Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection
Identifieur interne : 001343 ( Main/Exploration ); précédent : 001342; suivant : 001344Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection
Auteurs : Eu Suk Kim ; Pyoeng Gyun Choe ; Wan Beom Park ; Hong Sang Oh ; Eun Jung Kim ; Eun Young Nam ; Sun Hee Na ; Moonsuk Kim ; Kyoung-Ho Song ; Ji Hwan Bang ; Sang Won Park ; Hong Bin Kim ; Nam Joong Kim ; Myoung-Don OhSource :
- Journal of Korean Medical Science [ 1011-8934 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Chimiokine CXCL10 (sang), Chimiokines (sang), Créatinine (sang), Cytokines (sang), Dyspnée (étiologie), Femelle, Granulocytes neutrophiles (cytologie), Humains, Indice de gravité médicale, Infections à coronavirus (), Infections à coronavirus (anatomopathologie), Infections à coronavirus (sang), Interféron gamma (sang), Interleukine-6 (sang), Mâle, Numération des leucocytes, Oxygénation hyperbare, Sujet âgé, Temps de prothrombine, Température du corps, Test ELISA, Évolution de la maladie.
- MESH :
- anatomopathologie : Infections à coronavirus.
- cytologie : Granulocytes neutrophiles.
- sang : Chimiokine CXCL10, Chimiokines, Créatinine, Cytokines, Infections à coronavirus, Interféron gamma, Interleukine-6.
- étiologie : Dyspnée.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Indice de gravité médicale, Infections à coronavirus, Mâle, Numération des leucocytes, Oxygénation hyperbare, Sujet âgé, Temps de prothrombine, Température du corps, Test ELISA, Évolution de la maladie.
English descriptors
- KwdEn :
- Adult, Aged, Body Temperature, Chemokine CXCL10 (blood), Chemokines (blood), Coronavirus Infections (blood), Coronavirus Infections (complications), Coronavirus Infections (pathology), Creatinine (blood), Cytokines (blood), Disease Progression, Dyspnea (etiology), Enzyme-Linked Immunosorbent Assay, Female, Humans, Hyperbaric Oxygenation, Interferon-gamma (blood), Interleukin-6 (blood), Leukocyte Count, Male, Middle Aged, Neutrophils (cytology), Prothrombin Time, Severity of Illness Index.
- MESH :
- chemical , blood : Chemokine CXCL10, Chemokines, Creatinine, Cytokines, Interferon-gamma, Interleukin-6.
- blood : Coronavirus Infections.
- complications : Coronavirus Infections.
- cytology : Neutrophils.
- etiology : Dyspnea.
- pathology : Coronavirus Infections.
- Adult, Aged, Body Temperature, Disease Progression, Enzyme-Linked Immunosorbent Assay, Female, Humans, Hyperbaric Oxygenation, Leukocyte Count, Male, Middle Aged, Prothrombin Time, Severity of Illness Index.
Abstract
Clinical progression over time and cytokine profiles have not been well defined in patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection. We included 17 patients with laboratory-confirmed MERS-CoV during the 2015 outbreak in Korea. Clinical and laboratory parameters were collected prospectively. Serum cytokine and chemokine levels in serial serum samples were measured using enzyme-linked immunosorbent assay. All patients presented with fever. The median time to defervescence was 18 days. Nine patients required oxygen supplementation and classified into severe group. In the severe group, chest infiltrates suddenly began to worsen around day 7 of illness, and dyspnea developed at the end of the first week and became apparent in the second week. Median time from symptom onset to oxygen supplementation was 8 days. The severe group had higher neutrophil counts during week 1 than the mild group (4,500 vs. 2,200/µL,
Url:
DOI: 10.3346/jkms.2016.31.11.1717
PubMed: 27709848
PubMed Central: 5056202
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>Clinical progression over time and cytokine profiles have not been well defined in patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection. We included 17 patients with laboratory-confirmed MERS-CoV during the 2015 outbreak in Korea. Clinical and laboratory parameters were collected prospectively. Serum cytokine and chemokine levels in serial serum samples were measured using enzyme-linked immunosorbent assay. All patients presented with fever. The median time to defervescence was 18 days. Nine patients required oxygen supplementation and classified into severe group. In the severe group, chest infiltrates suddenly began to worsen around day 7 of illness, and dyspnea developed at the end of the first week and became apparent in the second week. Median time from symptom onset to oxygen supplementation was 8 days. The severe group had higher neutrophil counts during week 1 than the mild group (4,500 vs. 2,200/µL, <italic>P</italic>
= 0.026). In the second week of illness, the severe group had higher serum levels of IL-6 (54 vs. 4 pg/mL, <italic>P</italic>
= 0.006) and CXCL-10 (2,642 vs. 382 pg/mL, <italic>P</italic>
< 0.001). IFN-α response was not observed in mild cases. Our data shows that clinical condition may suddenly deteriorate around 7 days of illness and the serum levels of IL-6 and CXCL-10 was significantly elevated in MERS-CoV patients who developed severe diseases.</p>
</div>
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</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Bang, Ji Hwan" sort="Bang, Ji Hwan" uniqKey="Bang J" first="Ji Hwan" last="Bang">Ji Hwan Bang</name>
<name sortKey="Choe, Pyoeng Gyun" sort="Choe, Pyoeng Gyun" uniqKey="Choe P" first="Pyoeng Gyun" last="Choe">Pyoeng Gyun Choe</name>
<name sortKey="Kim, Eu Suk" sort="Kim, Eu Suk" uniqKey="Kim E" first="Eu Suk" last="Kim">Eu Suk Kim</name>
<name sortKey="Kim, Eun Jung" sort="Kim, Eun Jung" uniqKey="Kim E" first="Eun Jung" last="Kim">Eun Jung Kim</name>
<name sortKey="Kim, Hong Bin" sort="Kim, Hong Bin" uniqKey="Kim H" first="Hong Bin" last="Kim">Hong Bin Kim</name>
<name sortKey="Kim, Moonsuk" sort="Kim, Moonsuk" uniqKey="Kim M" first="Moonsuk" last="Kim">Moonsuk Kim</name>
<name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam Joong" last="Kim">Nam Joong Kim</name>
<name sortKey="Na, Sun Hee" sort="Na, Sun Hee" uniqKey="Na S" first="Sun Hee" last="Na">Sun Hee Na</name>
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<name sortKey="Oh, Hong Sang" sort="Oh, Hong Sang" uniqKey="Oh H" first="Hong Sang" last="Oh">Hong Sang Oh</name>
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<name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name>
<name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name>
<name sortKey="Song, Kyoung Ho" sort="Song, Kyoung Ho" uniqKey="Song K" first="Kyoung-Ho" last="Song">Kyoung-Ho Song</name>
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