Predictors of mortality in Middle East respiratory syndrome (MERS).
Identifieur interne : 000804 ( PubMed/Checkpoint ); précédent : 000803; suivant : 000805Predictors of mortality in Middle East respiratory syndrome (MERS).
Auteurs : Ki-Ho Hong [Corée du Sud] ; Jae-Phil Choi [Corée du Sud] ; Seon-Hui Hong [Corée du Sud] ; Jeewon Lee [Corée du Sud] ; Ji-Soo Kwon [Corée du Sud] ; Sun-Mi Kim [Corée du Sud] ; Se Yoon Park [Corée du Sud] ; Ji-Young Rhee [Corée du Sud] ; Baek-Nam Kim ; Hee Jung Choi [Corée du Sud] ; Eui-Cheol Shin [Corée du Sud] ; Hyunjoo Pai [Corée du Sud] ; Su-Hyung Park [Corée du Sud] ; Sung-Han Kim [Corée du Sud]Source :
- Thorax [ 1468-3296 ] ; 2018.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Charge virale, Coronavirus.
- mortalité : Infections à coronavirus.
- sang : Anticorps antiviraux, Cytokines.
- Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Mâle, Réaction de polymérisation en chaine en temps réel, Taux de survie.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Antibodies, Viral, Cytokines.
- genetics : Coronavirus, Viral Load.
- mortality : Coronavirus Infections.
- Female, Humans, Male, Middle Aged, Real-Time Polymerase Chain Reaction, Risk Factors, Survival Rate.
Abstract
We evaluated the clinical characteristics, cytokine/chemokine concentrations, viral shedding and antibody kinetics in 30 patients with Middle East respiratory syndrome (MERS), including 6 non-survivors admitted to 3 MERS-designated hospitals. Old age, low albumin, altered mentality and high pneumonia severity index score at admission were risk factors for mortality. In addition, severe signs of inflammation at initial presentation (at hospital days 1-4), such as high inducible protein-10 (p=0.0013), monocyte chemoattractant protein-1 (p=0.0007) and interleukin 6 (p=0.0007) concentrations, and poor viral control (high viral load at hospital days 5-10, p<0.001) without adequate antibody titres (low antibody titre at hospital days 11-16, p=0.07) during the course of disease, were associated with mortality.
DOI: 10.1136/thoraxjnl-2016-209313
PubMed: 28724637
Affiliations:
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pubmed:28724637Le document en format XML
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<term>Infections à coronavirus (mortalité)</term>
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<front><div type="abstract" xml:lang="en">We evaluated the clinical characteristics, cytokine/chemokine concentrations, viral shedding and antibody kinetics in 30 patients with Middle East respiratory syndrome (MERS), including 6 non-survivors admitted to 3 MERS-designated hospitals. Old age, low albumin, altered mentality and high pneumonia severity index score at admission were risk factors for mortality. In addition, severe signs of inflammation at initial presentation (at hospital days 1-4), such as high inducible protein-10 (p=0.0013), monocyte chemoattractant protein-1 (p=0.0007) and interleukin 6 (p=0.0007) concentrations, and poor viral control (high viral load at hospital days 5-10, p<0.001) without adequate antibody titres (low antibody titre at hospital days 11-16, p=0.07) during the course of disease, were associated with mortality.</div>
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<Abstract><AbstractText>We evaluated the clinical characteristics, cytokine/chemokine concentrations, viral shedding and antibody kinetics in 30 patients with Middle East respiratory syndrome (MERS), including 6 non-survivors admitted to 3 MERS-designated hospitals. Old age, low albumin, altered mentality and high pneumonia severity index score at admission were risk factors for mortality. In addition, severe signs of inflammation at initial presentation (at hospital days 1-4), such as high inducible protein-10 (p=0.0013), monocyte chemoattractant protein-1 (p=0.0007) and interleukin 6 (p=0.0007) concentrations, and poor viral control (high viral load at hospital days 5-10, p<0.001) without adequate antibody titres (low antibody titre at hospital days 11-16, p=0.07) during the course of disease, were associated with mortality.</AbstractText>
<CopyrightInformation>© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.</CopyrightInformation>
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<ForeName>Ki-Ho</ForeName>
<Initials>KH</Initials>
<AffiliationInfo><Affiliation>Department of Laboratory Medicine, Seoul Medical Center, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y" EqualContrib="Y"><LastName>Choi</LastName>
<ForeName>Jae-Phil</ForeName>
<Initials>JP</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul Medical Center, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y" EqualContrib="Y"><LastName>Hong</LastName>
<ForeName>Seon-Hui</ForeName>
<Initials>SH</Initials>
<AffiliationInfo><Affiliation>Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Jeewon</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kwon</LastName>
<ForeName>Ji-Soo</ForeName>
<Initials>JS</Initials>
<AffiliationInfo><Affiliation>Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Sun-Mi</ForeName>
<Initials>SM</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Se Yoon</ForeName>
<Initials>SY</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rhee</LastName>
<ForeName>Ji-Young</ForeName>
<Initials>JY</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Internal Medicine, Dankook University Hospital, Cheonan, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Baek-Nam</ForeName>
<Initials>BN</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Inje University Sanggye-Paik Hospital, Seoul, Rebulic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Choi</LastName>
<ForeName>Hee Jung</ForeName>
<Initials>HJ</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Ewha Womans University Hospital, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shin</LastName>
<ForeName>Eui-Cheol</ForeName>
<Initials>EC</Initials>
<AffiliationInfo><Affiliation>Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pai</LastName>
<ForeName>Hyunjoo</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Han Yang University Hospital, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Su-Hyung</ForeName>
<Initials>SH</Initials>
<AffiliationInfo><Affiliation>Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Sung-Han</ForeName>
<Initials>SH</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016422">Letter</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>07</Month>
<Day>19</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Thorax</MedlineTA>
<NlmUniqueID>0417353</NlmUniqueID>
<ISSNLinking>0040-6376</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017934" MajorTopicYN="N">Coronavirus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">infection control</Keyword>
<Keyword MajorTopicYN="Y">respiratory infection</Keyword>
<Keyword MajorTopicYN="Y">viral infection</Keyword>
</KeywordList>
<CoiStatement>Competing interests: None declared.</CoiStatement>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>08</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2017</Year>
<Month>05</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>05</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>7</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>11</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>7</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28724637</ArticleId>
<ArticleId IdType="pii">thoraxjnl-2016-209313</ArticleId>
<ArticleId IdType="doi">10.1136/thoraxjnl-2016-209313</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Corée du Sud</li>
</country>
<region><li>Région capitale de Séoul</li>
</region>
<settlement><li>Séoul</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Kim, Baek Nam" sort="Kim, Baek Nam" uniqKey="Kim B" first="Baek-Nam" last="Kim">Baek-Nam Kim</name>
</noCountry>
<country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Hong, Ki Ho" sort="Hong, Ki Ho" uniqKey="Hong K" first="Ki-Ho" last="Hong">Ki-Ho Hong</name>
</region>
<name sortKey="Choi, Hee Jung" sort="Choi, Hee Jung" uniqKey="Choi H" first="Hee Jung" last="Choi">Hee Jung Choi</name>
<name sortKey="Choi, Jae Phil" sort="Choi, Jae Phil" uniqKey="Choi J" first="Jae-Phil" last="Choi">Jae-Phil Choi</name>
<name sortKey="Hong, Seon Hui" sort="Hong, Seon Hui" uniqKey="Hong S" first="Seon-Hui" last="Hong">Seon-Hui Hong</name>
<name sortKey="Kim, Sun Mi" sort="Kim, Sun Mi" uniqKey="Kim S" first="Sun-Mi" last="Kim">Sun-Mi Kim</name>
<name sortKey="Kim, Sung Han" sort="Kim, Sung Han" uniqKey="Kim S" first="Sung-Han" last="Kim">Sung-Han Kim</name>
<name sortKey="Kwon, Ji Soo" sort="Kwon, Ji Soo" uniqKey="Kwon J" first="Ji-Soo" last="Kwon">Ji-Soo Kwon</name>
<name sortKey="Lee, Jeewon" sort="Lee, Jeewon" uniqKey="Lee J" first="Jeewon" last="Lee">Jeewon Lee</name>
<name sortKey="Pai, Hyunjoo" sort="Pai, Hyunjoo" uniqKey="Pai H" first="Hyunjoo" last="Pai">Hyunjoo Pai</name>
<name sortKey="Park, Se Yoon" sort="Park, Se Yoon" uniqKey="Park S" first="Se Yoon" last="Park">Se Yoon Park</name>
<name sortKey="Park, Su Hyung" sort="Park, Su Hyung" uniqKey="Park S" first="Su-Hyung" last="Park">Su-Hyung Park</name>
<name sortKey="Rhee, Ji Young" sort="Rhee, Ji Young" uniqKey="Rhee J" first="Ji-Young" last="Rhee">Ji-Young Rhee</name>
<name sortKey="Shin, Eui Cheol" sort="Shin, Eui Cheol" uniqKey="Shin E" first="Eui-Cheol" last="Shin">Eui-Cheol Shin</name>
</country>
</tree>
</affiliations>
</record>
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