[Dromedary camels and Middle East respiratory syndrome: MERS coronavirus in the 'ship of the desert'].
Identifieur interne : 001842 ( PubMed/Corpus ); précédent : 001841; suivant : 001843[Dromedary camels and Middle East respiratory syndrome: MERS coronavirus in the 'ship of the desert'].
Auteurs : Chantal B E M. Reusken ; Bart L. Haagmans ; Marion P G. KoopmansSource :
- Nederlands tijdschrift voor geneeskunde [ 1876-8784 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Coronavirus Infections.
- epidemiology : Middle East.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- transmission : Coronavirus Infections.
- veterinary : Disease Reservoirs.
- virology : Camelus, Disease Reservoirs.
- Animals, Humans, Syndrome, Zoonoses.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel coronavirus, identified in patients with respiratory symptoms in the Middle East. Accumulating evidence points to dromedary camels as being reservoirs. MERS-CoV has been isolated from dromedaries, and dromedary MERS-CoV is nearly identical to human MERS-CoV. Camel and human MERS-CoV genome sequences from the same geographic areas cluster together. Both on the Arabian Peninsula and in Africa high percentages of adult dromedaries are seropositive for MERS-CoV. Young dromedaries (≤ 2 years) are more often acutely infected than adult camels. This means that the risk of human infection may be higher in camel breeding season (spring) when more naïve camels are present. Antibodies appeared to be present in dromedaries as early as 1992, while the first case in humans was recognised in 2012. Underdiagnosis, differences in risk profile, or subtle differences in the genetic make-up of MERS-CoV may explain the absence of MERS in humans before 2012, and in Africa.
PubMed: 25248734
Links to Exploration step
pubmed:25248734Le document en format XML
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<author><name sortKey="Reusken, Chantal B E M" sort="Reusken, Chantal B E M" uniqKey="Reusken C" first="Chantal B E M" last="Reusken">Chantal B E M. Reusken</name>
<affiliation><nlm:affiliation>Erasmus MC, afd. Viroscience, Rotterdam.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name>
</author>
<author><name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P G" last="Koopmans">Marion P G. Koopmans</name>
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<series><title level="j">Nederlands tijdschrift voor geneeskunde</title>
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<term>Camelus (virology)</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (transmission)</term>
<term>Disease Reservoirs (veterinary)</term>
<term>Disease Reservoirs (virology)</term>
<term>Humans</term>
<term>Middle East (epidemiology)</term>
<term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term>
<term>Syndrome</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term>
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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel coronavirus, identified in patients with respiratory symptoms in the Middle East. Accumulating evidence points to dromedary camels as being reservoirs. MERS-CoV has been isolated from dromedaries, and dromedary MERS-CoV is nearly identical to human MERS-CoV. Camel and human MERS-CoV genome sequences from the same geographic areas cluster together. Both on the Arabian Peninsula and in Africa high percentages of adult dromedaries are seropositive for MERS-CoV. Young dromedaries (≤ 2 years) are more often acutely infected than adult camels. This means that the risk of human infection may be higher in camel breeding season (spring) when more naïve camels are present. Antibodies appeared to be present in dromedaries as early as 1992, while the first case in humans was recognised in 2012. Underdiagnosis, differences in risk profile, or subtle differences in the genetic make-up of MERS-CoV may explain the absence of MERS in humans before 2012, and in Africa.</div>
</front>
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<Abstract><AbstractText>Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel coronavirus, identified in patients with respiratory symptoms in the Middle East. Accumulating evidence points to dromedary camels as being reservoirs. MERS-CoV has been isolated from dromedaries, and dromedary MERS-CoV is nearly identical to human MERS-CoV. Camel and human MERS-CoV genome sequences from the same geographic areas cluster together. Both on the Arabian Peninsula and in Africa high percentages of adult dromedaries are seropositive for MERS-CoV. Young dromedaries (≤ 2 years) are more often acutely infected than adult camels. This means that the risk of human infection may be higher in camel breeding season (spring) when more naïve camels are present. Antibodies appeared to be present in dromedaries as early as 1992, while the first case in humans was recognised in 2012. Underdiagnosis, differences in risk profile, or subtle differences in the genetic make-up of MERS-CoV may explain the absence of MERS in humans before 2012, and in Africa.</AbstractText>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Reusken</LastName>
<ForeName>Chantal B E M</ForeName>
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<VernacularTitle>Dromedaris en 'Middle East respiratory syndrome': MERS-coronavirus in het 'schip van de woestijn'.</VernacularTitle>
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