Predictors of mortality in Middle East respiratory syndrome (MERS).
Identifieur interne : 000852 ( Main/Exploration ); précédent : 000851; suivant : 000853Predictors of mortality in Middle East respiratory syndrome (MERS).
Auteurs : Ki-Ho Hong [Corée du Sud] ; Jae-Phil Choi [Corée du Sud] ; Seon-Hui Hong [Corée du Sud] ; Jeewon Lee [Corée du Sud] ; Ji-Soo Kwon [Corée du Sud] ; Sun-Mi Kim [Corée du Sud] ; Se Yoon Park [Corée du Sud] ; Ji-Young Rhee [Corée du Sud] ; Baek-Nam Kim ; Hee Jung Choi [Corée du Sud] ; Eui-Cheol Shin [Corée du Sud] ; Hyunjoo Pai [Corée du Sud] ; Su-Hyung Park [Corée du Sud] ; Sung-Han Kim [Corée du Sud]Source :
- Thorax [ 1468-3296 ] ; 2018.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Charge virale, Coronavirus.
- mortalité : Infections à coronavirus.
- sang : Anticorps antiviraux, Cytokines.
- Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Mâle, Réaction de polymérisation en chaine en temps réel, Taux de survie.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Antibodies, Viral, Cytokines.
- genetics : Coronavirus, Viral Load.
- mortality : Coronavirus Infections.
- Female, Humans, Male, Middle Aged, Real-Time Polymerase Chain Reaction, Risk Factors, Survival Rate.
Abstract
We evaluated the clinical characteristics, cytokine/chemokine concentrations, viral shedding and antibody kinetics in 30 patients with Middle East respiratory syndrome (MERS), including 6 non-survivors admitted to 3 MERS-designated hospitals. Old age, low albumin, altered mentality and high pneumonia severity index score at admission were risk factors for mortality. In addition, severe signs of inflammation at initial presentation (at hospital days 1-4), such as high inducible protein-10 (p=0.0013), monocyte chemoattractant protein-1 (p=0.0007) and interleukin 6 (p=0.0007) concentrations, and poor viral control (high viral load at hospital days 5-10, p<0.001) without adequate antibody titres (low antibody titre at hospital days 11-16, p=0.07) during the course of disease, were associated with mortality.
DOI: 10.1136/thoraxjnl-2016-209313
PubMed: 28724637
Affiliations:
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Le document en format XML
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first="Baek-Nam" last="Kim">Baek-Nam Kim</name><affiliation><nlm:affiliation>Department of Internal Medicine, Inje University Sanggye-Paik Hospital, Seoul, Rebulic of Korea.</nlm:affiliation><wicri:noCountry code="subField">Rebulic of Korea</wicri:noCountry></affiliation></author><author><name sortKey="Choi, Hee Jung" sort="Choi, Hee Jung" uniqKey="Choi H" first="Hee Jung" last="Choi">Hee Jung Choi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Ewha Womans University Hospital, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Ewha Womans University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Shin, Eui Cheol" sort="Shin, Eui Cheol" uniqKey="Shin E" first="Eui-Cheol" last="Shin">Eui-Cheol 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Séoul</region></placeName></affiliation></author><author><name sortKey="Choi, Jae Phil" sort="Choi, Jae Phil" uniqKey="Choi J" first="Jae-Phil" last="Choi">Jae-Phil Choi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Seoul Medical Center, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Hong, Seon Hui" sort="Hong, Seon Hui" uniqKey="Hong S" first="Seon-Hui" last="Hong">Seon-Hui Hong</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Jeewon" sort="Lee, Jeewon" uniqKey="Lee J" first="Jeewon" last="Lee">Jeewon Lee</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Kwon, Ji Soo" sort="Kwon, Ji Soo" uniqKey="Kwon J" first="Ji-Soo" last="Kwon">Ji-Soo Kwon</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Sun Mi" sort="Kim, Sun Mi" uniqKey="Kim S" first="Sun-Mi" last="Kim">Sun-Mi Kim</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Se Yoon" sort="Park, Se Yoon" uniqKey="Park S" first="Se Yoon" last="Park">Se Yoon Park</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Rhee, Ji Young" sort="Rhee, Ji Young" uniqKey="Rhee J" first="Ji-Young" last="Rhee">Ji-Young Rhee</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Diseases, Department of Internal Medicine, Dankook University Hospital, Cheonan, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Infectious Diseases, Department of Internal Medicine, Dankook University Hospital, Cheonan</wicri:regionArea><wicri:noRegion>Cheonan</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Baek Nam" sort="Kim, Baek Nam" uniqKey="Kim B" first="Baek-Nam" last="Kim">Baek-Nam Kim</name><affiliation><nlm:affiliation>Department of Internal Medicine, Inje University Sanggye-Paik Hospital, Seoul, Rebulic of Korea.</nlm:affiliation><wicri:noCountry code="subField">Rebulic of Korea</wicri:noCountry></affiliation></author><author><name sortKey="Choi, Hee Jung" sort="Choi, Hee Jung" uniqKey="Choi H" first="Hee Jung" last="Choi">Hee Jung Choi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Ewha Womans University Hospital, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Ewha Womans University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Shin, Eui Cheol" sort="Shin, Eui Cheol" uniqKey="Shin E" first="Eui-Cheol" last="Shin">Eui-Cheol Shin</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Pai, Hyunjoo" sort="Pai, Hyunjoo" uniqKey="Pai H" first="Hyunjoo" last="Pai">Hyunjoo Pai</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Han Yang University Hospital, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Han Yang University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Su Hyung" sort="Park, Su Hyung" uniqKey="Park S" first="Su-Hyung" last="Park">Su-Hyung Park</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Sung Han" sort="Kim, Sung Han" uniqKey="Kim S" first="Sung-Han" last="Kim">Sung-Han Kim</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Thorax</title><idno type="eISSN">1468-3296</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Viral (blood)</term><term>Coronavirus (genetics)</term><term>Coronavirus Infections (mortality)</term><term>Cytokines (blood)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Real-Time Polymerase Chain Reaction</term><term>Risk Factors</term><term>Survival Rate</term><term>Viral Load (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Anticorps antiviraux (sang)</term><term>Charge virale (génétique)</term><term>Coronavirus (génétique)</term><term>Cytokines (sang)</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus (mortalité)</term><term>Mâle</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Taux de survie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term><term>Viral Load</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Charge virale</term><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Cytokines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Real-Time Polymerase Chain Reaction</term><term>Risk Factors</term><term>Survival Rate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Taux de survie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We evaluated the clinical characteristics, cytokine/chemokine concentrations, viral shedding and antibody kinetics in 30 patients with Middle East respiratory syndrome (MERS), including 6 non-survivors admitted to 3 MERS-designated hospitals. Old age, low albumin, altered mentality and high pneumonia severity index score at admission were risk factors for mortality. In addition, severe signs of inflammation at initial presentation (at hospital days 1-4), such as high inducible protein-10 (p=0.0013), monocyte chemoattractant protein-1 (p=0.0007) and interleukin 6 (p=0.0007) concentrations, and poor viral control (high viral load at hospital days 5-10, p<0.001) without adequate antibody titres (low antibody titre at hospital days 11-16, p=0.07) during the course of disease, were associated with mortality.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><noCountry><name sortKey="Kim, Baek Nam" sort="Kim, Baek Nam" uniqKey="Kim B" first="Baek-Nam" last="Kim">Baek-Nam Kim</name></noCountry><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Hong, Ki Ho" sort="Hong, Ki Ho" uniqKey="Hong K" first="Ki-Ho" last="Hong">Ki-Ho Hong</name></region><name sortKey="Choi, Hee Jung" sort="Choi, Hee Jung" uniqKey="Choi H" first="Hee Jung" last="Choi">Hee Jung Choi</name><name sortKey="Choi, Jae Phil" sort="Choi, Jae Phil" uniqKey="Choi J" first="Jae-Phil" last="Choi">Jae-Phil Choi</name><name sortKey="Hong, Seon Hui" sort="Hong, Seon Hui" uniqKey="Hong S" first="Seon-Hui" last="Hong">Seon-Hui Hong</name><name sortKey="Kim, Sun Mi" sort="Kim, Sun Mi" uniqKey="Kim S" first="Sun-Mi" last="Kim">Sun-Mi Kim</name><name sortKey="Kim, Sung Han" sort="Kim, Sung Han" uniqKey="Kim S" first="Sung-Han" last="Kim">Sung-Han Kim</name><name sortKey="Kwon, Ji Soo" sort="Kwon, Ji Soo" uniqKey="Kwon J" first="Ji-Soo" last="Kwon">Ji-Soo Kwon</name><name sortKey="Lee, Jeewon" sort="Lee, Jeewon" uniqKey="Lee J" first="Jeewon" last="Lee">Jeewon Lee</name><name sortKey="Pai, Hyunjoo" sort="Pai, Hyunjoo" uniqKey="Pai H" first="Hyunjoo" last="Pai">Hyunjoo Pai</name><name sortKey="Park, Se Yoon" sort="Park, Se Yoon" uniqKey="Park S" first="Se Yoon" last="Park">Se Yoon Park</name><name sortKey="Park, Su Hyung" sort="Park, Su Hyung" uniqKey="Park S" first="Su-Hyung" last="Park">Su-Hyung Park</name><name sortKey="Rhee, Ji Young" sort="Rhee, Ji Young" uniqKey="Rhee J" first="Ji-Young" last="Rhee">Ji-Young Rhee</name><name sortKey="Shin, Eui Cheol" sort="Shin, Eui Cheol" uniqKey="Shin E" first="Eui-Cheol" last="Shin">Eui-Cheol Shin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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