Predicting protein structural class by incorporating patterns of over-represented k-mers into the general form of Chou's PseAAC.
Identifieur interne : 002222 ( Main/Exploration ); précédent : 002221; suivant : 002223Predicting protein structural class by incorporating patterns of over-represented k-mers into the general form of Chou's PseAAC.
Auteurs : Yu-Fang Qin [République populaire de Chine] ; Chun-Hua Wang ; Xiao-Qing Yu ; Jie Zhu ; Tai-Gang Liu ; Xiao-Qi ZhengSource :
- Protein and peptide letters [ 1875-5305 ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Amino Acids, Proteins.
- chemical , classification : Proteins.
- Algorithms, Computational Biology, Databases, Protein, Neural Networks, Computer, Protein Folding, Protein Structure, Tertiary, Sequence Analysis, Protein, Support Vector Machine.
Abstract
Computational prediction of protein structural class based on sequence data remains a challenging problem in current protein science. In this paper, a new feature extraction approach based on relative polypeptide composition is introduced. This approach could take into account the background distribution of a given k-mer under a Markov model of order k-2, and avoid the curse of dimensionality with the increase of k by using a T-statistic feature selection strategy. The selected features are then fed to a support vector machine to perform the prediction. To verify the performance of our method, jackknife cross-validation tests are performed on four widely used benchmark datasets. Comparison of our results with existing methods shows that our method provides satisfactory performance for structural class prediction.
DOI: 10.2174/092986612799789350
PubMed: 22316305
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Computational prediction of protein structural class based on sequence data remains a challenging problem in current protein science. In this paper, a new feature extraction approach based on relative polypeptide composition is introduced. This approach could take into account the background distribution of a given k-mer under a Markov model of order k-2, and avoid the curse of dimensionality with the increase of k by using a T-statistic feature selection strategy. The selected features are then fed to a support vector machine to perform the prediction. To verify the performance of our method, jackknife cross-validation tests are performed on four widely used benchmark datasets. Comparison of our results with existing methods shows that our method provides satisfactory performance for structural class prediction.</div>
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<name sortKey="Yu, Xiao Qing" sort="Yu, Xiao Qing" uniqKey="Yu X" first="Xiao-Qing" last="Yu">Xiao-Qing Yu</name>
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<name sortKey="Zhu, Jie" sort="Zhu, Jie" uniqKey="Zhu J" first="Jie" last="Zhu">Jie Zhu</name>
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