Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Identifieur interne : 000965 ( Pmc/Checkpoint ); précédent : 000964; suivant : 000966Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Auteurs : Jaffar A. Al-Tawfiq [États-Unis] ; Ziad A. Memish [États-Unis]Source :
- Expert Review of Anti-Infective Therapy [ 1478-7210 ] ; 2016.
Abstract
Url:
DOI: 10.1080/14787210.2017.1271712
PubMed: 27937060
PubMed Central: 7103731
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:7103731Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV)</title><author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name><affiliation><nlm:aff id="AFF0001"><institution>Specialty Internal Medicine, Johns Hopkins Aramco Healthcare</institution>, Dhahran,<country>Kingdom of Saudi Arabia</country></nlm:aff><wicri:noCountry code="nlm country">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>Department of Medicine, Indiana University School of Medicine</institution>, Indianapolis, IN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><affiliation><nlm:aff id="AFF0003"><institution>Department of Medicine, Ministry of Health</institution>, Riyadh,<country>Kingdom of Saudi Arabia</country></nlm:aff><wicri:noCountry code="nlm country">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0004"><institution>Hubert Department of Global Health, Rollins School of Public Health, Emory University</institution>, Atlanta, GA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27937060</idno><idno type="pmc">7103731</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103731</idno><idno type="RBID">PMC:7103731</idno><idno type="doi">10.1080/14787210.2017.1271712</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001321</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001321</idno><idno type="wicri:Area/Pmc/Curation">001321</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001321</idno><idno type="wicri:Area/Pmc/Checkpoint">000965</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000965</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV)</title><author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name><affiliation><nlm:aff id="AFF0001"><institution>Specialty Internal Medicine, Johns Hopkins Aramco Healthcare</institution>, Dhahran,<country>Kingdom of Saudi Arabia</country></nlm:aff><wicri:noCountry code="nlm country">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>Department of Medicine, Indiana University School of Medicine</institution>, Indianapolis, IN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><affiliation><nlm:aff id="AFF0003"><institution>Department of Medicine, Ministry of Health</institution>, Riyadh,<country>Kingdom of Saudi Arabia</country></nlm:aff><wicri:noCountry code="nlm country">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0004"><institution>Hubert Department of Global Health, Rollins School of Public Health, Emory University</institution>, Atlanta, GA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Expert Review of Anti-Infective Therapy</title><idno type="ISSN">1478-7210</idno><idno type="eISSN">1744-8336</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p><bold>Introduction:</bold> The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an important emerging respiratory pathogen. MERS-CoV resulted in multiple hospital outbreaks within and outside the Arabian Peninsula. The disease has a high case fatality rate, with the need for a therapeutic option.</p><p><bold>Areas covered:</bold> In this review, we provide an overview of the progress in the development of therapeutic strategies for MERS. We searched PubMed, Embase, Cochrane, Scopus, and Google Scholar, using the following terms: ‘MERS’, ‘MERS-CoV’, ‘Middle East respiratory syndrome’ in combination with ‘treatment’ or ‘therapy’.</p><p><bold>Expert commentary:</bold> There are multiple agents tried <italic>in vitro</italic> and <italic>in vivo</italic>. None of these agents were used in large clinical studies. Available clinical studies are limited to the use of the combination of interferon and other agents. These clinical studies are based solely on case reports and case series. There are no prospective or randomized trials. There is a need to have prospective and randomized clinical trials for the therapy of MERS-CoV. However, this strategy might be hampered by the sporadic cases outside the large hospital outbreaks.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA. Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A McGeer</name></author><author><name sortKey="Perl, Tm" uniqKey="Perl T">TM Perl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Perl, Tm" uniqKey="Perl T">TM Perl</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Momattin, H" uniqKey="Momattin H">H Momattin</name></author><author><name sortKey="Mohammed, K" uniqKey="Mohammed K">K Mohammed</name></author><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Kao, Ry" uniqKey="Kao R">RY Kao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Randall, Re" uniqKey="Randall R">RE Randall</name></author><author><name sortKey="Goodbourn, S" uniqKey="Goodbourn S">S Goodbourn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hart, Bj" uniqKey="Hart B">BJ Hart</name></author><author><name sortKey="Dyall, J" uniqKey="Dyall J">J Dyall</name></author><author><name sortKey="Postnikova, E" uniqKey="Postnikova E">E Postnikova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Martellaro, C" uniqKey="Martellaro C">C Martellaro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adedeji, Ao" uniqKey="Adedeji A">AO Adedeji</name></author><author><name sortKey="Sarafianos, Sg" uniqKey="Sarafianos S">SG Sarafianos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Jf W" uniqKey="Chan J">JF-W Chan</name></author><author><name sortKey="Yao, Y" uniqKey="Yao Y">Y Yao</name></author><author><name sortKey="Yeung, M L" uniqKey="Yeung M">M-L Yeung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wilde, Ah" uniqKey="De Wilde A">AH De Wilde</name></author><author><name sortKey="Jochmans, D" uniqKey="Jochmans D">D Jochmans</name></author><author><name sortKey="Posthuma, Cc" uniqKey="Posthuma C">CC Posthuma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shirato, K" uniqKey="Shirato K">K Shirato</name></author><author><name sortKey="Kawase, M" uniqKey="Kawase M">M Kawase</name></author><author><name sortKey="Matsuyama, S" uniqKey="Matsuyama S">S Matsuyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q Liu</name></author><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wilde, Ah" uniqKey="De Wilde A">AH De Wilde</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Oudshoorn, D" uniqKey="Oudshoorn D">D Oudshoorn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wilde, Ah" uniqKey="De Wilde A">AH De Wilde</name></author><author><name sortKey="Zevenhoven Dobbe, Jc" uniqKey="Zevenhoven Dobbe J">JC Zevenhoven-Dobbe</name></author><author><name sortKey="Van Der Meer, Y" uniqKey="Van Der Meer Y">Y van der Meer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossignol, J F" uniqKey="Rossignol J">J-F Rossignol</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, N" uniqKey="Zhou N">N Zhou</name></author><author><name sortKey="Pan, T" uniqKey="Pan T">T Pan</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pan, Q" uniqKey="Pan Q">Q Pan</name></author><author><name sortKey="De Ruiter, Pe" uniqKey="De Ruiter P">PE De Ruiter</name></author><author><name sortKey="Metselaar, Hj" uniqKey="Metselaar H">HJ Metselaar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Channappanavar, R" uniqKey="Channappanavar R">R Channappanavar</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Xia, S" uniqKey="Xia S">S Xia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Perera, Rapm" uniqKey="Perera R">RAPM Perera</name></author><author><name sortKey="Kayali, G" uniqKey="Kayali G">G Kayali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agrawal, As" uniqKey="Agrawal A">AS Agrawal</name></author><author><name sortKey="Ying, T" uniqKey="Ying T">T Ying</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qiu, H" uniqKey="Qiu H">H Qiu</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S Sun</name></author><author><name sortKey="Xiao, H" uniqKey="Xiao H">H Xiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Rasmussen, Al" uniqKey="Rasmussen A">AL Rasmussen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ying, T" uniqKey="Ying T">T Ying</name></author><author><name sortKey="Prabakaran, P" uniqKey="Prabakaran P">P Prabakaran</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Momattin, H" uniqKey="Momattin H">H Momattin</name></author><author><name sortKey="Dib, J" uniqKey="Dib J">J Dib</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Omrani, As" uniqKey="Omrani A">AS Omrani</name></author><author><name sortKey="Saad, Mm" uniqKey="Saad M">MM Saad</name></author><author><name sortKey="Baig, K" uniqKey="Baig K">K Baig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khalid, I" uniqKey="Khalid I">I Khalid</name></author><author><name sortKey="Alraddadi, Bm" uniqKey="Alraddadi B">BM Alraddadi</name></author><author><name sortKey="Dairi, Y" uniqKey="Dairi Y">Y Dairi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shalhoub, S" uniqKey="Shalhoub S">S Shalhoub</name></author><author><name sortKey="Farahat, F" uniqKey="Farahat F">F Farahat</name></author><author><name sortKey="Al Jiffri, A" uniqKey="Al Jiffri A">A Al-Jiffri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Ghamdi, M" uniqKey="Al Ghamdi M">M Al Ghamdi</name></author><author><name sortKey="Alghamdi, Km" uniqKey="Alghamdi K">KM Alghamdi</name></author><author><name sortKey="Ghandoora, Y" uniqKey="Ghandoora Y">Y Ghandoora</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Uj" uniqKey="Kim U">UJ Kim</name></author><author><name sortKey="Won, E J" uniqKey="Won E">E-J Won</name></author><author><name sortKey="Kee, S J" uniqKey="Kee S">S-J Kee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spanakis, N" uniqKey="Spanakis N">N Spanakis</name></author><author><name sortKey="Tsiodras, S" uniqKey="Tsiodras S">S Tsiodras</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khalid, M" uniqKey="Khalid M">M Khalid</name></author><author><name sortKey="Al Rabiah, F" uniqKey="Al Rabiah F">F Al Rabiah</name></author><author><name sortKey="Khan, B" uniqKey="Khan B">B Khan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malik, A" uniqKey="Malik A">A Malik</name></author><author><name sortKey="El Masry, Km" uniqKey="El Masry K">KM El Masry</name></author><author><name sortKey="Ravi, M" uniqKey="Ravi M">M Ravi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khalid, M" uniqKey="Khalid M">M Khalid</name></author><author><name sortKey="Khan, B" uniqKey="Khan B">B Khan</name></author><author><name sortKey="Al Rabiah, F" uniqKey="Al Rabiah F">F Al Rabiah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, H" uniqKey="Lee H">H Lee</name></author><author><name sortKey="Ki, C S" uniqKey="Ki C">C-S Ki</name></author><author><name sortKey="Sung, H" uniqKey="Sung H">H Sung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ohnuma, K" uniqKey="Ohnuma K">K Ohnuma</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Hatano, R" uniqKey="Hatano R">R Hatano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pascal, Ke" uniqKey="Pascal K">KE Pascal</name></author><author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name></author><author><name sortKey="Mujica, Ao" uniqKey="Mujica A">AO Mujica</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Kou, Z" uniqKey="Kou Z">Z Kou</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Wan, Y" uniqKey="Wan Y">Y Wan</name></author><author><name sortKey="Liu, P" uniqKey="Liu P">P Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author><author><name sortKey="Zuo, T" uniqKey="Zuo T">T Zuo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, X C" uniqKey="Tang X">X-C Tang</name></author><author><name sortKey="Agnihothram, Ss" uniqKey="Agnihothram S">SS Agnihothram</name></author><author><name sortKey="Jiao, Y" uniqKey="Jiao Y">Y Jiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ying, T" uniqKey="Ying T">T Ying</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Ju, Tw" uniqKey="Ju T">TW Ju</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mou, H" uniqKey="Mou H">H Mou</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Van Kuppeveld, Fjm" uniqKey="Van Kuppeveld F">FJM van Kuppeveld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, Rf" uniqKey="Johnson R">RF Johnson</name></author><author><name sortKey="Bagci, U" uniqKey="Bagci U">U Bagci</name></author><author><name sortKey="Keith, L" uniqKey="Keith L">L Keith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corti, D" uniqKey="Corti D">D Corti</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Pedotti, M" uniqKey="Pedotti M">M Pedotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luke, T" uniqKey="Luke T">T Luke</name></author><author><name sortKey="Wu, H" uniqKey="Wu H">H Wu</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H Mou</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lambeir, A M" uniqKey="Lambeir A">A-M Lambeir</name></author><author><name sortKey="Durinx, C" uniqKey="Durinx C">C Durinx</name></author><author><name sortKey="Scharpe, S" uniqKey="Scharpe S">S Scharpé</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boonacker, E" uniqKey="Boonacker E">E Boonacker</name></author><author><name sortKey="Van Noorden, Cj" uniqKey="Van Noorden C">CJ Van Noorden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hung, If" uniqKey="Hung I">IF Hung</name></author><author><name sortKey="To, Kk" uniqKey="To K">KK To</name></author><author><name sortKey="Lee, C K" uniqKey="Lee C">C-K Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luke, Tc" uniqKey="Luke T">TC Luke</name></author><author><name sortKey="Kilbane, Em" uniqKey="Kilbane E">EM Kilbane</name></author><author><name sortKey="Jackson, Jl" uniqKey="Jackson J">JL Jackson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, X X" uniqKey="Wu ">-X-X Wu</name></author><author><name sortKey="Gao, H N" uniqKey="Gao H">H-N Gao</name></author><author><name sortKey="Wu, H B" uniqKey="Wu H">H-B Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kong, Lk" uniqKey="Kong L">LK Kong</name></author><author><name sortKey="Zhou, Bp" uniqKey="Zhou B">BP Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mair Jenkins, J" uniqKey="Mair Jenkins J">J Mair-Jenkins</name></author><author><name sortKey="Saavedra Campos, M" uniqKey="Saavedra Campos M">M Saavedra-Campos</name></author><author><name sortKey="Baillie, Jk" uniqKey="Baillie J">JK Baillie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arabi, Ym" uniqKey="Arabi Y">YM Arabi</name></author><author><name sortKey="Arifi, Aa" uniqKey="Arifi A">AA Arifi</name></author><author><name sortKey="Balkhy, Hh" uniqKey="Balkhy H">HH Balkhy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kapoor, M" uniqKey="Kapoor M">M Kapoor</name></author><author><name sortKey="Pringle, K" uniqKey="Pringle K">K Pringle</name></author><author><name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arabi, Y" uniqKey="Arabi Y">Y Arabi</name></author><author><name sortKey="Balkhy, H" uniqKey="Balkhy H">H Balkhy</name></author><author><name sortKey="Hajeer, Ah" uniqKey="Hajeer A">AH Hajeer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alshukairi, An" uniqKey="Alshukairi A">AN Alshukairi</name></author><author><name sortKey="Khalid, I" uniqKey="Khalid I">I Khalid</name></author><author><name sortKey="Ahmed, Wa" uniqKey="Ahmed W">WA Ahmed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author><author><name sortKey="Albarrak, Am" uniqKey="Albarrak A">AM Albarrak</name></author><author><name sortKey="Omrani, As" uniqKey="Omrani A">AS Omrani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Wb" uniqKey="Park W">WB Park</name></author><author><name sortKey="Perera, Rapm" uniqKey="Perera R">RAPM Perera</name></author><author><name sortKey="Choe, Pg" uniqKey="Choe P">PG Choe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arabi, Ym" uniqKey="Arabi Y">YM Arabi</name></author><author><name sortKey="Hajeer, Ah" uniqKey="Hajeer A">AH Hajeer</name></author><author><name sortKey="Luke, T" uniqKey="Luke T">T Luke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Long, Y" uniqKey="Long Y">Y Long</name></author><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name></author><author><name sortKey="Wang, B" uniqKey="Wang B">B Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Auyeung, T" uniqKey="Auyeung T">T Auyeung</name></author><author><name sortKey="Lee, J" uniqKey="Lee J">J Lee</name></author><author><name sortKey="Lai, W" uniqKey="Lai W">W Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author><author><name sortKey="Allen Chan, Kc" uniqKey="Allen Chan K">KC Allen Chan</name></author><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Belouzard, S" uniqKey="Belouzard S">S Belouzard</name></author><author><name sortKey="Millet, Jk" uniqKey="Millet J">JK Millet</name></author><author><name sortKey="Licitra, Bn" uniqKey="Licitra B">BN Licitra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dyall, J" uniqKey="Dyall J">J Dyall</name></author><author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name></author><author><name sortKey="Hart, Bj" uniqKey="Hart B">BJ Hart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uyeki, Tm" uniqKey="Uyeki T">TM Uyeki</name></author><author><name sortKey="Erlandson, Kj" uniqKey="Erlandson K">KJ Erlandson</name></author><author><name sortKey="Korch, G" uniqKey="Korch G">G Korch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sakamoto, S" uniqKey="Sakamoto S">S Sakamoto</name></author><author><name sortKey="Tanaka, H" uniqKey="Tanaka H">H Tanaka</name></author><author><name sortKey="Morimoto, S" uniqKey="Morimoto S">S Morimoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Modjarrad, K" uniqKey="Modjarrad K">K Modjarrad</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Expert Rev Anti Infect Ther</journal-id><journal-id journal-id-type="iso-abbrev">Expert Rev Anti Infect Ther</journal-id><journal-id journal-id-type="publisher-id">IERZ</journal-id><journal-id journal-id-type="publisher-id">ierz20</journal-id><journal-title-group><journal-title>Expert Review of Anti-Infective Therapy</journal-title></journal-title-group><issn pub-type="ppub">1478-7210</issn><issn pub-type="epub">1744-8336</issn><publisher><publisher-name>Taylor & Francis</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27937060</article-id><article-id pub-id-type="pmc">7103731</article-id><article-id pub-id-type="publisher-id">1271712</article-id><article-id pub-id-type="doi">10.1080/14787210.2017.1271712</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV)</article-title><alt-title alt-title-type="running-authors">J. A. AL-TAWFIQ AND Z. A. MEMISH</alt-title><alt-title alt-title-type="running-title">EXPERT REVIEW OF ANTI-INFECTIVE THERAPY</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Al-Tawfiq</surname><given-names>Jaffar A.</given-names></name><xref ref-type="aff" rid="AFF0001"><sup>a</sup></xref><xref ref-type="aff" rid="AFF0002"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Memish</surname><given-names>Ziad A.</given-names></name><xref ref-type="aff" rid="AFF0003"><sup>c</sup></xref><xref ref-type="aff" rid="AFF0004"><sup>d</sup></xref><xref ref-type="corresp" rid="AN0001"></xref></contrib><aff id="AFF0001"><label>a</label><institution>Specialty Internal Medicine, Johns Hopkins Aramco Healthcare</institution>, Dhahran,<country>Kingdom of Saudi Arabia</country></aff><aff id="AFF0002"><label>b</label><institution>Department of Medicine, Indiana University School of Medicine</institution>, Indianapolis, IN,<country>USA</country></aff><aff id="AFF0003"><label>c</label><institution>Department of Medicine, Ministry of Health</institution>, Riyadh,<country>Kingdom of Saudi Arabia</country></aff><aff id="AFF0004"><label>d</label><institution>Hubert Department of Global Health, Rollins School of Public Health, Emory University</institution>, Atlanta, GA,<country>USA</country></aff></contrib-group><author-notes><corresp id="AN0001">CONTACT Ziad A. Memish <email xlink:href="Jaffar.tawfiq@jhah.com">Jaffar.tawfiq@jhah.com</email><institution>College of Medicine, Alfaisal University</institution>, <addr-line>P.O. Box 54146</addr-line>, Riyadh 11514, <country>Kingdom of Saudi Arabia</country></corresp></author-notes><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>24</day><month>12</month><year>2016</year></pub-date><volume>15</volume><issue>3</issue><fpage seq="8">269</fpage><lpage>275</lpage><history><date date-type="received"><day>22</day><month>9</month><year>2016</year></date><date date-type="accepted"><day>09</day><month>12</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 Informa UK Limited, trading as Taylor & Francis Group</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Informa UK Limited, trading as Taylor & Francis Group</copyright-holder><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="IERZ_15_1271712.pdf"></self-uri><abstract><title>ABSTRACT</title><p><bold>Introduction:</bold> The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an important emerging respiratory pathogen. MERS-CoV resulted in multiple hospital outbreaks within and outside the Arabian Peninsula. The disease has a high case fatality rate, with the need for a therapeutic option.</p><p><bold>Areas covered:</bold> In this review, we provide an overview of the progress in the development of therapeutic strategies for MERS. We searched PubMed, Embase, Cochrane, Scopus, and Google Scholar, using the following terms: ‘MERS’, ‘MERS-CoV’, ‘Middle East respiratory syndrome’ in combination with ‘treatment’ or ‘therapy’.</p><p><bold>Expert commentary:</bold> There are multiple agents tried <italic>in vitro</italic> and <italic>in vivo</italic>. None of these agents were used in large clinical studies. Available clinical studies are limited to the use of the combination of interferon and other agents. These clinical studies are based solely on case reports and case series. There are no prospective or randomized trials. There is a need to have prospective and randomized clinical trials for the therapy of MERS-CoV. However, this strategy might be hampered by the sporadic cases outside the large hospital outbreaks.</p></abstract><kwd-group kwd-group-type="author"><title>KEYWORDS</title><kwd>MERS-CoV</kwd><kwd>interferon</kwd><kwd>ribavirin</kwd><kwd>pegylated interferon</kwd><kwd>therapy</kwd></kwd-group><funding-group><funding-statement>This paper was not funded.</funding-statement></funding-group><counts><table-count count="4"></table-count><ref-count count="75"></ref-count><page-count count="7"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name></noRegion><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000965 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000965 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:7103731
|texte= Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:27937060" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |