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System L: heteromeric exchangers of large, neutral amino acids involved in directional transport.

Identifieur interne : 003190 ( Main/Exploration ); précédent : 003189; suivant : 003191

System L: heteromeric exchangers of large, neutral amino acids involved in directional transport.

Auteurs : François Verrey [Suisse]

Source :

RBID : pubmed:12634921

Descripteurs français

English descriptors

Abstract

The plasma membrane transport system L is in many cells the only (efficient) pathway for the import of large branched and aromatic neutral amino acids. The corresponding transporters are hetero(di)mers composed of a catalytic subunit (LAT1 or LAT2=light chain=glycoprotein-associated amino acid transporter) associated covalently with the glycoprotein 4F2hc/CD98 (heavy chain). The tissue distribution of LAT1 suggests that it is involved mainly in transporting amino acids into growing cells and across some endothelial/epithelial secretory barriers, whereas the localization of LAT2 indicates that it is mainly involved in the basolateral efflux step of transepithelial (re)absorptive amino acid transport. However, system L transporters are obligatory amino acid exchangers with 1:1 stoichiometry, with similar (but not identical) intra- and extracellular substrate selectivities and with highly asymmetrical apparent affinities (low affinity inside). Therefore, net directional transport of large, neutral amino acids by system L depends on the parallel expression of a unidirectional transporter with overlapping selectivity (for instance systems A or N) that provides/recycles amino acids that drive system L exchange function. By mediating the regulated flux of these exchange substrates, unidirectional transporters control the activity of system L.

DOI: 10.1007/s00424-002-0973-z
PubMed: 12634921


Affiliations:

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Le document en format XML

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<term>Membranes intracellulaires (métabolisme)</term>
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