Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection.
Identifieur interne : 000F47 ( PubMed/Corpus ); précédent : 000F46; suivant : 000F48Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection.
Auteurs : Eu Suk Kim ; Pyoeng Gyun Choe ; Wan Beom Park ; Hong Sang Oh ; Eun Jung Kim ; Eun Young Nam ; Sun Hee Na ; Moonsuk Kim ; Kyoung Ho Song ; Ji Hwan Bang ; Sang Won Park ; Hong Bin Kim ; Nam Joong Kim ; Myoung Don OhSource :
- Journal of Korean medical science [ 1598-6357 ] ; 2016.
English descriptors
- KwdEn :
- Adult, Aged, Body Temperature, Chemokine CXCL10 (blood), Chemokines (blood), Coronavirus Infections (blood), Coronavirus Infections (complications), Coronavirus Infections (pathology), Creatinine (blood), Cytokines (blood), Disease Progression, Dyspnea (etiology), Enzyme-Linked Immunosorbent Assay, Female, Humans, Hyperbaric Oxygenation, Interferon-gamma (blood), Interleukin-6 (blood), Leukocyte Count, Male, Middle Aged, Neutrophils (cytology), Prothrombin Time, Severity of Illness Index.
- MESH :
- chemical , blood : Chemokine CXCL10, Chemokines, Creatinine, Cytokines, Interferon-gamma, Interleukin-6.
- blood : Coronavirus Infections.
- complications : Coronavirus Infections.
- cytology : Neutrophils.
- etiology : Dyspnea.
- pathology : Coronavirus Infections.
- Adult, Aged, Body Temperature, Disease Progression, Enzyme-Linked Immunosorbent Assay, Female, Humans, Hyperbaric Oxygenation, Leukocyte Count, Male, Middle Aged, Prothrombin Time, Severity of Illness Index.
Abstract
Clinical progression over time and cytokine profiles have not been well defined in patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection. We included 17 patients with laboratory-confirmed MERS-CoV during the 2015 outbreak in Korea. Clinical and laboratory parameters were collected prospectively. Serum cytokine and chemokine levels in serial serum samples were measured using enzyme-linked immunosorbent assay. All patients presented with fever. The median time to defervescence was 18 days. Nine patients required oxygen supplementation and classified into severe group. In the severe group, chest infiltrates suddenly began to worsen around day 7 of illness, and dyspnea developed at the end of the first week and became apparent in the second week. Median time from symptom onset to oxygen supplementation was 8 days. The severe group had higher neutrophil counts during week 1 than the mild group (4,500 vs. 2,200/μL, P = 0.026). In the second week of illness, the severe group had higher serum levels of IL-6 (54 vs. 4 pg/mL, P = 0.006) and CXCL-10 (2,642 vs. 382 pg/mL, P < 0.001). IFN-α response was not observed in mild cases. Our data shows that clinical condition may suddenly deteriorate around 7 days of illness and the serum levels of IL-6 and CXCL-10 was significantly elevated in MERS-CoV patients who developed severe diseases.
DOI: 10.3346/jkms.2016.31.11.1717
PubMed: 27709848
Links to Exploration step
pubmed:27709848Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection.</title><author><name sortKey="Kim, Eu Suk" sort="Kim, Eu Suk" uniqKey="Kim E" first="Eu Suk" last="Kim">Eu Suk Kim</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Choe, Pyoeng Gyun" sort="Choe, Pyoeng Gyun" uniqKey="Choe P" first="Pyoeng Gyun" last="Choe">Pyoeng Gyun Choe</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Oh, Hong Sang" sort="Oh, Hong Sang" uniqKey="Oh H" first="Hong Sang" last="Oh">Hong Sang Oh</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Eun Jung" sort="Kim, Eun Jung" uniqKey="Kim E" first="Eun Jung" last="Kim">Eun Jung Kim</name></author><author><name sortKey="Nam, Eun Young" sort="Nam, Eun Young" uniqKey="Nam E" first="Eun Young" last="Nam">Eun Young Nam</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Na, Sun Hee" sort="Na, Sun Hee" uniqKey="Na S" first="Sun Hee" last="Na">Sun Hee Na</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Moonsuk" sort="Kim, Moonsuk" uniqKey="Kim M" first="Moonsuk" last="Kim">Moonsuk Kim</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Song, Kyoung Ho" sort="Song, Kyoung Ho" uniqKey="Song K" first="Kyoung Ho" last="Song">Kyoung Ho Song</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Bang, Ji Hwan" sort="Bang, Ji Hwan" uniqKey="Bang J" first="Ji Hwan" last="Bang">Ji Hwan Bang</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Hong Bin" sort="Kim, Hong Bin" uniqKey="Kim H" first="Hong Bin" last="Kim">Hong Bin Kim</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam Joong" last="Kim">Nam Joong Kim</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung Don" last="Oh">Myoung Don Oh</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. mdohmd@snu.ac.kr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27709848</idno><idno type="pmid">27709848</idno><idno type="doi">10.3346/jkms.2016.31.11.1717</idno><idno type="wicri:Area/PubMed/Corpus">000F47</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F47</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection.</title><author><name sortKey="Kim, Eu Suk" sort="Kim, Eu Suk" uniqKey="Kim E" first="Eu Suk" last="Kim">Eu Suk Kim</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Choe, Pyoeng Gyun" sort="Choe, Pyoeng Gyun" uniqKey="Choe P" first="Pyoeng Gyun" last="Choe">Pyoeng Gyun Choe</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Oh, Hong Sang" sort="Oh, Hong Sang" uniqKey="Oh H" first="Hong Sang" last="Oh">Hong Sang Oh</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Eun Jung" sort="Kim, Eun Jung" uniqKey="Kim E" first="Eun Jung" last="Kim">Eun Jung Kim</name></author><author><name sortKey="Nam, Eun Young" sort="Nam, Eun Young" uniqKey="Nam E" first="Eun Young" last="Nam">Eun Young Nam</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Na, Sun Hee" sort="Na, Sun Hee" uniqKey="Na S" first="Sun Hee" last="Na">Sun Hee Na</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Moonsuk" sort="Kim, Moonsuk" uniqKey="Kim M" first="Moonsuk" last="Kim">Moonsuk Kim</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Song, Kyoung Ho" sort="Song, Kyoung Ho" uniqKey="Song K" first="Kyoung Ho" last="Song">Kyoung Ho Song</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Bang, Ji Hwan" sort="Bang, Ji Hwan" uniqKey="Bang J" first="Ji Hwan" last="Bang">Ji Hwan Bang</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Hong Bin" sort="Kim, Hong Bin" uniqKey="Kim H" first="Hong Bin" last="Kim">Hong Bin Kim</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam Joong" last="Kim">Nam Joong Kim</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung Don" last="Oh">Myoung Don Oh</name><affiliation><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. mdohmd@snu.ac.kr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of Korean medical science</title><idno type="eISSN">1598-6357</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Body Temperature</term><term>Chemokine CXCL10 (blood)</term><term>Chemokines (blood)</term><term>Coronavirus Infections (blood)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (pathology)</term><term>Creatinine (blood)</term><term>Cytokines (blood)</term><term>Disease Progression</term><term>Dyspnea (etiology)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Hyperbaric Oxygenation</term><term>Interferon-gamma (blood)</term><term>Interleukin-6 (blood)</term><term>Leukocyte Count</term><term>Male</term><term>Middle Aged</term><term>Neutrophils (cytology)</term><term>Prothrombin Time</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Chemokine CXCL10</term><term>Chemokines</term><term>Creatinine</term><term>Cytokines</term><term>Interferon-gamma</term><term>Interleukin-6</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Neutrophils</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyspnea</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Body Temperature</term><term>Disease Progression</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Hyperbaric Oxygenation</term><term>Leukocyte Count</term><term>Male</term><term>Middle Aged</term><term>Prothrombin Time</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Clinical progression over time and cytokine profiles have not been well defined in patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection. We included 17 patients with laboratory-confirmed MERS-CoV during the 2015 outbreak in Korea. Clinical and laboratory parameters were collected prospectively. Serum cytokine and chemokine levels in serial serum samples were measured using enzyme-linked immunosorbent assay. All patients presented with fever. The median time to defervescence was 18 days. Nine patients required oxygen supplementation and classified into severe group. In the severe group, chest infiltrates suddenly began to worsen around day 7 of illness, and dyspnea developed at the end of the first week and became apparent in the second week. Median time from symptom onset to oxygen supplementation was 8 days. The severe group had higher neutrophil counts during week 1 than the mild group (4,500 vs. 2,200/μL, P = 0.026). In the second week of illness, the severe group had higher serum levels of IL-6 (54 vs. 4 pg/mL, P = 0.006) and CXCL-10 (2,642 vs. 382 pg/mL, P < 0.001). IFN-α response was not observed in mild cases. Our data shows that clinical condition may suddenly deteriorate around 7 days of illness and the serum levels of IL-6 and CXCL-10 was significantly elevated in MERS-CoV patients who developed severe diseases.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27709848</PMID><DateCompleted><Year>2017</Year><Month>03</Month><Day>29</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1598-6357</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><Issue>11</Issue><PubDate><Year>2016</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Journal of Korean medical science</Title><ISOAbbreviation>J. Korean Med. Sci.</ISOAbbreviation></Journal><ArticleTitle>Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection.</ArticleTitle><Pagination><MedlinePgn>1717-1725</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3346/jkms.2016.31.11.1717</ELocationID><Abstract><AbstractText>Clinical progression over time and cytokine profiles have not been well defined in patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection. We included 17 patients with laboratory-confirmed MERS-CoV during the 2015 outbreak in Korea. Clinical and laboratory parameters were collected prospectively. Serum cytokine and chemokine levels in serial serum samples were measured using enzyme-linked immunosorbent assay. All patients presented with fever. The median time to defervescence was 18 days. Nine patients required oxygen supplementation and classified into severe group. In the severe group, chest infiltrates suddenly began to worsen around day 7 of illness, and dyspnea developed at the end of the first week and became apparent in the second week. Median time from symptom onset to oxygen supplementation was 8 days. The severe group had higher neutrophil counts during week 1 than the mild group (4,500 vs. 2,200/μL, P = 0.026). In the second week of illness, the severe group had higher serum levels of IL-6 (54 vs. 4 pg/mL, P = 0.006) and CXCL-10 (2,642 vs. 382 pg/mL, P < 0.001). IFN-α response was not observed in mild cases. Our data shows that clinical condition may suddenly deteriorate around 7 days of illness and the serum levels of IL-6 and CXCL-10 was significantly elevated in MERS-CoV patients who developed severe diseases.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Eu Suk</ForeName><Initials>ES</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-7132-0157</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Choe</LastName><ForeName>Pyoeng Gyun</ForeName><Initials>PG</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-6794-7918</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Wan Beom</ForeName><Initials>WB</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-0022-9625</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oh</LastName><ForeName>Hong Sang</ForeName><Initials>HS</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-4535-6305</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Eun Jung</ForeName><Initials>EJ</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-3302-7827</Identifier></Author><Author ValidYN="Y"><LastName>Nam</LastName><ForeName>Eun Young</ForeName><Initials>EY</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-2488-3226</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Na</LastName><ForeName>Sun Hee</ForeName><Initials>SH</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-9605-7807</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Moonsuk</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-8640-939X</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Kyoung Ho</ForeName><Initials>KH</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-4517-3840</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bang</LastName><ForeName>Ji Hwan</ForeName><Initials>JH</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-7628-1182</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Sang Won</ForeName><Initials>SW</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-0550-1897</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Hong Bin</ForeName><Initials>HB</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-6262-372X</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Nam Joong</ForeName><Initials>NJ</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-6793-9467</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oh</LastName><ForeName>Myoung Don</ForeName><Initials>MD</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-2344-7695</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. mdohmd@snu.ac.kr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Korea (South)</Country><MedlineTA>J Korean Med Sci</MedlineTA><NlmUniqueID>8703518</NlmUniqueID><ISSNLinking>1011-8934</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C114753">CXCL10 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054357">Chemokine CXCL10</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018925">Chemokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance></Chemical><Chemical><RegistryNumber>82115-62-6</RegistryNumber><NameOfSubstance UI="D007371">Interferon-gamma</NameOfSubstance></Chemical><Chemical><RegistryNumber>AYI8EX34EU</RegistryNumber><NameOfSubstance UI="D003404">Creatinine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001831" MajorTopicYN="N">Body Temperature</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054357" MajorTopicYN="N">Chemokine CXCL10</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018925" MajorTopicYN="N">Chemokines</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003404" MajorTopicYN="N">Creatinine</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004417" MajorTopicYN="N">Dyspnea</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006931" MajorTopicYN="N">Hyperbaric Oxygenation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007371" MajorTopicYN="N">Interferon-gamma</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007958" MajorTopicYN="N">Leukocyte Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009504" MajorTopicYN="N">Neutrophils</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011517" MajorTopicYN="N">Prothrombin Time</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">CXCL-10</Keyword><Keyword MajorTopicYN="Y">Chemokine</Keyword><Keyword MajorTopicYN="Y">Clinical Progression</Keyword><Keyword MajorTopicYN="Y">Coronavirus</Keyword><Keyword MajorTopicYN="Y">Cytokine</Keyword><Keyword MajorTopicYN="Y">IFN-α</Keyword><Keyword MajorTopicYN="Y">IL-6</Keyword><Keyword MajorTopicYN="Y">MERS</Keyword><Keyword MajorTopicYN="Y">Severity</Keyword></KeywordList><CoiStatement>The authors have no potential conflicts of interest to disclose.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>04</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>06</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>3</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27709848</ArticleId><ArticleId IdType="pii">31.1717</ArticleId><ArticleId IdType="doi">10.3346/jkms.2016.31.11.1717</ArticleId><ArticleId IdType="pmc">PMC5056202</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Int J Infect Dis. 2014 Dec;29:301-6</Citation><ArticleIdList><ArticleId IdType="pubmed">25303830</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2004 Oct 1;39(7):1071-5</Citation><ArticleIdList><ArticleId IdType="pubmed">15472864</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2012 Nov 8;367 (19):1814-20</Citation><ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2003 May 24;361(9371):1767-72</Citation><ArticleIdList><ArticleId IdType="pubmed">12781535</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Exp Immunol. 2004 Apr;136(1):95-103</Citation><ArticleIdList><ArticleId IdType="pubmed">15030519</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2014 May 1;209(9):1331-42</Citation><ArticleIdList><ArticleId IdType="pubmed">24065148</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2007 Sep 15;45(6):723-31</Citation><ArticleIdList><ArticleId IdType="pubmed">17712756</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2016 Sep 29;375(13):1303-5</Citation><ArticleIdList><ArticleId IdType="pubmed">27682053</ArticleId></ArticleIdList></Reference><Reference><Citation>Osong Public Health Res Perspect. 2015 Aug;6(4):269-78</Citation><ArticleIdList><ArticleId IdType="pubmed">26473095</ArticleId></ArticleIdList></Reference><Reference><Citation>J Korean Med Sci. 2015 Jul;30(7):835-6</Citation><ArticleIdList><ArticleId IdType="pubmed">26130942</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):769-74</Citation><ArticleIdList><ArticleId IdType="pubmed">24367104</ArticleId></ArticleIdList></Reference><Reference><Citation>MBio. 2014 May 20;5(3):e01174-14</Citation><ArticleIdList><ArticleId IdType="pubmed">24846384</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16598-603</Citation><ArticleIdList><ArticleId IdType="pubmed">24062443</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2006 Oct;12(10):1203-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16964257</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2015 Dec;21(12 ):2186-9</Citation><ArticleIdList><ArticleId IdType="pubmed">26583829</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2011;6(10):e26050</Citation><ArticleIdList><ArticleId IdType="pubmed">22022504</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2013 Aug 1;369(5):407-16</Citation><ArticleIdList><ArticleId IdType="pubmed">23782161</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2014 Jul 15;59(2):160-5</Citation><ArticleIdList><ArticleId IdType="pubmed">24723278</ArticleId></ArticleIdList></Reference><Reference><Citation>J Korean Med Sci. 2015 Nov;30(11):1701-5</Citation><ArticleIdList><ArticleId IdType="pubmed">26539018</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Intern Med. 2014 Mar 18;160(6):389-97</Citation><ArticleIdList><ArticleId IdType="pubmed">24474051</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2013 Sep;13(9):752-61</Citation><ArticleIdList><ArticleId IdType="pubmed">23891402</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2013 Dec 15;208(12):1962-7</Citation><ArticleIdList><ArticleId IdType="pubmed">23990573</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2014 Feb 14;9(2):e88716</Citation><ArticleIdList><ArticleId IdType="pubmed">24551142</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F47 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000F47 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:27709848
|texte= Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:27709848" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |