microRNAs and lung cancer: tumors and 22-mers
Identifieur interne : 002669 ( Main/Exploration ); précédent : 002668; suivant : 002670microRNAs and lung cancer: tumors and 22-mers
Auteurs : Liqin Du [États-Unis] ; Alexander Pertsemlidis [États-Unis]Source :
- Cancer and Metastasis Reviews [ 0167-7659 ] ; 2010-03-01.
Descripteurs français
- KwdFr :
- Animaux, Carcinome pulmonaire non à petites cellules (), Carcinome pulmonaire non à petites cellules (anatomopathologie), Carcinome pulmonaire non à petites cellules (diagnostic), Carcinome pulmonaire non à petites cellules (génétique), Ciblage de gène (), Gènes suppresseurs de tumeur (physiologie), Humains, Métastase tumorale, Néovascularisation pathologique (génétique), Prolifération cellulaire, Pronostic, Régulation de l'expression des gènes tumoraux, Thérapie génétique (), Transformation cellulaire néoplasique (génétique), Tumeurs du poumon (), Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (diagnostic), Tumeurs du poumon (génétique), microARN (génétique), microARN (physiologie).
- MESH :
- anatomopathologie : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- diagnostic : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- génétique : Carcinome pulmonaire non à petites cellules, Néovascularisation pathologique, Transformation cellulaire néoplasique, Tumeurs du poumon, microARN.
- physiologie : Gènes suppresseurs de tumeur, microARN.
- Animaux, Carcinome pulmonaire non à petites cellules, Ciblage de gène, Humains, Métastase tumorale, Prolifération cellulaire, Pronostic, Régulation de l'expression des gènes tumoraux, Thérapie génétique, Tumeurs du poumon.
English descriptors
- KwdEn :
- Animals, Carcinoma, Non-Small-Cell Lung (diagnosis), Carcinoma, Non-Small-Cell Lung (genetics), Carcinoma, Non-Small-Cell Lung (pathology), Carcinoma, Non-Small-Cell Lung (therapy), Cell Proliferation, Cell Transformation, Neoplastic (genetics), Gene Expression Regulation, Neoplastic, Gene Targeting (methods), Genes, Tumor Suppressor (physiology), Genetic Therapy (methods), Humans, Lung Neoplasms (diagnosis), Lung Neoplasms (genetics), Lung Neoplasms (pathology), Lung Neoplasms (therapy), Lung cancer, MicroRNAs (genetics), MicroRNAs (physiology), Neoplasm Metastasis, Neovascularization, Pathologic (genetics), Prognosis, microRNA.
- MESH :
- chemical , genetics : MicroRNAs.
- diagnosis : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- genetics : Carcinoma, Non-Small-Cell Lung, Cell Transformation, Neoplastic, Lung Neoplasms, Neovascularization, Pathologic.
- methods : Gene Targeting, Genetic Therapy.
- pathology : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- physiology : Genes, Tumor Suppressor, MicroRNAs.
- therapy : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- Animals, Cell Proliferation, Gene Expression Regulation, Neoplastic, Humans, Neoplasm Metastasis, Prognosis.
Abstract
Abstract: Work over the last decade has revealed novel regulatory mechanisms in pathological disease states that are mediated by microRNAs and has inspired researchers to begin elucidating the specific roles of miRNAs in the regulation of genes involved in cancer development and progression. Recently, miRNAs have been explored as therapeutic targets and diagnostic markers of cancer. In this paper, we review recent advances in the study of miRNAs involved in tumorigenesis, focusing on miRNA regulation of genes that have been demonstrated to play critical roles in lung cancer development. We discuss miRNA regulation of genes that play critical roles in the process of malignant transformation, angiogenesis and tumor metastasis, the dysregulation of miRNA expression in cancer development, and the development of miRNA-based diagnostics and therapeutics.
Url:
DOI: 10.1007/s10555-010-9204-9
Affiliations:
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Le document en format XML
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Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, 75390-8807, Dallas, TX</wicri:regionArea><wicri:noRegion>TX</wicri:noRegion></affiliation></author><author><name sortKey="Pertsemlidis, Alexander" sort="Pertsemlidis, Alexander" uniqKey="Pertsemlidis A" first="Alexander" last="Pertsemlidis">Alexander Pertsemlidis</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, 75390-8591, Dallas, TX</wicri:regionArea><wicri:noRegion>TX</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Cancer and Metastasis Reviews</title><title level="j" type="abbrev">Cancer Metastasis Rev</title><idno type="ISSN">0167-7659</idno><idno type="eISSN">1573-7233</idno><imprint><publisher>Springer US; http://www.springer-ny.com</publisher><pubPlace>Boston</pubPlace><date type="published" when="2010-03-01">2010-03-01</date><biblScope unit="volume">29</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="109">109</biblScope><biblScope unit="page" to="122">122</biblScope></imprint><idno type="ISSN">0167-7659</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0167-7659</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Carcinoma, Non-Small-Cell Lung (diagnosis)</term><term>Carcinoma, Non-Small-Cell Lung (genetics)</term><term>Carcinoma, Non-Small-Cell Lung (pathology)</term><term>Carcinoma, Non-Small-Cell Lung (therapy)</term><term>Cell Proliferation</term><term>Cell Transformation, Neoplastic (genetics)</term><term>Gene Expression Regulation, Neoplastic</term><term>Gene Targeting (methods)</term><term>Genes, Tumor Suppressor (physiology)</term><term>Genetic Therapy (methods)</term><term>Humans</term><term>Lung Neoplasms (diagnosis)</term><term>Lung Neoplasms (genetics)</term><term>Lung Neoplasms (pathology)</term><term>Lung Neoplasms (therapy)</term><term>Lung cancer</term><term>MicroRNAs (genetics)</term><term>MicroRNAs (physiology)</term><term>Neoplasm Metastasis</term><term>Neovascularization, Pathologic (genetics)</term><term>Prognosis</term><term>microRNA</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Carcinome pulmonaire non à petites cellules ()</term><term>Carcinome pulmonaire non à petites cellules (anatomopathologie)</term><term>Carcinome pulmonaire non à petites cellules (diagnostic)</term><term>Carcinome pulmonaire non à petites cellules (génétique)</term><term>Ciblage de gène ()</term><term>Gènes suppresseurs de tumeur (physiologie)</term><term>Humains</term><term>Métastase tumorale</term><term>Néovascularisation pathologique (génétique)</term><term>Prolifération cellulaire</term><term>Pronostic</term><term>Régulation de l'expression des gènes tumoraux</term><term>Thérapie génétique ()</term><term>Transformation cellulaire néoplasique (génétique)</term><term>Tumeurs du poumon ()</term><term>Tumeurs du poumon (anatomopathologie)</term><term>Tumeurs du poumon (diagnostic)</term><term>Tumeurs du poumon (génétique)</term><term>microARN (génétique)</term><term>microARN (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>MicroRNAs</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Cell Transformation, Neoplastic</term><term>Lung Neoplasms</term><term>Neovascularization, Pathologic</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Néovascularisation pathologique</term><term>Transformation cellulaire néoplasique</term><term>Tumeurs du poumon</term><term>microARN</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Gene Targeting</term><term>Genetic Therapy</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Gènes suppresseurs de tumeur</term><term>microARN</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Genes, Tumor Suppressor</term><term>MicroRNAs</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Proliferation</term><term>Gene Expression Regulation, Neoplastic</term><term>Humans</term><term>Neoplasm Metastasis</term><term>Prognosis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Carcinome pulmonaire non à petites cellules</term><term>Ciblage de gène</term><term>Humains</term><term>Métastase tumorale</term><term>Prolifération cellulaire</term><term>Pronostic</term><term>Régulation de l'expression des gènes tumoraux</term><term>Thérapie génétique</term><term>Tumeurs du poumon</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Work over the last decade has revealed novel regulatory mechanisms in pathological disease states that are mediated by microRNAs and has inspired researchers to begin elucidating the specific roles of miRNAs in the regulation of genes involved in cancer development and progression. Recently, miRNAs have been explored as therapeutic targets and diagnostic markers of cancer. In this paper, we review recent advances in the study of miRNAs involved in tumorigenesis, focusing on miRNA regulation of genes that have been demonstrated to play critical roles in lung cancer development. We discuss miRNA regulation of genes that play critical roles in the process of malignant transformation, angiogenesis and tumor metastasis, the dysregulation of miRNA expression in cancer development, and the development of miRNA-based diagnostics and therapeutics.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Du, Liqin" sort="Du, Liqin" uniqKey="Du L" first="Liqin" last="Du">Liqin Du</name></noRegion><name sortKey="Pertsemlidis, Alexander" sort="Pertsemlidis, Alexander" uniqKey="Pertsemlidis A" first="Alexander" last="Pertsemlidis">Alexander Pertsemlidis</name><name sortKey="Pertsemlidis, Alexander" sort="Pertsemlidis, Alexander" uniqKey="Pertsemlidis A" first="Alexander" last="Pertsemlidis">Alexander Pertsemlidis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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