vaccines, beta-Defensins.
- prevention & control : Coronavirus Infections.
- Animals, Cell Line, Tumor, Chlorocebus aethiops, Female, Humans, Mice, Mice, Inbred C57BL, THP-1 Cells, Vero Cells.

Abstract

Antimicrobial peptides (AMPs) are primarily known for their innate immune defense against invading microorganisms, including viruses. In addition, recent research has suggested their modulatory activity in immune induction. Given that most subunit vaccines require an adjuvant to achieve effective immune induction through the activation of innate immunity, AMPs are plausible candidate molecules for stimulating not only innate immune but also adaptive immune responses.

DOI: 10.1186/s12985-018-1035-2
PubMed: 30089512

Affiliations:

Corée du Sud

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000820
to stream PubMed, to step Curation: 000820

Links to Exploration step

pubmed:30089512

Le document en format XML

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<term>Antibodies, Viral (blood)</term>
<term>Antigens, Viral (chemistry)</term>
<term>Antigens, Viral (immunology)</term>
<term>Antiviral Agents (immunology)</term>
<term>Cell Line, Tumor</term>
<term>Chlorocebus aethiops</term>
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<term>Coronavirus Infections (prevention & control)</term>
<term>Female</term>
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<term>Vaccines, Subunit (administration & dosage)</term>
<term>Vaccines, Subunit (immunology)</term>
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<term>Cellules Vero</term>
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<term>Vaccins antiviraux (immunologie)</term>
<term>Vaccins sous-unitaires (administration et posologie)</term>
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<front><div type="abstract" xml:lang="en">Antimicrobial peptides (AMPs) are primarily known for their innate immune defense against invading microorganisms, including viruses. In addition, recent research has suggested their modulatory activity in immune induction. Given that most subunit vaccines require an adjuvant to achieve effective immune induction through the activation of innate immunity, AMPs are plausible candidate molecules for stimulating not only innate immune but also adaptive immune responses.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30089512</PMID>
<DateCompleted><Year>2018</Year>
<Month>12</Month>
<Day>27</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1743-422X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>15</Volume>
<Issue>1</Issue>
<PubDate><Year>2018</Year>
<Month>08</Month>
<Day>08</Day>
</PubDate>
</JournalIssue>
<Title>Virology journal</Title>
<ISOAbbreviation>Virol. J.</ISOAbbreviation>
</Journal>
<ArticleTitle>Human β-defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen-specific immunity.</ArticleTitle>
<Pagination><MedlinePgn>124</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s12985-018-1035-2</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">Antimicrobial peptides (AMPs) are primarily known for their innate immune defense against invading microorganisms, including viruses. In addition, recent research has suggested their modulatory activity in immune induction. Given that most subunit vaccines require an adjuvant to achieve effective immune induction through the activation of innate immunity, AMPs are plausible candidate molecules for stimulating not only innate immune but also adaptive immune responses.</AbstractText>
<AbstractText Label="RESULTS">In this study, we investigated the ability of human β-defensin (HBD) 2 to promote antiviral immunity in vitro and in vivo using a receptor-binding domain (RBD) of Middle East respiratory syndrome-coronavirus (MERS-CoV) spike protein (S RBD) as a model antigen (Ag). When HBD 2-conjugated S RBD was used to treat THP-1 human monocytic cells, the expression levels of antiviral (IFN-β, IFN-γ, MxA, PKR, and RNaseL) and primary immune-inducing (NOD2, TNF-α, IL-1β, and IL-6) molecules were enhanced compared to those expressed after treatment with S RBD only. The expression of chemokines capable of recruiting leukocytes, including monocytes/macrophages, natural killer cells, granulocytes, T cells, and dendritic cells, was also increased following HBD 2-conjugated S RBD treatment. More important, immunization of mice with HBD 2-conjugated S RBD enhanced the immunogenicity of the S RBD and elicited a higher S RBD-specific neutralizing antibody response than S RBD alone.</AbstractText>
<AbstractText Label="CONCLUSIONS">We conclude that HBD 2 activates the primary antiviral innate immune response and may also mediate the induction of an effective adaptive immune response against a conjugated Ag.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Ju</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Biology and the Institute for Molecular Biology and Genetics, Chonbuk National University, Jeonju, 54896, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Ye Lin</ForeName>
<Initials>YL</Initials>
<AffiliationInfo><Affiliation>Department of Bioactive Material Sciences and Institute of Bioactive Materials, Chonbuk National University, Jeonju, 54896, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jang</LastName>
<ForeName>Sun-Hee</ForeName>
<Initials>SH</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Biology and the Institute for Molecular Biology and Genetics, Chonbuk National University, Jeonju, 54896, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jang</LastName>
<ForeName>Yong-Suk</ForeName>
<Initials>YS</Initials>
<Identifier Source="ORCID">0000-0002-1675-4224</Identifier>
<AffiliationInfo><Affiliation>Department of Molecular Biology and the Institute for Molecular Biology and Genetics, Chonbuk National University, Jeonju, 54896, Korea. yongsuk@jbnu.ac.kr.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Bioactive Material Sciences and Institute of Bioactive Materials, Chonbuk National University, Jeonju, 54896, Korea. yongsuk@jbnu.ac.kr.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>CRC-16-01-KRICT</GrantID>
<Agency>Korea National Research Counsil of Science & Technology</Agency>
<Country>International</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>08</Month>
<Day>08</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Virol J</MedlineTA>
<NlmUniqueID>101231645</NlmUniqueID>
<ISSNLinking>1743-422X</ISSNLinking>
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Human β-defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen-specific immunity.

Human β-defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen-specific immunity.

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