Interactions of bovine serum albumin with aluminum polyoxocations and aluminum hydroxide.
Identifieur interne : 002D17 ( Main/Exploration ); précédent : 002D16; suivant : 002D18Interactions of bovine serum albumin with aluminum polyoxocations and aluminum hydroxide.
Auteurs : Olivier Deschaume ; Kirill L. Shafran ; Carole C. PerrySource :
- Langmuir : the ACS journal of surfaces and colloids [ 0743-7463 ] ; 2006.
Descripteurs français
- KwdFr :
- Aluminium (), Animaux, Bovins, Cations (), Concentration en ions d'hydrogène, Conformation moléculaire, Diffraction des rayons X, Diffusion de rayonnements, Hydroxyde d'aluminium (), Hydroxydes (), Nanoparticules (), Relation dose-effet des médicaments, Spectroscopie par résonance magnétique, Sérumalbumine bovine (), Température.
- MESH :
- Aluminium, Animaux, Bovins, Cations, Concentration en ions d'hydrogène, Conformation moléculaire, Diffraction des rayons X, Diffusion de rayonnements, Hydroxyde d'aluminium, Hydroxydes, Nanoparticules, Relation dose-effet des médicaments, Spectroscopie par résonance magnétique, Sérumalbumine bovine, Température.
English descriptors
- KwdEn :
- Aluminum (chemistry), Aluminum Hydroxide (chemistry), Animals, Cations (chemistry), Cattle, Dose-Response Relationship, Drug, Hydrogen-Ion Concentration, Hydroxides (chemistry), Magnetic Resonance Spectroscopy, Molecular Conformation, Nanoparticles (chemistry), Scattering, Radiation, Serum Albumin, Bovine (chemistry), Temperature, X-Ray Diffraction.
- MESH :
- chemical , chemistry : Aluminum, Aluminum Hydroxide, Cations, Hydroxides, Serum Albumin, Bovine.
- chemistry : Nanoparticles.
- Animals, Cattle, Dose-Response Relationship, Drug, Hydrogen-Ion Concentration, Magnetic Resonance Spectroscopy, Molecular Conformation, Scattering, Radiation, Temperature, X-Ray Diffraction.
Abstract
Interactions of aqueous solutions of aluminum polyoxocations (Al13-mers and Al30-mers) and aluminum hydroxide suspensions of varying particle sizes (26, 55, and 82 nm) with a model protein, bovine serum albumin (BSA), have been investigated using potentiometry, conductometry, viscometry, 27Al solution NMR, UV-vis spectroscopy, dynamic light scattering, zeta-potential measurements, thermogravimetry, X-ray diffraction, and scanning electron microscopy. Increasing amounts of BSA partially convert Al13-mers and, to a larger extent, Al30-mers into amorphous Al hydroxide without gel formation. At the same time, BSA molecules can form unstable aggregates in the Al polyoxocation solutions which redisperse easily upon standing. In the case of Al hydroxide sols, BSA addition causes substantial gelation, the extent of which is proportional to the amount of BSA added and inversely related to the Al hydroxide particle size. Upon freeze-drying or centrifugation of Al species-BSA solutions, an interesting sheetlike morphology with 150-200 nm wide nanoribbons is observed for pure Al hydroxide nanoparticles and for solutions of Al polyoxocations with the highest amount of BSA studied. On the basis of the combined solution, colloidal and solid-state characterization of model Al species-BSA systems, a qualitative model of possible interactions in the Al polyoxocation-BSA and Al hydroxide-BSA systems is proposed wherein core-shell hybrid nanoparticles are formed from protein "core" and Al polyoxocation "shell" or Al hydroxide "core" and protein "shell".
DOI: 10.1021/la061285h
PubMed: 17107003
Affiliations:
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Le document en format XML
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<term>Cations (chemistry)</term>
<term>Cattle</term>
<term>Dose-Response Relationship, Drug</term>
<term>Hydrogen-Ion Concentration</term>
<term>Hydroxides (chemistry)</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Molecular Conformation</term>
<term>Nanoparticles (chemistry)</term>
<term>Scattering, Radiation</term>
<term>Serum Albumin, Bovine (chemistry)</term>
<term>Temperature</term>
<term>X-Ray Diffraction</term>
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<term>Cations ()</term>
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<term>Conformation moléculaire</term>
<term>Diffraction des rayons X</term>
<term>Diffusion de rayonnements</term>
<term>Hydroxyde d'aluminium ()</term>
<term>Hydroxydes ()</term>
<term>Nanoparticules ()</term>
<term>Relation dose-effet des médicaments</term>
<term>Spectroscopie par résonance magnétique</term>
<term>Sérumalbumine bovine ()</term>
<term>Température</term>
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<term>Aluminum Hydroxide</term>
<term>Cations</term>
<term>Hydroxides</term>
<term>Serum Albumin, Bovine</term>
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<term>Dose-Response Relationship, Drug</term>
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<term>Magnetic Resonance Spectroscopy</term>
<term>Molecular Conformation</term>
<term>Scattering, Radiation</term>
<term>Temperature</term>
<term>X-Ray Diffraction</term>
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<term>Animaux</term>
<term>Bovins</term>
<term>Cations</term>
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<term>Conformation moléculaire</term>
<term>Diffraction des rayons X</term>
<term>Diffusion de rayonnements</term>
<term>Hydroxyde d'aluminium</term>
<term>Hydroxydes</term>
<term>Nanoparticules</term>
<term>Relation dose-effet des médicaments</term>
<term>Spectroscopie par résonance magnétique</term>
<term>Sérumalbumine bovine</term>
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<front><div type="abstract" xml:lang="en">Interactions of aqueous solutions of aluminum polyoxocations (Al13-mers and Al30-mers) and aluminum hydroxide suspensions of varying particle sizes (26, 55, and 82 nm) with a model protein, bovine serum albumin (BSA), have been investigated using potentiometry, conductometry, viscometry, 27Al solution NMR, UV-vis spectroscopy, dynamic light scattering, zeta-potential measurements, thermogravimetry, X-ray diffraction, and scanning electron microscopy. Increasing amounts of BSA partially convert Al13-mers and, to a larger extent, Al30-mers into amorphous Al hydroxide without gel formation. At the same time, BSA molecules can form unstable aggregates in the Al polyoxocation solutions which redisperse easily upon standing. In the case of Al hydroxide sols, BSA addition causes substantial gelation, the extent of which is proportional to the amount of BSA added and inversely related to the Al hydroxide particle size. Upon freeze-drying or centrifugation of Al species-BSA solutions, an interesting sheetlike morphology with 150-200 nm wide nanoribbons is observed for pure Al hydroxide nanoparticles and for solutions of Al polyoxocations with the highest amount of BSA studied. On the basis of the combined solution, colloidal and solid-state characterization of model Al species-BSA systems, a qualitative model of possible interactions in the Al polyoxocation-BSA and Al hydroxide-BSA systems is proposed wherein core-shell hybrid nanoparticles are formed from protein "core" and Al polyoxocation "shell" or Al hydroxide "core" and protein "shell".</div>
</front>
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<name sortKey="Perry, Carole C" sort="Perry, Carole C" uniqKey="Perry C" first="Carole C" last="Perry">Carole C. Perry</name>
<name sortKey="Shafran, Kirill L" sort="Shafran, Kirill L" uniqKey="Shafran K" first="Kirill L" last="Shafran">Kirill L. Shafran</name>
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