Synthesis of 2′‐Aminoalkyl‐Substituted Fluorinated Nucleobases and Their Influence on the Kinetic Properties of Hammerhead Ribozymes

Synthesis of 2′‐Aminoalkyl‐Substituted Fluorinated Nucleobases and Their Influence on the Kinetic Properties of Hammerhead Ribozymes

Source :

• ChemBioChem [ 1439-4227 ] ; 2004-05-03.

Descripteurs français

• KwdFr :
  • ARN catalytique (), ARN catalytique (métabolisme), Catalyse, Cinétique, Conformation d'acide nucléique, Données de séquences moléculaires, Fluor (), Ribonucléosides (), Ribonucléosides (métabolisme), Ribonucléosides (synthèse chimique), Spécificité du substrat, Séquence nucléotidique, Thermodynamique.
• MESH :
  • métabolisme : ARN catalytique, Ribonucléosides.
  • synthèse chimique : Ribonucléosides.
  • ARN catalytique, Catalyse, Cinétique, Conformation d'acide nucléique, Données de séquences moléculaires, Fluor, Ribonucléosides, Spécificité du substrat, Séquence nucléotidique, Thermodynamique.

English descriptors

• KwdEn :
  • Base Sequence, Catalysis, Fluorine (chemistry), Kinetics, Molecular Sequence Data, Nucleic Acid Conformation, RNA, Catalytic (chemistry), RNA, Catalytic (metabolism), Ribonucleosides (chemical synthesis), Ribonucleosides (chemistry), Ribonucleosides (metabolism), Substrate Specificity, Thermodynamics.
• MESH :
  • chemical , chemical synthesis : Ribonucleosides.
  • chemical , chemistry : Fluorine, RNA, Catalytic, Ribonucleosides.
  • chemical , metabolism : RNA, Catalytic, Ribonucleosides.
• Teeft :
  • Ach2, Amersham biosciences, Analogue, Anhydrous, Anhydrous pyridine, Aqueous solution, Artificial nucleosides, Base Sequence, Base pair, Bch2, Benzimidazole, Black bars, Carom, Catalysis, Catalytic activity, Cdcl3, Chem, Chembiochem, Cleavage, Cleavage rates, Cleavage reactions, Crude product, Dropwise, Dropwise addition, Duplex, Engels, Equiv, Gene expression, Gmbh, Hammerhead, Hammerhead ribozyme, Hammerhead ribozymes, Harom, Hphth, Hydrogen bonds, Kgaa, Kinetic analysis, Kinetic parameters, Kinetic properties, Kinetics, Methyl bromoacetate, Mgso4, Mismatch, Mismatch complexes, Mismatch variants, Mmol, Molecular Sequence Data, Mutation, Natural nucleosides, Nucleic Acid Conformation, Nucleobase, Nucleobase analogues, Nucleobases, Nucleoside, Nucleoside analogue, Nucleoside analogues, Organic extracts, Phosphoroamidite, Point mutations, Possible substrates, Primary alcohol, Pyridine, Reaction mixture, Reaction rates, Ribozyme, Ribozymes, Rna, Room temperature, Sichch3, Sodium hydride, Substrate Specificity, Sugar moiety, Tetrabutylammonium fluoride, Thermodynamic data, Thermodynamics, Universal nucleobases, Unmodified, Unmodified ribozyme, Verlag, Verlag gmbh, Weinheim, Weinheim chembiochem, White foam.

Abstract

• https://api.istex.fr/ark:/67375/WNG-XKWPVQLC-9/fulltext.pdf

Affiliations:

• Allemagne

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