Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases
Identifieur interne : 001A45 ( Main/Exploration ); précédent : 001A44; suivant : 001A46Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases
Auteurs : Frances E. Terry ; Leonard Moise ; Rebecca F. Martin ; Melissa Torres ; Nils Pilotte ; Steven A. Williams ; Anne S. De GrootSource :
- Expert Review of Vaccines [ 1476-0584 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Vaccins.
- immunologie : Maladies négligées, Vaccins.
- isolement et purification : Vaccins.
- épidémiologie : Maladies transmissibles émergentes.
- Biologie informatique, Climat tropical, Génomique, Humains, Maladies négligées, Maladies transmissibles émergentes.
English descriptors
- KwdEn :
- Communicable Diseases, Emerging (epidemiology), Communicable Diseases, Emerging (prevention & control), Computational Biology (methods), Genomics (methods), Humans, Neglected Diseases (immunology), Neglected Diseases (prevention & control), Tropical Climate, Vaccines (genetics), Vaccines (immunology), Vaccines (isolation & purification).
- MESH :
- chemical , genetics : Vaccines.
- epidemiology : Communicable Diseases, Emerging.
- immunology : Neglected Diseases, Vaccines.
- chemical , isolation & purification : Vaccines.
- methods : Computational Biology, Genomics.
- prevention & control : Communicable Diseases, Emerging, Neglected Diseases.
- Humans, Tropical Climate.
Abstract
Vaccines have been invaluable for global health, saving lives and reducing healthcare costs, while also raising the quality of human life. However, newly emerging infectious diseases (EID) and more well-established tropical disease pathogens present complex challenges to vaccine developers; in particular, neglected tropical diseases, which are most prevalent among the world’s poorest, include many pathogens with large sizes, multistage life cycles and a variety of nonhuman vectors. EID such as MERS-CoV and H7N9 are highly pathogenic for humans. For many of these pathogens, while their genomes are available, immune correlates of protection are currently unknown. These complexities make developing vaccines for EID and neglected tropical diseases all the more difficult. In this review, we describe the implementation of an immunoinformatics-driven approach to systematically search for key determinants of immunity in newly available genome sequence data and design vaccines. This approach holds promise for the development of 21st century vaccines, improving human health everywhere.
Url:
DOI: 10.1586/14760584.2015.955478
PubMed: 25193104
PubMed Central: 4743591
Affiliations:
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Le document en format XML
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Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases</title><author><name sortKey="Terry, Frances E" sort="Terry, Frances E" uniqKey="Terry F" first="Frances E" last="Terry">Frances E. Terry</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Moise, Leonard" sort="Moise, Leonard" uniqKey="Moise L" first="Leonard" last="Moise">Leonard Moise</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Martin, Rebecca F" sort="Martin, Rebecca F" uniqKey="Martin R" first="Rebecca F" last="Martin">Rebecca F. 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However, newly emerging infectious diseases (EID) and more well-established tropical disease pathogens present complex challenges to vaccine developers; in particular, neglected tropical diseases, which are most prevalent among the world’s poorest, include many pathogens with large sizes, multistage life cycles and a variety of nonhuman vectors. EID such as MERS-CoV and H7N9 are highly pathogenic for humans. For many of these pathogens, while their genomes are available, immune correlates of protection are currently unknown. These complexities make developing vaccines for EID and neglected tropical diseases all the more difficult. In this review, we describe the implementation of an immunoinformatics-driven approach to systematically search for key determinants of immunity in newly available genome sequence data and design vaccines. This approach holds promise for the development of 21st century vaccines, improving human health everywhere.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Milne Price, S" uniqKey="Milne Price S">S Milne-Price</name></author><author><name sortKey="Miazgowicz, Kl" uniqKey="Miazgowicz K">KL Miazgowicz</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Macarthur, C" uniqKey="Macarthur C">C MacArthur</name></author><author><name sortKey="Mubila, L" uniqKey="Mubila L">L Mubila</name></author><author><name sortKey="Baker, S" uniqKey="Baker S">S Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arce, A" uniqKey="Arce A">A Arce</name></author><author><name sortKey="Estirado, A" 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sortKey="Stibraniova, I" uniqKey="Stibraniova I">I Štibrániová</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author><author><name sortKey="Einck, L" uniqKey="Einck L">L Einck</name></author><author><name sortKey="Moise, L" uniqKey="Moise L">L Moise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murray, Cj" uniqKey="Murray C">CJ Murray</name></author><author><name sortKey="Vos, T" uniqKey="Vos T">T Vos</name></author><author><name sortKey="Lozano, R" uniqKey="Lozano R">R Lozano</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="De Groot, Anne S" sort="De Groot, Anne S" uniqKey="De Groot A" first="Anne S" last="De Groot">Anne S. De Groot</name><name sortKey="Martin, Rebecca F" sort="Martin, Rebecca F" uniqKey="Martin R" first="Rebecca F" last="Martin">Rebecca F. Martin</name><name sortKey="Moise, Leonard" sort="Moise, Leonard" uniqKey="Moise L" first="Leonard" last="Moise">Leonard Moise</name><name sortKey="Pilotte, Nils" sort="Pilotte, Nils" uniqKey="Pilotte N" first="Nils" last="Pilotte">Nils Pilotte</name><name sortKey="Terry, Frances E" sort="Terry, Frances E" uniqKey="Terry F" first="Frances E" last="Terry">Frances E. Terry</name><name sortKey="Torres, Melissa" sort="Torres, Melissa" uniqKey="Torres M" first="Melissa" last="Torres">Melissa Torres</name><name sortKey="Williams, Steven A" sort="Williams, Steven A" uniqKey="Williams S" first="Steven A" last="Williams">Steven A. Williams</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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