Live-attenuated bivalent measles virus-derived vaccines targeting Middle East respiratory syndrome coronavirus induce robust and multifunctional T cell responses against both viruses in an appropriate mouse model
Identifieur interne : 000745 ( Pmc/Curation ); précédent : 000744; suivant : 000746Live-attenuated bivalent measles virus-derived vaccines targeting Middle East respiratory syndrome coronavirus induce robust and multifunctional T cell responses against both viruses in an appropriate mouse model
Auteurs : Bianca S. Bodmer [Allemagne] ; Anna H. Fiedler [Allemagne] ; Jan R. H. Hanauer [Allemagne] ; Steffen Prüfer [Allemagne] ; Michael D. Mühlebach [Allemagne]Source :
- Virology [ 0042-6822 ] ; 2018.
Abstract
Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to occur, making it one of the WHO´s targets for accelerated vaccine development. One vaccine candidate is based on live-attenuated measles virus (MV) vaccine encoding the MERS-CoV spike glycoprotein (MERS-S). MVvac2-MERS-S(H) induces robust humoral and cellular immunity against MERS-S mediating protection. Here, the induction and nature of immunity after vaccination with MVvac2-MERS-S(H) or novel MVvac2-MERS-N were further characterized. We focused on the necessity for vector replication and the nature of induced T cells, since functional CD8+ T cells contribute importantly to clearance of MERS-CoV. While no immunity against MERS-CoV or MV was detected in MV-susceptible mice after immunization with UV-inactivated virus, replication-competent MVvac2-MERS-S(H) triggered robust neutralizing antibody titers also in adult mice. Furthermore, a significant fraction of MERS CoV-specific CD8+ T cells and MV-specific CD4+ T cells simultaneously expressing IFN-γ and TNF-α were induced, revealing that MVvac2-MERS-S(H) induces multifunctional cellular immunity.
Url:
DOI: 10.1016/j.virol.2018.05.028
PubMed: 29902727
PubMed Central: 7118890
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<front><div type="abstract" xml:lang="en"><p>Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to occur, making it one of the WHO´s targets for accelerated vaccine development. One vaccine candidate is based on live-attenuated measles virus (MV) vaccine encoding the MERS-CoV spike glycoprotein (MERS-S). MV<sub>vac2</sub>
-MERS-S(H) induces robust humoral and cellular immunity against MERS-S mediating protection. Here, the induction and nature of immunity after vaccination with MV<sub>vac2</sub>
-MERS-S(H) or novel MV<sub>vac2</sub>
-MERS-N were further characterized. We focused on the necessity for vector replication and the nature of induced T cells, since functional CD8<sup>+</sup>
T cells contribute importantly to clearance of MERS-CoV. While no immunity against MERS-CoV or MV was detected in MV-susceptible mice after immunization with UV-inactivated virus, replication-competent MV<sub>vac2</sub>
-MERS-S(H) triggered robust neutralizing antibody titers also in adult mice. Furthermore, a significant fraction of MERS CoV-specific CD8<sup>+</sup>
T cells and MV-specific CD4<sup>+</sup>
T cells simultaneously expressing IFN-γ and TNF-α were induced, revealing that MV<sub>vac2</sub>
-MERS-S(H) induces multifunctional cellular immunity.</p>
</div>
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</TEI>
<pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Virology</journal-id>
<journal-id journal-id-type="iso-abbrev">Virology</journal-id>
<journal-title-group><journal-title>Virology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0042-6822</issn>
<issn pub-type="epub">1096-0341</issn>
<publisher><publisher-name>Elsevier Inc.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">29902727</article-id>
<article-id pub-id-type="pmc">7118890</article-id>
<article-id pub-id-type="publisher-id">S0042-6822(18)30169-7</article-id>
<article-id pub-id-type="doi">10.1016/j.virol.2018.05.028</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Live-attenuated bivalent measles virus-derived vaccines targeting Middle East respiratory syndrome coronavirus induce robust and multifunctional T cell responses against both viruses in an appropriate mouse model</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" id="au0005"><name><surname>Bodmer</surname>
<given-names>Bianca S.</given-names>
</name>
<xref rid="aff0005" ref-type="aff">a</xref>
<xref rid="aff0010" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au0010"><name><surname>Fiedler</surname>
<given-names>Anna H.</given-names>
</name>
<xref rid="aff0005" ref-type="aff">a</xref>
<xref rid="aff0010" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au0015"><name><surname>Hanauer</surname>
<given-names>Jan R.H.</given-names>
</name>
<xref rid="aff0005" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="au0020"><name><surname>Prüfer</surname>
<given-names>Steffen</given-names>
</name>
<xref rid="aff0005" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="au0025"><name><surname>Mühlebach</surname>
<given-names>Michael D.</given-names>
</name>
<email>Michael.Muehlebach@pei.de</email>
<xref rid="aff0005" ref-type="aff">a</xref>
<xref rid="aff0010" ref-type="aff">b</xref>
<xref rid="cor1" ref-type="corresp">⁎</xref>
</contrib>
</contrib-group>
<aff id="aff0005"><label>a</label>
Product Testing of IVMPs, Div. of Veterinary Medicine, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, D-63225 Langen, Germany</aff>
<aff id="aff0010"><label>b</label>
German Center for Infection Research, Langen, Germany</aff>
<author-notes><corresp id="cor1"><label>⁎</label>
Corresponding author. <email>Michael.Muehlebach@pei.de</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release"><day>11</day>
<month>6</month>
<year>2018</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>8</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub"><day>11</day>
<month>6</month>
<year>2018</year>
</pub-date>
<volume>521</volume>
<fpage>99</fpage>
<lpage>107</lpage>
<history><date date-type="received"><day>16</day>
<month>2</month>
<year>2018</year>
</date>
<date date-type="rev-recd"><day>4</day>
<month>5</month>
<year>2018</year>
</date>
<date date-type="accepted"><day>31</day>
<month>5</month>
<year>2018</year>
</date>
</history>
<permissions><copyright-statement>© 2018 Elsevier Inc.</copyright-statement>
<copyright-year>2018</copyright-year>
<copyright-holder>Elsevier Inc.</copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract id="ab0010"><p>Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to occur, making it one of the WHO´s targets for accelerated vaccine development. One vaccine candidate is based on live-attenuated measles virus (MV) vaccine encoding the MERS-CoV spike glycoprotein (MERS-S). MV<sub>vac2</sub>
-MERS-S(H) induces robust humoral and cellular immunity against MERS-S mediating protection. Here, the induction and nature of immunity after vaccination with MV<sub>vac2</sub>
-MERS-S(H) or novel MV<sub>vac2</sub>
-MERS-N were further characterized. We focused on the necessity for vector replication and the nature of induced T cells, since functional CD8<sup>+</sup>
T cells contribute importantly to clearance of MERS-CoV. While no immunity against MERS-CoV or MV was detected in MV-susceptible mice after immunization with UV-inactivated virus, replication-competent MV<sub>vac2</sub>
-MERS-S(H) triggered robust neutralizing antibody titers also in adult mice. Furthermore, a significant fraction of MERS CoV-specific CD8<sup>+</sup>
T cells and MV-specific CD4<sup>+</sup>
T cells simultaneously expressing IFN-γ and TNF-α were induced, revealing that MV<sub>vac2</sub>
-MERS-S(H) induces multifunctional cellular immunity.</p>
</abstract>
<abstract abstract-type="author-highlights" id="ab0015"><title>Highlights</title>
<p><list list-type="simple" id="li0005"><list-item id="u0005"><label>•</label>
<p id="p0005">Measles vaccine virus encoding MERS-CoV N induce N-specific T ell responses.</p>
</list-item>
<list-item id="u0010"><label>•</label>
<p id="p0010">Only live recombinant vaccine triggers immunity.</p>
</list-item>
<list-item id="u0015"><label>•</label>
<p id="p0015">MERS-vaccine candidates work also in adult animals.</p>
</list-item>
<list-item id="u0020"><label>•</label>
<p id="p0020">Multifunctional antigen-specific T cells targeting MERS-S are induced by recombinant MV<sub>vac2</sub>
-MERS-S(H).</p>
</list-item>
</list>
</p>
</abstract>
<kwd-group id="keys0005"><title>Keywords</title>
<kwd>Vaccine platform</kwd>
<kwd>Measles Virus</kwd>
<kwd>Multifunctional T cells</kwd>
<kwd>MERS Coronavirus</kwd>
<kwd>Antibody responses</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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