MersV1, Main, Exploration, bibRecord, 000A72

Adult severe encephalitis/encephalopathy with a reversible splenial lesion of the corpus callosum

Identifieur interne : 000A72 ( Main/Exploration ); précédent : 000A71; suivant : 000A73

Adult severe encephalitis/encephalopathy with a reversible splenial lesion of the corpus callosum

Auteurs : Xi-Jing Mao ; Bo-Chi Zhu ; Ting-Min Yu ; Gang Yao

Source :

Medicine [ 0025-7974 ] ; 2018.

RBID : PMC:6039641

Descripteurs français

KwdFr :
- Adulte, Corps calleux (anatomopathologie), Encéphalite (), Encéphalite (anatomopathologie), Encéphalite (diagnostic), Encéphalite (imagerie diagnostique), Humains, Imagerie par résonance magnétique, Mâle, Troubles de la mémoire (étiologie), État de mal épileptique (étiologie).
MESH :
- anatomopathologie : Corps calleux, Encéphalite.
- diagnostic : Encéphalite.
- imagerie diagnostique : Encéphalite.
- étiologie : Troubles de la mémoire, État de mal épileptique.
- Adulte, Encéphalite, Humains, Imagerie par résonance magnétique, Mâle.

English descriptors

KwdEn :
- Adult, Corpus Callosum (pathology), Encephalitis (complications), Encephalitis (diagnosis), Encephalitis (diagnostic imaging), Encephalitis (pathology), Humans, Magnetic Resonance Imaging, Male, Memory Disorders (etiology), Status Epilepticus (etiology).
MESH :
- complications : Encephalitis.
- diagnosis : Encephalitis.
- diagnostic imaging : Encephalitis.
- etiology : Memory Disorders, Status Epilepticus.
- pathology : Corpus Callosum, Encephalitis.
- Adult, Humans, Magnetic Resonance Imaging, Male.

Abstract

AbstractRationale:

Clinically mild encephalitis/encephalopathy with a reversible splenial lesion of the corpus callosum (MERS) is a recently identified clinically and radiologically distinct syndrome. Clinical symptoms and lesions on the magnetic resonance imaging (MRI) often disappear in 1 week or a few weeks. However, MERS manifesting as a severe clinical course with significant sequela has not yet been reported.

Patient concerns:

A 42-year-old male presented with a 3-day history of headache, fever, and irrational speech. Physical examination showed a body temperature of 39.5°C, dysarthria, dyscalculia, recent memory disturbance, and otherwise normal vital signs. The patient developed status epilepticus and progressive consciousness disturbance. MRI showed abnormal patchy signals in the splenium of the corpus callosum.

Diagnosis:

The clinical feature and the characteristic of MRI are mostly consistent with MERS. At the same time, we made a differential diagnosis by testing the NMDARAb, AMPA1Ab, AMPA2Ab, LG1Ab, CASPR2Ab, GABABRAb in CSF and serum.

Interventions:

The subject was treated with ganciclovir, antiepileptic, and antipyretic therapy.

Outcomes:

The subject was living a virtually normal life with persistent mild memory disturbance. MRI showed that the abnormal signals in the splenium of the corpus callosum had disappeared, but hyperintensity on T2-weighted and FLAIR imaging was noted in the centrum semiovale.

Lessons:

MERS is a rare clinicoradiological syndrome, which can manifest as severe symptoms as well. Early diagnosis and treatment should be emphasized, and the diagnostic value of MRI is highlighted. Clinicians should be alert to the potential sequela.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039641

DOI: 10.1097/MD.0000000000011324
PubMed: 29953022
PubMed Central: 6039641

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Adult severe encephalitis/encephalopathy with a reversible splenial lesion of the corpus callosum</title>
<author><name sortKey="Mao, Xi Jing" sort="Mao, Xi Jing" uniqKey="Mao X" first="Xi-Jing" last="Mao">Xi-Jing Mao</name>
</author>
<author><name sortKey="Zhu, Bo Chi" sort="Zhu, Bo Chi" uniqKey="Zhu B" first="Bo-Chi" last="Zhu">Bo-Chi Zhu</name>
</author>
<author><name sortKey="Yu, Ting Min" sort="Yu, Ting Min" uniqKey="Yu T" first="Ting-Min" last="Yu">Ting-Min Yu</name>
</author>
<author><name sortKey="Yao, Gang" sort="Yao, Gang" uniqKey="Yao G" first="Gang" last="Yao">Gang Yao</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">29953022</idno>
<idno type="pmc">6039641</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039641</idno>
<idno type="RBID">PMC:6039641</idno>
<idno type="doi">10.1097/MD.0000000000011324</idno>
<date when="2018">2018</date>
<idno type="wicri:Area/Pmc/Corpus">000772</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000772</idno>
<idno type="wicri:Area/Pmc/Curation">000772</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000772</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000644</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000644</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:29953022</idno>
<idno type="wicri:Area/PubMed/Corpus">000850</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000850</idno>
<idno type="wicri:Area/PubMed/Curation">000850</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000850</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000A21</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A21</idno>
<idno type="wicri:Area/Ncbi/Merge">001E83</idno>
<idno type="wicri:Area/Ncbi/Curation">001E83</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001E83</idno>
<idno type="wicri:doubleKey">0025-7974:2018:Mao X:adult:severe:encephalitis</idno>
<idno type="wicri:Area/Main/Merge">000A75</idno>
<idno type="wicri:Area/Main/Curation">000A72</idno>
<idno type="wicri:Area/Main/Exploration">000A72</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Adult severe encephalitis/encephalopathy with a reversible splenial lesion of the corpus callosum</title>
<author><name sortKey="Mao, Xi Jing" sort="Mao, Xi Jing" uniqKey="Mao X" first="Xi-Jing" last="Mao">Xi-Jing Mao</name>
</author>
<author><name sortKey="Zhu, Bo Chi" sort="Zhu, Bo Chi" uniqKey="Zhu B" first="Bo-Chi" last="Zhu">Bo-Chi Zhu</name>
</author>
<author><name sortKey="Yu, Ting Min" sort="Yu, Ting Min" uniqKey="Yu T" first="Ting-Min" last="Yu">Ting-Min Yu</name>
</author>
<author><name sortKey="Yao, Gang" sort="Yao, Gang" uniqKey="Yao G" first="Gang" last="Yao">Gang Yao</name>
</author>
</analytic>
<series><title level="j">Medicine</title>
<idno type="ISSN">0025-7974</idno>
<idno type="eISSN">1536-5964</idno>
<imprint><date when="2018">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Corpus Callosum (pathology)</term>
<term>Encephalitis (complications)</term>
<term>Encephalitis (diagnosis)</term>
<term>Encephalitis (diagnostic imaging)</term>
<term>Encephalitis (pathology)</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Memory Disorders (etiology)</term>
<term>Status Epilepticus (etiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Corps calleux (anatomopathologie)</term>
<term>Encéphalite ()</term>
<term>Encéphalite (anatomopathologie)</term>
<term>Encéphalite (diagnostic)</term>
<term>Encéphalite (imagerie diagnostique)</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Mâle</term>
<term>Troubles de la mémoire (étiologie)</term>
<term>État de mal épileptique (étiologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Corps calleux</term>
<term>Encéphalite</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Encephalitis</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Encephalitis</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Encéphalite</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Encephalitis</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Memory Disorders</term>
<term>Status Epilepticus</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Encéphalite</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Callosum</term>
<term>Encephalitis</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Troubles de la mémoire</term>
<term>État de mal épileptique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Encéphalite</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Mâle</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<sec><title>Rationale:</title>
<p>Clinically mild encephalitis/encephalopathy with a reversible splenial lesion of the corpus callosum (MERS) is a recently identified clinically and radiologically distinct syndrome. Clinical symptoms and lesions on the magnetic resonance imaging (MRI) often disappear in 1 week or a few weeks. However, MERS manifesting as a severe clinical course with significant sequela has not yet been reported.</p>
</sec>
<sec><title>Patient concerns:</title>
<p>A 42-year-old male presented with a 3-day history of headache, fever, and irrational speech. Physical examination showed a body temperature of 39.5°C, dysarthria, dyscalculia, recent memory disturbance, and otherwise normal vital signs. The patient developed status epilepticus and progressive consciousness disturbance. MRI showed abnormal patchy signals in the splenium of the corpus callosum.</p>
</sec>
<sec><title>Diagnosis:</title>
<p>The clinical feature and the characteristic of MRI are mostly consistent with MERS. At the same time, we made a differential diagnosis by testing the NMDARAb, AMPA1Ab, AMPA2Ab, LG1Ab, CASPR2Ab, GABABRAb in CSF and serum.</p>
</sec>
<sec><title>Interventions:</title>
<p>The subject was treated with ganciclovir, antiepileptic, and antipyretic therapy.</p>
</sec>
<sec><title>Outcomes:</title>
<p>The subject was living a virtually normal life with persistent mild memory disturbance. MRI showed that the abnormal signals in the splenium of the corpus callosum had disappeared, but hyperintensity on T2-weighted and FLAIR imaging was noted in the centrum semiovale.</p>
</sec>
<sec><title>Lessons:</title>
<p>MERS is a rare clinicoradiological syndrome, which can manifest as severe symptoms as well. Early diagnosis and treatment should be emphasized, and the diagnostic value of MRI is highlighted. Clinicians should be alert to the potential sequela.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ono, D" uniqKey="Ono D">D Ono</name>
</author>
<author><name sortKey="Shibue, Y" uniqKey="Shibue Y">Y Shibue</name>
</author>
<author><name sortKey="Kurokawa, M" uniqKey="Kurokawa M">M Kurokawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fang, Q" uniqKey="Fang Q">Q Fang</name>
</author>
<author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name>
</author>
<author><name sortKey="Chen, Q" uniqKey="Chen Q">Q Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hong, Jy" uniqKey="Hong J">JY Hong</name>
</author>
<author><name sortKey="Park, Jk" uniqKey="Park J">JK Park</name>
</author>
<author><name sortKey="Kim, Sh" uniqKey="Kim S">SH Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Doherty, Mj" uniqKey="Doherty M">MJ Doherty</name>
</author>
<author><name sortKey="Watson, Nf" uniqKey="Watson N">NF Watson</name>
</author>
<author><name sortKey="Jayadev, S" uniqKey="Jayadev S">S Jayadev</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Takanashi, J" uniqKey="Takanashi J">J Takanashi</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Mao, Xi Jing" sort="Mao, Xi Jing" uniqKey="Mao X" first="Xi-Jing" last="Mao">Xi-Jing Mao</name>
<name sortKey="Yao, Gang" sort="Yao, Gang" uniqKey="Yao G" first="Gang" last="Yao">Gang Yao</name>
<name sortKey="Yu, Ting Min" sort="Yu, Ting Min" uniqKey="Yu T" first="Ting-Min" last="Yu">Ting-Min Yu</name>
<name sortKey="Zhu, Bo Chi" sort="Zhu, Bo Chi" uniqKey="Zhu B" first="Bo-Chi" last="Zhu">Bo-Chi Zhu</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A72 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A72 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:6039641
   |texte=   Adult severe encephalitis/encephalopathy with a reversible splenial lesion of the corpus callosum
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:29953022" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

Serveur d'exploration MERS

Adult severe encephalitis/encephalopathy with a reversible splenial lesion of the corpus callosum

Adult severe encephalitis/encephalopathy with a reversible splenial lesion of the corpus callosum

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.