Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Identifieur interne : 000F70 ( Main/Exploration ); précédent : 000F69; suivant : 000F71Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Auteurs : Jaffar A. Al-Tawfiq [États-Unis] ; Ziad A. Memish [États-Unis]Source :
- Expert Review of Anti-Infective Therapy [ 1478-7210 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- traitement médicamenteux : Infections à coronavirus, Maladies transmissibles émergentes.
- usage thérapeutique : Antiviraux.
- Animaux, Association de médicaments, Coronavirus du syndrome respiratoire du Moyen-Orient, Essais cliniques comme sujet, Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antiviral Agents.
- drug effects : Middle East Respiratory Syndrome Coronavirus.
- drug therapy : Communicable Diseases, Emerging, Coronavirus Infections.
- Animals, Clinical Trials as Topic, Drug Therapy, Combination, Humans.
Abstract
Url:
DOI: 10.1080/14787210.2017.1271712
PubMed: 27937060
PubMed Central: 7103731
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV)</title><author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name><affiliation><nlm:aff id="AFF0001"><institution>Specialty Internal Medicine, Johns Hopkins Aramco Healthcare</institution>, Dhahran,<country>Kingdom of Saudi Arabia</country></nlm:aff><wicri:noCountry code="nlm country">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>Department of Medicine, Indiana University School of Medicine</institution>, Indianapolis, IN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><affiliation><nlm:aff id="AFF0003"><institution>Department of Medicine, Ministry of Health</institution>, Riyadh,<country>Kingdom of Saudi Arabia</country></nlm:aff><wicri:noCountry code="nlm country">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0004"><institution>Hubert Department of Global Health, Rollins School of Public Health, Emory University</institution>, Atlanta, GA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27937060</idno><idno type="pmc">7103731</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103731</idno><idno type="RBID">PMC:7103731</idno><idno type="doi">10.1080/14787210.2017.1271712</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001321</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001321</idno><idno type="wicri:Area/Pmc/Curation">001321</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001321</idno><idno type="wicri:Area/Pmc/Checkpoint">000965</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000965</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:27937060</idno><idno type="wicri:Area/PubMed/Corpus">000E54</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E54</idno><idno type="wicri:Area/PubMed/Curation">000E54</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E54</idno><idno type="wicri:Area/PubMed/Checkpoint">000A70</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A70</idno><idno type="wicri:Area/Ncbi/Merge">001880</idno><idno type="wicri:Area/Ncbi/Curation">001880</idno><idno type="wicri:Area/Ncbi/Checkpoint">001880</idno><idno type="wicri:doubleKey">1478-7210:2016:Al Tawfiq J:update:on:therapeutic</idno><idno type="wicri:Area/Main/Merge">000F73</idno><idno type="wicri:Area/Main/Curation">000F70</idno><idno type="wicri:Area/Main/Exploration">000F70</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV)</title><author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name><affiliation><nlm:aff id="AFF0001"><institution>Specialty Internal Medicine, Johns Hopkins Aramco Healthcare</institution>, Dhahran,<country>Kingdom of Saudi Arabia</country></nlm:aff><wicri:noCountry code="nlm country">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>Department of Medicine, Indiana University School of Medicine</institution>, Indianapolis, IN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><affiliation><nlm:aff id="AFF0003"><institution>Department of Medicine, Ministry of Health</institution>, Riyadh,<country>Kingdom of Saudi Arabia</country></nlm:aff><wicri:noCountry code="nlm country">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0004"><institution>Hubert Department of Global Health, Rollins School of Public Health, Emory University</institution>, Atlanta, GA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Expert Review of Anti-Infective Therapy</title><idno type="ISSN">1478-7210</idno><idno type="eISSN">1744-8336</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (therapeutic use)</term><term>Clinical Trials as Topic</term><term>Communicable Diseases, Emerging (drug therapy)</term><term>Coronavirus Infections (drug therapy)</term><term>Drug Therapy, Combination</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (usage thérapeutique)</term><term>Association de médicaments</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Essais cliniques comme sujet</term><term>Humains</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Maladies transmissibles émergentes (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Communicable Diseases, Emerging</term><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Maladies transmissibles émergentes</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Clinical Trials as Topic</term><term>Drug Therapy, Combination</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Association de médicaments</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Essais cliniques comme sujet</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p><bold>Introduction:</bold> The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an important emerging respiratory pathogen. MERS-CoV resulted in multiple hospital outbreaks within and outside the Arabian Peninsula. The disease has a high case fatality rate, with the need for a therapeutic option.</p><p><bold>Areas covered:</bold> In this review, we provide an overview of the progress in the development of therapeutic strategies for MERS. We searched PubMed, Embase, Cochrane, Scopus, and Google Scholar, using the following terms: ‘MERS’, ‘MERS-CoV’, ‘Middle East respiratory syndrome’ in combination with ‘treatment’ or ‘therapy’.</p><p><bold>Expert commentary:</bold> There are multiple agents tried <italic>in vitro</italic> and <italic>in vivo</italic>. None of these agents were used in large clinical studies. Available clinical studies are limited to the use of the combination of interferon and other agents. These clinical studies are based solely on case reports and case series. There are no prospective or randomized trials. There is a need to have prospective and randomized clinical trials for the therapy of MERS-CoV. However, this strategy might be hampered by the sporadic cases outside the large hospital outbreaks.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA. 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Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author><author><name sortKey="Allen Chan, Kc" uniqKey="Allen Chan K">KC Allen Chan</name></author><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Belouzard, S" uniqKey="Belouzard S">S Belouzard</name></author><author><name sortKey="Millet, Jk" uniqKey="Millet J">JK Millet</name></author><author><name sortKey="Licitra, Bn" uniqKey="Licitra B">BN Licitra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dyall, J" uniqKey="Dyall J">J Dyall</name></author><author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name></author><author><name sortKey="Hart, Bj" uniqKey="Hart B">BJ Hart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uyeki, Tm" uniqKey="Uyeki T">TM Uyeki</name></author><author><name sortKey="Erlandson, Kj" uniqKey="Erlandson K">KJ Erlandson</name></author><author><name sortKey="Korch, G" uniqKey="Korch G">G Korch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sakamoto, S" uniqKey="Sakamoto S">S Sakamoto</name></author><author><name sortKey="Tanaka, H" uniqKey="Tanaka H">H Tanaka</name></author><author><name sortKey="Morimoto, S" uniqKey="Morimoto S">S Morimoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Modjarrad, K" uniqKey="Modjarrad K">K Modjarrad</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name></noRegion><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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