System L: heteromeric exchangers of large, neutral amino acids involved in directional transport.
Identifieur interne : 002467 ( PubMed/Curation ); précédent : 002466; suivant : 002468System L: heteromeric exchangers of large, neutral amino acids involved in directional transport.
Auteurs : François Verrey [Suisse]Source :
- Pflugers Archiv : European journal of physiology [ 0031-6768 ] ; 2003.
Descripteurs français
- KwdFr :
- Acides aminés neutres (métabolisme), Animaux, Concentration osmolaire, Humains, Membranes intracellulaires (métabolisme), Répartition dans les tissus, Système L de transport d'acides aminés (), Système L de transport d'acides aminés (physiologie), Système y+ de transport d'acides aminés, Transport biologique, Transporteur-1 d'acides aminés neutres à longue chaîne (analyse), Transporteur-1 d'acides aminés neutres à longue chaîne (métabolisme), Épithélium (métabolisme).
- MESH :
- analyse : Transporteur-1 d'acides aminés neutres à longue chaîne.
- métabolisme : Acides aminés neutres, Membranes intracellulaires, Transporteur-1 d'acides aminés neutres à longue chaîne, Épithélium.
- physiologie : Système L de transport d'acides aminés.
- Animaux, Concentration osmolaire, Humains, Répartition dans les tissus, Système L de transport d'acides aminés, Système y+ de transport d'acides aminés, Transport biologique.
English descriptors
- KwdEn :
- Amino Acid Transport System L (chemistry), Amino Acid Transport System L (physiology), Amino Acid Transport System y+, Amino Acids, Neutral (metabolism), Animals, Biological Transport, Epithelium (metabolism), Fusion Regulatory Protein 1, Light Chains (analysis), Fusion Regulatory Protein 1, Light Chains (metabolism), Fusion Regulatory Protein-1 (analysis), Humans, Intracellular Membranes (metabolism), Large Neutral Amino Acid-Transporter 1 (analysis), Large Neutral Amino Acid-Transporter 1 (metabolism), Osmolar Concentration, Tissue Distribution.
- MESH :
- chemical , analysis : Fusion Regulatory Protein 1, Light Chains, Fusion Regulatory Protein-1, Large Neutral Amino Acid-Transporter 1.
- chemical , chemistry : Amino Acid Transport System L.
- chemical , metabolism : Amino Acids, Neutral, Fusion Regulatory Protein 1, Light Chains, Large Neutral Amino Acid-Transporter 1.
- chemical , physiology : Amino Acid Transport System L.
- chemical : Amino Acid Transport System y+.
- metabolism : Epithelium, Intracellular Membranes.
- Animals, Biological Transport, Humans, Osmolar Concentration, Tissue Distribution.
Abstract
The plasma membrane transport system L is in many cells the only (efficient) pathway for the import of large branched and aromatic neutral amino acids. The corresponding transporters are hetero(di)mers composed of a catalytic subunit (LAT1 or LAT2=light chain=glycoprotein-associated amino acid transporter) associated covalently with the glycoprotein 4F2hc/CD98 (heavy chain). The tissue distribution of LAT1 suggests that it is involved mainly in transporting amino acids into growing cells and across some endothelial/epithelial secretory barriers, whereas the localization of LAT2 indicates that it is mainly involved in the basolateral efflux step of transepithelial (re)absorptive amino acid transport. However, system L transporters are obligatory amino acid exchangers with 1:1 stoichiometry, with similar (but not identical) intra- and extracellular substrate selectivities and with highly asymmetrical apparent affinities (low affinity inside). Therefore, net directional transport of large, neutral amino acids by system L depends on the parallel expression of a unidirectional transporter with overlapping selectivity (for instance systems A or N) that provides/recycles amino acids that drive system L exchange function. By mediating the regulated flux of these exchange substrates, unidirectional transporters control the activity of system L.
DOI: 10.1007/s00424-002-0973-z
PubMed: 12634921
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pubmed:12634921Le document en format XML
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<term>Fusion Regulatory Protein 1, Light Chains</term>
<term>Large Neutral Amino Acid-Transporter 1</term>
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<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Amino Acid Transport System L</term>
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<term>Intracellular Membranes</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acides aminés neutres</term>
<term>Membranes intracellulaires</term>
<term>Transporteur-1 d'acides aminés neutres à longue chaîne</term>
<term>Épithélium</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Système L de transport d'acides aminés</term>
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<term>Biological Transport</term>
<term>Humans</term>
<term>Osmolar Concentration</term>
<term>Tissue Distribution</term>
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<term>Humains</term>
<term>Répartition dans les tissus</term>
<term>Système L de transport d'acides aminés</term>
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<front><div type="abstract" xml:lang="en">The plasma membrane transport system L is in many cells the only (efficient) pathway for the import of large branched and aromatic neutral amino acids. The corresponding transporters are hetero(di)mers composed of a catalytic subunit (LAT1 or LAT2=light chain=glycoprotein-associated amino acid transporter) associated covalently with the glycoprotein 4F2hc/CD98 (heavy chain). The tissue distribution of LAT1 suggests that it is involved mainly in transporting amino acids into growing cells and across some endothelial/epithelial secretory barriers, whereas the localization of LAT2 indicates that it is mainly involved in the basolateral efflux step of transepithelial (re)absorptive amino acid transport. However, system L transporters are obligatory amino acid exchangers with 1:1 stoichiometry, with similar (but not identical) intra- and extracellular substrate selectivities and with highly asymmetrical apparent affinities (low affinity inside). Therefore, net directional transport of large, neutral amino acids by system L depends on the parallel expression of a unidirectional transporter with overlapping selectivity (for instance systems A or N) that provides/recycles amino acids that drive system L exchange function. By mediating the regulated flux of these exchange substrates, unidirectional transporters control the activity of system L.</div>
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<Abstract><AbstractText>The plasma membrane transport system L is in many cells the only (efficient) pathway for the import of large branched and aromatic neutral amino acids. The corresponding transporters are hetero(di)mers composed of a catalytic subunit (LAT1 or LAT2=light chain=glycoprotein-associated amino acid transporter) associated covalently with the glycoprotein 4F2hc/CD98 (heavy chain). The tissue distribution of LAT1 suggests that it is involved mainly in transporting amino acids into growing cells and across some endothelial/epithelial secretory barriers, whereas the localization of LAT2 indicates that it is mainly involved in the basolateral efflux step of transepithelial (re)absorptive amino acid transport. However, system L transporters are obligatory amino acid exchangers with 1:1 stoichiometry, with similar (but not identical) intra- and extracellular substrate selectivities and with highly asymmetrical apparent affinities (low affinity inside). Therefore, net directional transport of large, neutral amino acids by system L depends on the parallel expression of a unidirectional transporter with overlapping selectivity (for instance systems A or N) that provides/recycles amino acids that drive system L exchange function. By mediating the regulated flux of these exchange substrates, unidirectional transporters control the activity of system L.</AbstractText>
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