Abnormal iron homeostasis and neurodegeneration
Identifieur interne : 002062 ( Main/Exploration ); précédent : 002061; suivant : 002063Abnormal iron homeostasis and neurodegeneration
Auteurs : Barry B. Muhoberac [États-Unis] ; Ruben Vidal [États-Unis]Source :
- Frontiers in Aging Neuroscience [ 1663-4365 ] ; 2013.
Abstract
Abnormal iron metabolism is observed in many neurodegenerative diseases, however, only two have shown dysregulation of brain iron homeostasis as the primary cause of neurodegeneration. Herein, we review one of these - hereditary ferritinopathy (HF) or neuroferritinopathy, which is an autosomal dominant, adult onset degenerative disease caused by mutations in the ferritin light chain (FTL) gene. HF has a clinical phenotype characterized by a progressive movement disorder, behavioral disturbances, and cognitive impairment. The main pathologic findings are cystic cavitation of the basal ganglia, the presence of ferritin inclusion bodies (IBs), and substantial iron deposition. Mutant FTL subunits have altered sequence and length but assemble into soluble 24-mers that are ultrastructurally indistinguishable from those of the wild type. Crystallography shows substantial localized disruption of the normally tiny 4-fold pores between the ferritin subunits because of unraveling of the C-termini into multiple polypeptide conformations. This structural alteration causes attenuated net iron incorporation leading to cellular iron mishandling, ferritin aggregation, and oxidative damage at physiological concentrations of iron and ascorbate. A transgenic murine model parallels several features of HF, including a progressive neurological phenotype, ferritin IB formation, and misregulation of iron metabolism. These studies provide a working hypothesis for the pathogenesis of HF by implicating (1) a loss of normal ferritin function that triggers iron accumulation and overproduction of ferritin polypeptides, and (2) a gain of toxic function through radical production, ferritin aggregation, and oxidative stress. Importantly, the finding that ferritin aggregation can be reversed by iron chelators and oxidative damage can be inhibited by radical trapping may be used for clinical investigation. This work provides new insights into the role of abnormal iron metabolism in neurodegeneration.
Url:
DOI: 10.3389/fnagi.2013.00032
PubMed: 23908629
PubMed Central: 3726993
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001330
- to stream Pmc, to step Curation: 001330
- to stream Pmc, to step Checkpoint: 001266
- to stream PubMed, to step Corpus: 001C35
- to stream PubMed, to step Curation: 001C35
- to stream PubMed, to step Checkpoint: 001C09
- to stream Ncbi, to step Merge: 000B03
- to stream Ncbi, to step Curation: 000B03
- to stream Ncbi, to step Checkpoint: 000B03
- to stream Main, to step Merge: 002086
- to stream Main, to step Curation: 002062
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Abnormal iron homeostasis and neurodegeneration</title>
<author><name sortKey="Muhoberac, Barry B" sort="Muhoberac, Barry B" uniqKey="Muhoberac B" first="Barry B." last="Muhoberac">Barry B. Muhoberac</name>
<affiliation wicri:level="4"><nlm:aff id="aff1"><institution>Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis</institution>
<country>Indianapolis, IN, USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Microbiology, The University of Manitoba, Winnipeg, Manitoba, R3T 2N2</wicri:regionArea>
<orgName type="university">Université du Manitoba</orgName>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vidal, Ruben" sort="Vidal, Ruben" uniqKey="Vidal R" first="Ruben" last="Vidal">Ruben Vidal</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><institution>Division Neuropathology, Indiana Alzheimer Disease Center and Department of Pathology and Laboratory Medicine, Indiana University School of Medicine</institution>
<country>Indianapolis, IN, USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Microbiology, The University of Manitoba, Winnipeg, Manitoba, R3T 2N2</wicri:regionArea>
<orgName type="university">Université du Manitoba</orgName>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23908629</idno>
<idno type="pmc">3726993</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726993</idno>
<idno type="RBID">PMC:3726993</idno>
<idno type="doi">10.3389/fnagi.2013.00032</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">001330</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001330</idno>
<idno type="wicri:Area/Pmc/Curation">001330</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001330</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001266</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001266</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:23908629</idno>
<idno type="wicri:Area/PubMed/Corpus">001C35</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C35</idno>
<idno type="wicri:Area/PubMed/Curation">001C35</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001C35</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001C09</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001C09</idno>
<idno type="wicri:Area/Ncbi/Merge">000B03</idno>
<idno type="wicri:Area/Ncbi/Curation">000B03</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000B03</idno>
<idno type="wicri:Area/Main/Merge">002086</idno>
<idno type="wicri:Area/Main/Curation">002062</idno>
<idno type="wicri:Area/Main/Exploration">002062</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Abnormal iron homeostasis and neurodegeneration</title>
<author><name sortKey="Muhoberac, Barry B" sort="Muhoberac, Barry B" uniqKey="Muhoberac B" first="Barry B." last="Muhoberac">Barry B. Muhoberac</name>
<affiliation wicri:level="4"><nlm:aff id="aff1"><institution>Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis</institution>
<country>Indianapolis, IN, USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Microbiology, The University of Manitoba, Winnipeg, Manitoba, R3T 2N2</wicri:regionArea>
<orgName type="university">Université du Manitoba</orgName>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vidal, Ruben" sort="Vidal, Ruben" uniqKey="Vidal R" first="Ruben" last="Vidal">Ruben Vidal</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><institution>Division Neuropathology, Indiana Alzheimer Disease Center and Department of Pathology and Laboratory Medicine, Indiana University School of Medicine</institution>
<country>Indianapolis, IN, USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Microbiology, The University of Manitoba, Winnipeg, Manitoba, R3T 2N2</wicri:regionArea>
<orgName type="university">Université du Manitoba</orgName>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Frontiers in Aging Neuroscience</title>
<idno type="eISSN">1663-4365</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Abnormal iron metabolism is observed in many neurodegenerative diseases, however, only two have shown dysregulation of brain iron homeostasis as the primary cause of neurodegeneration. Herein, we review one of these - hereditary ferritinopathy (HF) or neuroferritinopathy, which is an autosomal dominant, adult onset degenerative disease caused by mutations in the ferritin light chain (FTL) gene. HF has a clinical phenotype characterized by a progressive movement disorder, behavioral disturbances, and cognitive impairment. The main pathologic findings are cystic cavitation of the basal ganglia, the presence of ferritin inclusion bodies (IBs), and substantial iron deposition. Mutant FTL subunits have altered sequence and length but assemble into soluble 24-mers that are ultrastructurally indistinguishable from those of the wild type. Crystallography shows substantial localized disruption of the normally tiny 4-fold pores between the ferritin subunits because of unraveling of the C-termini into multiple polypeptide conformations. This structural alteration causes attenuated net iron incorporation leading to cellular iron mishandling, ferritin aggregation, and oxidative damage at physiological concentrations of iron and ascorbate. A transgenic murine model parallels several features of HF, including a progressive neurological phenotype, ferritin IB formation, and misregulation of iron metabolism. These studies provide a working hypothesis for the pathogenesis of HF by implicating (1) a loss of normal ferritin function that triggers iron accumulation and overproduction of ferritin polypeptides, and (2) a gain of toxic function through radical production, ferritin aggregation, and oxidative stress. Importantly, the finding that ferritin aggregation can be reversed by iron chelators and oxidative damage can be inhibited by radical trapping may be used for clinical investigation. This work provides new insights into the role of abnormal iron metabolism in neurodegeneration.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ayton, S" uniqKey="Ayton S">S. Ayton</name>
</author>
<author><name sortKey="Lei, P" uniqKey="Lei P">P. Lei</name>
</author>
<author><name sortKey="Bush, A I" uniqKey="Bush A">A. I. Bush</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baraibar, M A" uniqKey="Baraibar M">M. A. Baraibar</name>
</author>
<author><name sortKey="Barbeito, A G" uniqKey="Barbeito A">A. G. Barbeito</name>
</author>
<author><name sortKey="Muhoberac, B B" uniqKey="Muhoberac B">B. B. Muhoberac</name>
</author>
<author><name sortKey="Vidal, R" uniqKey="Vidal R">R. Vidal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baraibar, M A" uniqKey="Baraibar M">M. A. Baraibar</name>
</author>
<author><name sortKey="Barbeito, A G" uniqKey="Barbeito A">A. G. Barbeito</name>
</author>
<author><name sortKey="Muhoberac, B B" uniqKey="Muhoberac B">B. B. Muhoberac</name>
</author>
<author><name sortKey="Vidal, R" uniqKey="Vidal R">R. Vidal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baraibar, M A" uniqKey="Baraibar M">M. A. Baraibar</name>
</author>
<author><name sortKey="Muhoberac, B B" uniqKey="Muhoberac B">B. B. Muhoberac</name>
</author>
<author><name sortKey="Garringer, H J" uniqKey="Garringer H">H. J. Garringer</name>
</author>
<author><name sortKey="Hurley, T D" uniqKey="Hurley T">T. D. Hurley</name>
</author>
<author><name sortKey="Vidal, R" uniqKey="Vidal R">R. Vidal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barbeito, A G" uniqKey="Barbeito A">A. G. Barbeito</name>
</author>
<author><name sortKey="Garringer, H J" uniqKey="Garringer H">H. J. Garringer</name>
</author>
<author><name sortKey="Baraibar, M A" uniqKey="Baraibar M">M. A. Baraibar</name>
</author>
<author><name sortKey="Gao, X" uniqKey="Gao X">X. Gao</name>
</author>
<author><name sortKey="Arredondo, M" uniqKey="Arredondo M">M. Arredondo</name>
</author>
<author><name sortKey="Nu Ez, M T" uniqKey="Nu Ez M">M. T. Núñez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barbeito, A G" uniqKey="Barbeito A">A. G. Barbeito</name>
</author>
<author><name sortKey="Levade, T" uniqKey="Levade T">T. Levade</name>
</author>
<author><name sortKey="Delisle, M B" uniqKey="Delisle M">M. B. Delisle</name>
</author>
<author><name sortKey="Ghetti, B" uniqKey="Ghetti B">B. Ghetti</name>
</author>
<author><name sortKey="Vidal, R" uniqKey="Vidal R">R. Vidal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Berg, D" uniqKey="Berg D">D. Berg</name>
</author>
<author><name sortKey="Youdim, M B" uniqKey="Youdim M">M. B. Youdim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Caparros Lefebvre, D" uniqKey="Caparros Lefebvre D">D. Caparros-Lefebvre</name>
</author>
<author><name sortKey="Destee, A" uniqKey="Destee A">A. Destee</name>
</author>
<author><name sortKey="Petit, H" uniqKey="Petit H">H. Petit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chinnery, P F" uniqKey="Chinnery P">P. F. Chinnery</name>
</author>
<author><name sortKey="Crompton, D E" uniqKey="Crompton D">D. E. Crompton</name>
</author>
<author><name sortKey="Birchall, D" uniqKey="Birchall D">D. Birchall</name>
</author>
<author><name sortKey="Jackson, M J" uniqKey="Jackson M">M. J. Jackson</name>
</author>
<author><name sortKey="Coulthard, A" uniqKey="Coulthard A">A. Coulthard</name>
</author>
<author><name sortKey="Lombes, A" uniqKey="Lombes A">A. Lombès</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Crichton, R R" uniqKey="Crichton R">R. R. Crichton</name>
</author>
<author><name sortKey="Declercq, J P" uniqKey="Declercq J">J. P. Declercq</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Curtis, A R" uniqKey="Curtis A">A. R. Curtis</name>
</author>
<author><name sortKey="Fey, C" uniqKey="Fey C">C. Fey</name>
</author>
<author><name sortKey="Morris, C M" uniqKey="Morris C">C. M. Morris</name>
</author>
<author><name sortKey="Bindoff, L A" uniqKey="Bindoff L">L. A. Bindoff</name>
</author>
<author><name sortKey="Ince, P G" uniqKey="Ince P">P. G. Ince</name>
</author>
<author><name sortKey="Chinnery, P F" uniqKey="Chinnery P">P. F. Chinnery</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deng, X" uniqKey="Deng X">X. Deng</name>
</author>
<author><name sortKey="Vidal, R" uniqKey="Vidal R">R. Vidal</name>
</author>
<author><name sortKey="Englander, E W" uniqKey="Englander E">E. W. Englander</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Devos, D" uniqKey="Devos D">D. Devos</name>
</author>
<author><name sortKey="Tchofo, P J" uniqKey="Tchofo P">P. J. Tchofo</name>
</author>
<author><name sortKey="Vuillaume, I" uniqKey="Vuillaume I">I. Vuillaume</name>
</author>
<author><name sortKey="Destee, A" uniqKey="Destee A">A. Destée</name>
</author>
<author><name sortKey="Batey, S" uniqKey="Batey S">S. Batey</name>
</author>
<author><name sortKey="Burn, J" uniqKey="Burn J">J. Burn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Firdaus, W J J" uniqKey="Firdaus W">W. J. J. Firdaus</name>
</author>
<author><name sortKey="Wyttenbach, A" uniqKey="Wyttenbach A">A. Wyttenbach</name>
</author>
<author><name sortKey="Giuliano, P" uniqKey="Giuliano P">P. Giuliano</name>
</author>
<author><name sortKey="Kretz Remy, C" uniqKey="Kretz Remy C">C. Kretz-Remy</name>
</author>
<author><name sortKey="Currie, R W" uniqKey="Currie R">R. W. Currie</name>
</author>
<author><name sortKey="Arrigo, A P" uniqKey="Arrigo A">A.-P. Arrigo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Graf, E" uniqKey="Graf E">E. Graf</name>
</author>
<author><name sortKey="Mahoney, J R" uniqKey="Mahoney J">J. R. Mahoney</name>
</author>
<author><name sortKey="Bryant, R G" uniqKey="Bryant R">R. G. Bryant</name>
</author>
<author><name sortKey="Eaton, J W" uniqKey="Eaton J">J. W. Eaton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kubota, A" uniqKey="Kubota A">A. Kubota</name>
</author>
<author><name sortKey="Hida, A" uniqKey="Hida A">A. Hida</name>
</author>
<author><name sortKey="Ichikawa, Y" uniqKey="Ichikawa Y">Y. Ichikawa</name>
</author>
<author><name sortKey="Momose, Y" uniqKey="Momose Y">Y. Momose</name>
</author>
<author><name sortKey="Goto, J" uniqKey="Goto J">J. Goto</name>
</author>
<author><name sortKey="Igeta, Y" uniqKey="Igeta Y">Y. Igeta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lansbury, P T" uniqKey="Lansbury P">P. T. Lansbury</name>
</author>
<author><name sortKey="Lashuel, H A" uniqKey="Lashuel H">H. A. Lashuel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maciel, P" uniqKey="Maciel P">P. Maciel</name>
</author>
<author><name sortKey="Cruz, V T" uniqKey="Cruz V">V. T. Cruz</name>
</author>
<author><name sortKey="Constante, M" uniqKey="Constante M">M. Constante</name>
</author>
<author><name sortKey="Iniesta, I" uniqKey="Iniesta I">I. Iniesta</name>
</author>
<author><name sortKey="Costa, M C" uniqKey="Costa M">M. C. Costa</name>
</author>
<author><name sortKey="Gallati, S" uniqKey="Gallati S">S. Gallati</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mancuso, M" uniqKey="Mancuso M">M. Mancuso</name>
</author>
<author><name sortKey="Davidzon, G" uniqKey="Davidzon G">G. Davidzon</name>
</author>
<author><name sortKey="Kurlan, R M" uniqKey="Kurlan R">R. M. Kurlan</name>
</author>
<author><name sortKey="Tawil, R" uniqKey="Tawil R">R. Tawil</name>
</author>
<author><name sortKey="Bonilla, E" uniqKey="Bonilla E">E. Bonilla</name>
</author>
<author><name sortKey="Di Mauro, S" uniqKey="Di Mauro S">S. Di Mauro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcneill, A" uniqKey="Mcneill A">A. McNeill</name>
</author>
<author><name sortKey="Birchall, D" uniqKey="Birchall D">D. Birchall</name>
</author>
<author><name sortKey="Hayflick, S J" uniqKey="Hayflick S">S. J. Hayflick</name>
</author>
<author><name sortKey="Gregory, A" uniqKey="Gregory A">A. Gregory</name>
</author>
<author><name sortKey="Schenk, J F" uniqKey="Schenk J">J. F. Schenk</name>
</author>
<author><name sortKey="Zimmerman, E A" uniqKey="Zimmerman E">E. A. Zimmerman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muhoberac, B B" uniqKey="Muhoberac B">B. B. Muhoberac</name>
</author>
<author><name sortKey="Baraibar, M A" uniqKey="Baraibar M">M. A. Baraibar</name>
</author>
<author><name sortKey="Vidal, R" uniqKey="Vidal R">R. Vidal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murphy, M P" uniqKey="Murphy M">M. P. Murphy</name>
</author>
<author><name sortKey="Holmgren, A" uniqKey="Holmgren A">A. Holmgren</name>
</author>
<author><name sortKey="Larsson, N G" uniqKey="Larsson N">N. G. Larsson</name>
</author>
<author><name sortKey="Halliwell, B" uniqKey="Halliwell B">B. Halliwell</name>
</author>
<author><name sortKey="Chang, C J" uniqKey="Chang C">C. J. Chang</name>
</author>
<author><name sortKey="Kalyanaraman, B" uniqKey="Kalyanaraman B">B. Kalyanaraman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ohta, E" uniqKey="Ohta E">E. Ohta</name>
</author>
<author><name sortKey="Nagasaka, T" uniqKey="Nagasaka T">T. Nagasaka</name>
</author>
<author><name sortKey="Shindo, K" uniqKey="Shindo K">K. Shindo</name>
</author>
<author><name sortKey="Toma, S" uniqKey="Toma S">S. Toma</name>
</author>
<author><name sortKey="Nagasaka, K" uniqKey="Nagasaka K">K. Nagasaka</name>
</author>
<author><name sortKey="Ohta, K" uniqKey="Ohta K">K. Ohta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ory Magne, F" uniqKey="Ory Magne F">F. Ory-Magne</name>
</author>
<author><name sortKey="Brefel Courbon, C" uniqKey="Brefel Courbon C">C. Brefel-Courbon</name>
</author>
<author><name sortKey="Payoux, P" uniqKey="Payoux P">P. Payoux</name>
</author>
<author><name sortKey="Debruxelles, S" uniqKey="Debruxelles S">S. Debruxelles</name>
</author>
<author><name sortKey="Sibon, I" uniqKey="Sibon I">I. Sibon</name>
</author>
<author><name sortKey="Goizet, C" uniqKey="Goizet C">C. Goizet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rice, M E" uniqKey="Rice M">M. E. Rice</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Santambrogio, P" uniqKey="Santambrogio P">P. Santambrogio</name>
</author>
<author><name sortKey="Levi, S" uniqKey="Levi S">S. Levi</name>
</author>
<author><name sortKey="Arosio, P" uniqKey="Arosio P">P. Arosio</name>
</author>
<author><name sortKey="Palagi, L" uniqKey="Palagi L">L. Palagi</name>
</author>
<author><name sortKey="Vecchio, G" uniqKey="Vecchio G">G. Vecchio</name>
</author>
<author><name sortKey="Lawson" uniqKey="Lawson">Lawson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Santambrogio, P" uniqKey="Santambrogio P">P. Santambrogio</name>
</author>
<author><name sortKey="Levi, S" uniqKey="Levi S">S. Levi</name>
</author>
<author><name sortKey="Cozzi, A" uniqKey="Cozzi A">A. Cozzi</name>
</author>
<author><name sortKey="Rovida, E" uniqKey="Rovida E">E. Rovida</name>
</author>
<author><name sortKey="Albertini, A" uniqKey="Albertini A">A. Albertini</name>
</author>
<author><name sortKey="Arosio, P" uniqKey="Arosio P">P. Arosio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schroder, J M" uniqKey="Schroder J">J. M. Schröder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vidal, R" uniqKey="Vidal R">R. Vidal</name>
</author>
<author><name sortKey="Ghetti, B" uniqKey="Ghetti B">B. Ghetti</name>
</author>
<author><name sortKey="Takao, M" uniqKey="Takao M">M. Takao</name>
</author>
<author><name sortKey="Brefel Courbon, C" uniqKey="Brefel Courbon C">C. Brefel-Courbon</name>
</author>
<author><name sortKey="Uro Coste, E" uniqKey="Uro Coste E">E. Uro-Coste</name>
</author>
<author><name sortKey="Glazier, B S" uniqKey="Glazier B">B. S. Glazier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vidal, R" uniqKey="Vidal R">R. Vidal</name>
</author>
<author><name sortKey="Delisle, M B" uniqKey="Delisle M">M. B. Delisle</name>
</author>
<author><name sortKey="Ghetti, B" uniqKey="Ghetti B">B. Ghetti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vidal, R" uniqKey="Vidal R">R. Vidal</name>
</author>
<author><name sortKey="Miravalle, L" uniqKey="Miravalle L">L. Miravalle</name>
</author>
<author><name sortKey="Gao, X" uniqKey="Gao X">X. Gao</name>
</author>
<author><name sortKey="Barbeito, A G" uniqKey="Barbeito A">A. G. Barbeito</name>
</author>
<author><name sortKey="Baraibar, M A" uniqKey="Baraibar M">M. A. Baraibar</name>
</author>
<author><name sortKey="Hekmatyar, S K" uniqKey="Hekmatyar S">S. K. Hekmatyar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zecca, L" uniqKey="Zecca L">L. Zecca</name>
</author>
<author><name sortKey="Youdim, M B H" uniqKey="Youdim M">M. B. H. Youdim</name>
</author>
<author><name sortKey="Riederer, P" uniqKey="Riederer P">P. Riederer</name>
</author>
<author><name sortKey="Connor, J R" uniqKey="Connor J">J. R. Connor</name>
</author>
<author><name sortKey="Crichton, R R" uniqKey="Crichton R">R. R. Crichton</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Manitoba</li>
</region>
<settlement><li>Winnipeg</li>
</settlement>
<orgName><li>Université du Manitoba</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Manitoba"><name sortKey="Muhoberac, Barry B" sort="Muhoberac, Barry B" uniqKey="Muhoberac B" first="Barry B." last="Muhoberac">Barry B. Muhoberac</name>
</region>
<name sortKey="Vidal, Ruben" sort="Vidal, Ruben" uniqKey="Vidal R" first="Ruben" last="Vidal">Ruben Vidal</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002062 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002062 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:3726993 |texte= Abnormal iron homeostasis and neurodegeneration }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23908629" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |