Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome)
Identifieur interne : 001275 ( Main/Exploration ); précédent : 001274; suivant : 001276Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome)
Auteurs : David S. HuiSource :
- Clinics in Chest Medicine [ 0272-5231 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient.
- épidémiologie : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- Animaux, Chiroptera, Humains.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- epidemiology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus.
- Animals, Chiroptera, Humans.
Abstract
Bats are the natural reservoirs of severe acute respiratory syndrome (SARS)-like coronaviruses (CoVs) and likely the reservoir of Middle East respiratory syndrome (MERS)-CoV. The clinical features of SARS-CoV infection and MERS-CoV infection are similar but MERS-CoV infection progresses to respiratory failure more rapidly. Although the estimated pandemic potential of MERS-CoV is lower than that of SARS-CoV, the case fatality rate of MERS is higher. The transmission route and the possibility of other intermediary animal sources remain uncertain among many sporadic primary cases. Clinical trial options for MERS-CoV infection include monotherapy and combination therapy.
Url:
DOI: 10.1016/j.ccm.2016.11.007
PubMed: 28159163
PubMed Central: 7131795
Affiliations:
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Le document en format XML
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<term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term>
<term>Severe Acute Respiratory Syndrome (diagnosis)</term>
<term>Severe Acute Respiratory Syndrome (epidemiology)</term>
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<term>Infections à coronavirus (épidémiologie)</term>
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<front><div type="abstract" xml:lang="en"><p>Bats are the natural reservoirs of severe acute respiratory syndrome (SARS)-like coronaviruses (CoVs) and likely the reservoir of Middle East respiratory syndrome (MERS)-CoV. The clinical features of SARS-CoV infection and MERS-CoV infection are similar but MERS-CoV infection progresses to respiratory failure more rapidly. Although the estimated pandemic potential of MERS-CoV is lower than that of SARS-CoV, the case fatality rate of MERS is higher. The transmission route and the possibility of other intermediary animal sources remain uncertain among many sporadic primary cases. Clinical trial options for MERS-CoV infection include monotherapy and combination therapy.</p>
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<tree><noCountry><name sortKey="Hui, David S" sort="Hui, David S" uniqKey="Hui D" first="David S." last="Hui">David S. Hui</name>
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