Influence of Propofol and Fentanyl on Deep Brain Stimulation of the Subthalamic Nucleus
Identifieur interne : 001C21 ( Main/Exploration ); précédent : 001C20; suivant : 001C22Influence of Propofol and Fentanyl on Deep Brain Stimulation of the Subthalamic Nucleus
Auteurs : Wonki Kim [Corée du Sud] ; In Ho Song [Corée du Sud] ; Yong Hoon Lim [Corée du Sud] ; Mi-Ryoung Kim [Corée du Sud] ; Young Eun Kim [Corée du Sud] ; Jae Ha Hwang [Corée du Sud] ; In Keyoung Kim [Corée du Sud] ; Sang Woo Song [Corée du Sud] ; Jin Wook Kim [Corée du Sud] ; Woong-Woo Lee [Corée du Sud] ; Han-Joon Kim [Corée du Sud] ; Cheolyoung Kim [Corée du Sud] ; Hee Chan Kim [Corée du Sud] ; In Young Kim [Corée du Sud] ; Hee Pyoung Park [Corée du Sud] ; Dong Gyu Kim [Corée du Sud] ; Beom Seok Jeon [Corée du Sud] ; Sun Ha Paek [Corée du Sud]Source :
- Journal of Korean Medical Science [ 1011-8934 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Anesthésiques intraveineux (pharmacologie), Femelle, Fentanyl (pharmacologie), Humains, Imagerie par résonance magnétique, Indice de gravité médicale, Maladie de Parkinson (), Microélectrodes, Mâle, Noyau subthalamique (), Noyau subthalamique (physiologie), Propofol (pharmacologie), Stimulation cérébrale profonde, Sujet âgé, Tomodensitométrie, Électrodes implantées.
- MESH :
- pharmacologie : Anesthésiques intraveineux, Fentanyl, Propofol.
- physiologie : Noyau subthalamique.
- Adulte d'âge moyen, Femelle, Humains, Imagerie par résonance magnétique, Indice de gravité médicale, Maladie de Parkinson, Microélectrodes, Mâle, Noyau subthalamique, Stimulation cérébrale profonde, Sujet âgé, Tomodensitométrie, Électrodes implantées.
English descriptors
- KwdEn :
- Aged, Anesthetics, Intravenous (pharmacology), Deep Brain Stimulation, Electrodes, Implanted, Female, Fentanyl (pharmacology), Humans, Magnetic Resonance Imaging, Male, Microelectrodes, Middle Aged, Parkinson Disease (prevention & control), Propofol (pharmacology), Severity of Illness Index, Subthalamic Nucleus (drug effects), Subthalamic Nucleus (physiology), Tomography, X-Ray Computed.
- MESH :
- chemical , pharmacology : Anesthetics, Intravenous, Fentanyl, Propofol.
- drug effects : Subthalamic Nucleus.
- physiology : Subthalamic Nucleus.
- prevention & control : Parkinson Disease.
- Aged, Deep Brain Stimulation, Electrodes, Implanted, Female, Humans, Magnetic Resonance Imaging, Male, Microelectrodes, Middle Aged, Severity of Illness Index, Tomography, X-Ray Computed.
Abstract
We investigated the effect of propofol and fentanyl on microelectrode recording (MER) and its clinical applicability during subthalamic nucleus (STN) deep brain stimulation (DBS) surgery. We analyzed 8 patients with Parkinson's disease, underwent bilateral STN DBS with MER. Their left sides were done under awake and then their right sides were done with a continuous infusion of propofol and fentanyl under local anesthesia. The electrode position was evaluated by preoperative MRI and postoperative CT. The clinical outcomes were assessed at six months after surgery. We isolated single unit activities from the left and the right side MERs. There was no significant difference in the mean firing rate between the left side MERs (38.7±16.8 spikes/sec, n=78) and the right side MERs (35.5±17.2 spikes/sec, n=66). The bursting pattern of spikes was more frequently observed in the right STN than in the left STN. All the electrode positions were within the STNs on both sides and the off-time Unified Parkinson's Disease Rating Scale part III scores at six months after surgery decreased by 67% of the preoperative level. In this study, a continuous infusion of propofol and fentanyl did not significantly interfere with the MER signals from the STN. The results of this study suggest that propofol and fentanyl can be used for STN DBS in patients with advanced Parkinson's disease improving the overall experience of the patients.
Url:
DOI: 10.3346/jkms.2014.29.9.1278
PubMed: 25246748
PubMed Central: 4168183
Affiliations:
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Sud</country><wicri:regionArea>Department of Neurosurgery, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Song, Sang Woo" sort="Song, Sang Woo" uniqKey="Song S" first="Sang Woo" last="Song">Sang Woo Song</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurosurgery, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Jin Wook" sort="Kim, Jin Wook" uniqKey="Kim J" first="Jin Wook" last="Kim">Jin Wook Kim</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurosurgery, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Woong Woo" sort="Lee, Woong Woo" uniqKey="Lee W" first="Woong-Woo" last="Lee">Woong-Woo Lee</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurology, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Han Joon" sort="Kim, Han Joon" uniqKey="Kim H" first="Han-Joon" last="Kim">Han-Joon Kim</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurology, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Cheolyoung" sort="Kim, Cheolyoung" uniqKey="Kim C" first="Cheolyoung" last="Kim">Cheolyoung Kim</name><affiliation wicri:level="3"><nlm:aff id="A4">Medical Imaging Laboratory and CyberMed, Inc., Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du 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Sud</country><wicri:regionArea>Department of Neurology, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A8">Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Paek, Sun Ha" sort="Paek, Sun Ha" uniqKey="Paek S" first="Sun Ha" last="Paek">Sun Ha Paek</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurosurgery, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A8">Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A9">Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" 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College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Song, In Ho" sort="Song, In Ho" uniqKey="Song I" first="In Ho" last="Song">In Ho Song</name><affiliation wicri:level="1"><nlm:aff id="A2">Medical Device Development Center, Osong Medical Innovation Foundation, Cheongwon, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Medical Device Development Center, Osong Medical Innovation Foundation, Cheongwon</wicri:regionArea><wicri:noRegion>Cheongwon</wicri:noRegion></affiliation></author><author><name sortKey="Lim, Yong Hoon" sort="Lim, Yong Hoon" uniqKey="Lim Y" first="Yong Hoon" last="Lim">Yong Hoon Lim</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurosurgery, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Mi Ryoung" sort="Kim, Mi Ryoung" uniqKey="Kim M" first="Mi-Ryoung" last="Kim">Mi-Ryoung Kim</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurosurgery, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Young Eun" sort="Kim, Young Eun" uniqKey="Kim Y" first="Young Eun" last="Kim">Young Eun Kim</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurology, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Hwang, Jae Ha" sort="Hwang, Jae Ha" uniqKey="Hwang J" first="Jae Ha" last="Hwang">Jae Ha Hwang</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurosurgery, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, In Keyoung" sort="Kim, In Keyoung" uniqKey="Kim I" first="In Keyoung" last="Kim">In Keyoung Kim</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurosurgery, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Song, Sang Woo" sort="Song, Sang Woo" uniqKey="Song S" first="Sang Woo" last="Song">Sang Woo Song</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurosurgery, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Jin Wook" sort="Kim, Jin Wook" uniqKey="Kim J" first="Jin Wook" last="Kim">Jin Wook Kim</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurosurgery, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Woong Woo" sort="Lee, Woong Woo" uniqKey="Lee W" first="Woong-Woo" last="Lee">Woong-Woo Lee</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurology, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Han Joon" sort="Kim, Han Joon" uniqKey="Kim H" first="Han-Joon" last="Kim">Han-Joon Kim</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurology, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Cheolyoung" sort="Kim, Cheolyoung" uniqKey="Kim C" first="Cheolyoung" last="Kim">Cheolyoung Kim</name><affiliation wicri:level="3"><nlm:aff id="A4">Medical Imaging Laboratory and CyberMed, Inc., Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Medical Imaging Laboratory and CyberMed, Inc., Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Hee Chan" sort="Kim, Hee Chan" uniqKey="Kim H" first="Hee Chan" last="Kim">Hee Chan Kim</name><affiliation wicri:level="3"><nlm:aff id="A5">Department of Medical Engineering, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Medical Engineering, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, In Young" sort="Kim, In Young" uniqKey="Kim I" first="In Young" last="Kim">In Young Kim</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Biomedical Engineering, Hanyang University, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Biomedical Engineering, Hanyang University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Hee Pyoung" sort="Park, Hee Pyoung" uniqKey="Park H" first="Hee Pyoung" last="Park">Hee Pyoung Park</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Anaesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Anaesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Dong Gyu" sort="Kim, Dong Gyu" uniqKey="Kim D" first="Dong Gyu" last="Kim">Dong Gyu Kim</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurosurgery, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jeon, Beom Seok" sort="Jeon, Beom Seok" uniqKey="Jeon B" first="Beom Seok" last="Jeon">Beom Seok Jeon</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurology, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A8">Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Paek, Sun Ha" sort="Paek, Sun Ha" uniqKey="Paek S" first="Sun Ha" last="Paek">Sun Ha Paek</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurosurgery, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A8">Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A9">Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Cancer Research Institute, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A10">Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Clinical Research Institute, Seoul National University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Korean Medical Science</title><idno type="ISSN">1011-8934</idno><idno type="eISSN">1598-6357</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Anesthetics, Intravenous (pharmacology)</term><term>Deep Brain Stimulation</term><term>Electrodes, Implanted</term><term>Female</term><term>Fentanyl (pharmacology)</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Microelectrodes</term><term>Middle Aged</term><term>Parkinson Disease (prevention & control)</term><term>Propofol (pharmacology)</term><term>Severity of Illness Index</term><term>Subthalamic Nucleus (drug effects)</term><term>Subthalamic Nucleus (physiology)</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Anesthésiques intraveineux (pharmacologie)</term><term>Femelle</term><term>Fentanyl (pharmacologie)</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Indice de gravité médicale</term><term>Maladie de Parkinson ()</term><term>Microélectrodes</term><term>Mâle</term><term>Noyau subthalamique ()</term><term>Noyau subthalamique (physiologie)</term><term>Propofol (pharmacologie)</term><term>Stimulation cérébrale profonde</term><term>Sujet âgé</term><term>Tomodensitométrie</term><term>Électrodes implantées</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anesthetics, Intravenous</term><term>Fentanyl</term><term>Propofol</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anesthésiques intraveineux</term><term>Fentanyl</term><term>Propofol</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Noyau subthalamique</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Deep Brain Stimulation</term><term>Electrodes, Implanted</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Microelectrodes</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Indice de gravité médicale</term><term>Maladie de Parkinson</term><term>Microélectrodes</term><term>Mâle</term><term>Noyau subthalamique</term><term>Stimulation cérébrale profonde</term><term>Sujet âgé</term><term>Tomodensitométrie</term><term>Électrodes implantées</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We investigated the effect of propofol and fentanyl on microelectrode recording (MER) and its clinical applicability during subthalamic nucleus (STN) deep brain stimulation (DBS) surgery. We analyzed 8 patients with Parkinson's disease, underwent bilateral STN DBS with MER. Their left sides were done under awake and then their right sides were done with a continuous infusion of propofol and fentanyl under local anesthesia. The electrode position was evaluated by preoperative MRI and postoperative CT. The clinical outcomes were assessed at six months after surgery. We isolated single unit activities from the left and the right side MERs. There was no significant difference in the mean firing rate between the left side MERs (38.7±16.8 spikes/sec, n=78) and the right side MERs (35.5±17.2 spikes/sec, n=66). The bursting pattern of spikes was more frequently observed in the right STN than in the left STN. All the electrode positions were within the STNs on both sides and the off-time Unified Parkinson's Disease Rating Scale part III scores at six months after surgery decreased by 67% of the preoperative level. In this study, a continuous infusion of propofol and fentanyl did not significantly interfere with the MER signals from the STN. The results of this study suggest that propofol and fentanyl can be used for STN DBS in patients with advanced Parkinson's disease improving the overall experience of the patients.</p><sec><title>Graphical Abstract</title><p><graphic xlink:href="jkms-29-1278-ab001.jpg" position="float" orientation="portrait"></graphic></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Benabid, Al" uniqKey="Benabid A">AL Benabid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hutchison, Wd" uniqKey="Hutchison W">WD Hutchison</name></author><author><name sortKey="Allan, Rj" uniqKey="Allan R">RJ Allan</name></author><author><name sortKey="Opitz, H" uniqKey="Opitz H">H Opitz</name></author><author><name sortKey="Levy, R" uniqKey="Levy R">R Levy</name></author><author><name sortKey="Dostrovsky, Jo" uniqKey="Dostrovsky J">JO Dostrovsky</name></author><author><name sortKey="Lang, Ae" 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Ostrem</name></author><author><name sortKey="Turner, Rs" uniqKey="Turner R">RS Turner</name></author><author><name sortKey="Shimamoto, Sa" uniqKey="Shimamoto S">SA Shimamoto</name></author><author><name sortKey="Starr, Pa" uniqKey="Starr P">PA Starr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steigerwald, F" uniqKey="Steigerwald F">F Steigerwald</name></author><author><name sortKey="Potter, M" uniqKey="Potter M">M Pötter</name></author><author><name sortKey="Herzog, J" uniqKey="Herzog J">J Herzog</name></author><author><name sortKey="Pinsker, M" uniqKey="Pinsker M">M Pinsker</name></author><author><name sortKey="Kopper, F" uniqKey="Kopper F">F Kopper</name></author><author><name sortKey="Mehdorn, H" uniqKey="Mehdorn H">H Mehdorn</name></author><author><name sortKey="Deuschl, G" uniqKey="Deuschl G">G Deuschl</name></author><author><name sortKey="Volkmann, J" uniqKey="Volkmann J">J Volkmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weinberger, M" uniqKey="Weinberger M">M Weinberger</name></author><author><name sortKey="Mahant, N" uniqKey="Mahant N">N Mahant</name></author><author><name sortKey="Hutchison, Wd" uniqKey="Hutchison W">WD Hutchison</name></author><author><name sortKey="Lozano, Am" uniqKey="Lozano A">AM Lozano</name></author><author><name sortKey="Moro, E" uniqKey="Moro E">E Moro</name></author><author><name sortKey="Hodaie, M" uniqKey="Hodaie M">M Hodaie</name></author><author><name sortKey="Lang, Ae" uniqKey="Lang A">AE Lang</name></author><author><name sortKey="Dostrovsky, Jo" uniqKey="Dostrovsky J">JO Dostrovsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hutchison, Wd" uniqKey="Hutchison W">WD Hutchison</name></author><author><name sortKey="Lang, Ae" uniqKey="Lang A">AE Lang</name></author><author><name sortKey="Dostrovsky, Jo" uniqKey="Dostrovsky J">JO Dostrovsky</name></author><author><name sortKey="Lozano, Am" uniqKey="Lozano A">AM Lozano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Bj" uniqKey="Anderson B">BJ Anderson</name></author><author><name sortKey="Marks, Pv" uniqKey="Marks P">PV Marks</name></author><author><name sortKey="Futter, Me" uniqKey="Futter M">ME Futter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bohmdorfer, W" uniqKey="Bohmdorfer W">W Böhmdorfer</name></author><author><name sortKey="Schwarzinger, P" uniqKey="Schwarzinger P">P Schwarzinger</name></author><author><name sortKey="Binder, S" uniqKey="Binder S">S Binder</name></author><author><name sortKey="Sporn, P" uniqKey="Sporn P">P Sporn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Velly, Lj" uniqKey="Velly L">LJ Velly</name></author><author><name sortKey="Rey, Mf" uniqKey="Rey M">MF Rey</name></author><author><name sortKey="Bruder, Nj" uniqKey="Bruder N">NJ Bruder</name></author><author><name sortKey="Gouvitsos, Fa" uniqKey="Gouvitsos F">FA Gouvitsos</name></author><author><name sortKey="Witjas, T" uniqKey="Witjas T">T Witjas</name></author><author><name sortKey="Regis, Jm" uniqKey="Regis J">JM Regis</name></author><author><name sortKey="Peragut, Jc" uniqKey="Peragut J">JC Peragut</name></author><author><name sortKey="Gouin, Fm" uniqKey="Gouin F">FM Gouin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Venkatraghavan, L" uniqKey="Venkatraghavan L">L Venkatraghavan</name></author><author><name sortKey="Luciano, M" uniqKey="Luciano M">M Luciano</name></author><author><name sortKey="Manninen, P" uniqKey="Manninen P">P Manninen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kim, Wonki" sort="Kim, Wonki" uniqKey="Kim W" first="Wonki" last="Kim">Wonki Kim</name></region><name sortKey="Hwang, Jae Ha" sort="Hwang, Jae Ha" uniqKey="Hwang J" first="Jae Ha" last="Hwang">Jae Ha Hwang</name><name sortKey="Jeon, Beom Seok" sort="Jeon, Beom Seok" uniqKey="Jeon B" first="Beom Seok" last="Jeon">Beom Seok Jeon</name><name sortKey="Jeon, Beom Seok" sort="Jeon, Beom Seok" uniqKey="Jeon B" first="Beom Seok" last="Jeon">Beom Seok Jeon</name><name sortKey="Kim, Cheolyoung" sort="Kim, Cheolyoung" uniqKey="Kim C" first="Cheolyoung" last="Kim">Cheolyoung Kim</name><name sortKey="Kim, Dong Gyu" sort="Kim, Dong Gyu" uniqKey="Kim D" first="Dong Gyu" last="Kim">Dong Gyu Kim</name><name sortKey="Kim, Han Joon" sort="Kim, Han Joon" uniqKey="Kim H" first="Han-Joon" last="Kim">Han-Joon Kim</name><name sortKey="Kim, Hee Chan" sort="Kim, Hee Chan" uniqKey="Kim H" first="Hee Chan" last="Kim">Hee Chan Kim</name><name sortKey="Kim, In Keyoung" sort="Kim, In Keyoung" uniqKey="Kim I" first="In Keyoung" last="Kim">In Keyoung Kim</name><name sortKey="Kim, In Young" sort="Kim, In Young" uniqKey="Kim I" first="In Young" last="Kim">In Young Kim</name><name sortKey="Kim, Jin Wook" sort="Kim, Jin Wook" uniqKey="Kim J" first="Jin Wook" last="Kim">Jin Wook Kim</name><name sortKey="Kim, Mi Ryoung" sort="Kim, Mi Ryoung" uniqKey="Kim M" first="Mi-Ryoung" last="Kim">Mi-Ryoung Kim</name><name sortKey="Kim, Young Eun" sort="Kim, Young Eun" uniqKey="Kim Y" first="Young Eun" last="Kim">Young Eun Kim</name><name sortKey="Lee, Woong Woo" sort="Lee, Woong Woo" uniqKey="Lee W" first="Woong-Woo" last="Lee">Woong-Woo Lee</name><name sortKey="Lim, Yong Hoon" sort="Lim, Yong Hoon" uniqKey="Lim Y" first="Yong Hoon" last="Lim">Yong Hoon Lim</name><name sortKey="Paek, Sun Ha" sort="Paek, Sun Ha" uniqKey="Paek S" first="Sun Ha" last="Paek">Sun Ha Paek</name><name sortKey="Paek, Sun Ha" sort="Paek, Sun Ha" uniqKey="Paek S" first="Sun Ha" last="Paek">Sun Ha Paek</name><name sortKey="Paek, Sun Ha" sort="Paek, Sun Ha" uniqKey="Paek S" first="Sun Ha" last="Paek">Sun Ha Paek</name><name sortKey="Paek, Sun Ha" sort="Paek, Sun Ha" uniqKey="Paek S" first="Sun Ha" last="Paek">Sun Ha Paek</name><name sortKey="Park, Hee Pyoung" sort="Park, Hee Pyoung" uniqKey="Park H" first="Hee Pyoung" last="Park">Hee Pyoung Park</name><name sortKey="Song, In Ho" sort="Song, In Ho" uniqKey="Song I" first="In Ho" last="Song">In Ho Song</name><name sortKey="Song, Sang Woo" sort="Song, Sang Woo" uniqKey="Song S" first="Sang Woo" last="Song">Sang Woo Song</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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