Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015
Identifieur interne : 000F77 ( Main/Exploration ); précédent : 000F76; suivant : 000F78Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015
Auteurs : Jean-Louis Excler ; Christopher J. Delvecchio ; Ryan E. Wiley ; Marni Williams ; In-Kyu Yoon ; Kayvon Modjarrad ; Mohamed Boujelal ; Vasee S. Moorthy ; Ahmad Salah Hersi ; Jerome H. KimSource :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux, Arabie saoudite, Chameaux, Coopération internationale, Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Coronavirus du syndrome respiratoire du Moyen-Orient (métabolisme), Glycoprotéine de spicule des coronavirus (immunologie), Glycoprotéine de spicule des coronavirus (métabolisme), Humains, Infections à coronavirus (), Infections à coronavirus (médecine vétérinaire), Infections à coronavirus (virologie), Recherche biomédicale, Vaccins antiviraux (immunologie).
- MESH :
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Vaccins antiviraux.
- médecine vétérinaire : Infections à coronavirus.
- métabolisme : Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus.
- virologie : Infections à coronavirus.
- Animaux, Anticorps antiviraux, Arabie saoudite, Chameaux, Coopération internationale, Humains, Infections à coronavirus, Recherche biomédicale.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral, Biomedical Research, Camelus, Coronavirus Infections (prevention & control), Coronavirus Infections (veterinary), Coronavirus Infections (virology), Humans, International Cooperation, Middle East Respiratory Syndrome Coronavirus (immunology), Middle East Respiratory Syndrome Coronavirus (metabolism), Saudi Arabia, Spike Glycoprotein, Coronavirus (immunology), Spike Glycoprotein, Coronavirus (metabolism), Viral Vaccines (immunology).
- MESH :
- chemical , immunology : Spike Glycoprotein, Coronavirus, Viral Vaccines.
- chemical , metabolism : Spike Glycoprotein, Coronavirus.
- chemical : Antibodies, Viral.
- immunology : Middle East Respiratory Syndrome Coronavirus.
- metabolism : Middle East Respiratory Syndrome Coronavirus.
- prevention & control : Coronavirus Infections.
- veterinary : Coronavirus Infections.
- virology : Coronavirus Infections.
- Animals, Biomedical Research, Camelus, Humans, International Cooperation, Saudi Arabia.
Abstract
Middle East respiratory syndrome (MERS) remains a serious international public health threat. With the goal of accelerating the development of countermeasures against MERS coronavirus (MERS-CoV), funding agencies, nongovernmental organizations, and researchers across the world assembled in Riyadh, Saudi Arabia, on November 14–15, 2015, to discuss vaccine development challenges. The meeting was spearheaded by the Saudi Ministry of Health and co-organized by the International Vaccine Institute, South Korea. Accelerating the development of a preventive vaccine requires a better understanding of MERS epidemiology, transmission, and pathogenesis in humans and animals. A combination of rodent and nonhuman primate models should be considered in evaluating and developing preventive and therapeutic vaccine candidates. Dromedary camels should be considered for the development of veterinary vaccines. Several vaccine technology platforms targeting the MERS-CoV spike protein were discussed. Mechanisms to maximize investment, provide robust data, and affect public health are urgently needed.
Url:
DOI: 10.3201/eid2208.160229
PubMed: 27439020
PubMed Central: 4982192
Affiliations:
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Le document en format XML
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With the goal of accelerating the development of countermeasures against MERS coronavirus (MERS-CoV), funding agencies, nongovernmental organizations, and researchers across the world assembled in Riyadh, Saudi Arabia, on November 14–15, 2015, to discuss vaccine development challenges. The meeting was spearheaded by the Saudi Ministry of Health and co-organized by the International Vaccine Institute, South Korea. Accelerating the development of a preventive vaccine requires a better understanding of MERS epidemiology, transmission, and pathogenesis in humans and animals. A combination of rodent and nonhuman primate models should be considered in evaluating and developing preventive and therapeutic vaccine candidates. Dromedary camels should be considered for the development of veterinary vaccines. Several vaccine technology platforms targeting the MERS-CoV spike protein were discussed. Mechanisms to maximize investment, provide robust data, and affect public health are urgently needed.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Boujelal, Mohamed" sort="Boujelal, Mohamed" uniqKey="Boujelal M" first="Mohamed" last="Boujelal">Mohamed Boujelal</name><name sortKey="Delvecchio, Christopher J" sort="Delvecchio, Christopher J" uniqKey="Delvecchio C" first="Christopher J." last="Delvecchio">Christopher J. Delvecchio</name><name sortKey="Excler, Jean Louis" sort="Excler, Jean Louis" uniqKey="Excler J" first="Jean-Louis" last="Excler">Jean-Louis Excler</name><name sortKey="Hersi, Ahmad Salah" sort="Hersi, Ahmad Salah" uniqKey="Hersi A" first="Ahmad Salah" last="Hersi">Ahmad Salah Hersi</name><name sortKey="Kim, Jerome H" sort="Kim, Jerome H" uniqKey="Kim J" first="Jerome H." last="Kim">Jerome H. Kim</name><name sortKey="Modjarrad, Kayvon" sort="Modjarrad, Kayvon" uniqKey="Modjarrad K" first="Kayvon" last="Modjarrad">Kayvon Modjarrad</name><name sortKey="Moorthy, Vasee S" sort="Moorthy, Vasee S" uniqKey="Moorthy V" first="Vasee S." last="Moorthy">Vasee S. Moorthy</name><name sortKey="Wiley, Ryan E" sort="Wiley, Ryan E" uniqKey="Wiley R" first="Ryan E." last="Wiley">Ryan E. Wiley</name><name sortKey="Williams, Marni" sort="Williams, Marni" uniqKey="Williams M" first="Marni" last="Williams">Marni Williams</name><name sortKey="Yoon, In Kyu" sort="Yoon, In Kyu" uniqKey="Yoon I" first="In-Kyu" last="Yoon">In-Kyu Yoon</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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