Serveur d'exploration MERS

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Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome)

Identifieur interne : 001293 ( Pmc/Curation ); précédent : 001292; suivant : 001294

Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome)

Auteurs : David S. Hui

Source :

RBID : PMC:7131795

Abstract

Bats are the natural reservoirs of severe acute respiratory syndrome (SARS)-like coronaviruses (CoVs) and likely the reservoir of Middle East respiratory syndrome (MERS)-CoV. The clinical features of SARS-CoV infection and MERS-CoV infection are similar but MERS-CoV infection progresses to respiratory failure more rapidly. Although the estimated pandemic potential of MERS-CoV is lower than that of SARS-CoV, the case fatality rate of MERS is higher. The transmission route and the possibility of other intermediary animal sources remain uncertain among many sporadic primary cases. Clinical trial options for MERS-CoV infection include monotherapy and combination therapy.


Url:
DOI: 10.1016/j.ccm.2016.11.007
PubMed: 28159163
PubMed Central: 7131795

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Links to Exploration step

PMC:7131795

Le document en format XML

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<p>Bats are the natural reservoirs of severe acute respiratory syndrome (SARS)-like coronaviruses (CoVs) and likely the reservoir of Middle East respiratory syndrome (MERS)-CoV. The clinical features of SARS-CoV infection and MERS-CoV infection are similar but MERS-CoV infection progresses to respiratory failure more rapidly. Although the estimated pandemic potential of MERS-CoV is lower than that of SARS-CoV, the case fatality rate of MERS is higher. The transmission route and the possibility of other intermediary animal sources remain uncertain among many sporadic primary cases. Clinical trial options for MERS-CoV infection include monotherapy and combination therapy.</p>
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<pmc article-type="review-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Clin Chest Med</journal-id>
<journal-id journal-id-type="iso-abbrev">Clin. Chest Med</journal-id>
<journal-title-group>
<journal-title>Clinics in Chest Medicine</journal-title>
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<issn pub-type="ppub">0272-5231</issn>
<issn pub-type="epub">1557-8216</issn>
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<article-meta>
<article-id pub-id-type="pmid">28159163</article-id>
<article-id pub-id-type="pmc">7131795</article-id>
<article-id pub-id-type="publisher-id">S0272-5231(16)30128-9</article-id>
<article-id pub-id-type="doi">10.1016/j.ccm.2016.11.007</article-id>
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<subj-group subj-group-type="heading">
<subject>Article</subject>
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<title-group>
<article-title>Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome)</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" id="au1">
<name>
<surname>Hui</surname>
<given-names>David S.</given-names>
</name>
<degrees>MD</degrees>
<email>dschui@cuhk.edu.hk</email>
</contrib>
</contrib-group>
<aff id="aff1">Department of Medicine & Therapeutics, Stanley Ho Center for Emerging Infectious Diseases, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China</aff>
<pub-date pub-type="pmc-release">
<day>16</day>
<month>12</month>
<year>2016</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub">
<month>3</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>16</day>
<month>12</month>
<year>2016</year>
</pub-date>
<volume>38</volume>
<issue>1</issue>
<fpage>71</fpage>
<lpage>86</lpage>
<permissions>
<copyright-statement>© 2016 Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2016</copyright-year>
<copyright-holder>Elsevier Inc.</copyright-holder>
<license>
<license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract abstract-type="teaser" id="abs0010">
<p>Bats are the natural reservoirs of severe acute respiratory syndrome (SARS)-like coronaviruses (CoVs) and likely the reservoir of Middle East respiratory syndrome (MERS)-CoV. The clinical features of SARS-CoV infection and MERS-CoV infection are similar but MERS-CoV infection progresses to respiratory failure more rapidly. Although the estimated pandemic potential of MERS-CoV is lower than that of SARS-CoV, the case fatality rate of MERS is higher. The transmission route and the possibility of other intermediary animal sources remain uncertain among many sporadic primary cases. Clinical trial options for MERS-CoV infection include monotherapy and combination therapy.</p>
</abstract>
<kwd-group id="kwrds0010">
<title>Keywords</title>
<kwd>SARS-CoV</kwd>
<kwd>MERS-CoV</kwd>
<kwd>Respiratory tract infections</kwd>
<kwd>Clinical features</kwd>
<kwd>Pathogenesis</kwd>
<kwd>Treatment</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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