Biochip Platforms for DNA Diagnostics
Identifieur interne : 002912 ( Main/Exploration ); précédent : 002911; suivant : 002913Biochip Platforms for DNA Diagnostics
Auteurs : Anil K. Deisingh [États-Unis] ; Adilah Guiseppi-Wilson [États-Unis] ; Anthony Guiseppi-Elie [États-Unis]Source :
- Integrated Analytical Systems
Abstract
Abstract: This chapter looks at the use of microlithographically fabricated biochip platforms for DNA diagnostics and prognostics, although protein and RNA biochips are also briefly considered. Biodetection methods such as ion-selective electrodes (ISEs), microelectromechanical systems (MEMS) devices such as microcantilevers, optical, piezoelectric-based acoustic wave, and mass spectrometry are briefly discussed. Emphasis is given to label-free electrochemical (impedimetric, voltammet-ric, and amperometric) detection. The production of DNA biochips is highlighted as are the operation and design of the experiments to reveal gene expression and SNP data. Applications discussed include the monitoring of microbes, cancer classification studies, and patient stratification in drug development. Finally, challenges and issues facing the development of diagnostic and prognostic biochips are discussed in detail.
Url:
DOI: 10.1007/978-0-387-72719-6_14
Affiliations:
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Deisingh</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Bioelectronics, Biosensors and Biochips (C3B), Department of Chemical and Biomolecular Engineering, Department of Bioengineering, Clemson University, 100, Technology Drive, 29625, Anderson, South Carolina</wicri:regionArea><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Guiseppi Wilson, Adilah" sort="Guiseppi Wilson, Adilah" uniqKey="Guiseppi Wilson A" first="Adilah" last="Guiseppi-Wilson">Adilah Guiseppi-Wilson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>ABTECH Scientific, Inc., 800 East Leigh Street, 23219, Richmond, Virginia</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Guiseppi Elie, Anthony" sort="Guiseppi Elie, Anthony" uniqKey="Guiseppi Elie A" first="Anthony" last="Guiseppi-Elie">Anthony Guiseppi-Elie</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Bioelectronics, Biosensors and Biochips (C3B), Department of Chemical and Biomolecular Engineering, Department of Bioengineering, Clemson University, 100, Technology Drive, 29625, Anderson, South Carolina</wicri:regionArea><placeName><region type="state">Caroline du Sud</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="s" type="main" xml:lang="en">Integrated Analytical Systems</title><title level="s" type="abbrev">Integrated Analytical Systems</title></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: This chapter looks at the use of microlithographically fabricated biochip platforms for DNA diagnostics and prognostics, although protein and RNA biochips are also briefly considered. Biodetection methods such as ion-selective electrodes (ISEs), microelectromechanical systems (MEMS) devices such as microcantilevers, optical, piezoelectric-based acoustic wave, and mass spectrometry are briefly discussed. Emphasis is given to label-free electrochemical (impedimetric, voltammet-ric, and amperometric) detection. The production of DNA biochips is highlighted as are the operation and design of the experiments to reveal gene expression and SNP data. Applications discussed include the monitoring of microbes, cancer classification studies, and patient stratification in drug development. Finally, challenges and issues facing the development of diagnostic and prognostic biochips are discussed in detail.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Sud</li><li>Virginie</li></region></list><tree><country name="États-Unis"><region name="Caroline du Sud"><name sortKey="Deisingh, Anil K" sort="Deisingh, Anil K" uniqKey="Deisingh A" first="Anil K." last="Deisingh">Anil K. Deisingh</name></region><name sortKey="Guiseppi Elie, Anthony" sort="Guiseppi Elie, Anthony" uniqKey="Guiseppi Elie A" first="Anthony" last="Guiseppi-Elie">Anthony Guiseppi-Elie</name><name sortKey="Guiseppi Elie, Anthony" sort="Guiseppi Elie, Anthony" uniqKey="Guiseppi Elie A" first="Anthony" last="Guiseppi-Elie">Anthony Guiseppi-Elie</name><name sortKey="Guiseppi Wilson, Adilah" sort="Guiseppi Wilson, Adilah" uniqKey="Guiseppi Wilson A" first="Adilah" last="Guiseppi-Wilson">Adilah Guiseppi-Wilson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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