System L: heteromeric exchangers of large, neutral amino acids involved in directional transport.
Identifieur interne : 002467 ( PubMed/Curation ); précédent : 002466; suivant : 002468System L: heteromeric exchangers of large, neutral amino acids involved in directional transport.
Auteurs : François Verrey [Suisse]Source :
- Pflugers Archiv : European journal of physiology [ 0031-6768 ] ; 2003.
Descripteurs français
- KwdFr :
- Acides aminés neutres (métabolisme), Animaux, Concentration osmolaire, Humains, Membranes intracellulaires (métabolisme), Répartition dans les tissus, Système L de transport d'acides aminés (), Système L de transport d'acides aminés (physiologie), Système y+ de transport d'acides aminés, Transport biologique, Transporteur-1 d'acides aminés neutres à longue chaîne (analyse), Transporteur-1 d'acides aminés neutres à longue chaîne (métabolisme), Épithélium (métabolisme).
- MESH :
- analyse : Transporteur-1 d'acides aminés neutres à longue chaîne.
- métabolisme : Acides aminés neutres, Membranes intracellulaires, Transporteur-1 d'acides aminés neutres à longue chaîne, Épithélium.
- physiologie : Système L de transport d'acides aminés.
- Animaux, Concentration osmolaire, Humains, Répartition dans les tissus, Système L de transport d'acides aminés, Système y+ de transport d'acides aminés, Transport biologique.
English descriptors
- KwdEn :
- Amino Acid Transport System L (chemistry), Amino Acid Transport System L (physiology), Amino Acid Transport System y+, Amino Acids, Neutral (metabolism), Animals, Biological Transport, Epithelium (metabolism), Fusion Regulatory Protein 1, Light Chains (analysis), Fusion Regulatory Protein 1, Light Chains (metabolism), Fusion Regulatory Protein-1 (analysis), Humans, Intracellular Membranes (metabolism), Large Neutral Amino Acid-Transporter 1 (analysis), Large Neutral Amino Acid-Transporter 1 (metabolism), Osmolar Concentration, Tissue Distribution.
- MESH :
- chemical , analysis : Fusion Regulatory Protein 1, Light Chains, Fusion Regulatory Protein-1, Large Neutral Amino Acid-Transporter 1.
- chemical , chemistry : Amino Acid Transport System L.
- chemical , metabolism : Amino Acids, Neutral, Fusion Regulatory Protein 1, Light Chains, Large Neutral Amino Acid-Transporter 1.
- chemical , physiology : Amino Acid Transport System L.
- chemical : Amino Acid Transport System y+.
- metabolism : Epithelium, Intracellular Membranes.
- Animals, Biological Transport, Humans, Osmolar Concentration, Tissue Distribution.
Abstract
The plasma membrane transport system L is in many cells the only (efficient) pathway for the import of large branched and aromatic neutral amino acids. The corresponding transporters are hetero(di)mers composed of a catalytic subunit (LAT1 or LAT2=light chain=glycoprotein-associated amino acid transporter) associated covalently with the glycoprotein 4F2hc/CD98 (heavy chain). The tissue distribution of LAT1 suggests that it is involved mainly in transporting amino acids into growing cells and across some endothelial/epithelial secretory barriers, whereas the localization of LAT2 indicates that it is mainly involved in the basolateral efflux step of transepithelial (re)absorptive amino acid transport. However, system L transporters are obligatory amino acid exchangers with 1:1 stoichiometry, with similar (but not identical) intra- and extracellular substrate selectivities and with highly asymmetrical apparent affinities (low affinity inside). Therefore, net directional transport of large, neutral amino acids by system L depends on the parallel expression of a unidirectional transporter with overlapping selectivity (for instance systems A or N) that provides/recycles amino acids that drive system L exchange function. By mediating the regulated flux of these exchange substrates, unidirectional transporters control the activity of system L.
DOI: 10.1007/s00424-002-0973-z
PubMed: 12634921
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aminés neutres (métabolisme)</term><term>Animaux</term><term>Concentration osmolaire</term><term>Humains</term><term>Membranes intracellulaires (métabolisme)</term><term>Répartition dans les tissus</term><term>Système L de transport d'acides aminés ()</term><term>Système L de transport d'acides aminés (physiologie)</term><term>Système y+ de transport d'acides aminés</term><term>Transport biologique</term><term>Transporteur-1 d'acides aminés neutres à longue chaîne (analyse)</term><term>Transporteur-1 d'acides aminés neutres à longue chaîne (métabolisme)</term><term>Épithélium (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Fusion Regulatory Protein 1, Light Chains</term><term>Fusion Regulatory Protein-1</term><term>Large Neutral Amino Acid-Transporter 1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Amino Acid Transport System L</term></keywords><keywords scheme="MESH" 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xml:lang="fr"><term>Système L de transport d'acides aminés</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biological Transport</term><term>Humans</term><term>Osmolar Concentration</term><term>Tissue Distribution</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Concentration osmolaire</term><term>Humains</term><term>Répartition dans les tissus</term><term>Système L de transport d'acides aminés</term><term>Système y+ de transport d'acides aminés</term><term>Transport biologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The plasma membrane transport system L is in many cells the only (efficient) pathway for the import of large branched and aromatic neutral amino acids. The corresponding transporters are hetero(di)mers composed of a catalytic subunit (LAT1 or LAT2=light chain=glycoprotein-associated amino acid transporter) associated covalently with the glycoprotein 4F2hc/CD98 (heavy chain). The tissue distribution of LAT1 suggests that it is involved mainly in transporting amino acids into growing cells and across some endothelial/epithelial secretory barriers, whereas the localization of LAT2 indicates that it is mainly involved in the basolateral efflux step of transepithelial (re)absorptive amino acid transport. However, system L transporters are obligatory amino acid exchangers with 1:1 stoichiometry, with similar (but not identical) intra- and extracellular substrate selectivities and with highly asymmetrical apparent affinities (low affinity inside). Therefore, net directional transport of large, neutral amino acids by system L depends on the parallel expression of a unidirectional transporter with overlapping selectivity (for instance systems A or N) that provides/recycles amino acids that drive system L exchange function. By mediating the regulated flux of these exchange substrates, unidirectional transporters control the activity of system L.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12634921</PMID><DateCompleted><Year>2003</Year><Month>10</Month><Day>14</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0031-6768</ISSN><JournalIssue CitedMedium="Print"><Volume>445</Volume><Issue>5</Issue><PubDate><Year>2003</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Pflugers Archiv : European journal of physiology</Title><ISOAbbreviation>Pflugers Arch.</ISOAbbreviation></Journal><ArticleTitle>System L: heteromeric exchangers of large, neutral amino acids involved in directional transport.</ArticleTitle><Pagination><MedlinePgn>529-33</MedlinePgn></Pagination><Abstract><AbstractText>The plasma membrane transport system L is in many cells the only (efficient) pathway for the import of large branched and aromatic neutral amino acids. The corresponding transporters are hetero(di)mers composed of a catalytic subunit (LAT1 or LAT2=light chain=glycoprotein-associated amino acid transporter) associated covalently with the glycoprotein 4F2hc/CD98 (heavy chain). The tissue distribution of LAT1 suggests that it is involved mainly in transporting amino acids into growing cells and across some endothelial/epithelial secretory barriers, whereas the localization of LAT2 indicates that it is mainly involved in the basolateral efflux step of transepithelial (re)absorptive amino acid transport. However, system L transporters are obligatory amino acid exchangers with 1:1 stoichiometry, with similar (but not identical) intra- and extracellular substrate selectivities and with highly asymmetrical apparent affinities (low affinity inside). Therefore, net directional transport of large, neutral amino acids by system L depends on the parallel expression of a unidirectional transporter with overlapping selectivity (for instance systems A or N) that provides/recycles amino acids that drive system L exchange function. By mediating the regulated flux of these exchange substrates, unidirectional transporters control the activity of system L.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Verrey</LastName><ForeName>François</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>University of Zurich, Institute of Physiology, Winterthurerstrasse 190, 8057 Zürich, Switzerland. verrey@access.unizh.ch</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2002</Year><Month>11</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Pflugers Arch</MedlineTA><NlmUniqueID>0154720</NlmUniqueID><ISSNLinking>0031-6768</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D027062">Amino Acid Transport System L</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D027182">Amino Acid Transport System y+</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D021542">Amino Acids, Neutral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D027301">Fusion Regulatory Protein 1, Light Chains</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D027261">Fusion Regulatory Protein-1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D027283">Large Neutral Amino Acid-Transporter 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C420646">SLC7A8 protein, human</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D027062" MajorTopicYN="N">Amino Acid Transport System L</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D027182" MajorTopicYN="Y">Amino Acid Transport System y+</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D021542" MajorTopicYN="N">Amino Acids, Neutral</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001692" MajorTopicYN="N">Biological Transport</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004848" MajorTopicYN="N">Epithelium</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D027301" MajorTopicYN="N">Fusion Regulatory Protein 1, Light Chains</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D027261" MajorTopicYN="N">Fusion Regulatory Protein-1</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007425" MajorTopicYN="N">Intracellular Membranes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D027283" MajorTopicYN="N">Large Neutral Amino Acid-Transporter 1</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009994" MajorTopicYN="N">Osmolar Concentration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014018" MajorTopicYN="N">Tissue Distribution</DescriptorName></MeshHeading></MeshHeadingList><NumberOfReferences>39</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>3</Month><Day>14</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>10</Month><Day>15</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>3</Month><Day>14</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12634921</ArticleId><ArticleId IdType="doi">10.1007/s00424-002-0973-z</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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