Adult severe encephalitis/encephalopathy with a reversible splenial lesion of the corpus callosum
Identifieur interne : 000A72 ( Main/Curation ); précédent : 000A71; suivant : 000A73Adult severe encephalitis/encephalopathy with a reversible splenial lesion of the corpus callosum
Auteurs : Xi-Jing Mao ; Bo-Chi Zhu ; Ting-Min Yu ; Gang YaoSource :
- Medicine [ 0025-7974 ] ; 2018.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Corps calleux, Encéphalite.
- diagnostic : Encéphalite.
- imagerie diagnostique : Encéphalite.
- étiologie : Troubles de la mémoire, État de mal épileptique.
- Adulte, Encéphalite, Humains, Imagerie par résonance magnétique, Mâle.
English descriptors
- KwdEn :
- MESH :
- complications : Encephalitis.
- diagnosis : Encephalitis.
- diagnostic imaging : Encephalitis.
- etiology : Memory Disorders, Status Epilepticus.
- pathology : Corpus Callosum, Encephalitis.
- Adult, Humans, Magnetic Resonance Imaging, Male.
Abstract
Clinically mild encephalitis/encephalopathy with a reversible splenial lesion of the corpus callosum (MERS) is a recently identified clinically and radiologically distinct syndrome. Clinical symptoms and lesions on the magnetic resonance imaging (MRI) often disappear in 1 week or a few weeks. However, MERS manifesting as a severe clinical course with significant sequela has not yet been reported.
A 42-year-old male presented with a 3-day history of headache, fever, and irrational speech. Physical examination showed a body temperature of 39.5°C, dysarthria, dyscalculia, recent memory disturbance, and otherwise normal vital signs. The patient developed status epilepticus and progressive consciousness disturbance. MRI showed abnormal patchy signals in the splenium of the corpus callosum.
The clinical feature and the characteristic of MRI are mostly consistent with MERS. At the same time, we made a differential diagnosis by testing the NMDARAb, AMPA1Ab, AMPA2Ab, LG1Ab, CASPR2Ab, GABABRAb in CSF and serum.
The subject was treated with ganciclovir, antiepileptic, and antipyretic therapy.
The subject was living a virtually normal life with persistent mild memory disturbance. MRI showed that the abnormal signals in the splenium of the corpus callosum had disappeared, but hyperintensity on T2-weighted and FLAIR imaging was noted in the centrum semiovale.
MERS is a rare clinicoradiological syndrome, which can manifest as severe symptoms as well. Early diagnosis and treatment should be emphasized, and the diagnostic value of MRI is highlighted. Clinicians should be alert to the potential sequela.
Url:
DOI: 10.1097/MD.0000000000011324
PubMed: 29953022
PubMed Central: 6039641
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PMC:6039641Le document en format XML
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<author><name sortKey="Zhu, Bo Chi" sort="Zhu, Bo Chi" uniqKey="Zhu B" first="Bo-Chi" last="Zhu">Bo-Chi Zhu</name>
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<author><name sortKey="Yu, Ting Min" sort="Yu, Ting Min" uniqKey="Yu T" first="Ting-Min" last="Yu">Ting-Min Yu</name>
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<author><name sortKey="Yao, Gang" sort="Yao, Gang" uniqKey="Yao G" first="Gang" last="Yao">Gang Yao</name>
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<author><name sortKey="Zhu, Bo Chi" sort="Zhu, Bo Chi" uniqKey="Zhu B" first="Bo-Chi" last="Zhu">Bo-Chi Zhu</name>
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<series><title level="j">Medicine</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Corpus Callosum (pathology)</term>
<term>Encephalitis (complications)</term>
<term>Encephalitis (diagnosis)</term>
<term>Encephalitis (diagnostic imaging)</term>
<term>Encephalitis (pathology)</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Memory Disorders (etiology)</term>
<term>Status Epilepticus (etiology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Corps calleux (anatomopathologie)</term>
<term>Encéphalite ()</term>
<term>Encéphalite (anatomopathologie)</term>
<term>Encéphalite (diagnostic)</term>
<term>Encéphalite (imagerie diagnostique)</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Mâle</term>
<term>Troubles de la mémoire (étiologie)</term>
<term>État de mal épileptique (étiologie)</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Corps calleux</term>
<term>Encéphalite</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Encephalitis</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Encephalitis</term>
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<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Encéphalite</term>
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<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Encephalitis</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Memory Disorders</term>
<term>Status Epilepticus</term>
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<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Encéphalite</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Callosum</term>
<term>Encephalitis</term>
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<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Troubles de la mémoire</term>
<term>État de mal épileptique</term>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<sec><title>Rationale:</title>
<p>Clinically mild encephalitis/encephalopathy with a reversible splenial lesion of the corpus callosum (MERS) is a recently identified clinically and radiologically distinct syndrome. Clinical symptoms and lesions on the magnetic resonance imaging (MRI) often disappear in 1 week or a few weeks. However, MERS manifesting as a severe clinical course with significant sequela has not yet been reported.</p>
</sec>
<sec><title>Patient concerns:</title>
<p>A 42-year-old male presented with a 3-day history of headache, fever, and irrational speech. Physical examination showed a body temperature of 39.5°C, dysarthria, dyscalculia, recent memory disturbance, and otherwise normal vital signs. The patient developed status epilepticus and progressive consciousness disturbance. MRI showed abnormal patchy signals in the splenium of the corpus callosum.</p>
</sec>
<sec><title>Diagnosis:</title>
<p>The clinical feature and the characteristic of MRI are mostly consistent with MERS. At the same time, we made a differential diagnosis by testing the NMDARAb, AMPA1Ab, AMPA2Ab, LG1Ab, CASPR2Ab, GABABRAb in CSF and serum.</p>
</sec>
<sec><title>Interventions:</title>
<p>The subject was treated with ganciclovir, antiepileptic, and antipyretic therapy.</p>
</sec>
<sec><title>Outcomes:</title>
<p>The subject was living a virtually normal life with persistent mild memory disturbance. MRI showed that the abnormal signals in the splenium of the corpus callosum had disappeared, but hyperintensity on T2-weighted and FLAIR imaging was noted in the centrum semiovale.</p>
</sec>
<sec><title>Lessons:</title>
<p>MERS is a rare clinicoradiological syndrome, which can manifest as severe symptoms as well. Early diagnosis and treatment should be emphasized, and the diagnostic value of MRI is highlighted. Clinicians should be alert to the potential sequela.</p>
</sec>
</div>
</front>
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