MersV1, Main, Curation, bibRecord, 003630

Bridging the prebiotic and RNA worlds: prebiotic RNA synthesis on clay.

Identifieur interne : 003630 ( Main/Curation ); précédent : 003629; suivant : 003631

Bridging the prebiotic and RNA worlds: prebiotic RNA synthesis on clay.

Auteurs : G. Ertem ; K J Prabahar ; P C Joshi ; J P Ferris

Source :

Journal of biomolecular structure & dynamics [ 1538-0254 ] ; 2000.

RBID : pubmed:22607426

Descripteurs français

KwdFr :
- ARN, Bentonite, Catalyse, Nucléotides, Oligonucléotides, Origine de la vie, Prébiotiques.
MESH :
- ARN, Bentonite, Catalyse, Nucléotides, Oligonucléotides, Origine de la vie, Prébiotiques.

English descriptors

KwdEn :
- Bentonite, Catalysis, Nucleotides, Oligonucleotides, Origin of Life, Prebiotics, RNA.
MESH :
- chemical : Bentonite, Nucleotides, Oligonucleotides, Prebiotics, RNA.
- Catalysis, Origin of Life.

Abstract

Abstract Progress towards the laboratory demonstration of the steps in the prebiotic origin of the RNA world is reviewed. Montmorillonite clay catalyzes the formation of RNAs containing 6-14 monomer units from the activated mononucleotides of A, C, G, I and U. The RNAs formed have 3', 5'- and 2', 5'-links, pyrophosphate links and have both linear and cyclic chains. The purine oligonucleotides have more 3', 5'- links while the pyrimidine nucleotides have more 2', 5'-linkages. Template-directed synthesis on the heterogeneous oligo(C)s formed on mont- morillonite yields the corresponding oligo(G)s. The dimer fraction formed in the reaction of a binary mixture of a purine and pyrimidine nucleotide shows sequence selectivity with about a 20 fold excess of the 5'-purine-pyrimidine dimer over that of the 5'-pyrimidine-purine dimer. RNAs as long as 50 mers are formed by the elongation of a decamer bound to montmorillonite by the daily addition of activated monomer to it over a 14-day time period.

DOI: 10.1080/07391102.2000.10506623
PubMed: 22607426

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G. Ertem

<affiliation><nlm:affiliation>a      Department of Chemistry   ,  Rensselaer Polytechnic Institute   ,    Troy   ,    NY   ,    12180.</nlm:affiliation>
<wicri:noCountry code="subField">12180</wicri:noCountry>
</affiliation>

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract   Progress towards the laboratory demonstration of the steps in the prebiotic origin of the RNA world is reviewed. Montmorillonite clay catalyzes the formation of RNAs containing 6-14 monomer units from the activated mononucleotides of A, C, G, I and U. The RNAs formed have 3', 5'- and 2', 5'-links, pyrophosphate links and have both linear and cyclic chains. The purine oligonucleotides have more 3', 5'- links while the pyrimidine nucleotides have more 2', 5'-linkages. Template-directed synthesis on the heterogeneous oligo(C)s formed on mont- morillonite yields the corresponding oligo(G)s. The dimer fraction formed in the reaction of a binary mixture of a purine and pyrimidine nucleotide shows sequence selectivity with about a 20 fold excess of the 5'-purine-pyrimidine dimer over that of the 5'-pyrimidine-purine dimer. RNAs as long as 50 mers are formed by the elongation of a decamer bound to montmorillonite by the daily addition of activated monomer to it over a 14-day time period.</div>
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Bridging the prebiotic and RNA worlds: prebiotic RNA synthesis on clay.

Bridging the prebiotic and RNA worlds: prebiotic RNA synthesis on clay.

Source :

Descripteurs français

English descriptors

Abstract

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Links to Exploration step

Curation

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki