A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
Identifieur interne : 001923 ( Main/Exploration ); précédent : 001922; suivant : 001924A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
Auteurs : Vineet D. Menachery ; Boyd L. Yount ; Kari Debbink ; Sudhakar Agnihothram ; Lisa E. Gralinski ; Jessica A. Plante ; Rachel L. Graham ; Trevor Scobey ; Xing-Yi Ge [République populaire de Chine] ; Eric F. Donaldson ; Scott H. Randell ; Antonio Lanzavecchia [Suisse] ; Wayne A. Marasco ; Zhengli-Li Shi [République populaire de Chine] ; Ralph S. BaricSource :
- Nature Medicine [ 1078-8956 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps monoclonaux (immunologie), Cellules épithéliales (anatomopathologie), Cellules épithéliales (virologie), Chiroptera (virologie), Femelle, Humains, Lignée cellulaire, Phylogénie, Poumon (virologie), Réplication virale, Souris de lignée BALB C, Syndrome respiratoire aigu sévère (virologie), Tests de neutralisation, Virulence, Virus du SRAS (immunologie), Virus du SRAS (pathogénicité), Virus du SRAS (physiologie), Épidémies.
- MESH :
- anatomopathologie : Cellules épithéliales.
- immunologie : Anticorps antiviraux, Anticorps monoclonaux, Virus du SRAS.
- pathogénicité : Virus du SRAS.
- physiologie : Virus du SRAS.
- virologie : Cellules épithéliales, Chiroptera, Poumon, Syndrome respiratoire aigu sévère.
- Animaux, Femelle, Humains, Lignée cellulaire, Phylogénie, Réplication virale, Souris de lignée BALB C, Tests de neutralisation, Virulence, Épidémies.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (immunology), Antibodies, Viral (immunology), Cell Line, Chiroptera (virology), Epidemics, Epithelial Cells (pathology), Epithelial Cells (virology), Female, Humans, Lung (virology), Mice, Inbred BALB C, Neutralization Tests, Phylogeny, SARS Virus (immunology), SARS Virus (pathogenicity), SARS Virus (physiology), Severe Acute Respiratory Syndrome (virology), Virulence, Virus Replication.
- MESH :
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Viral.
- immunology : SARS Virus.
- pathogenicity : SARS Virus.
- pathology : Epithelial Cells.
- physiology : SARS Virus.
- virology : Chiroptera, Epithelial Cells, Lung, Severe Acute Respiratory Syndrome.
- Animals, Cell Line, Epidemics, Female, Humans, Mice, Inbred BALB C, Neutralization Tests, Phylogeny, Virulence, Virus Replication.
Abstract
Ralph Baric, Vineet Menachery and colleagues characterize a SARS-like coronavirus circulating in Chinese horseshoe bats to determine its potential to infect primary human airway epithelial cells, cause disease in mice and respond to available therapeutics.
The online version of this article (doi:10.1038/nm.3985) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/nm.3985
PubMed: 26552008
PubMed Central: 4797993
Affiliations:
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Le document en format XML
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Chapel Hill, North Carolina USA</nlm:aff>
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Chapel Hill, North Carolina USA</nlm:aff>
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<author><name sortKey="Lanzavecchia, Antonio" sort="Lanzavecchia, Antonio" uniqKey="Lanzavecchia A" first="Antonio" last="Lanzavecchia">Antonio Lanzavecchia</name>
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<institution>Institute for Research in Biomedicine, Bellinzona Institute of Microbiology,</institution>
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Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Zurich</wicri:regionArea>
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<author><name sortKey="Marasco, Wayne A" sort="Marasco, Wayne A" uniqKey="Marasco W" first="Wayne A" last="Marasco">Wayne A. Marasco</name>
<affiliation><nlm:aff id="Aff8">Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts USA</nlm:aff>
<wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry>
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<institution>Department of Medicine,</institution>
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Boston, Massachusetts USA</nlm:aff>
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<author><name sortKey="Shi, Zhengli Li" sort="Shi, Zhengli Li" uniqKey="Shi Z" first="Zhengli-Li" last="Shi">Zhengli-Li Shi</name>
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Wuhan, China</nlm:aff>
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<author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name>
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Chapel Hill, North Carolina USA</nlm:aff>
<wicri:noCountry code="subfield">North Carolina USA</wicri:noCountry>
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Chapel Hill, North Carolina USA</nlm:aff>
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<series><title level="j">Nature Medicine</title>
<idno type="ISSN">1078-8956</idno>
<idno type="eISSN">1546-170X</idno>
<imprint><date when="2015">2015</date>
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<term>Antibodies, Monoclonal (immunology)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Cell Line</term>
<term>Chiroptera (virology)</term>
<term>Epidemics</term>
<term>Epithelial Cells (pathology)</term>
<term>Epithelial Cells (virology)</term>
<term>Female</term>
<term>Humans</term>
<term>Lung (virology)</term>
<term>Mice, Inbred BALB C</term>
<term>Neutralization Tests</term>
<term>Phylogeny</term>
<term>SARS Virus (immunology)</term>
<term>SARS Virus (pathogenicity)</term>
<term>SARS Virus (physiology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Virulence</term>
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<term>Anticorps antiviraux (immunologie)</term>
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<term>Lignée cellulaire</term>
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<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Tests de neutralisation</term>
<term>Virulence</term>
<term>Virus du SRAS (immunologie)</term>
<term>Virus du SRAS (pathogénicité)</term>
<term>Virus du SRAS (physiologie)</term>
<term>Épidémies</term>
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<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Epithelial Cells</term>
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<term>Syndrome respiratoire aigu sévère</term>
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<term>Epithelial Cells</term>
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<term>Severe Acute Respiratory Syndrome</term>
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<front><div type="abstract" xml:lang="en"><p id="Par2">Ralph Baric, Vineet Menachery and colleagues characterize a SARS-like coronavirus circulating in Chinese horseshoe bats to determine its potential to infect primary human airway epithelial cells, cause disease in mice and respond to available therapeutics.</p>
<sec><title>Supplementary information</title>
<p>The online version of this article (doi:10.1038/nm.3985) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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<author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
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<biblStruct><analytic><author><name sortKey="He, B" uniqKey="He B">B He</name>
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<biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F Li</name>
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<biblStruct><analytic><author><name sortKey="Qiu, X" uniqKey="Qiu X">X Qiu</name>
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<biblStruct><analytic><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name>
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<author><name sortKey="Donaldson, Ef" uniqKey="Donaldson E">EF Donaldson</name>
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<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
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<author><name sortKey="Zaki, Sherif R" uniqKey="Zaki S">Sherif R. Zaki</name>
</author>
<author><name sortKey="Baric, Ralph" uniqKey="Baric R">Ralph Baric</name>
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<name sortKey="Scobey, Trevor" sort="Scobey, Trevor" uniqKey="Scobey T" first="Trevor" last="Scobey">Trevor Scobey</name>
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