Live-attenuated bivalent measles virus-derived vaccines targeting Middle East respiratory syndrome coronavirus induce robust and multifunctional T cell responses against both viruses in an appropriate mouse model
Identifieur interne : 000921 ( Main/Exploration ); précédent : 000920; suivant : 000922Live-attenuated bivalent measles virus-derived vaccines targeting Middle East respiratory syndrome coronavirus induce robust and multifunctional T cell responses against both viruses in an appropriate mouse model
Auteurs : Bianca S. Bodmer [Allemagne] ; Anna H. Fiedler [Allemagne] ; Jan R. H. Hanauer [Allemagne] ; Steffen Prüfer [Allemagne] ; Michael D. Mühlebach [Allemagne]Source :
- Virology [ 0042-6822 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (immunologie), Immunité cellulaire, Infections à coronavirus (), Infections à coronavirus (immunologie), Lymphocytes T CD8+ (immunologie), Modèles animaux de maladie humaine, Souris de lignée BALB C, Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie), Vaccins atténués (immunologie), Virus de la rougeole.
- MESH :
- génétique : Glycoprotéine de spicule des coronavirus, Vaccins antiviraux.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Infections à coronavirus, Lymphocytes T CD8+, Vaccins antiviraux, Vaccins atténués.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- Animaux, Immunité cellulaire, Infections à coronavirus, Modèles animaux de maladie humaine, Souris de lignée BALB C, Virus de la rougeole.
English descriptors
- KwdEn :
- Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), CD8-Positive T-Lymphocytes (immunology), Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Disease Models, Animal, Immunity, Cellular, Measles virus, Mice, Inbred BALB C, Middle East Respiratory Syndrome Coronavirus (immunology), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology), Vaccines, Attenuated (immunology), Viral Vaccines (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , genetics : Spike Glycoprotein, Coronavirus, Viral Vaccines.
- immunology : CD8-Positive T-Lymphocytes, Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus, Spike Glycoprotein, Coronavirus, Vaccines, Attenuated, Viral Vaccines.
- prevention & control : Coronavirus Infections.
- Animals, Disease Models, Animal, Immunity, Cellular, Measles virus, Mice, Inbred BALB C.
Abstract
Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to occur, making it one of the WHO´s targets for accelerated vaccine development. One vaccine candidate is based on live-attenuated measles virus (MV) vaccine encoding the MERS-CoV spike glycoprotein (MERS-S). MVvac2-MERS-S(H) induces robust humoral and cellular immunity against MERS-S mediating protection. Here, the induction and nature of immunity after vaccination with MVvac2-MERS-S(H) or novel MVvac2-MERS-N were further characterized. We focused on the necessity for vector replication and the nature of induced T cells, since functional CD8+ T cells contribute importantly to clearance of MERS-CoV. While no immunity against MERS-CoV or MV was detected in MV-susceptible mice after immunization with UV-inactivated virus, replication-competent MVvac2-MERS-S(H) triggered robust neutralizing antibody titers also in adult mice. Furthermore, a significant fraction of MERS CoV-specific CD8+ T cells and MV-specific CD4+ T cells simultaneously expressing IFN-γ and TNF-α were induced, revealing that MVvac2-MERS-S(H) induces multifunctional cellular immunity.
Url:
DOI: 10.1016/j.virol.2018.05.028
PubMed: 29902727
PubMed Central: 7118890
Affiliations:
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Le document en format XML
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Fiedler</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Product Testing of IVMPs, Div. of Veterinary Medicine, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, D-63225 Langen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Product Testing of IVMPs, Div. of Veterinary Medicine, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, D-63225 Langen</wicri:regionArea><wicri:noRegion>63225 Langen</wicri:noRegion><wicri:noRegion>63225 Langen</wicri:noRegion><wicri:noRegion>D-63225 Langen</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0010">German Center for Infection Research, Langen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research, Langen</wicri:regionArea><wicri:noRegion>Langen</wicri:noRegion><wicri:noRegion>Langen</wicri:noRegion><wicri:noRegion>Langen</wicri:noRegion></affiliation></author><author><name sortKey="Hanauer, Jan R H" sort="Hanauer, Jan R H" uniqKey="Hanauer J" first="Jan R. H." last="Hanauer">Jan R. H. Hanauer</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Product Testing of IVMPs, Div. of Veterinary Medicine, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, D-63225 Langen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Product Testing of IVMPs, Div. of Veterinary Medicine, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, D-63225 Langen</wicri:regionArea><wicri:noRegion>63225 Langen</wicri:noRegion><wicri:noRegion>63225 Langen</wicri:noRegion><wicri:noRegion>D-63225 Langen</wicri:noRegion></affiliation></author><author><name sortKey="Prufer, Steffen" sort="Prufer, Steffen" uniqKey="Prufer S" first="Steffen" last="Prüfer">Steffen Prüfer</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Product Testing of IVMPs, Div. of Veterinary Medicine, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, D-63225 Langen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Product Testing of IVMPs, Div. of Veterinary Medicine, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, D-63225 Langen</wicri:regionArea><wicri:noRegion>63225 Langen</wicri:noRegion><wicri:noRegion>63225 Langen</wicri:noRegion><wicri:noRegion>D-63225 Langen</wicri:noRegion></affiliation></author><author><name sortKey="Muhlebach, Michael D" sort="Muhlebach, Michael D" uniqKey="Muhlebach M" first="Michael D." last="Mühlebach">Michael D. Mühlebach</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Product Testing of IVMPs, Div. of Veterinary Medicine, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, D-63225 Langen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Product Testing of IVMPs, Div. of Veterinary Medicine, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, D-63225 Langen</wicri:regionArea><wicri:noRegion>63225 Langen</wicri:noRegion><wicri:noRegion>63225 Langen</wicri:noRegion><wicri:noRegion>D-63225 Langen</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0010">German Center for Infection Research, Langen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research, Langen</wicri:regionArea><wicri:noRegion>Langen</wicri:noRegion><wicri:noRegion>Langen</wicri:noRegion><wicri:noRegion>Langen</wicri:noRegion></affiliation></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><idno type="eISSN">1096-0341</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Neutralizing (blood)</term><term>Antibodies, Viral (blood)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (prevention & control)</term><term>Disease Models, Animal</term><term>Immunity, Cellular</term><term>Measles virus</term><term>Mice, Inbred BALB C</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Spike Glycoprotein, Coronavirus (genetics)</term><term>Spike Glycoprotein, Coronavirus (immunology)</term><term>Vaccines, Attenuated (immunology)</term><term>Viral Vaccines (genetics)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Anticorps neutralisants (sang)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Glycoprotéine de spicule des coronavirus (génétique)</term><term>Glycoprotéine de spicule des coronavirus (immunologie)</term><term>Immunité cellulaire</term><term>Infections à coronavirus ()</term><term>Infections à coronavirus (immunologie)</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Modèles animaux de maladie humaine</term><term>Souris de lignée BALB C</term><term>Vaccins antiviraux (génétique)</term><term>Vaccins antiviraux (immunologie)</term><term>Vaccins atténués (immunologie)</term><term>Virus de la rougeole</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Spike Glycoprotein, Coronavirus</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine de spicule des coronavirus</term><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Glycoprotéine de spicule des coronavirus</term><term>Infections à coronavirus</term><term>Lymphocytes T CD8+</term><term>Vaccins antiviraux</term><term>Vaccins atténués</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term><term>Coronavirus Infections</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Spike Glycoprotein, Coronavirus</term><term>Vaccines, Attenuated</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Immunity, Cellular</term><term>Measles virus</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Immunité cellulaire</term><term>Infections à coronavirus</term><term>Modèles animaux de maladie humaine</term><term>Souris de lignée BALB C</term><term>Virus de la rougeole</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to occur, making it one of the WHO´s targets for accelerated vaccine development. One vaccine candidate is based on live-attenuated measles virus (MV) vaccine encoding the MERS-CoV spike glycoprotein (MERS-S). MV<sub>vac2</sub>-MERS-S(H) induces robust humoral and cellular immunity against MERS-S mediating protection. Here, the induction and nature of immunity after vaccination with MV<sub>vac2</sub>-MERS-S(H) or novel MV<sub>vac2</sub>-MERS-N were further characterized. We focused on the necessity for vector replication and the nature of induced T cells, since functional CD8<sup>+</sup> T cells contribute importantly to clearance of MERS-CoV. While no immunity against MERS-CoV or MV was detected in MV-susceptible mice after immunization with UV-inactivated virus, replication-competent MV<sub>vac2</sub>-MERS-S(H) triggered robust neutralizing antibody titers also in adult mice. Furthermore, a significant fraction of MERS CoV-specific CD8<sup>+</sup> T cells and MV-specific CD4<sup>+</sup> T cells simultaneously expressing IFN-γ and TNF-α were induced, revealing that MV<sub>vac2</sub>-MERS-S(H) induces multifunctional cellular immunity.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S. Agnihothram</name></author><author><name sortKey="Gopal, R" uniqKey="Gopal R">R. Gopal</name></author><author><name sortKey="Yount, B L" uniqKey="Yount B">B.L. Yount</name></author><author><name sortKey="Donaldson, E F" uniqKey="Donaldson E">E.F. Donaldson</name></author><author><name sortKey="Menachery, V D" uniqKey="Menachery V">V.D. Menachery</name></author><author><name sortKey="Graham, R L" uniqKey="Graham R">R.L. Graham</name></author><author><name sortKey="Scobey, T D" uniqKey="Scobey T">T.D. 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Fiedler</name><name sortKey="Fiedler, Anna H" sort="Fiedler, Anna H" uniqKey="Fiedler A" first="Anna H." last="Fiedler">Anna H. Fiedler</name><name sortKey="Hanauer, Jan R H" sort="Hanauer, Jan R H" uniqKey="Hanauer J" first="Jan R. H." last="Hanauer">Jan R. H. Hanauer</name><name sortKey="Muhlebach, Michael D" sort="Muhlebach, Michael D" uniqKey="Muhlebach M" first="Michael D." last="Mühlebach">Michael D. Mühlebach</name><name sortKey="Muhlebach, Michael D" sort="Muhlebach, Michael D" uniqKey="Muhlebach M" first="Michael D." last="Mühlebach">Michael D. Mühlebach</name><name sortKey="Prufer, Steffen" sort="Prufer, Steffen" uniqKey="Prufer S" first="Steffen" last="Prüfer">Steffen Prüfer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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