Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection.
Identifieur interne : 001778 ( Main/Exploration ); précédent : 001777; suivant : 001779Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection.
Auteurs : Kayla M. Peck [États-Unis] ; Adam S. Cockrell [États-Unis] ; Boyd L. Yount [États-Unis] ; Trevor Scobey [États-Unis] ; Ralph S. Baric [États-Unis] ; Mark T. Heise [États-Unis]Source :
- Journal of virology [ 1098-5514 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient (métabolisme), Dipeptidyl peptidase 4 (), Dipeptidyl peptidase 4 (génétique), Dipeptidyl peptidase 4 (métabolisme), Données de séquences moléculaires, Glycosylation, Infections à coronavirus (), Modèles moléculaires, Pénétration virale, Souris, Spécificité d'espèce, Séquence d'acides aminés, Technique d'immunofluorescence.
- MESH :
- génétique : Dipeptidyl peptidase 4.
- métabolisme : Coronavirus du syndrome respiratoire du Moyen-Orient, Dipeptidyl peptidase 4.
- Animaux, Dipeptidyl peptidase 4, Données de séquences moléculaires, Glycosylation, Infections à coronavirus, Modèles moléculaires, Pénétration virale, Souris, Spécificité d'espèce, Séquence d'acides aminés, Technique d'immunofluorescence.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Coronavirus Infections (prevention & control), Dipeptidyl Peptidase 4 (chemistry), Dipeptidyl Peptidase 4 (genetics), Dipeptidyl Peptidase 4 (metabolism), Fluorescent Antibody Technique, Glycosylation, Mice, Middle East Respiratory Syndrome Coronavirus (metabolism), Models, Molecular, Molecular Sequence Data, Species Specificity, Virus Internalization.
- MESH :
- chemical , chemistry : Dipeptidyl Peptidase 4.
- chemical , genetics : Dipeptidyl Peptidase 4.
- chemical , metabolism : Dipeptidyl Peptidase 4.
- metabolism : Middle East Respiratory Syndrome Coronavirus.
- prevention & control : Coronavirus Infections.
- Amino Acid Sequence, Animals, Fluorescent Antibody Technique, Glycosylation, Mice, Models, Molecular, Molecular Sequence Data, Species Specificity, Virus Internalization.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an entry receptor. Mouse DPP4 (mDPP4) does not support MERS-CoV entry; however, changes at positions 288 and 330 can confer permissivity. Position 330 changes the charge and glycosylation state of mDPP4. We show that glycosylation is a major factor impacting DPP4 receptor function. These results provide insight into DPP4 species-specific differences impacting MERS-CoV host range and may inform MERS-CoV mouse model development.
DOI: 10.1128/JVI.03445-14
PubMed: 25653445
Affiliations:
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Le document en format XML
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<term>Dipeptidyl Peptidase 4 (genetics)</term>
<term>Dipeptidyl Peptidase 4 (metabolism)</term>
<term>Fluorescent Antibody Technique</term>
<term>Glycosylation</term>
<term>Mice</term>
<term>Middle East Respiratory Syndrome Coronavirus (metabolism)</term>
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<term>Molecular Sequence Data</term>
<term>Species Specificity</term>
<term>Virus Internalization</term>
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<term>Coronavirus du syndrome respiratoire du Moyen-Orient (métabolisme)</term>
<term>Dipeptidyl peptidase 4 ()</term>
<term>Dipeptidyl peptidase 4 (génétique)</term>
<term>Dipeptidyl peptidase 4 (métabolisme)</term>
<term>Données de séquences moléculaires</term>
<term>Glycosylation</term>
<term>Infections à coronavirus ()</term>
<term>Modèles moléculaires</term>
<term>Pénétration virale</term>
<term>Souris</term>
<term>Spécificité d'espèce</term>
<term>Séquence d'acides aminés</term>
<term>Technique d'immunofluorescence</term>
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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an entry receptor. Mouse DPP4 (mDPP4) does not support MERS-CoV entry; however, changes at positions 288 and 330 can confer permissivity. Position 330 changes the charge and glycosylation state of mDPP4. We show that glycosylation is a major factor impacting DPP4 receptor function. These results provide insight into DPP4 species-specific differences impacting MERS-CoV host range and may inform MERS-CoV mouse model development. </div>
</front>
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<tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Peck, Kayla M" sort="Peck, Kayla M" uniqKey="Peck K" first="Kayla M" last="Peck">Kayla M. Peck</name>
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<name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name>
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<name sortKey="Yount, Boyd L" sort="Yount, Boyd L" uniqKey="Yount B" first="Boyd L" last="Yount">Boyd L. Yount</name>
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