Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015
Identifieur interne : 000893 ( Pmc/Curation ); précédent : 000892; suivant : 000894Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015
Auteurs : Jean-Louis Excler ; Christopher J. Delvecchio ; Ryan E. Wiley ; Marni Williams ; In-Kyu Yoon ; Kayvon Modjarrad ; Mohamed Boujelal ; Vasee S. Moorthy ; Ahmad Salah Hersi ; Jerome H. KimSource :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2016.
Abstract
Middle East respiratory syndrome (MERS) remains a serious international public health threat. With the goal of accelerating the development of countermeasures against MERS coronavirus (MERS-CoV), funding agencies, nongovernmental organizations, and researchers across the world assembled in Riyadh, Saudi Arabia, on November 14–15, 2015, to discuss vaccine development challenges. The meeting was spearheaded by the Saudi Ministry of Health and co-organized by the International Vaccine Institute, South Korea. Accelerating the development of a preventive vaccine requires a better understanding of MERS epidemiology, transmission, and pathogenesis in humans and animals. A combination of rodent and nonhuman primate models should be considered in evaluating and developing preventive and therapeutic vaccine candidates. Dromedary camels should be considered for the development of veterinary vaccines. Several vaccine technology platforms targeting the MERS-CoV spike protein were discussed. Mechanisms to maximize investment, provide robust data, and affect public health are urgently needed.
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DOI: 10.3201/eid2208.160229
PubMed: 27439020
PubMed Central: 4982192
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Wiley</name></author><author><name sortKey="Williams, Marni" sort="Williams, Marni" uniqKey="Williams M" first="Marni" last="Williams">Marni Williams</name></author><author><name sortKey="Yoon, In Kyu" sort="Yoon, In Kyu" uniqKey="Yoon I" first="In-Kyu" last="Yoon">In-Kyu Yoon</name></author><author><name sortKey="Modjarrad, Kayvon" sort="Modjarrad, Kayvon" uniqKey="Modjarrad K" first="Kayvon" last="Modjarrad">Kayvon Modjarrad</name></author><author><name sortKey="Boujelal, Mohamed" sort="Boujelal, Mohamed" uniqKey="Boujelal M" first="Mohamed" last="Boujelal">Mohamed Boujelal</name></author><author><name sortKey="Moorthy, Vasee S" sort="Moorthy, Vasee S" uniqKey="Moorthy V" first="Vasee S." last="Moorthy">Vasee S. 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Delvecchio</name></author><author><name sortKey="Wiley, Ryan E" sort="Wiley, Ryan E" uniqKey="Wiley R" first="Ryan E." last="Wiley">Ryan E. Wiley</name></author><author><name sortKey="Williams, Marni" sort="Williams, Marni" uniqKey="Williams M" first="Marni" last="Williams">Marni Williams</name></author><author><name sortKey="Yoon, In Kyu" sort="Yoon, In Kyu" uniqKey="Yoon I" first="In-Kyu" last="Yoon">In-Kyu Yoon</name></author><author><name sortKey="Modjarrad, Kayvon" sort="Modjarrad, Kayvon" uniqKey="Modjarrad K" first="Kayvon" last="Modjarrad">Kayvon Modjarrad</name></author><author><name sortKey="Boujelal, Mohamed" sort="Boujelal, Mohamed" uniqKey="Boujelal M" first="Mohamed" last="Boujelal">Mohamed Boujelal</name></author><author><name sortKey="Moorthy, Vasee S" sort="Moorthy, Vasee S" uniqKey="Moorthy V" first="Vasee S." last="Moorthy">Vasee S. Moorthy</name></author><author><name sortKey="Hersi, Ahmad Salah" sort="Hersi, Ahmad Salah" uniqKey="Hersi A" first="Ahmad Salah" last="Hersi">Ahmad Salah Hersi</name></author><author><name sortKey="Kim, Jerome H" sort="Kim, Jerome H" uniqKey="Kim J" first="Jerome H." last="Kim">Jerome H. Kim</name></author></analytic><series><title level="j">Emerging Infectious Diseases</title><idno type="ISSN">1080-6040</idno><idno type="eISSN">1080-6059</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome (MERS) remains a serious international public health threat. With the goal of accelerating the development of countermeasures against MERS coronavirus (MERS-CoV), funding agencies, nongovernmental organizations, and researchers across the world assembled in Riyadh, Saudi Arabia, on November 14–15, 2015, to discuss vaccine development challenges. The meeting was spearheaded by the Saudi Ministry of Health and co-organized by the International Vaccine Institute, South Korea. Accelerating the development of a preventive vaccine requires a better understanding of MERS epidemiology, transmission, and pathogenesis in humans and animals. A combination of rodent and nonhuman primate models should be considered in evaluating and developing preventive and therapeutic vaccine candidates. Dromedary camels should be considered for the development of veterinary vaccines. Several vaccine technology platforms targeting the MERS-CoV spike protein were discussed. Mechanisms to maximize investment, provide robust data, and affect public health are urgently needed.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="meeting-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Emerg Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Emerging Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">EID</journal-id><journal-title-group><journal-title>Emerging Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">1080-6040</issn><issn pub-type="epub">1080-6059</issn><publisher><publisher-name>Centers for Disease Control and Prevention</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27439020</article-id><article-id pub-id-type="pmc">4982192</article-id><article-id pub-id-type="publisher-id">16-0229</article-id><article-id pub-id-type="doi">10.3201/eid2208.160229</article-id><article-categories><subj-group subj-group-type="heading"><subject>Online Report</subject></subj-group><subj-group subj-group-type="article-type"><subject>Online Report</subject></subj-group><subj-group subj-group-type="TOC-title"><subject>Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015</subject></subj-group></article-categories><title-group><article-title>Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015</article-title><alt-title alt-title-type="running-head">Toward Developing a Preventive MERS-CoV Vaccine</alt-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Excler</surname><given-names>Jean-Louis</given-names></name></contrib><contrib contrib-type="author"><name><surname>Delvecchio</surname><given-names>Christopher J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wiley</surname><given-names>Ryan E.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Williams</surname><given-names>Marni</given-names></name></contrib><contrib contrib-type="author"><name><surname>Yoon</surname><given-names>In-Kyu</given-names></name></contrib><contrib contrib-type="author"><name><surname>Modjarrad</surname><given-names>Kayvon</given-names></name></contrib><contrib contrib-type="author"><name><surname>Boujelal</surname><given-names>Mohamed</given-names></name></contrib><contrib contrib-type="author"><name><surname>Moorthy</surname><given-names>Vasee S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hersi</surname><given-names>Ahmad Salah</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Jerome H.</given-names></name></contrib><contrib contrib-type="author"><collab>on behalf of the MERS-CoV Vaccine Working Group</collab><xref ref-type="fn" rid="FN1"><sup>1</sup></xref><xref ref-type="fn" rid="FN2"><sup>2</sup></xref></contrib><aff id="aff1">International Vaccine Institute, Seoul, South Korea (J.-L. Excler, I.-K. Yoon, J.H. Kim);</aff><aff id="aff2">Shift Health, Toronto, Ontario, Canada (C.J. Delvecchio, R.E. Wiley, M. Williams);</aff><aff id="aff3">Walter Reed Army Institute of Research, Silver Spring, Maryland, USA (K. Modjarrad);</aff><aff id="aff4">King Abdullah International Medical Research Center, Riyadh, Saudi Arabia (M. Boujelal);</aff><aff id="aff5">World Health Organization, Geneva, Switzerland (V.S. Moorthy);</aff><aff id="aff6">Ministry of Health, Riyadh (A.S. Hersi)</aff></contrib-group><author-notes><corresp id="cor1">Address for correspondence: Jean-Louis Excler, International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, Gwanak-gu, Seoul, South Korea; email: <email xlink:href="JeanLouis.Excler@ivi.int">JeanLouis.Excler@ivi.int</email></corresp></author-notes><pub-date pub-type="ppub"><month>8</month><year>2016</year></pub-date><volume>22</volume><issue>8</issue><elocation-id>e160229</elocation-id><abstract><p>Middle East respiratory syndrome (MERS) remains a serious international public health threat. With the goal of accelerating the development of countermeasures against MERS coronavirus (MERS-CoV), funding agencies, nongovernmental organizations, and researchers across the world assembled in Riyadh, Saudi Arabia, on November 14–15, 2015, to discuss vaccine development challenges. The meeting was spearheaded by the Saudi Ministry of Health and co-organized by the International Vaccine Institute, South Korea. Accelerating the development of a preventive vaccine requires a better understanding of MERS epidemiology, transmission, and pathogenesis in humans and animals. A combination of rodent and nonhuman primate models should be considered in evaluating and developing preventive and therapeutic vaccine candidates. Dromedary camels should be considered for the development of veterinary vaccines. Several vaccine technology platforms targeting the MERS-CoV spike protein were discussed. Mechanisms to maximize investment, provide robust data, and affect public health are urgently needed.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords: </title><kwd>MERS-CoV</kwd><kwd>coronavirus</kwd><kwd>animal models</kwd><kwd>vaccine</kwd><kwd>prevention</kwd><kwd>therapeutic antibodies</kwd><kwd>Saudi Arabia</kwd><kwd>viruses</kwd><kwd>zoonosis</kwd><kwd>Middle East respiratory syndrome</kwd><kwd>coronavirus</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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