Curation
Accueil
Racine
Curation
Exploration
Accueil
Racine
Accueil
Racine

Serveur d'exploration MERS

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

[Synthesis of modified oligodeoxyribonucleotides containing 9-(2'-amino-2'-deoxy-beta-D-arabinofuranosyl)adenine].

Identifieur interne : 003C01 ( Main/Curation ); précédent : 003C00; suivant : 003C02

[Synthesis of modified oligodeoxyribonucleotides containing 9-(2'-amino-2'-deoxy-beta-D-arabinofuranosyl)adenine].

Auteurs : E M Zubin ; S I Antsypovich ; T S Oretskaya ; E A Romanova ; E M Volkov ; V N Tashlitski ; Z A Shabarova

Source :

RBID : pubmed:9490617

Descripteurs français

English descriptors

Abstract

A method for preparing a modified derivative of 2'-amino-2'-deoxy-arabino-adenosine ready for directed insertion into an oligonucleotide chain during solid-phase synthesis was elaborated. A series of the title oligonucleotides (6-25-mers) containing a 2'-amino-2'-deoxy-arabino-adenosine fragment were prepared. A high reactivity of the 2'-amino group during the acylation with carboxylic acid anhydrides was demonstrated. It was shown that the insertion of the modified fragments into oligonucleotides did not inhibit the formation of the DNA duplex.

PubMed: 9490617

Links toward previous steps (curation, corpus...)

Links to Exploration step

pubmed:9490617

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">[Synthesis of modified oligodeoxyribonucleotides containing 9-(2'-amino-2'-deoxy-beta-D-arabinofuranosyl)adenine].</title>
<author>
<name sortKey="Zubin, E M" sort="Zubin, E M" uniqKey="Zubin E" first="E M" last="Zubin">E M Zubin</name>
</author>
<author>
<name sortKey="Antsypovich, S I" sort="Antsypovich, S I" uniqKey="Antsypovich S" first="S I" last="Antsypovich">S I Antsypovich</name>
</author>
<author>
<name sortKey="Oretskaya, T S" sort="Oretskaya, T S" uniqKey="Oretskaya T" first="T S" last="Oretskaya">T S Oretskaya</name>
</author>
<author>
<name sortKey="Romanova, E A" sort="Romanova, E A" uniqKey="Romanova E" first="E A" last="Romanova">E A Romanova</name>
</author>
<author>
<name sortKey="Volkov, E M" sort="Volkov, E M" uniqKey="Volkov E" first="E M" last="Volkov">E M Volkov</name>
</author>
<author>
<name sortKey="Tashlitski, V N" sort="Tashlitski, V N" uniqKey="Tashlitski V" first="V N" last="Tashlitski">V N Tashlitski</name>
</author>
<author>
<name sortKey="Shabarova, Z A" sort="Shabarova, Z A" uniqKey="Shabarova Z" first="Z A" last="Shabarova">Z A Shabarova</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="1997">1997</date>
<idno type="RBID">pubmed:9490617</idno>
<idno type="pmid">9490617</idno>
<idno type="wicri:Area/PubMed/Corpus">002702</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002702</idno>
<idno type="wicri:Area/PubMed/Curation">002702</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002702</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002560</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002560</idno>
<idno type="wicri:Area/Ncbi/Merge">002B02</idno>
<idno type="wicri:Area/Ncbi/Curation">002B02</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002B02</idno>
<idno type="wicri:doubleKey">0132-3423:1997:Zubin E:synthesis:of:modified</idno>
<idno type="wicri:Area/Main/Merge">003C52</idno>
<idno type="wicri:Area/Main/Curation">003C01</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">[Synthesis of modified oligodeoxyribonucleotides containing 9-(2'-amino-2'-deoxy-beta-D-arabinofuranosyl)adenine].</title>
<author>
<name sortKey="Zubin, E M" sort="Zubin, E M" uniqKey="Zubin E" first="E M" last="Zubin">E M Zubin</name>
</author>
<author>
<name sortKey="Antsypovich, S I" sort="Antsypovich, S I" uniqKey="Antsypovich S" first="S I" last="Antsypovich">S I Antsypovich</name>
</author>
<author>
<name sortKey="Oretskaya, T S" sort="Oretskaya, T S" uniqKey="Oretskaya T" first="T S" last="Oretskaya">T S Oretskaya</name>
</author>
<author>
<name sortKey="Romanova, E A" sort="Romanova, E A" uniqKey="Romanova E" first="E A" last="Romanova">E A Romanova</name>
</author>
<author>
<name sortKey="Volkov, E M" sort="Volkov, E M" uniqKey="Volkov E" first="E M" last="Volkov">E M Volkov</name>
</author>
<author>
<name sortKey="Tashlitski, V N" sort="Tashlitski, V N" uniqKey="Tashlitski V" first="V N" last="Tashlitski">V N Tashlitski</name>
</author>
<author>
<name sortKey="Shabarova, Z A" sort="Shabarova, Z A" uniqKey="Shabarova Z" first="Z A" last="Shabarova">Z A Shabarova</name>
</author>
</analytic>
<series>
<title level="j">Bioorganicheskaia khimiia</title>
<idno type="ISSN">0132-3423</idno>
<imprint>
<date when="1997" type="published">1997</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Acylation</term>
<term>Amines (chemistry)</term>
<term>Anhydrides (chemistry)</term>
<term>DNA (chemistry)</term>
<term>Oligodeoxyribonucleotides (chemical synthesis)</term>
<term>Oligodeoxyribonucleotides (chemistry)</term>
<term>Vidarabine (chemistry)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>ADN ()</term>
<term>Acylation</term>
<term>Amines ()</term>
<term>Anhydrides ()</term>
<term>Oligodésoxyribonucléotides ()</term>
<term>Oligodésoxyribonucléotides (synthèse chimique)</term>
<term>Vidarabine ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en">
<term>Oligodeoxyribonucleotides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en">
<term>Amines</term>
<term>Anhydrides</term>
<term>DNA</term>
<term>Oligodeoxyribonucleotides</term>
<term>Vidarabine</term>
</keywords>
<keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr">
<term>Oligodésoxyribonucléotides</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Acylation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>ADN</term>
<term>Acylation</term>
<term>Amines</term>
<term>Anhydrides</term>
<term>Oligodésoxyribonucléotides</term>
<term>Vidarabine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">A method for preparing a modified derivative of 2'-amino-2'-deoxy-arabino-adenosine ready for directed insertion into an oligonucleotide chain during solid-phase synthesis was elaborated. A series of the title oligonucleotides (6-25-mers) containing a 2'-amino-2'-deoxy-arabino-adenosine fragment were prepared. A high reactivity of the 2'-amino group during the acylation with carboxylic acid anhydrides was demonstrated. It was shown that the insertion of the modified fragments into oligonucleotides did not inhibit the formation of the DNA duplex.</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003C01 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 003C01 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Main
   |étape=   Curation
   |type=    RBID
   |clé=     pubmed:9490617
   |texte=   [Synthesis of modified oligodeoxyribonucleotides containing 9-(2'-amino-2'-deoxy-beta-D-arabinofuranosyl)adenine].
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i   -Sk "pubmed:9490617" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1
Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021