Bridging the prebiotic and RNA worlds: prebiotic RNA synthesis on clay.
Identifieur interne : 003630 ( Main/Exploration ); précédent : 003629; suivant : 003631Bridging the prebiotic and RNA worlds: prebiotic RNA synthesis on clay.
Auteurs : G. Ertem ; K J Prabahar ; P C Joshi ; J P FerrisSource :
- Journal of biomolecular structure & dynamics [ 1538-0254 ] ; 2000.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical : Bentonite, Nucleotides, Oligonucleotides, Prebiotics, RNA.
- Catalysis, Origin of Life.
Abstract
Abstract Progress towards the laboratory demonstration of the steps in the prebiotic origin of the RNA world is reviewed. Montmorillonite clay catalyzes the formation of RNAs containing 6-14 monomer units from the activated mononucleotides of A, C, G, I and U. The RNAs formed have 3', 5'- and 2', 5'-links, pyrophosphate links and have both linear and cyclic chains. The purine oligonucleotides have more 3', 5'- links while the pyrimidine nucleotides have more 2', 5'-linkages. Template-directed synthesis on the heterogeneous oligo(C)s formed on mont- morillonite yields the corresponding oligo(G)s. The dimer fraction formed in the reaction of a binary mixture of a purine and pyrimidine nucleotide shows sequence selectivity with about a 20 fold excess of the 5'-purine-pyrimidine dimer over that of the 5'-pyrimidine-purine dimer. RNAs as long as 50 mers are formed by the elongation of a decamer bound to montmorillonite by the daily addition of activated monomer to it over a 14-day time period.
DOI: 10.1080/07391102.2000.10506623
PubMed: 22607426
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002606
- to stream PubMed, to step Curation: 002606
- to stream PubMed, to step Checkpoint: 002454
- to stream Ncbi, to step Merge: 000962
- to stream Ncbi, to step Curation: 000962
- to stream Ncbi, to step Checkpoint: 000962
- to stream Main, to step Merge: 003672
- to stream Main, to step Curation: 003630
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bridging the prebiotic and RNA worlds: prebiotic RNA synthesis on clay.</title>
<author><name sortKey="Ertem, G" sort="Ertem, G" uniqKey="Ertem G" first="G" last="Ertem">G. Ertem</name>
<affiliation><nlm:affiliation>a Department of Chemistry , Rensselaer Polytechnic Institute , Troy , NY , 12180.</nlm:affiliation>
<wicri:noCountry code="subField">12180</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Prabahar, K J" sort="Prabahar, K J" uniqKey="Prabahar K" first="K J" last="Prabahar">K J Prabahar</name>
</author>
<author><name sortKey="Joshi, P C" sort="Joshi, P C" uniqKey="Joshi P" first="P C" last="Joshi">P C Joshi</name>
</author>
<author><name sortKey="Ferris, J P" sort="Ferris, J P" uniqKey="Ferris J" first="J P" last="Ferris">J P Ferris</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2000">2000</date>
<idno type="RBID">pubmed:22607426</idno>
<idno type="pmid">22607426</idno>
<idno type="doi">10.1080/07391102.2000.10506623</idno>
<idno type="wicri:Area/PubMed/Corpus">002606</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002606</idno>
<idno type="wicri:Area/PubMed/Curation">002606</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002606</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002454</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002454</idno>
<idno type="wicri:Area/Ncbi/Merge">000962</idno>
<idno type="wicri:Area/Ncbi/Curation">000962</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000962</idno>
<idno type="wicri:Area/Main/Merge">003672</idno>
<idno type="wicri:Area/Main/Curation">003630</idno>
<idno type="wicri:Area/Main/Exploration">003630</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Bridging the prebiotic and RNA worlds: prebiotic RNA synthesis on clay.</title>
<author><name sortKey="Ertem, G" sort="Ertem, G" uniqKey="Ertem G" first="G" last="Ertem">G. Ertem</name>
<affiliation><nlm:affiliation>a Department of Chemistry , Rensselaer Polytechnic Institute , Troy , NY , 12180.</nlm:affiliation>
<wicri:noCountry code="subField">12180</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Prabahar, K J" sort="Prabahar, K J" uniqKey="Prabahar K" first="K J" last="Prabahar">K J Prabahar</name>
</author>
<author><name sortKey="Joshi, P C" sort="Joshi, P C" uniqKey="Joshi P" first="P C" last="Joshi">P C Joshi</name>
</author>
<author><name sortKey="Ferris, J P" sort="Ferris, J P" uniqKey="Ferris J" first="J P" last="Ferris">J P Ferris</name>
</author>
</analytic>
<series><title level="j">Journal of biomolecular structure & dynamics</title>
<idno type="eISSN">1538-0254</idno>
<imprint><date when="2000" type="published">2000</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bentonite</term>
<term>Catalysis</term>
<term>Nucleotides</term>
<term>Oligonucleotides</term>
<term>Origin of Life</term>
<term>Prebiotics</term>
<term>RNA</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN</term>
<term>Bentonite</term>
<term>Catalyse</term>
<term>Nucléotides</term>
<term>Oligonucléotides</term>
<term>Origine de la vie</term>
<term>Prébiotiques</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Bentonite</term>
<term>Nucleotides</term>
<term>Oligonucleotides</term>
<term>Prebiotics</term>
<term>RNA</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Catalysis</term>
<term>Origin of Life</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>ARN</term>
<term>Bentonite</term>
<term>Catalyse</term>
<term>Nucléotides</term>
<term>Oligonucléotides</term>
<term>Origine de la vie</term>
<term>Prébiotiques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract Progress towards the laboratory demonstration of the steps in the prebiotic origin of the RNA world is reviewed. Montmorillonite clay catalyzes the formation of RNAs containing 6-14 monomer units from the activated mononucleotides of A, C, G, I and U. The RNAs formed have 3', 5'- and 2', 5'-links, pyrophosphate links and have both linear and cyclic chains. The purine oligonucleotides have more 3', 5'- links while the pyrimidine nucleotides have more 2', 5'-linkages. Template-directed synthesis on the heterogeneous oligo(C)s formed on mont- morillonite yields the corresponding oligo(G)s. The dimer fraction formed in the reaction of a binary mixture of a purine and pyrimidine nucleotide shows sequence selectivity with about a 20 fold excess of the 5'-purine-pyrimidine dimer over that of the 5'-pyrimidine-purine dimer. RNAs as long as 50 mers are formed by the elongation of a decamer bound to montmorillonite by the daily addition of activated monomer to it over a 14-day time period.</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Ertem, G" sort="Ertem, G" uniqKey="Ertem G" first="G" last="Ertem">G. Ertem</name>
<name sortKey="Ferris, J P" sort="Ferris, J P" uniqKey="Ferris J" first="J P" last="Ferris">J P Ferris</name>
<name sortKey="Joshi, P C" sort="Joshi, P C" uniqKey="Joshi P" first="P C" last="Joshi">P C Joshi</name>
<name sortKey="Prabahar, K J" sort="Prabahar, K J" uniqKey="Prabahar K" first="K J" last="Prabahar">K J Prabahar</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003630 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003630 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:22607426 |texte= Bridging the prebiotic and RNA worlds: prebiotic RNA synthesis on clay. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22607426" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
This area was generated with Dilib version V0.6.33. |