Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases
Identifieur interne : 000F47 ( Pmc/Checkpoint ); précédent : 000F46; suivant : 000F48Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases
Auteurs : Frances E. Terry ; Leonard Moise ; Rebecca F. Martin ; Melissa Torres ; Nils Pilotte ; Steven A. Williams ; Anne S. De GrootSource :
- Expert Review of Vaccines [ 1476-0584 ] ; 2014.
Abstract
Vaccines have been invaluable for global health, saving lives and reducing healthcare costs, while also raising the quality of human life. However, newly emerging infectious diseases (EID) and more well-established tropical disease pathogens present complex challenges to vaccine developers; in particular, neglected tropical diseases, which are most prevalent among the world’s poorest, include many pathogens with large sizes, multistage life cycles and a variety of nonhuman vectors. EID such as MERS-CoV and H7N9 are highly pathogenic for humans. For many of these pathogens, while their genomes are available, immune correlates of protection are currently unknown. These complexities make developing vaccines for EID and neglected tropical diseases all the more difficult. In this review, we describe the implementation of an immunoinformatics-driven approach to systematically search for key determinants of immunity in newly available genome sequence data and design vaccines. This approach holds promise for the development of 21st century vaccines, improving human health everywhere.
Url:
DOI: 10.1586/14760584.2015.955478
PubMed: 25193104
PubMed Central: 4743591
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:4743591Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases</title><author><name sortKey="Terry, Frances E" sort="Terry, Frances E" uniqKey="Terry F" first="Frances E" last="Terry">Frances E. Terry</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Moise, Leonard" sort="Moise, Leonard" uniqKey="Moise L" first="Leonard" last="Moise">Leonard Moise</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Martin, Rebecca F" sort="Martin, Rebecca F" uniqKey="Martin R" first="Rebecca F" last="Martin">Rebecca F. Martin</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Torres, Melissa" sort="Torres, Melissa" uniqKey="Torres M" first="Melissa" last="Torres">Melissa Torres</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Pilotte, Nils" sort="Pilotte, Nils" uniqKey="Pilotte N" first="Nils" last="Pilotte">Nils Pilotte</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Williams, Steven A" sort="Williams, Steven A" uniqKey="Williams S" first="Steven A" last="Williams">Steven A. Williams</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="De Groot, Anne S" sort="De Groot, Anne S" uniqKey="De Groot A" first="Anne S" last="De Groot">Anne S. De Groot</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25193104</idno><idno type="pmc">4743591</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743591</idno><idno type="RBID">PMC:4743591</idno><idno type="doi">10.1586/14760584.2015.955478</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001323</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001323</idno><idno type="wicri:Area/Pmc/Curation">001323</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001323</idno><idno type="wicri:Area/Pmc/Checkpoint">000F47</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000F47</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases</title><author><name sortKey="Terry, Frances E" sort="Terry, Frances E" uniqKey="Terry F" first="Frances E" last="Terry">Frances E. Terry</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Moise, Leonard" sort="Moise, Leonard" uniqKey="Moise L" first="Leonard" last="Moise">Leonard Moise</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Martin, Rebecca F" sort="Martin, Rebecca F" uniqKey="Martin R" first="Rebecca F" last="Martin">Rebecca F. Martin</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Torres, Melissa" sort="Torres, Melissa" uniqKey="Torres M" first="Melissa" last="Torres">Melissa Torres</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Pilotte, Nils" sort="Pilotte, Nils" uniqKey="Pilotte N" first="Nils" last="Pilotte">Nils Pilotte</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Williams, Steven A" sort="Williams, Steven A" uniqKey="Williams S" first="Steven A" last="Williams">Steven A. Williams</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="De Groot, Anne S" sort="De Groot, Anne S" uniqKey="De Groot A" first="Anne S" last="De Groot">Anne S. De Groot</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></analytic><series><title level="j">Expert Review of Vaccines</title><idno type="ISSN">1476-0584</idno><idno type="eISSN">1744-8395</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Vaccines have been invaluable for global health, saving lives and reducing healthcare costs, while also raising the quality of human life. However, newly emerging infectious diseases (EID) and more well-established tropical disease pathogens present complex challenges to vaccine developers; in particular, neglected tropical diseases, which are most prevalent among the world’s poorest, include many pathogens with large sizes, multistage life cycles and a variety of nonhuman vectors. EID such as MERS-CoV and H7N9 are highly pathogenic for humans. For many of these pathogens, while their genomes are available, immune correlates of protection are currently unknown. These complexities make developing vaccines for EID and neglected tropical diseases all the more difficult. In this review, we describe the implementation of an immunoinformatics-driven approach to systematically search for key determinants of immunity in newly available genome sequence data and design vaccines. This approach holds promise for the development of 21st century vaccines, improving human health everywhere.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Milne Price, S" uniqKey="Milne Price S">S Milne-Price</name></author><author><name sortKey="Miazgowicz, Kl" uniqKey="Miazgowicz K">KL Miazgowicz</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Macarthur, C" uniqKey="Macarthur C">C MacArthur</name></author><author><name sortKey="Mubila, L" uniqKey="Mubila L">L Mubila</name></author><author><name sortKey="Baker, S" uniqKey="Baker S">S Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arce, A" uniqKey="Arce A">A Arce</name></author><author><name sortKey="Estirado, A" uniqKey="Estirado A">A Estirado</name></author><author><name sortKey="Ordobas, M" uniqKey="Ordobas M">M Ordobas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Montgomery, Sp" uniqKey="Montgomery S">SP Montgomery</name></author><author><name sortKey="Starr, Mc" uniqKey="Starr M">MC Starr</name></author><author><name sortKey="Cantey, Pt" uniqKey="Cantey P">PT Cantey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Settembre, Ec" uniqKey="Settembre E">EC Settembre</name></author><author><name sortKey="Dormitzer, Pr" uniqKey="Dormitzer P">PR Dormitzer</name></author><author><name sortKey="Rappuoli, R" uniqKey="Rappuoli R">R Rappuoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fries, Lf" uniqKey="Fries L">LF Fries</name></author><author><name sortKey="Smith, Ge" uniqKey="Smith G">GE Smith</name></author><author><name sortKey="Glenn, Gm" uniqKey="Glenn G">GM Glenn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, N" uniqKey="Zhang N">N Zhang</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author><author><name sortKey="Moise, L" uniqKey="Moise L">L Moise</name></author><author><name sortKey="Liu, R" uniqKey="Liu R">R Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hotez, Pj" uniqKey="Hotez P">PJ Hotez</name></author><author><name sortKey="Dumonteil, E" uniqKey="Dumonteil E">E Dumonteil</name></author><author><name sortKey="Heffernan, Mj" uniqKey="Heffernan M">MJ Heffernan</name></author><author><name sortKey="Bottazzi, Me" uniqKey="Bottazzi M">ME Bottazzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bockarie, Mj" uniqKey="Bockarie M">MJ Bockarie</name></author><author><name sortKey="Kelly Hope, La" uniqKey="Kelly Hope L">LA Kelly-Hope</name></author><author><name sortKey="Rebollo, M" uniqKey="Rebollo M">M Rebollo</name></author><author><name sortKey="Molyneux, Dh" uniqKey="Molyneux D">DH Molyneux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Molyneux, Dh" uniqKey="Molyneux D">DH Molyneux</name></author><author><name sortKey="Malecela, Mn" uniqKey="Malecela M">MN Malecela</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webster, Jp" uniqKey="Webster J">JP Webster</name></author><author><name sortKey="Molyneux, Dh" uniqKey="Molyneux D">DH Molyneux</name></author><author><name sortKey="Hotez, Pj" uniqKey="Hotez P">PJ Hotez</name></author><author><name sortKey="Fenwick, A" uniqKey="Fenwick A">A Fenwick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hotez, Pj" uniqKey="Hotez P">PJ Hotez</name></author><author><name sortKey="Diemert, D" uniqKey="Diemert D">D Diemert</name></author><author><name sortKey="Bacon, Km" uniqKey="Bacon K">KM Bacon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eisen, Ja" uniqKey="Eisen J">JA Eisen</name></author><author><name sortKey="Maccallum, Cj" uniqKey="Maccallum C">CJ MacCallum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blattman, Jn" uniqKey="Blattman J">JN Blattman</name></author><author><name sortKey="Sourdive, Dj" uniqKey="Sourdive D">DJ Sourdive</name></author><author><name sortKey="Murali Krishna, K" uniqKey="Murali Krishna K">K Murali-Krishna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harrer, T" uniqKey="Harrer T">T Harrer</name></author><author><name sortKey="Harrer, E" uniqKey="Harrer E">E Harrer</name></author><author><name sortKey="Kalams, Sa" uniqKey="Kalams S">SA Kalams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doolan, Dl" uniqKey="Doolan D">DL Doolan</name></author><author><name sortKey="Hoffman, Sl" uniqKey="Hoffman S">SL Hoffman</name></author><author><name sortKey="Southwood, S" uniqKey="Southwood S">S Southwood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gianfrani, C" uniqKey="Gianfrani C">C Gianfrani</name></author><author><name sortKey="Oseroff, C" uniqKey="Oseroff C">C Oseroff</name></author><author><name sortKey="Sidney, J" uniqKey="Sidney J">J Sidney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mok, H" uniqKey="Mok H">H Mok</name></author><author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name></author><author><name sortKey="Wright, Dw" uniqKey="Wright D">DW Wright</name></author><author><name sortKey="Crowe, Je" uniqKey="Crowe J">JE Crowe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gillespie, Gm" uniqKey="Gillespie G">GM Gillespie</name></author><author><name sortKey="Wills, Mr" uniqKey="Wills M">MR Wills</name></author><author><name sortKey="Appay, V" uniqKey="Appay V">V Appay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author><author><name sortKey="Berzofsky, Ja" uniqKey="Berzofsky J">JA Berzofsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moise, L" uniqKey="Moise L">L Moise</name></author><author><name sortKey="Buller, Rm" uniqKey="Buller R">RM Buller</name></author><author><name sortKey="Schriewer, J" uniqKey="Schriewer J">J Schriewer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moss, Sf" uniqKey="Moss S">SF Moss</name></author><author><name sortKey="Moise, L" uniqKey="Moise L">L Moise</name></author><author><name sortKey="Lee, Ds" uniqKey="Lee D">DS Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gregory, Sh" uniqKey="Gregory S">SH Gregory</name></author><author><name sortKey="Mott, S" uniqKey="Mott S">S Mott</name></author><author><name sortKey="Phung, J" uniqKey="Phung J">J Phung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petrovsky, N" uniqKey="Petrovsky N">N Petrovsky</name></author><author><name sortKey="Brusic, V" uniqKey="Brusic V">V Brusic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author><author><name sortKey="Martin, W" uniqKey="Martin W">W Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name></author><author><name sortKey="Sidney, J" uniqKey="Sidney J">J Sidney</name></author><author><name sortKey="Dow, C" uniqKey="Dow C">C Dow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elliott, Sl" uniqKey="Elliott S">SL Elliott</name></author><author><name sortKey="Suhrbier, A" uniqKey="Suhrbier A">A Suhrbier</name></author><author><name sortKey="Miles, Jj" uniqKey="Miles J">JJ Miles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rappuoli, R" uniqKey="Rappuoli R">R Rappuoli</name></author><author><name sortKey="Covacci, A" uniqKey="Covacci A">A Covacci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pederson, T" uniqKey="Pederson T">T Pederson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author><author><name sortKey="Martin, W" uniqKey="Martin W">W Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doytchinova, Ia" uniqKey="Doytchinova I">IA Doytchinova</name></author><author><name sortKey="Taylor, P" uniqKey="Taylor P">P Taylor</name></author><author><name sortKey="Flower, Dr" uniqKey="Flower D">DR Flower</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Plotkin, Sa" uniqKey="Plotkin S">SA Plotkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yao, B" uniqKey="Yao B">B Yao</name></author><author><name sortKey="Zheng, D" uniqKey="Zheng D">D Zheng</name></author><author><name sortKey="Liang, S" uniqKey="Liang S">S Liang</name></author><author><name sortKey="Zhang, C" uniqKey="Zhang C">C Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crotty, S" uniqKey="Crotty S">S Crotty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koita, Oa" uniqKey="Koita O">OA Koita</name></author><author><name sortKey="Dabitao, D" uniqKey="Dabitao D">D Dabitao</name></author><author><name sortKey="Mahamadou, I" uniqKey="Mahamadou I">I Mahamadou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcmurry, Ja" uniqKey="Mcmurry J">JA McMurry</name></author><author><name sortKey="Gregory, Sh" uniqKey="Gregory S">SH Gregory</name></author><author><name sortKey="Moise, L" uniqKey="Moise L">L Moise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author><author><name sortKey="Marcon, L" uniqKey="Marcon L">L Marcon</name></author><author><name sortKey="Bishop, Ea" uniqKey="Bishop E">EA Bishop</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author><author><name sortKey="Mcmurry, J" uniqKey="Mcmurry J">J McMurry</name></author><author><name sortKey="Marcon, L" uniqKey="Marcon L">L Marcon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schanen, Bc" uniqKey="Schanen B">BC Schanen</name></author><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author><author><name sortKey="Moise, L" uniqKey="Moise L">L Moise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Desrosiers, J" uniqKey="Desrosiers J">J Desrosiers</name></author><author><name sortKey="Aponte Pieras, Jr" uniqKey="Aponte Pieras J">JR Aponte-Pieras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mishra, S" uniqKey="Mishra S">S Mishra</name></author><author><name sortKey="Losikoff, Pt" uniqKey="Losikoff P">PT Losikoff</name></author><author><name sortKey="Self, Aa" uniqKey="Self A">AA Self</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author><author><name sortKey="Ardito, M" uniqKey="Ardito M">M Ardito</name></author><author><name sortKey="Moise, L" uniqKey="Moise L">L Moise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author><author><name sortKey="Moise, L" uniqKey="Moise L">L Moise</name></author><author><name sortKey="Martin, W" uniqKey="Martin W">W Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author><author><name sortKey="Ardito, M" uniqKey="Ardito M">M Ardito</name></author><author><name sortKey="Mcclaine, E" uniqKey="Mcclaine E">E McClaine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elfaki, Me" uniqKey="Elfaki M">ME Elfaki</name></author><author><name sortKey="Khalil, Ea" uniqKey="Khalil E">EA Khalil</name></author><author><name sortKey="Degroot, As" uniqKey="Degroot A">AS Degroot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gomez, M" uniqKey="Gomez M">M Gomez</name></author><author><name sortKey="Johnson, S" uniqKey="Johnson S">S Johnson</name></author><author><name sortKey="Gennaro, Ml" uniqKey="Gennaro M">ML Gennaro</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mcmurry, Ja" uniqKey="Mcmurry J">JA McMurry</name></author><author><name sortKey="Kimball, S" uniqKey="Kimball S">S Kimball</name></author><author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author><author><name sortKey="Ardito, M" uniqKey="Ardito M">M Ardito</name></author><author><name sortKey="Terry, F" uniqKey="Terry F">F Terry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Despommier, Dd" uniqKey="Despommier D">DD Despommier</name></author><author><name sortKey="Gwadz, Rw" uniqKey="Gwadz R">RW Gwadz</name></author><author><name sortKey="Hotez, Pj" uniqKey="Hotez P">PJ Hotez</name></author><author><name sortKey="Knirsch, Ca" uniqKey="Knirsch C">CA Knirsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gnanasekar, M" uniqKey="Gnanasekar M">M Gnanasekar</name></author><author><name sortKey="Rao, Kv" uniqKey="Rao K">KV Rao</name></author><author><name sortKey="He, Yx" uniqKey="He Y">YX He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hintz, M" uniqKey="Hintz M">M Hintz</name></author><author><name sortKey="Schares, G" uniqKey="Schares G">G Schares</name></author><author><name sortKey="Taubert, A" uniqKey="Taubert A">A Taubert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bowen, Dg" uniqKey="Bowen D">DG Bowen</name></author><author><name sortKey="Walker, Cm" uniqKey="Walker C">CM Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bailey, J" uniqKey="Bailey J">J Bailey</name></author><author><name sortKey="Blankson, Jn" uniqKey="Blankson J">JN Blankson</name></author><author><name sortKey="Wind Rotolo, M" uniqKey="Wind Rotolo M">M Wind-Rotolo</name></author><author><name sortKey="Siliciano, Rf" uniqKey="Siliciano R">RF Siliciano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falk, K" uniqKey="Falk K">K Falk</name></author><author><name sortKey="Rotzschke, O" uniqKey="Rotzschke O">O Rotzschke</name></author><author><name sortKey="Stevanovic, S" uniqKey="Stevanovic S">S Stevanovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rotzschke, O" uniqKey="Rotzschke O">O Rotzschke</name></author><author><name sortKey="Falk, K" uniqKey="Falk K">K Falk</name></author><author><name sortKey="Stevanovic, S" uniqKey="Stevanovic S">S Stevanovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sette, S" uniqKey="Sette S">S Sette</name></author><author><name sortKey="Sidney, J" uniqKey="Sidney J">J Sidney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Southwood, S" uniqKey="Southwood S">S Southwood</name></author><author><name sortKey="Sidney, J" uniqKey="Sidney J">J Sidney</name></author><author><name sortKey="Kondo, A" uniqKey="Kondo A">A Kondo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Messitt, Tj" uniqKey="Messitt T">TJ Messitt</name></author><author><name sortKey="Terry, F" uniqKey="Terry F">F Terry</name></author><author><name sortKey="Moise, L" uniqKey="Moise L">L Moise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moutaftsi, M" uniqKey="Moutaftsi M">M Moutaftsi</name></author><author><name sortKey="Peters, B" uniqKey="Peters B">B Peters</name></author><author><name sortKey="Pasquetto, V" uniqKey="Pasquetto V">V Pasquetto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moise, L" uniqKey="Moise L">L Moise</name></author><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cecil, Dl" uniqKey="Cecil D">DL Cecil</name></author><author><name sortKey="Holt, Ge" uniqKey="Holt G">GE Holt</name></author><author><name sortKey="Park, Kh" uniqKey="Park K">KH Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moise, L" uniqKey="Moise L">L Moise</name></author><author><name sortKey="Gutierrez, Ah" uniqKey="Gutierrez A">AH Gutierrez</name></author><author><name sortKey="Bailey Kellogg, C" uniqKey="Bailey Kellogg C">C Bailey-Kellogg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altschul, Sf" uniqKey="Altschul S">SF Altschul</name></author><author><name sortKey="Gish, W" uniqKey="Gish W">W Gish</name></author><author><name sortKey="Miller, W" uniqKey="Miller W">W Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, L" uniqKey="He L">L He</name></author><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author><author><name sortKey="Gutierrez, Ah" uniqKey="Gutierrez A">AH Gutierrez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Su, Lf" uniqKey="Su L">LF Su</name></author><author><name sortKey="Kidd, Ba" uniqKey="Kidd B">BA Kidd</name></author><author><name sortKey="Han, A" uniqKey="Han A">A Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chung, H" uniqKey="Chung H">H Chung</name></author><author><name sortKey="Pamp, Sj" uniqKey="Pamp S">SJ Pamp</name></author><author><name sortKey="Hill, Ja" uniqKey="Hill J">JA Hill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Yk" uniqKey="Lee Y">YK Lee</name></author><author><name sortKey="Mazmanian, Sk" uniqKey="Mazmanian S">SK Mazmanian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lathrop, Sk" uniqKey="Lathrop S">SK Lathrop</name></author><author><name sortKey="Bloom, Sm" uniqKey="Bloom S">SM Bloom</name></author><author><name sortKey="Rao, Sm" uniqKey="Rao S">SM Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saito, R" uniqKey="Saito R">R Saito</name></author><author><name sortKey="Smoot, Me" uniqKey="Smoot M">ME Smoot</name></author><author><name sortKey="Ono, K" uniqKey="Ono K">K Ono</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calvo Calle, Jm" uniqKey="Calvo Calle J">JM Calvo-Calle</name></author><author><name sortKey="Strug, I" uniqKey="Strug I">I Strug</name></author><author><name sortKey="Nastke, Md" uniqKey="Nastke M">MD Nastke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weber, Ca" uniqKey="Weber C">CA Weber</name></author><author><name sortKey="Mehta, Pj" uniqKey="Mehta P">PJ Mehta</name></author><author><name sortKey="Ardito, M" uniqKey="Ardito M">M Ardito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sette, A" uniqKey="Sette A">A Sette</name></author><author><name sortKey="Sidney, J" uniqKey="Sidney J">J Sidney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author><author><name sortKey="Bosma, A" uniqKey="Bosma A">A Bosma</name></author><author><name sortKey="Chinai, N" uniqKey="Chinai N">N Chinai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, X" uniqKey="Jin X">X Jin</name></author><author><name sortKey="Roberts, Cg" uniqKey="Roberts C">CG Roberts</name></author><author><name sortKey="Nixon, Df" uniqKey="Nixon D">DF Nixon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author><author><name sortKey="Bishop, E" uniqKey="Bishop E">E Bishop</name></author><author><name sortKey="Khan, B" uniqKey="Khan B">B Khan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koren, E" uniqKey="Koren E">E Koren</name></author><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author><author><name sortKey="Jawa, V" uniqKey="Jawa V">V Jawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, T" uniqKey="Cohen T">T Cohen</name></author><author><name sortKey="Moise, L" uniqKey="Moise L">L Moise</name></author><author><name sortKey="Ardito, M" uniqKey="Ardito M">M Ardito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomson, Sa" uniqKey="Thomson S">SA Thomson</name></author><author><name sortKey="Burrows, Sr" uniqKey="Burrows S">SR Burrows</name></author><author><name sortKey="Misko, Is" uniqKey="Misko I">IS Misko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez, F" uniqKey="Rodriguez F">F Rodriguez</name></author><author><name sortKey="Whitton, Jl" uniqKey="Whitton J">JL Whitton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="An, Ll" uniqKey="An L">LL An</name></author><author><name sortKey="Rodriguez, F" uniqKey="Rodriguez F">F Rodriguez</name></author><author><name sortKey="Harkins, S" uniqKey="Harkins S">S Harkins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Velders, Mp" uniqKey="Velders M">MP Velders</name></author><author><name sortKey="Weijzen, S" uniqKey="Weijzen S">S Weijzen</name></author><author><name sortKey="Eiben, Gl" uniqKey="Eiben G">GL Eiben</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Livingston, Bd" uniqKey="Livingston B">BD Livingston</name></author><author><name sortKey="Newman, M" uniqKey="Newman M">M Newman</name></author><author><name sortKey="Crimi, C" uniqKey="Crimi C">C Crimi</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Zy" uniqKey="Yang Z">ZY Yang</name></author><author><name sortKey="Werner, Hc" uniqKey="Werner H">HC Werner</name></author><author><name sortKey="Kong, Wp" uniqKey="Kong W">WP Kong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bethony, Jm" uniqKey="Bethony J">JM Bethony</name></author><author><name sortKey="Cole, Rn" uniqKey="Cole R">RN Cole</name></author><author><name sortKey="Guo, X" uniqKey="Guo X">X Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abi Abdallah, Ds" uniqKey="Abi Abdallah D">DS Abi Abdallah</name></author><author><name sortKey="Pavinski Bitar, A" uniqKey="Pavinski Bitar A">A Pavinski Bitar</name></author><author><name sortKey="Oliveira, F" uniqKey="Oliveira F">F Oliveira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oliveira, F" uniqKey="Oliveira F">F Oliveira</name></author><author><name sortKey="De Carvalho, Am" uniqKey="De Carvalho A">AM de Carvalho</name></author><author><name sortKey="De Oliveira, Ci" uniqKey="De Oliveira C">CI de Oliveira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kazimirova, M" uniqKey="Kazimirova M">M Kazimírová</name></author><author><name sortKey="Stibraniova, I" uniqKey="Stibraniova I">I Štibrániová</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, As" uniqKey="De Groot A">AS De Groot</name></author><author><name sortKey="Einck, L" uniqKey="Einck L">L Einck</name></author><author><name sortKey="Moise, L" uniqKey="Moise L">L Moise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murray, Cj" uniqKey="Murray C">CJ Murray</name></author><author><name sortKey="Vos, T" uniqKey="Vos T">T Vos</name></author><author><name sortKey="Lozano, R" uniqKey="Lozano R">R Lozano</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Expert Rev Vaccines</journal-id><journal-id journal-id-type="iso-abbrev">Expert Rev Vaccines</journal-id><journal-id journal-id-type="publisher-id">IERV</journal-id><journal-id journal-id-type="publisher-id">ierv20</journal-id><journal-title-group><journal-title>Expert Review of Vaccines</journal-title></journal-title-group><issn pub-type="ppub">1476-0584</issn><issn pub-type="epub">1744-8395</issn><publisher><publisher-name>Informa Healthcare</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25193104</article-id><article-id pub-id-type="pmc">4743591</article-id><article-id pub-id-type="doi">10.1586/14760584.2015.955478</article-id><article-id pub-id-type="publisher-id">955478</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases</article-title><alt-title alt-title-type="running-title">NTD/EID: time for T?</alt-title><alt-title alt-title-type="running-authors">Terry, Moise, Martin <italic>et al</italic>.</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Terry</surname><given-names>Frances E</given-names></name><xref ref-type="aff" rid="end-a1"></xref></contrib><contrib contrib-type="author"><name><surname>Moise</surname><given-names>Leonard</given-names></name><xref ref-type="aff" rid="end-a1"></xref><xref ref-type="aff" rid="end-a2"></xref></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Rebecca F</given-names></name><xref ref-type="aff" rid="end-a1"></xref></contrib><contrib contrib-type="author"><name><surname>Torres</surname><given-names>Melissa</given-names></name><xref ref-type="aff" rid="end-a3"></xref></contrib><contrib contrib-type="author"><name><surname>Pilotte</surname><given-names>Nils</given-names></name><xref ref-type="aff" rid="end-a3"></xref></contrib><contrib contrib-type="author"><name><surname>Williams</surname><given-names>Steven A</given-names></name><xref ref-type="aff" rid="end-a3"></xref></contrib><contrib contrib-type="author"><name><surname>De Groot</surname><given-names>Anne S</given-names></name><xref ref-type="corresp" rid="COR0001"></xref><xref ref-type="aff" rid="end-a1"></xref><xref ref-type="aff" rid="end-a2"></xref></contrib><aff id="end-a1"><sup>1</sup><institution>EpiVax, Inc.,</institution><addr-line>146 Clifford St, Providence, RI 02903,</addr-line><country>USA</country></aff><aff id="end-a2"><sup>2</sup><institution>Institute for Immunology and Informatics, University of Rhode Island,</institution><addr-line>80 Washington St, Providence, RI 02903,</addr-line><country>USA</country></aff><aff id="end-a3"><sup>3</sup><institution>Smith College,</institution><addr-line>Northampton, MA,</addr-line><country>USA</country></aff></contrib-group><author-notes><corresp id="COR0001">*Author for correspondence: <phone>+1 401 272 2123</phone><fax>+1 401 272 7562</fax><email xlink:href="dr.annie.degroot@gmail.com">dr.annie.degroot@gmail.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>05</day><month>9</month><year>2014</year></pub-date><volume>14</volume><issue>1</issue><fpage seq="4">21</fpage><lpage>35</lpage><permissions><copyright-statement>Informa UK, Ltd.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Informa UK, Ltd.</copyright-holder><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="IERV_14_955478.pdf"></self-uri><abstract><p>Vaccines have been invaluable for global health, saving lives and reducing healthcare costs, while also raising the quality of human life. However, newly emerging infectious diseases (EID) and more well-established tropical disease pathogens present complex challenges to vaccine developers; in particular, neglected tropical diseases, which are most prevalent among the world’s poorest, include many pathogens with large sizes, multistage life cycles and a variety of nonhuman vectors. EID such as MERS-CoV and H7N9 are highly pathogenic for humans. For many of these pathogens, while their genomes are available, immune correlates of protection are currently unknown. These complexities make developing vaccines for EID and neglected tropical diseases all the more difficult. In this review, we describe the implementation of an immunoinformatics-driven approach to systematically search for key determinants of immunity in newly available genome sequence data and design vaccines. This approach holds promise for the development of 21st century vaccines, improving human health everywhere.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords</title><kwd><italic>Brugia malayi</italic></kwd><kwd>computational vaccinology</kwd><kwd>EID</kwd><kwd>EpiMatrix</kwd><kwd>filarial</kwd><kwd>immunogenicity</kwd><kwd>immunoinformatics</kwd><kwd>immunomics</kwd><kwd>JanusMatrix</kwd><kwd>MHC</kwd><kwd>NTD</kwd><kwd>T cell</kwd><kwd>TCR</kwd><kwd>tregitope</kwd></kwd-group><counts><fig-count count="5"></fig-count><table-count count="2"></table-count><equation-count count="0"></equation-count><ref-count count="96"></ref-count><page-count count="15"></page-count></counts></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="De Groot, Anne S" sort="De Groot, Anne S" uniqKey="De Groot A" first="Anne S" last="De Groot">Anne S. De Groot</name><name sortKey="Martin, Rebecca F" sort="Martin, Rebecca F" uniqKey="Martin R" first="Rebecca F" last="Martin">Rebecca F. Martin</name><name sortKey="Moise, Leonard" sort="Moise, Leonard" uniqKey="Moise L" first="Leonard" last="Moise">Leonard Moise</name><name sortKey="Pilotte, Nils" sort="Pilotte, Nils" uniqKey="Pilotte N" first="Nils" last="Pilotte">Nils Pilotte</name><name sortKey="Terry, Frances E" sort="Terry, Frances E" uniqKey="Terry F" first="Frances E" last="Terry">Frances E. Terry</name><name sortKey="Torres, Melissa" sort="Torres, Melissa" uniqKey="Torres M" first="Melissa" last="Torres">Melissa Torres</name><name sortKey="Williams, Steven A" sort="Williams, Steven A" uniqKey="Williams S" first="Steven A" last="Williams">Steven A. Williams</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F47 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000F47 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:4743591
|texte= Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:25193104" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |