Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset
Identifieur interne : 000D58 ( Main/Exploration ); précédent : 000D57; suivant : 000D59Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset
Auteurs : Zhe Chen ; Linlin Bao ; Cong Chen ; Tingting Zou ; Ying Xue ; Fengdi Li ; Qi Lv ; Songzhi Gu ; Xiaopan Gao ; Sheng Cui ; Jianmin Wang ; Chuan Qin ; Qi Jin [République populaire de Chine]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps monoclonaux (métabolisme), Anticorps monoclonaux (usage thérapeutique), Anticorps neutralisants (immunologie), Attribution aléatoire, Callithrix, Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Dipeptidyl peptidase 4 (immunologie), Humains, Infections à coronavirus (immunologie), Modèles animaux de maladie humaine, Mâle, Réplication virale (immunologie).
- MESH :
- immunologie : Anticorps antiviraux, Anticorps neutralisants, Coronavirus du syndrome respiratoire du Moyen-Orient, Dipeptidyl peptidase 4, Infections à coronavirus, Réplication virale.
- métabolisme : Anticorps monoclonaux.
- usage thérapeutique : Anticorps monoclonaux.
- Animaux, Attribution aléatoire, Callithrix, Humains, Modèles animaux de maladie humaine, Mâle.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (metabolism), Antibodies, Monoclonal (therapeutic use), Antibodies, Neutralizing (immunology), Antibodies, Viral (immunology), Callithrix, Coronavirus Infections (immunology), Dipeptidyl Peptidase 4 (immunology), Disease Models, Animal, Humans, Male, Middle East Respiratory Syndrome Coronavirus (immunology), Random Allocation, Virus Replication (immunology).
- MESH :
- chemical , immunology : Antibodies, Neutralizing, Antibodies, Viral, Dipeptidyl Peptidase 4.
- chemical , metabolism : Antibodies, Monoclonal.
- chemical , therapeutic use : Antibodies, Monoclonal.
- immunology : Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus, Virus Replication.
- Animals, Callithrix, Disease Models, Animal, Humans, Male, Random Allocation.
Abstract
A human monoclonal antibody, MCA1, directly targeting the receptor-binding domain of Middle East respiratory syndrome coronavirus (MERS-CoV) S glycoprotein, was isolated from a human survivor. MCA1 highly neutralized MERS-CoV in vitro and completely inhibited viral replication in common marmosets.
Url:
DOI: 10.1093/infdis/jix209
PubMed: 28472421
PubMed Central: 7107363
Affiliations:
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Le document en format XML
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<term>Antibodies, Monoclonal (metabolism)</term>
<term>Antibodies, Monoclonal (therapeutic use)</term>
<term>Antibodies, Neutralizing (immunology)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Callithrix</term>
<term>Coronavirus Infections (immunology)</term>
<term>Dipeptidyl Peptidase 4 (immunology)</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
<term>Male</term>
<term>Middle East Respiratory Syndrome Coronavirus (immunology)</term>
<term>Random Allocation</term>
<term>Virus Replication (immunology)</term>
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<term>Anticorps antiviraux (immunologie)</term>
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<term>Anticorps monoclonaux (usage thérapeutique)</term>
<term>Anticorps neutralisants (immunologie)</term>
<term>Attribution aléatoire</term>
<term>Callithrix</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term>
<term>Dipeptidyl peptidase 4 (immunologie)</term>
<term>Humains</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Réplication virale (immunologie)</term>
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<term>Antibodies, Viral</term>
<term>Dipeptidyl Peptidase 4</term>
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<term>Anticorps neutralisants</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p>A human monoclonal antibody, MCA1, directly targeting the receptor-binding domain of Middle East respiratory syndrome coronavirus (MERS-CoV) S glycoprotein, was isolated from a human survivor. MCA1 highly neutralized MERS-CoV in vitro and completely inhibited viral replication in common marmosets. </p>
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