[Dromedary camels and Middle East respiratory syndrome: MERS coronavirus in the 'ship of the desert'].
Identifieur interne : 001A18 ( Main/Exploration ); précédent : 001A17; suivant : 001A19[Dromedary camels and Middle East respiratory syndrome: MERS coronavirus in the 'ship of the desert'].
Auteurs : Chantal B E M. Reusken [Pays-Bas] ; Bart L. Haagmans ; Marion P G. KoopmansSource :
- Nederlands tijdschrift voor geneeskunde [ 1876-8784 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Chameaux (virologie), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Humains, Infections à coronavirus (diagnostic), Infections à coronavirus (transmission), Moyen Orient (épidémiologie), Réservoirs d'agents pathogènes (médecine vétérinaire), Réservoirs d'agents pathogènes (virologie), Syndrome, Zoonoses.
- MESH :
- diagnostic : Infections à coronavirus.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- médecine vétérinaire : Réservoirs d'agents pathogènes.
- virologie : Chameaux, Réservoirs d'agents pathogènes.
- épidémiologie : Infections à coronavirus, Moyen Orient.
- Animaux, Humains, Syndrome, Zoonoses.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Coronavirus Infections.
- epidemiology : Middle East.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- transmission : Coronavirus Infections.
- veterinary : Disease Reservoirs.
- virology : Camelus, Disease Reservoirs.
- Animals, Humans, Syndrome, Zoonoses.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel coronavirus, identified in patients with respiratory symptoms in the Middle East. Accumulating evidence points to dromedary camels as being reservoirs. MERS-CoV has been isolated from dromedaries, and dromedary MERS-CoV is nearly identical to human MERS-CoV. Camel and human MERS-CoV genome sequences from the same geographic areas cluster together. Both on the Arabian Peninsula and in Africa high percentages of adult dromedaries are seropositive for MERS-CoV. Young dromedaries (≤ 2 years) are more often acutely infected than adult camels. This means that the risk of human infection may be higher in camel breeding season (spring) when more naïve camels are present. Antibodies appeared to be present in dromedaries as early as 1992, while the first case in humans was recognised in 2012. Underdiagnosis, differences in risk profile, or subtle differences in the genetic make-up of MERS-CoV may explain the absence of MERS in humans before 2012, and in Africa.
PubMed: 25248734
Affiliations:
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Le document en format XML
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Koopmans</name></author></analytic><series><title level="j">Nederlands tijdschrift voor geneeskunde</title><idno type="eISSN">1876-8784</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Camelus (virology)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (transmission)</term><term>Disease Reservoirs (veterinary)</term><term>Disease Reservoirs (virology)</term><term>Humans</term><term>Middle East (epidemiology)</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Syndrome</term><term>Zoonoses</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chameaux (virologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Humains</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (transmission)</term><term>Moyen Orient (épidémiologie)</term><term>Réservoirs d'agents pathogènes (médecine vétérinaire)</term><term>Réservoirs d'agents pathogènes (virologie)</term><term>Syndrome</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Middle East</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Réservoirs d'agents pathogènes</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Disease Reservoirs</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chameaux</term><term>Réservoirs d'agents pathogènes</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Camelus</term><term>Disease Reservoirs</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Moyen Orient</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Syndrome</term><term>Zoonoses</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Syndrome</term><term>Zoonoses</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel coronavirus, identified in patients with respiratory symptoms in the Middle East. Accumulating evidence points to dromedary camels as being reservoirs. MERS-CoV has been isolated from dromedaries, and dromedary MERS-CoV is nearly identical to human MERS-CoV. Camel and human MERS-CoV genome sequences from the same geographic areas cluster together. Both on the Arabian Peninsula and in Africa high percentages of adult dromedaries are seropositive for MERS-CoV. Young dromedaries (≤ 2 years) are more often acutely infected than adult camels. This means that the risk of human infection may be higher in camel breeding season (spring) when more naïve camels are present. Antibodies appeared to be present in dromedaries as early as 1992, while the first case in humans was recognised in 2012. Underdiagnosis, differences in risk profile, or subtle differences in the genetic make-up of MERS-CoV may explain the absence of MERS in humans before 2012, and in Africa.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li></region><settlement><li>Rotterdam</li></settlement></list><tree><noCountry><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name><name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P G" last="Koopmans">Marion P G. Koopmans</name></noCountry><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Reusken, Chantal B E M" sort="Reusken, Chantal B E M" uniqKey="Reusken C" first="Chantal B E M" last="Reusken">Chantal B E M. Reusken</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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